AcousticRobots: Smart acoustically powered micro-/nanoswimmers for precise biomedical applications
Adv Drug Deliv Rev. 2024 Feb 6:115201. doi: 10.1016/j.addr.2024.115201. Online ahead of print.ABSTRACTAlthough nanotechnology has evolutionarily progressed in biomedical field over the past decades, achieving satisfactory therapeutic effects remains difficult with limited delivery efficiency. Ultrasound could provide a deep penetration and maneuverable actuation to efficiently power micro-/nanoswimmers with little harm, offering an emerging and fascinating alternative to the active delivery platform. Recent advances in novel fabrication, controllable concepts like intelligent swarm and the integration of hybrid propulsions...
Source: Advanced Drug Delivery Reviews - February 8, 2024 Category: Drugs & Pharmacology Authors: Gege Wu Wei Xian Qing You Jingjing Zhang Xiaoyuan Chen Source Type: research
From concept to early clinical trials: 30 years of microbubble-based ultrasound-mediated drug delivery research
Adv Drug Deliv Rev. 2024 Feb 5:115199. doi: 10.1016/j.addr.2024.115199. Online ahead of print.ABSTRACTUltrasound mediated drug delivery, a promising therapeutic modality, has evolved remarkably over the past three decades. Initially designed to enhance contrast in ultrasound imaging, microbubbles have emerged as a main vector for drug delivery, offering targeted therapy with minimized side effects. This review addresses the historical progression of this technology, emphasizing the pivotal role microbubbles play in augmenting drug extravasation and targeted delivery. We explore the complex mechanisms behind this technology...
Source: Advanced Drug Delivery Reviews - February 7, 2024 Category: Drugs & Pharmacology Authors: Ayache Bouakaz Jean Michel Escoffre Source Type: research
Unlocking the Mitochondria for Nanomedicine-based Treatments: Overcoming Biological Barriers, Improving Designs, and Selecting Verification Techniques
Adv Drug Deliv Rev. 2024 Feb 5;207:115195. doi: 10.1016/j.addr.2024.115195. Online ahead of print.ABSTRACTEnhanced targeting approaches will support the treatment of diseases associated with dysfunctional mitochondria, which play critical roles in energy generation and cell survival. Obstacles to mitochondria-specific targeting include the presence of distinct biological barriers and the need to pass through (or avoid) various cell internalization mechanisms. A range of studies have reported the design of mitochondrially-targeted nanomedicines that navigate the complex routes required to influence mitochondrial function; n...
Source: Advanced Drug Delivery Reviews - February 7, 2024 Category: Drugs & Pharmacology Authors: Camilla Pegoraro In és Domingo-Ortí Inmaculada Conejos-S ánchez Mar ía J Vicent Source Type: research
Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings
Adv Drug Deliv Rev. 2024 Feb 3;207:115193. doi: 10.1016/j.addr.2024.115193. Online ahead of print.ABSTRACTThe favorable benefit-risk profile of polatuzumab vedotin, as demonstrated in a pivotal Phase Ib/II randomized study (GO29365; NCT02257567), coupled with the need for effective therapies in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), prompted the need to accelerate polatuzumab vedotin development. An integrated, fit-for-purpose clinical pharmacology package was designed to support regulatory approval. To address key clinical pharmacology questions without dedicated clinical pharmacology studies, we...
Source: Advanced Drug Delivery Reviews - February 4, 2024 Category: Drugs & Pharmacology Authors: Michael Z Liao Dan Lu Tong Lu Leonid Gibiansky Rong Deng Divya Samineni Randall Dere Andy Lin Jamie Hirata Ben-Quan Shen Donglu Zhang Dongwei Li Chunze Li Dale Miles Source Type: research
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond
Adv Drug Deliv Rev. 2024 Feb 1;206:115190. doi: 10.1016/j.addr.2024.115190. Online ahead of print.ABSTRACTmRNA-based vaccines are emerging as a promising alternative to standard cancer treatments and the conventional vaccines. Moreover, the FDA-approval of three nucleic acid based therapeutics (Onpattro, BNT162b2 and mRNA-1273) has further increased the interest and trust on this type of therapeutics. In order to achieve a significant therapeutic efficacy, the mRNA needs from a drug delivery system. In the last years, several delivery platforms have been explored, being the lipid nanoparticles (LNPs) the most well characte...
Source: Advanced Drug Delivery Reviews - February 2, 2024 Category: Drugs & Pharmacology Authors: Mariona Estap é Senti Luc ía García Del Valle Raymond M Schiffelers Source Type: research
Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery
Adv Drug Deliv Rev. 2024 Jan 28;206:115179. doi: 10.1016/j.addr.2024.115179. Online ahead of print.ABSTRACTType 1 diabetes mellitus (T1DM) is an autoimmune condition that results in the destruction of insulin-secreting β cells of the islets of Langerhans. Allogeneic islet transplantation could be a successful treatment for T1DM; however, it is limited by the need for effective, permanent immunosuppression to prevent graft rejection. Upon transplantation, islets are rejected through non-specific, alloantigen specific, and recurring autoimmune pathways. Immunosuppressive agents used for islet transplantation are generally s...
Source: Advanced Drug Delivery Reviews - January 29, 2024 Category: Drugs & Pharmacology Authors: T R Lansberry C L Stabler Source Type: research
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides
Adv Drug Deliv Rev. 2024 Jan 26;206:115189. doi: 10.1016/j.addr.2024.115189. Online ahead of print.ABSTRACTElastin-like polypeptides (ELP) are versatile, thermo-responsive polymers that can be conjugated to virtually any therapeutic cargo. Derived from short amino-acid sequences and abundant in humans, certain ELPs display low immunogenicity. Substrates for endogenous proteases, ELPs are biodegradable and thus, are candidate biomaterials. Peptides and proteins can be directly coupled with ELPs through genetic engineering, while other polymers and small molecules can be appended through covalent bioconjugation or non-covale...
Source: Advanced Drug Delivery Reviews - January 28, 2024 Category: Drugs & Pharmacology Authors: Alvin Phan J Andrew MacKay Source Type: research
Image-guided drug delivery: Biomedical and imaging advances
Adv Drug Deliv Rev. 2024 Jan 23;206:115187. doi: 10.1016/j.addr.2024.115187. Online ahead of print.NO ABSTRACTPMID:38272184 | DOI:10.1016/j.addr.2024.115187 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 25, 2024 Category: Drugs & Pharmacology Authors: Alexandros Marios Sofias Bing Guo Jian Xu Twan Lammers Source Type: research
Image-guided drug delivery: Nanoparticle and probe advances
Adv Drug Deliv Rev. 2024 Jan 23;206:115188. doi: 10.1016/j.addr.2024.115188. Online ahead of print.NO ABSTRACTPMID:38272185 | DOI:10.1016/j.addr.2024.115188 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 25, 2024 Category: Drugs & Pharmacology Authors: Bing Guo Alexandros Marios Sofias Twan Lammers Jian Xu Source Type: research
The immunostimulatory nature of mRNA lipid nanoparticles
Adv Drug Deliv Rev. 2024 Feb;205:115175. doi: 10.1016/j.addr.2023.115175. Epub 2024 Jan 11.ABSTRACTmRNA-Lipid nanoparticles (LNPs) are at the forefront of global medical research. With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the clinical potential of this platform was unleashed. Upon administering 16 billion doses that protected billions of people, it became clear that a fraction of them witnessed mild and in some cases even severe adverse effects. Therefore, it is paramount to define the safety along with the therapeutic efficacy of the mRNA-LNP platform for the successful translation of new ...
Source: Advanced Drug Delivery Reviews - January 13, 2024 Category: Drugs & Pharmacology Authors: Preeti Sharma Daniek Hoorn Anjaiah Aitha Dor Breier Dan Peer Source Type: research
Corrigendum to "Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers" [Adv. Drug Delivery Rev. 203 (2023) 115136]
Adv Drug Deliv Rev. 2024 Feb;205:115173. doi: 10.1016/j.addr.2023.115173. Epub 2024 Jan 9.NO ABSTRACTPMID:38199061 | DOI:10.1016/j.addr.2023.115173 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 10, 2024 Category: Drugs & Pharmacology Authors: Anan Yaghmur Jesper Østergaard Huiling Mu Source Type: research
Ultrasound-nanovesicles interplay for theranostics
Adv Drug Deliv Rev. 2024 Feb;205:115176. doi: 10.1016/j.addr.2023.115176. Epub 2024 Jan 9.ABSTRACTNanovesicles (NVs) are widely used in the treatment and diagnosis of diseases due to their excellent vascular permeability, good biocompatibility, high loading capacity, and easy functionalization. However, their yield and in vivo penetration depth limitations and their complex preparation processes still constrain their application and development. Ultrasound, as a fundamental external stimulus with deep tissue penetration, concentrated energy sources, and good safety, has been proven to be a patient-friendly and highly effic...
Source: Advanced Drug Delivery Reviews - January 10, 2024 Category: Drugs & Pharmacology Authors: Jingyi Liu Qing You Fuming Liang Lilusi Ma Ling Zhu Chen Wang Yanlian Yang Source Type: research
Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery
Adv Drug Deliv Rev. 2024 Jan 8;206:115178. doi: 10.1016/j.addr.2023.115178. Online ahead of print.ABSTRACTUltrasound-responsive agents have shown great potential as targeted drug delivery agents, effectively augmenting cell permeability and facilitating drug absorption. This review focuses on two specific agents, microbubbles and nanodroplets, and provides a sequential overview of their drug delivery process. Particular emphasis is given to the mechanical response of the agents under ultrasound, and the subsequent physical and biological effects on the cells. Finally, the state-of-the-art in their pre-clinical and clinical...
Source: Advanced Drug Delivery Reviews - January 10, 2024 Category: Drugs & Pharmacology Authors: Gazendra Shakya Marco Cattaneo Giulia Guerriero Anunay Prasanna Samuele Fiorini Outi Supponen Source Type: research
Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions
We describe the main principles and mechanisms underlying each method before diving into the corresponding biomedical applications. We identify areas of improvement as well as promising approaches with clinical translation potential.PMID:38184194 | DOI:10.1016/j.addr.2023.115177 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 6, 2024 Category: Drugs & Pharmacology Authors: Maria Eleni Karakatsani H éctor Estrada Zhenyue Chen Shy Shoham Xos é Luís Deán-Ben Daniel Razansky Source Type: research
Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions
We describe the main principles and mechanisms underlying each method before diving into the corresponding biomedical applications. We identify areas of improvement as well as promising approaches with clinical translation potential.PMID:38184194 | DOI:10.1016/j.addr.2023.115177 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - January 6, 2024 Category: Drugs & Pharmacology Authors: Maria Eleni Karakatsani H éctor Estrada Beltrán Zhenyue Chen Shy Shoham Xos é Luís Deán-Ben Daniel Razansky Source Type: research
