Hepatitis B surface antigen and hepatitis B RNA changes in HIV/hepatitis B virus co-infected participants receiving hepatitis B virus-active antiretroviral therapy
Conclusion:
This study supports current recommendations of TDF-based DUAL-HBV active ART for initial use in HIV/HBV co-infection. HBV RNA could be a useful marker of treatment response in HIV/HBV co-infected patients on HBV-active ART. (Source: AIDS)
Source: AIDS - June 1, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Interleukin-17A is associated with flow-mediated dilation and interleukin-4 with carotid plaque in persons with HIV
Conclusion:
Th17/ILC3 and Th2/ILC2-mediated immune mechanisms may have distinct roles in endothelial dysfunction and atherosclerotic plaque formation, respectively, in PWH. (Source: AIDS)
Source: AIDS - June 1, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Posttreatment monitoring by ASCL1/LHX8 methylation analysis in women with HIV treated for cervical intraepithelial neoplasia grade 2/3
Conclusion:
A negative ASCL1/LHX8 methylation test in follow-up is associated with a low rCIN2/3 risk and could serve as an objective test of cure and well tolerated alternative for HPV and/or cytology screening in the posttreatment monitoring of WWH. (Source: AIDS)
Source: AIDS - June 1, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Cardiovascular effects of intrauterine exposure to maternal HIV and antiretroviral therapy in Ethiopian infants followed from fetal life
Conclusion:
In offspring of Ethiopian women, intrauterine exposure to HIV and ART were not associated with cardiovascular changes from fetal life up to infanthood. (Source: AIDS)
Source: AIDS - June 1, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Tenofovir diphosphate in dried blood spots predicts future viremia in persons with HIV taking antiretroviral therapy in South Africa
Objectives:
Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is used as a biomarker of antiretroviral therapy (ART) adherence. Recent treatment studies have shown that TFV-DP predicts future viremia in persons with HIV (PWH) but there are few data from high-burden settings. We investigated whether TFV-DP in DBS predicts future viral breakthrough in South African PWH.
Design:
Prospective observational cohort.
Methods:
We enrolled 250 adults receiving tenofovir-containing regimens, currently virally suppressed ( (Source: AIDS)
Source: AIDS - June 1, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
HIV-1 pretreatment drug resistance negatively impacts outcomes of first-line antiretroviral treatment
Conclusion:
PDR was detected in 13% of study participants. PDR significantly increased the risk of virological failure of EFV-based ART. Accumulation of resistance at failure and inability to achieve virological resuppression illustrates the profound impact of PDR on treatment outcomes. (Source: AIDS)
Source: AIDS - June 1, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Plasma d-amino acids are associated with markers of immune activation and organ dysfunction in people with HIV
Conclusion:
Plasma d-AAs are associated with chronological age and correlated with markers of immune activation and organ decline, though variably, in PWH and controls. Their role in the biology of aging warrants further investigation. (Source: AIDS)
Source: AIDS - June 1, 2022 Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research
Cytokines in HIV infection: authors’ reply
No abstract available (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: Correspondence Source Type: research
Cytokines in HIV infection: different methods of assessment require different interpretations
No abstract available (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: Correspondence Source Type: research
Risk factors for atrial fibrillation in a multicenter United States clinical cohort of people with HIV infection
To assess atrial fibrillation risk factors in people with HIV, we identified incident atrial fibrillation in a large clinical cohort of people receiving care. Compared with 970 controls without atrial fibrillation, the 97 with adjudicated incident atrial fibrillation were older, less likely Hispanic, and had more coronary disease, heart failure, and chronic obstructive pulmonary disease. In multivariable analysis, nonuse of antiretroviral therapy and prescription of antiretroviral regimens with multiple core agents were associated with increased atrial fibrillation risk. (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: Research Letter Source Type: research
Air pollution and preclinical atherosclerotic cardiovascular disease in adolescents living with HIV: an opportunity for prevention
No abstract available (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: Editorial Comments Source Type: research
Strategies to improve HIV care outcomes for people with HIV who are out of care: the need for well designed health systems
No abstract available (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: Editorial Comments Source Type: research
Urine tuberculosis diagnostics in patients with advanced HIV
No abstract available (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: Editorial Comments Source Type: research
Using molecular epidemiology to trace the history of the injection-related HIV epidemic in New York City, 1985–2019
Conclusion:
These trends suggest a transition from parenteral to sexual transmission among PWID in NYC, suggesting that harm reduction, syringe exchange programs, and legalization of over-the-counter syringe sales in pharmacies have mitigated HIV risk by facilitating well tolerated injection among new PWID. (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
The impact of syringe services program closure on the risk of rebound HIV outbreaks among people who inject drugs: a modeling study
Conclusion:
Our analysis suggests that temporary interruption and permanent closure of existing SSPs operating in rural United States may lead to ‘rebound’ HIV outbreaks among PWID. To reach and sustain HIV epidemic control, it will be necessary to maintain existing and implement new SSPs in combination with other prevention interventions. (Source: AIDS)
Source: AIDS - May 1, 2022 Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
