"Future Directions" - Novel breakthrough developments in the fields of Drug Development & amp; Delivery, and Regenerative Medicine
Adv Drug Deliv Rev. 2023 Dec 13:115159. doi: 10.1016/j.addr.2023.115159. Online ahead of print.NO ABSTRACTPMID:38101476 | DOI:10.1016/j.addr.2023.115159 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - December 15, 2023 Category: Drugs & Pharmacology Authors: Katja Schenke-Layland Andrew MacKay Source Type: research
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Adv Drug Deliv Rev. 2023 Dec 6;204:115147. doi: 10.1016/j.addr.2023.115147. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which causes scarring in the lung parenchyma and thereby affects architecture and functioning of lung. It is an irreversible damage to lung functioning which is related to epithelial cell injury, immense accumulation of immune cells and inflammatory cytokines, and irregular recruitment of extracellular matrix. The inflammatory cytokines trigger the differentiation of fibroblasts into activated fibroblasts, also known as myofibrobla...
Source: Advanced Drug Delivery Reviews - December 8, 2023 Category: Drugs & Pharmacology Authors: Rimpy Diwan Himanshu N Bhatt Elfa Beaven Md Nurunnabi Source Type: research
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Adv Drug Deliv Rev. 2023 Dec 6;204:115147. doi: 10.1016/j.addr.2023.115147. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which causes scarring in the lung parenchyma and thereby affects architecture and functioning of lung. It is an irreversible damage to lung functioning which is related to epithelial cell injury, immense accumulation of immune cells and inflammatory cytokines, and irregular recruitment of extracellular matrix. The inflammatory cytokines trigger the differentiation of fibroblasts into activated fibroblasts, also known as myofibrobla...
Source: Advanced Drug Delivery Reviews - December 8, 2023 Category: Drugs & Pharmacology Authors: Rimpy Diwan Himanshu N Bhatt Elfa Beaven Md Nurunnabi Source Type: research
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Adv Drug Deliv Rev. 2023 Dec 6;204:115147. doi: 10.1016/j.addr.2023.115147. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which causes scarring in the lung parenchyma and thereby affects architecture and functioning of lung. It is an irreversible damage to lung functioning which is related to epithelial cell injury, immense accumulation of immune cells and inflammatory cytokines, and irregular recruitment of extracellular matrix. The inflammatory cytokines trigger the differentiation of fibroblasts into activated fibroblasts, also known as myofibrobla...
Source: Advanced Drug Delivery Reviews - December 8, 2023 Category: Drugs & Pharmacology Authors: Rimpy Diwan Himanshu N Bhatt Elfa Beaven Md Nurunnabi Source Type: research
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Adv Drug Deliv Rev. 2023 Dec 6;204:115147. doi: 10.1016/j.addr.2023.115147. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which causes scarring in the lung parenchyma and thereby affects architecture and functioning of lung. It is an irreversible damage to lung functioning which is related to epithelial cell injury, immense accumulation of immune cells and inflammatory cytokines, and irregular recruitment of extracellular matrix. The inflammatory cytokines trigger the differentiation of fibroblasts into activated fibroblasts, also known as myofibrobla...
Source: Advanced Drug Delivery Reviews - December 8, 2023 Category: Drugs & Pharmacology Authors: Rimpy Diwan Himanshu N Bhatt Elfa Beaven Md Nurunnabi Source Type: research
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Adv Drug Deliv Rev. 2023 Dec 6;204:115147. doi: 10.1016/j.addr.2023.115147. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which causes scarring in the lung parenchyma and thereby affects architecture and functioning of lung. It is an irreversible damage to lung functioning which is related to epithelial cell injury, immense accumulation of immune cells and inflammatory cytokines, and irregular recruitment of extracellular matrix. The inflammatory cytokines trigger the differentiation of fibroblasts into activated fibroblasts, also known as myofibrobla...
Source: Advanced Drug Delivery Reviews - December 8, 2023 Category: Drugs & Pharmacology Authors: Rimpy Diwan Himanshu N Bhatt Elfa Beaven Md Nurunnabi Source Type: research
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Adv Drug Deliv Rev. 2023 Dec 6;204:115147. doi: 10.1016/j.addr.2023.115147. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which causes scarring in the lung parenchyma and thereby affects architecture and functioning of lung. It is an irreversible damage to lung functioning which is related to epithelial cell injury, immense accumulation of immune cells and inflammatory cytokines, and irregular recruitment of extracellular matrix. The inflammatory cytokines trigger the differentiation of fibroblasts into activated fibroblasts, also known as myofibrobla...
Source: Advanced Drug Delivery Reviews - December 8, 2023 Category: Drugs & Pharmacology Authors: Rimpy Diwan Himanshu N Bhatt Elfa Beaven Md Nurunnabi Source Type: research
Microbubble-assisted ultrasound for inner ear drug delivery
Adv Drug Deliv Rev. 2023 Dec 1;204:115145. doi: 10.1016/j.addr.2023.115145. Online ahead of print.ABSTRACTTreating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound ("sonoporation") is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the...
Source: Advanced Drug Delivery Reviews - December 2, 2023 Category: Drugs & Pharmacology Authors: Fabrice Micaletti Jean-Michel Escoffre Sandrine Kerneis Ayache Bouakaz John J Galvin Luc Boullaud David Bakhos Source Type: research
Microbubble-assisted ultrasound for inner ear drug delivery
Adv Drug Deliv Rev. 2023 Dec 1;204:115145. doi: 10.1016/j.addr.2023.115145. Online ahead of print.ABSTRACTTreating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound ("sonoporation") is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the...
Source: Advanced Drug Delivery Reviews - December 2, 2023 Category: Drugs & Pharmacology Authors: Fabrice Micaletti Jean-Michel Escoffre Sandrine Kerneis Ayache Bouakaz John J Galvin Luc Boullaud David Bakhos Source Type: research
Microbubble-assisted ultrasound for inner ear drug delivery
Adv Drug Deliv Rev. 2023 Nov 30:115145. doi: 10.1016/j.addr.2023.115145. Online ahead of print.ABSTRACTTreating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound ("sonoporation") is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the mi...
Source: Advanced Drug Delivery Reviews - December 2, 2023 Category: Drugs & Pharmacology Authors: Fabrice Micaletti Jean-Michel Escoffre Sandrine Kerneis Ayache Bouakaz John J Galvin Luc Boullaud David Bakhos Source Type: research
Microbubble-assisted ultrasound for inner ear drug delivery
Adv Drug Deliv Rev. 2023 Nov 30:115145. doi: 10.1016/j.addr.2023.115145. Online ahead of print.ABSTRACTTreating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound ("sonoporation") is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the mi...
Source: Advanced Drug Delivery Reviews - December 2, 2023 Category: Drugs & Pharmacology Authors: Fabrice Micaletti Jean-Michel Escoffre Sandrine Kerneis Ayache Bouakaz John J Galvin Luc Boullaud David Bakhos Source Type: research
Microbubble-assisted ultrasound for inner ear drug delivery
Adv Drug Deliv Rev. 2023 Nov 30:115145. doi: 10.1016/j.addr.2023.115145. Online ahead of print.ABSTRACTTreating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound ("sonoporation") is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the mi...
Source: Advanced Drug Delivery Reviews - December 2, 2023 Category: Drugs & Pharmacology Authors: Fabrice Micaletti Jean-Michel Escoffre Sandrine Kerneis Ayache Bouakaz John J Galvin Luc Boullaud David Bakhos Source Type: research
Microbubble-assisted ultrasound for inner ear drug delivery
Adv Drug Deliv Rev. 2023 Nov 30:115145. doi: 10.1016/j.addr.2023.115145. Online ahead of print.ABSTRACTTreating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound ("sonoporation") is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the mi...
Source: Advanced Drug Delivery Reviews - December 2, 2023 Category: Drugs & Pharmacology Authors: Fabrice Micaletti Jean-Michel Escoffre Sandrine Kerneis Ayache Bouakaz John J Galvin Luc Boullaud David Bakhos Source Type: research
Long-acting inhaled medicines: Present and future
Adv Drug Deliv Rev. 2023 Nov 29:115146. doi: 10.1016/j.addr.2023.115146. Online ahead of print.ABSTRACTInhaled medicines continue to be an essential part of treatment for respiratory diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. In addition, inhalation technology, which is an active area of research and innovation to deliver medications via the lung to the bloodstream, offers potential advantages such as rapid onset of action, enhanced bioavailability, and reduced side effects for local treatments. Certain inhaled macromolecules and particles can also end up in different organs via ly...
Source: Advanced Drug Delivery Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: Chengqian Zhang Davide D'Angelo Francesca Buttini Mingshi Yang Source Type: research
In situ cellular hitchhiking of nanoparticles for drug delivery
Adv Drug Deliv Rev. 2023 Nov 24;204:115143. doi: 10.1016/j.addr.2023.115143. Online ahead of print.ABSTRACTSince the inception of the concept of "magic bullet", nanoparticles have evolved to be one of the most effective carriers in drug delivery. Nanoparticles improve the therapeutic efficacy of drugs offering benefits to treating various diseases. Unlike free drugs which freely diffuse and distribute through the body, nanoparticles protect the body from the drug by reducing non-specific interactions while also improving the drug's pharmacokinetics. Despite acquiring some FDA approvals, further clinical application of nano...
Source: Advanced Drug Delivery Reviews - November 26, 2023 Category: Drugs & Pharmacology Authors: Edidiong Udofa Zongmin Zhao Source Type: research
