Ultrasound-nanovesicles interplay for theranostics
Adv Drug Deliv Rev. 2024 Feb;205:115176. doi: 10.1016/j.addr.2023.115176. Epub 2024 Jan 9.ABSTRACTNanovesicles (NVs) are widely used in the treatment and diagnosis of diseases due to their excellent vascular permeability, good biocompatibility, high loading capacity, and easy functionalization. However, their yield and in vivo penetration depth limitations and their complex preparation processes still constrain their application and development. Ultrasound, as a fundamental external stimulus with deep tissue penetration, concentrated energy sources, and good safety, has been proven to be a patient-friendly and highly effic...
Source: Advanced Drug Delivery Reviews - January 10, 2024 Category: Drugs & Pharmacology Authors: Jingyi Liu Qing You Fuming Liang Lilusi Ma Ling Zhu Chen Wang Yanlian Yang Source Type: research
Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery
Adv Drug Deliv Rev. 2024 Jan 8;206:115178. doi: 10.1016/j.addr.2023.115178. Online ahead of print.ABSTRACTUltrasound-responsive agents have shown great potential as targeted drug delivery agents, effectively augmenting cell permeability and facilitating drug absorption. This review focuses on two specific agents, microbubbles and nanodroplets, and provides a sequential overview of their drug delivery process. Particular emphasis is given to the mechanical response of the agents under ultrasound, and the subsequent physical and biological effects on the cells. Finally, the state-of-the-art in their pre-clinical and clinical...
Source: Advanced Drug Delivery Reviews - January 10, 2024 Category: Drugs & Pharmacology Authors: Gazendra Shakya Marco Cattaneo Giulia Guerriero Anunay Prasanna Samuele Fiorini Outi Supponen Source Type: research
Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions
We describe the main principles and mechanisms underlying each method before diving into the corresponding biomedical applications. We identify areas of improvement as well as promising approaches with clinical translation potential.PMID:38184194 | DOI:10.1016/j.addr.2023.115177 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 6, 2024 Category: Drugs & Pharmacology Authors: Maria Eleni Karakatsani H éctor Estrada Zhenyue Chen Shy Shoham Xos é Luís Deán-Ben Daniel Razansky Source Type: research
Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions
We describe the main principles and mechanisms underlying each method before diving into the corresponding biomedical applications. We identify areas of improvement as well as promising approaches with clinical translation potential.PMID:38184194 | DOI:10.1016/j.addr.2023.115177 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 6, 2024 Category: Drugs & Pharmacology Authors: Maria Eleni Karakatsani H éctor Estrada Beltrán Zhenyue Chen Shy Shoham Xos é Luís Deán-Ben Daniel Razansky Source Type: research
Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions
We describe the main principles and mechanisms underlying each method before diving into the corresponding biomedical applications. We identify areas of improvement as well as promising approaches with clinical translation potential.PMID:38184194 | DOI:10.1016/j.addr.2023.115177 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 6, 2024 Category: Drugs & Pharmacology Authors: Maria Eleni Karakatsani H éctor Estrada Beltrán Zhenyue Chen Shy Shoham Xos é Luís Deán-Ben Daniel Razansky Source Type: research
Novel Discoveries and Clinical Advancements for Treating Onychomycosis: A Mechanistic Insight
Adv Drug Deliv Rev. 2023 Dec 29;205:115174. doi: 10.1016/j.addr.2023.115174. Online ahead of print.ABSTRACTOnychomycosis continues to be the most challenging disease condition for pharmaceutical scientists to develop an effective drug delivery system. Treatment challenges lie in incomplete cure and high relapse rate. Present compilation provides cumulative information on pathophysiology, diagnostic techniques, and conventional treatment strategies to manage onychomycosis. Novel technologies developed for successful delivery of antifungal molecules are also discussed in brief. Multidirectional information offered by this ar...
Source: Advanced Drug Delivery Reviews - December 31, 2023 Category: Drugs & Pharmacology Authors: Jitesh Kumar Behera Samarth Kumar Rajeev Sharma Ashay Jain Neeraj Kumar Garg Ajay Khopade Krutika K Sawant Ranjit Singh Pradip Nirbhavane Source Type: research
Novel Discoveries and Clinical Advancements for Treating Onychomycosis: A Mechanistic Insight
Adv Drug Deliv Rev. 2023 Dec 29;205:115174. doi: 10.1016/j.addr.2023.115174. Online ahead of print.ABSTRACTOnychomycosis continues to be the most challenging disease condition for pharmaceutical scientists to develop an effective drug delivery system. Treatment challenges lie in incomplete cure and high relapse rate. Present compilation provides cumulative information on pathophysiology, diagnostic techniques, and conventional treatment strategies to manage onychomycosis. Novel technologies developed for successful delivery of antifungal molecules are also discussed in brief. Multidirectional information offered by this ar...
Source: Advanced Drug Delivery Reviews - December 31, 2023 Category: Drugs & Pharmacology Authors: Jitesh Kumar Behera Samarth Kumar Rajeev Sharma Ashay Jain Neeraj Kumar Garg Ajay Khopade Krutika K Sawant Ranjit Singh Pradip Nirbhavane Source Type: research
Novel Discoveries and Clinical Advancements for Treating Onychomycosis: A Mechanistic Insight
Adv Drug Deliv Rev. 2023 Dec 29;205:115174. doi: 10.1016/j.addr.2023.115174. Online ahead of print.ABSTRACTOnychomycosis continues to be the most challenging disease condition for pharmaceutical scientists to develop an effective drug delivery system. Treatment challenges lie in incomplete cure and high relapse rate. Present compilation provides cumulative information on pathophysiology, diagnostic techniques, and conventional treatment strategies to manage onychomycosis. Novel technologies developed for successful delivery of antifungal molecules are also discussed in brief. Multidirectional information offered by this ar...
Source: Advanced Drug Delivery Reviews - December 31, 2023 Category: Drugs & Pharmacology Authors: Jitesh Kumar Behera Samarth Kumar Rajeev Sharma Ashay Jain Neeraj Kumar Garg Ajay Khopade Krutika K Sawant Ranjit Singh Pradip Nirbhavane Source Type: research
Novel Discoveries and Clinical Advancements for Treating Onychomycosis: A Mechanistic Insight
Adv Drug Deliv Rev. 2023 Dec 29:115174. doi: 10.1016/j.addr.2023.115174. Online ahead of print.ABSTRACTOnychomycosis continues to be the most challenging disease condition for pharmaceutical scientists to develop an effective drug delivery system. Treatment challenges lie in incomplete cure and high relapse rate. Present compilation provides cumulative information on pathophysiology, diagnostic techniques, and conventional treatment strategies to manage onychomycosis. Novel technologies developed for successful delivery of antifungal molecules are also discussed in brief. Multidirectional information offered by this articl...
Source: Advanced Drug Delivery Reviews - December 31, 2023 Category: Drugs & Pharmacology Authors: Jitesh Kumar Behera Samarth Kumar Rajeev Sharma Ashay Jain Neeraj Kumar Garg Ajay Khopade Krutika K Sawant Ranjit Singh Pradip Nirbhavane Source Type: research
Ultrasound Robotics for Precision Therapy
Adv Drug Deliv Rev. 2023 Dec 23:115164. doi: 10.1016/j.addr.2023.115164. Online ahead of print.ABSTRACTIn recent years, the application of microrobots in precision therapy has gained significant attention. The small size and maneuverability of these micromachines enable them to potentially access regions that are difficult to reach using traditional methods; thus, reducing off-target toxicities and maximizing treatment effectiveness. Specifically, acoustic actuation has emerged as a promising method to exert control. By harnessing the power of acoustic energy, these small machines potentially navigate the body, assemble at...
Source: Advanced Drug Delivery Reviews - December 25, 2023 Category: Drugs & Pharmacology Authors: Alexia Del Campo Fonseca Daniel Ahmed Source Type: research
Ultrasound Robotics for Precision Therapy
Adv Drug Deliv Rev. 2023 Dec 23:115164. doi: 10.1016/j.addr.2023.115164. Online ahead of print.ABSTRACTIn recent years, the application of microrobots in precision therapy has gained significant attention. The small size and maneuverability of these micromachines enable them to potentially access regions that are difficult to reach using traditional methods; thus, reducing off-target toxicities and maximizing treatment effectiveness. Specifically, acoustic actuation has emerged as a promising method to exert control. By harnessing the power of acoustic energy, these small machines potentially navigate the body, assemble at...
Source: Advanced Drug Delivery Reviews - December 25, 2023 Category: Drugs & Pharmacology Authors: Alexia Del Campo Fonseca Daniel Ahmed Source Type: research
Ultrasound Robotics for Precision Therapy
Adv Drug Deliv Rev. 2023 Dec 23:115164. doi: 10.1016/j.addr.2023.115164. Online ahead of print.ABSTRACTIn recent years, the application of microrobots in precision therapy has gained significant attention. The small size and maneuverability of these micromachines enable them to potentially access regions that are difficult to reach using traditional methods; thus, reducing off-target toxicities and maximizing treatment effectiveness. Specifically, acoustic actuation has emerged as a promising method to exert control. By harnessing the power of acoustic energy, these small machines potentially navigate the body, assemble at...
Source: Advanced Drug Delivery Reviews - December 25, 2023 Category: Drugs & Pharmacology Authors: Alexia Del Campo Fonseca Daniel Ahmed Source Type: research
Ultrasound Robotics for Precision Therapy
Adv Drug Deliv Rev. 2023 Dec 23:115164. doi: 10.1016/j.addr.2023.115164. Online ahead of print.ABSTRACTIn recent years, the application of microrobots in precision therapy has gained significant attention. The small size and maneuverability of these micromachines enable them to potentially access regions that are difficult to reach using traditional methods; thus, reducing off-target toxicities and maximizing treatment effectiveness. Specifically, acoustic actuation has emerged as a promising method to exert control. By harnessing the power of acoustic energy, these small machines potentially navigate the body, assemble at...
Source: Advanced Drug Delivery Reviews - December 25, 2023 Category: Drugs & Pharmacology Authors: Alexia Del Campo Fonseca Daniel Ahmed Source Type: research
Ultrasound Robotics for Precision Therapy
Adv Drug Deliv Rev. 2023 Dec 23:115164. doi: 10.1016/j.addr.2023.115164. Online ahead of print.ABSTRACTIn recent years, the application of microrobots in precision therapy has gained significant attention. The small size and maneuverability of these micromachines enable them to potentially access regions that are difficult to reach using traditional methods; thus, reducing off-target toxicities and maximizing treatment effectiveness. Specifically, acoustic actuation has emerged as a promising method to exert control. By harnessing the power of acoustic energy, these small machines potentially navigate the body, assemble at...
Source: Advanced Drug Delivery Reviews - December 25, 2023 Category: Drugs & Pharmacology Authors: Alexia Del Campo Fonseca Daniel Ahmed Source Type: research
Ultrasound Robotics for Precision Therapy
Adv Drug Deliv Rev. 2023 Dec 23:115164. doi: 10.1016/j.addr.2023.115164. Online ahead of print.ABSTRACTIn recent years, the application of microrobots in precision therapy has gained significant attention. The small size and maneuverability of these micromachines enable them to potentially access regions that are difficult to reach using traditional methods; thus, reducing off-target toxicities and maximizing treatment effectiveness. Specifically, acoustic actuation has emerged as a promising method to exert control. By harnessing the power of acoustic energy, these small machines potentially navigate the body, assemble at...
Source: Advanced Drug Delivery Reviews - December 25, 2023 Category: Drugs & Pharmacology Authors: Alexia Del Campo Fonseca Daniel Ahmed Source Type: research
