Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release
Adv Drug Deliv Rev. 2024 Mar 2:115239. doi: 10.1016/j.addr.2024.115239. Online ahead of print.ABSTRACTThe cellular barriers are major bottlenecks for bioactive compounds entering into cells to accomplish their biological functions, which limits their biomedical applications. Nanocarriers have demonstrated high potential and benefits for encapsulating bioactive compounds and efficiently delivering them into target cells by overcoming a cascade of intracellular barriers to achieve desirable therapeutic and diagnostic effects. In this review, we introduce the cellular barriers ahead of drug delivery and nanocarriers, as well ...
Source: Advanced Drug Delivery Reviews - March 4, 2024 Category: Drugs & Pharmacology Authors: Jing Liu Horacio Cabral Peng Mi Source Type: research
Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release
Adv Drug Deliv Rev. 2024 Mar 2:115239. doi: 10.1016/j.addr.2024.115239. Online ahead of print.ABSTRACTThe cellular barriers are major bottlenecks for bioactive compounds entering into cells to accomplish their biological functions, which limits their biomedical applications. Nanocarriers have demonstrated high potential and benefits for encapsulating bioactive compounds and efficiently delivering them into target cells by overcoming a cascade of intracellular barriers to achieve desirable therapeutic and diagnostic effects. In this review, we introduce the cellular barriers ahead of drug delivery and nanocarriers, as well ...
Source: Advanced Drug Delivery Reviews - March 4, 2024 Category: Drugs & Pharmacology Authors: Jing Liu Horacio Cabral Peng Mi Source Type: research
Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends
Adv Drug Deliv Rev. 2024 Feb 27:115217. doi: 10.1016/j.addr.2024.115217. Online ahead of print.ABSTRACTThe development of innovative products for treating acute and chronic wounds has become a significant topic in healthcare, resulting in numerous products and innovations over time. The growing number of patients with comorbidities and chronic diseases, which may significantly alter, delay, or inhibit normal wound healing, has introduced considerable new challenges into the wound management scenario. Researchers in academia have quickly identified promising solutions, and many advanced wound healing materials have recently...
Source: Advanced Drug Delivery Reviews - February 29, 2024 Category: Drugs & Pharmacology Authors: Pegah Sanjarnia Mat ías L Picchio Agustin N Polegre Solis Katharina Schuhladen Patricia M Fliss Nikolaos Politakos Lutz Metterhausen Marcelo Calder ón Ernesto R Osorio-Blanco Source Type: research
Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends
Adv Drug Deliv Rev. 2024 Feb 27:115217. doi: 10.1016/j.addr.2024.115217. Online ahead of print.ABSTRACTThe development of innovative products for treating acute and chronic wounds has become a significant topic in healthcare, resulting in numerous products and innovations over time. The growing number of patients with comorbidities and chronic diseases, which may significantly alter, delay, or inhibit normal wound healing, has introduced considerable new challenges into the wound management scenario. Researchers in academia have quickly identified promising solutions, and many advanced wound healing materials have recently...
Source: Advanced Drug Delivery Reviews - February 29, 2024 Category: Drugs & Pharmacology Authors: Pegah Sanjarnia Mat ías L Picchio Agustin N Polegre Solis Katharina Schuhladen Patricia M Fliss Nikolaos Politakos Lutz Metterhausen Marcelo Calder ón Ernesto R Osorio-Blanco Source Type: research
Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends
Adv Drug Deliv Rev. 2024 Feb 27:115217. doi: 10.1016/j.addr.2024.115217. Online ahead of print.ABSTRACTThe development of innovative products for treating acute and chronic wounds has become a significant topic in healthcare, resulting in numerous products and innovations over time. The growing number of patients with comorbidities and chronic diseases, which may significantly alter, delay, or inhibit normal wound healing, has introduced considerable new challenges into the wound management scenario. Researchers in academia have quickly identified promising solutions, and many advanced wound healing materials have recently...
Source: Advanced Drug Delivery Reviews - February 29, 2024 Category: Drugs & Pharmacology Authors: Pegah Sanjarnia Mat ías L Picchio Agustin N Polegre Solis Katharina Schuhladen Patricia M Fliss Nikolaos Politakos Lutz Metterhausen Marcelo Calder ón Ernesto R Osorio-Blanco Source Type: research
Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems
We present parallel developmental trajectories involving myelination that correlate with the onset of cognitive impairment in neurodevelopmental disorders and discuss the key challenges in the treatment of these chronic disorders. Recent developments in drug repurposing and nano/micro particle-based therapies are reviewed as a possible pathway to circumvent some of the main hurdles associated to the early intervention - patient's adherence and compliance, side effects, relapse - and faster route to possible treatment of these disorders. The strategy of drug encapsulation overcomes drug solubility and metabolism, with the p...
Source: Advanced Drug Delivery Reviews - February 25, 2024 Category: Drugs & Pharmacology Authors: May Rokach Corinne Portioli Sayanti Brahmachari Bianca Martins Estev ão Paolo Decuzzi Boaz Barak Source Type: research
Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems
We present parallel developmental trajectories involving myelination that correlate with the onset of cognitive impairment in neurodevelopmental disorders and discuss the key challenges in the treatment of these chronic disorders. Recent developments in drug repurposing and nano/micro particle-based therapies are reviewed as a possible pathway to circumvent some of the main hurdles associated to the early intervention - patient's adherence and compliance, side effects, relapse - and faster route to possible treatment of these disorders. The strategy of drug encapsulation overcomes drug solubility and metabolism, with the p...
Source: Advanced Drug Delivery Reviews - February 25, 2024 Category: Drugs & Pharmacology Authors: May Rokach Corinne Portioli Sayanti Brahmachari Bianca Martins Estev ão Paolo Decuzzi Boaz Barak Source Type: research
Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems
We present parallel developmental trajectories involving myelination that correlate with the onset of cognitive impairment in neurodevelopmental disorders and discuss the key challenges in the treatment of these chronic disorders. Recent developments in drug repurposing and nano/micro particle-based therapies are reviewed as a possible pathway to circumvent some of the main hurdles associated to the early intervention - patient's adherence and compliance, side effects, relapse - and faster route to possible treatment of these disorders. The strategy of drug encapsulation overcomes drug solubility and metabolism, with the p...
Source: Advanced Drug Delivery Reviews - February 25, 2024 Category: Drugs & Pharmacology Authors: May Rokach Corinne Portioli Sayanti Brahmachari Bianca Martins Estev ão Paolo Decuzzi Boaz Barak Source Type: research
Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems
We present parallel developmental trajectories involving myelination that correlate with the onset of cognitive impairment in neurodevelopmental disorders and discuss the key challenges in the treatment of these chronic disorders. Recent developments in drug repurposing and nano/micro particle-based therapies are reviewed as a possible pathway to circumvent some of the main hurdles associated to the early intervention - patient's adherence and compliance, side effects, relapse - and faster route to possible treatment of these disorders. The strategy of drug encapsulation overcomes drug solubility and metabolism, with the p...
Source: Advanced Drug Delivery Reviews - February 25, 2024 Category: Drugs & Pharmacology Authors: May Rokach Corinne Portioli Sayanti Brahmachari Bianca Martins Estev ão Paolo Decuzzi Boaz Barak Source Type: research
Interactions between nanoparticles and pathological changes of vascular in Alzheimer's disease
Adv Drug Deliv Rev. 2024 Feb 22:115219. doi: 10.1016/j.addr.2024.115219. Online ahead of print.ABSTRACTEmerging evidence suggests that vascular pathological changes play a pivotal role in the pathogenesis of Alzheimer's disease (AD). The dysfunction of the cerebral vasculature occurs in the early course of AD, characterized by alterations in vascular morphology, diminished cerebral blood flow (CBF), impairment of the neurovascular unit (NVU), vasculature inflammation, and cerebral amyloid angiopathy. Vascular dysfunction not only facilitates the influx of neurotoxic substances into the brain, triggering inflammation and im...
Source: Advanced Drug Delivery Reviews - February 24, 2024 Category: Drugs & Pharmacology Authors: Ting Lei Zixiao Yang Hanmei Li Meng Qin Huile Gao Source Type: research
Non-viral delivery of RNA for therapeutic T cell engineering
Adv Drug Deliv Rev. 2024 Feb 22:115215. doi: 10.1016/j.addr.2024.115215. Online ahead of print.ABSTRACTAdoptive T cell transfer has shown great success in treating blood cancers, resulting in a growing number of FDA-approved therapies using chimeric antigen receptor (CAR)-engineered T cells. However, the effectiveness of this treatment for solid tumors is still not satisfactory, emphasizing the need for improved T cell engineering strategies and combination approaches. Currently, CAR T cells are mainly manufactured using gammaretroviral and lentiviral vectors due to their high transduction efficiency. However, there are co...
Source: Advanced Drug Delivery Reviews - February 24, 2024 Category: Drugs & Pharmacology Authors: Dominika Berdecka Stefaan C De Smedt Winnok H De Vos Kevin Braeckmans Source Type: research
Interactions between nanoparticles and pathological changes of vascular in Alzheimer's disease
Adv Drug Deliv Rev. 2024 Feb 22:115219. doi: 10.1016/j.addr.2024.115219. Online ahead of print.ABSTRACTEmerging evidence suggests that vascular pathological changes play a pivotal role in the pathogenesis of Alzheimer's disease (AD). The dysfunction of the cerebral vasculature occurs in the early course of AD, characterized by alterations in vascular morphology, diminished cerebral blood flow (CBF), impairment of the neurovascular unit (NVU), vasculature inflammation, and cerebral amyloid angiopathy. Vascular dysfunction not only facilitates the influx of neurotoxic substances into the brain, triggering inflammation and im...
Source: Advanced Drug Delivery Reviews - February 24, 2024 Category: Drugs & Pharmacology Authors: Ting Lei Zixiao Yang Hanmei Li Meng Qin Huile Gao Source Type: research
Non-viral delivery of RNA for therapeutic T cell engineering
Adv Drug Deliv Rev. 2024 Feb 22:115215. doi: 10.1016/j.addr.2024.115215. Online ahead of print.ABSTRACTAdoptive T cell transfer has shown great success in treating blood cancers, resulting in a growing number of FDA-approved therapies using chimeric antigen receptor (CAR)-engineered T cells. However, the effectiveness of this treatment for solid tumors is still not satisfactory, emphasizing the need for improved T cell engineering strategies and combination approaches. Currently, CAR T cells are mainly manufactured using gammaretroviral and lentiviral vectors due to their high transduction efficiency. However, there are co...
Source: Advanced Drug Delivery Reviews - February 24, 2024 Category: Drugs & Pharmacology Authors: Dominika Berdecka Stefaan C De Smedt Winnok H De Vos Kevin Braeckmans Source Type: research
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration
Adv Drug Deliv Rev. 2024 Feb 22;207:115214. doi: 10.1016/j.addr.2024.115214. Online ahead of print.ABSTRACTLow back pain stands as a pervasive global health concern, afflicting almost 80% of adults at some point in their lives with nearly 40% attributable to intervertebral disc degeneration (IVDD). As only symptomatic relief can be offered to patients there is a dire need for innovative treatments.Given the accumulating evidence that multiple microRNAs (miRs) are dysregulated during IVDD, they could have a huge potential against this debilitating condition. The way miRs can profoundly modulate signaling pathways and influe...
Source: Advanced Drug Delivery Reviews - February 23, 2024 Category: Drugs & Pharmacology Authors: Hussein H Genedy Paul Humbert Bilel Laoulaou Brian Le Moal Marion Fusellier Catherine Passirani Catherine Le Visage J érôme Guicheux Élise Lepeltier Johann Clouet Source Type: research
The interaction between particles and vascular endothelium in blood flow
Adv Drug Deliv Rev. 2024 Feb 20:115216. doi: 10.1016/j.addr.2024.115216. Online ahead of print.ABSTRACTParticle-based drug delivery systems have shown promising application potential to treat human diseases; however, an incomplete understanding of their interactions with vascular endothelium in blood flow prevents their inclusion into mainstream clinical applications. The flow behaviors of nano/micro-sized particles in the blood are disturbed by many external/internal factors, including blood constituents, particle properties, and endothelium bioactivities, affecting the fate of particles in vivo and therapeutic effects fo...
Source: Advanced Drug Delivery Reviews - February 22, 2024 Category: Drugs & Pharmacology Authors: Xiaotong Li Jiahui Zou Zhongshan He Yanhua Sun Xiangrong Song Wei He Source Type: research
