Tenofovir diphosphate in dried blood spots predicts future viremia in persons with HIV taking antiretroviral therapy in South Africa

Objectives: Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is used as a biomarker of antiretroviral therapy (ART) adherence. Recent treatment studies have shown that TFV-DP predicts future viremia in persons with HIV (PWH) but there are few data from high-burden settings. We investigated whether TFV-DP in DBS predicts future viral breakthrough in South African PWH. Design: Prospective observational cohort. Methods: We enrolled 250 adults receiving tenofovir-containing regimens, currently virally suppressed (
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research