Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection
Conclusion:
We identified potentially important differences in SARS-CoV-2-specific CD4+ and CD8+ T cells in PWH and HIV-negative participants that might have implications for long-term immunity conferred by natural infection. HIV status strongly predicted the presence of PASC. Larger and more detailed studies of PASC in PWH are urgently needed. (Source: AIDS)
Source: AIDS - September 10, 2022 Category: Infectious Diseases Tags: FAST TRACK Source Type: research
Vertical anti-SARS-CoV-2 monoclonal antibody transfer from mothers to HIV-exposed and unexposed infants
No abstract available (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: Correspondence Source Type: research
New diagnosis of HIV with Cryptococcus neoformans infection presenting as a pleural syndrome
No abstract available (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: Correspondence Source Type: research
Mitoquinone mesylate attenuates brain inflammation in humanized mouse model of chronic HIV infection
No abstract available (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: Correspondence Source Type: research
Universal HIV screening in the emergency department: an interrupted time series analysis
We performed a calendar-matched, 12-month, before (November 27, 2017 to November 26, 2018) and after (November 27, 2018 to November 26, 2019) study, to assess the utility of an emergency department-based HIV screening program. There were 710 and 14 335 patients screened for HIV during the pre and post-best practice alert (BPA) periods, respectively, representing more than a 20-fold increase in HIV screening following BPA implementation. Total HIV positive tests increased 5-fold following BPA implementation. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: Research Letters Source Type: research
Effects of the androgen receptor inhibitor enzalutamide on the pharmacokinetics of dolutegravir and tenofovir: a case report
Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug–drug interactions with some antiretrovirals. No major differences on the main dolutegravir and tenofovir pharmokinetocs were observed in this case report when comparing baseline assessments with those following the introduction of enzalutamide, also when given at higher doses, in a 63-year-old male living with HIV and prostate cancer. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: Research Letters Source Type: research
HIV accelerates clonal hematopoiesis and cardiovascular aging
No abstract available (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: Editorial Comments Source Type: research
Can simplified antiretroviral drug combination therapies resist resistance?
No abstract available (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: Editorial Comments Source Type: research
Transaminitis prevalence among HIV-infected adults eligible for tuberculosis preventive therapy
Conclusion:
Prevalence of severe transaminitis was low among PWH without culture-confirmed TB in this setting, and is therefore, unlikely to be a major barrier to scaling-up TPT. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: CONCISE COMMUNICATIONS Source Type: research
Drug use stigma, antiretroviral therapy use, and HIV viral suppression in a community-based sample of people with HIV who inject drugs
Conclusion:
Drug use stigma may be a barrier to HIV viral suppression among people with HIV who inject drugs, thereby hindering efforts to achieve HIV control. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: CONCISE COMMUNICATIONS Source Type: research
Industrial mining and HIV risk: evidence from 39 mine openings across 16 countries in sub-Saharan Africa
Conclusion:
The findings suggest that in our sample of households surrounding industrial mines, HIV infection risks substantially increase upon mine opening. Existing strategies for addressing mining-related risks for HIV transmission seem to be insufficient. Further efforts for mitigating and monitoring impacts of mines are needed. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection
Conclusion:
The identification of DNAm sites independently predicting survival may improve our understanding of prognosis and potential therapeutic targets among PWH. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
Patterns of objectively measured physical activity differ between men living with and without HIV
Conclusions:
Physical activity measures differed significantly by HIV serostatus and VL. Higher L6 among PLWH with detectable VL may indicate reduced amount or quality of sleep compared to PLWH without detectable VL and PWOH. Lower M10 among PLWH indicates lower amounts of physical activity compared to PWOH. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
High seroconversion rate and SARS-CoV-2 Delta neutralization in people with HIV vaccinated with BNT162b2
Objectives:
To assess humoral responses to SARS-CoV-2 Delta-variant in people with HIV (PWH) after BNT162b2-vaccination.
Design:
Multicenter cohort study of PWH with CD4+ cell count less than 500 cells/μl and viral load less than 50 copies/ml on stable antiretroviral therapy for at least 3 months.
Methods:
Anti-SARS-CoV-2 receptor-binding-domain IgG antibodies (anti-RBD IgG) were quantified and neutralization capacity was evaluated by ELISA/GenScript and virus-neutralization-test against the D614G-strain, beta and delta variants before vaccination (day 0) and 1 month after complete schedule (M1).
Re...
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Neurodevelopmental outcomes of HIV/antiretroviral drug perinatally exposed uninfected children aged 3–6 years
Conclusions:
Among a large cohort of 3–6 year old CAHEU from eastern/southern Africa, group-mean composite ND scores averaged within the low-normal range; with differences noted by country, maternal clinical and socioeconomic factors. (Source: AIDS)
Source: AIDS - August 27, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
