Engineering metabolism to modulate immunity
Adv Drug Deliv Rev. 2023 Nov 5:115122. doi: 10.1016/j.addr.2023.115122. Online ahead of print.ABSTRACTMetabolic programming and reprogramming have emerged as pivotal mechanisms for altering immune cell function. Thus, immunometabolism has become an attractive target area for treatment of immune-mediated disorders. Nonetheless, many hurdles to delivering metabolic cues persist. In this review, we consider how biomaterials are poised to transform manipulation of immune cell metabolism through integrated control of metabolic configurations to affect outcomes in autoimmunity, regeneration, transplant, and cancer. We emphasize ...
Source: Advanced Drug Delivery Reviews - November 7, 2023 Category: Drugs & Pharmacology Authors: Senta M Kapnick Corinne A Martin Christopher M Jewell Source Type: research
Engineering metabolism to modulate immunity
Adv Drug Deliv Rev. 2023 Nov 5:115122. doi: 10.1016/j.addr.2023.115122. Online ahead of print.ABSTRACTMetabolic programming and reprogramming have emerged as pivotal mechanisms for altering immune cell function. Thus, immunometabolism has become an attractive target area for treatment of immune-mediated disorders. Nonetheless, many hurdles to delivering metabolic cues persist. In this review, we consider how biomaterials are poised to transform manipulation of immune cell metabolism through integrated control of metabolic configurations to affect outcomes in autoimmunity, regeneration, transplant, and cancer. We emphasize ...
Source: Advanced Drug Delivery Reviews - November 7, 2023 Category: Drugs & Pharmacology Authors: Senta M Kapnick Corinne A Martin Christopher M Jewell Source Type: research
Cellular and molecular imaging of CAR-T cell-based immunotherapy
Adv Drug Deliv Rev. 2023 Nov 4:115135. doi: 10.1016/j.addr.2023.115135. Online ahead of print.ABSTRACTChimeric Antigen Receptor T cell (CAR-T) therapy has emerged as a transformative therapeutic strategy for hematological malignancies. However, its efficacy in treating solid tumors remains limited. An in-depth and comprehensive understanding of CAR-T cell signaling pathways and the ability to track CAR-T cell biodistribution and activation in real-time within the tumor microenvironment will be instrumental in designing the next generation of CAR-T cells for solid tumor therapy. This review summarizes the signaling network ...
Source: Advanced Drug Delivery Reviews - November 6, 2023 Category: Drugs & Pharmacology Authors: Longwei Liu Chi Woo Yoon Zhou Yuan Tianze Guo Yunjia Qu Peixiang He Xi Yu Ziyue Zhu Praopim Limsakul Yingxiao Wang Source Type: research
Cellular and molecular imaging of CAR-T cell-based immunotherapy
Adv Drug Deliv Rev. 2023 Nov 4:115135. doi: 10.1016/j.addr.2023.115135. Online ahead of print.ABSTRACTChimeric Antigen Receptor T cell (CAR-T) therapy has emerged as a transformative therapeutic strategy for hematological malignancies. However, its efficacy in treating solid tumors remains limited. An in-depth and comprehensive understanding of CAR-T cell signaling pathways and the ability to track CAR-T cell biodistribution and activation in real-time within the tumor microenvironment will be instrumental in designing the next generation of CAR-T cells for solid tumor therapy. This review summarizes the signaling network ...
Source: Advanced Drug Delivery Reviews - November 6, 2023 Category: Drugs & Pharmacology Authors: Longwei Liu Chi Woo Yoon Zhou Yuan Tianze Guo Yunjia Qu Peixiang He Xi Yu Ziyue Zhu Praopim Limsakul Yingxiao Wang Source Type: research
Overcoming biological barriers by virus-like drug particles for drug delivery
This article provides an overview of VLPs, covering their structural classifications, deliverable drugs, potential physiological barriers in drug delivery, strategies for overcoming these barriers, and future prospects.PMID:37926218 | DOI:10.1016/j.addr.2023.115134 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - November 5, 2023 Category: Drugs & Pharmacology Authors: Yu-Ling Chen Chun-Jie Bao Jia-Lun Duan Ying Xie Wan-Liang Lu Source Type: research
Overcoming biological barriers by virus-like drug particles for drug delivery
This article provides an overview of VLPs, covering their structural classifications, deliverable drugs, potential physiological barriers in drug delivery, strategies for overcoming these barriers, and future prospects.PMID:37926218 | DOI:10.1016/j.addr.2023.115134 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - November 5, 2023 Category: Drugs & Pharmacology Authors: Yu-Ling Chen Chun-Jie Bao Jia-Lun Duan Ying Xie Wan-Liang Lu Source Type: research
Ultrasound-Activatable and Skin-associated Minimally Invasive Microdevices for Smart Drug Delivery and Diagnosis
Adv Drug Deliv Rev. 2023 Nov 2:115133. doi: 10.1016/j.addr.2023.115133. Online ahead of print.ABSTRACTUltrasound-activatable and skin-associated minimally invasive microdevices (USMIMs) have garnered significant attention in the domains of smart drug delivery and biomedical diagnosis for on-demand healthcare, owing to their outstanding wearability, flexibility, and comfort. In this review, we present a comprehensive overview of the noteworthy advancements in USMIMs, with a specific focus on device design, potential applications, challenges, and future prospects. The classification of such microdevices primarily encompasses...
Source: Advanced Drug Delivery Reviews - November 4, 2023 Category: Drugs & Pharmacology Authors: Qi Zeng Guanyue Li Wei Chen Source Type: research
Nanomedicines to treat rare neurological disorders: The case of Krabbe disease
Adv Drug Deliv Rev. 2023 Oct 31;203:115132. doi: 10.1016/j.addr.2023.115132. Online ahead of print.ABSTRACTThe brain remains one of the most challenging therapeutic targets due to the low and selective permeability of the blood-brain barrier and complex architecture of the brain tissue. Nanomedicines, despite their relatively large size compared to small molecules and nucleic acids, are being heavily investigated as vehicles to delivery therapeutics into the brain. Here we elaborate on how nanomedicines may be used to treat rare neurodevelopmental disorders, using Krabbe disease (globoid cell leukodystrophy) to frame the d...
Source: Advanced Drug Delivery Reviews - November 2, 2023 Category: Drugs & Pharmacology Authors: Thomas Lee Moore Giovanna Pannuzzo Gabriella Costabile Anna Lisa Palange Raffaele Span ò Miguel Ferreira Adriana Carol Eleonora Graziano Paolo Decuzzi Venera Cardile Source Type: research
Nanomedicines to treat rare neurological disorders: The case of Krabbe disease
Adv Drug Deliv Rev. 2023 Oct 31:115132. doi: 10.1016/j.addr.2023.115132. Online ahead of print.ABSTRACTThe brain remains one of the most challenging therapeutic targets due to the low and selective permeability of the blood - brain barrier and complex architecture of the brain tissue. Nanomedicines, despite their relatively large size compared to small molecules and nucleic acids, are being heavily investigated as vehicles to delivery therapeutics into the brain. Here we elaborate on how nanomedicines may be used to treat rare neurodevelopmental disorders, using Krabbe disease (globoid cell leukodystrophy) to frame the dis...
Source: Advanced Drug Delivery Reviews - November 2, 2023 Category: Drugs & Pharmacology Authors: Thomas Lee Moore Giovanna Pannuzzo Gabriella Costabile Anna Lisa Palange Raffaele Span ò Miguel Ferreira Adriana Carol Eleonora Graziano Paolo Decuzzi Venera Cardile Source Type: research
Nanomedicines to treat rare neurological disorders: The case of Krabbe disease
Adv Drug Deliv Rev. 2023 Oct 31:115132. doi: 10.1016/j.addr.2023.115132. Online ahead of print.ABSTRACTThe brain remains one of the most challenging therapeutic targets due to the low and selective permeability of the blood - brain barrier and complex architecture of the brain tissue. Nanomedicines, despite their relatively large size compared to small molecules and nucleic acids, are being heavily investigated as vehicles to delivery therapeutics into the brain. Here we elaborate on how nanomedicines may be used to treat rare neurodevelopmental disorders, using Krabbe disease (globoid cell leukodystrophy) to frame the dis...
Source: Advanced Drug Delivery Reviews - November 2, 2023 Category: Drugs & Pharmacology Authors: Thomas Lee Moore Giovanna Pannuzzo Gabriella Costabile Anna Lisa Palange Raffaele Span ò Miguel Ferreira Adriana Carol Eleonora Graziano Paolo Decuzzi Venera Cardile Source Type: research
Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway
Adv Drug Deliv Rev. 2023 Oct 30:115130. doi: 10.1016/j.addr.2023.115130. Online ahead of print.ABSTRACTOral administration is the preferred route of drug delivery in clinical practice due to its noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal tract (GIT) plays a crucial role in facilitating the targeted delivery of oral drugs. However, the GIT presents multiple barriers that impede drug absorption, including the gastric barrier in the stomach and the mucus and epithelial barriers in the intestine. In recent decades, nanotechnology has emerged as a promising approach for overcoming th...
Source: Advanced Drug Delivery Reviews - November 1, 2023 Category: Drugs & Pharmacology Authors: Ding Wang Qi Jiang Zhefan Dong Tingting Meng Fuqiang Hu Jianwei Wang Hong Yuan Source Type: research
Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway
Adv Drug Deliv Rev. 2023 Oct 30:115130. doi: 10.1016/j.addr.2023.115130. Online ahead of print.ABSTRACTOral administration is the preferred route of drug delivery in clinical practice due to its noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal tract (GIT) plays a crucial role in facilitating the targeted delivery of oral drugs. However, the GIT presents multiple barriers that impede drug absorption, including the gastric barrier in the stomach and the mucus and epithelial barriers in the intestine. In recent decades, nanotechnology has emerged as a promising approach for overcoming th...
Source: Advanced Drug Delivery Reviews - November 1, 2023 Category: Drugs & Pharmacology Authors: Ding Wang Qi Jiang Zhefan Dong Tingting Meng Fuqiang Hu Jianwei Wang Hong Yuan Source Type: research
Injectable Systems for Long-lasting Insulin Therapy
Adv Drug Deliv Rev. 2023 Oct 26:115121. doi: 10.1016/j.addr.2023.115121. Online ahead of print.ABSTRACTInsulin therapy is the mainstay to treat diabetes charactered by hyperglycemia. However, its short half-life of only 4-6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue products that have up to 42 h of glycemic control. However, these insulin analogues still require once- or twice-daily injections for optimal glycemic control and have poor patient compliance and adherence issues. To achieve insulin release for mo...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kumar Kulldeep Niloy Tao L Lowe Source Type: research
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease
Adv Drug Deliv Rev. 2023 Oct 26:115117. doi: 10.1016/j.addr.2023.115117. Online ahead of print.ABSTRACTOral administration is the preferred route of administration based on the convenience for and compliance of the patient. Oral nanomedicines have been developed to overcome the limitations of free drugs and overcome gastrointestinal (GI) barriers, which are heterogeneous across healthy and diseased populations. This review aims to provide a comprehensive overview and comparison of the oral nanomedicine biointeractions in the gastrointestinal tract (GIT) in health and disease (GI and extra-GI diseases) and highlight emergin...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Cheng Chen Ana Beloqui Yining Xu Source Type: research
Emerging drug delivery systems with traditional routes - A roadmap to chronic inflammatory diseases
Adv Drug Deliv Rev. 2023 Oct 28;203:115119. doi: 10.1016/j.addr.2023.115119. Online ahead of print.ABSTRACTInflammation is prevalent and inevitable in daily life but can generally be accommodated by the immune systems. However, incapable self-healing and persistent inflammation can progress to chronic inflammation, leading to prevalent or fatal chronic diseases. This review comprehensively covers the topic of emerging drug delivery systems (DDSs) for the treatment of chronic inflammatory diseases (CIDs). First, we introduce the basic biology of the chronic inflammatory process and provide an overview of the main CIDs of th...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kiyoon Min Abhishek Sahu Sae Hyun Jeon Giyoong Tae Source Type: research
