Revolutionizing Drug Formulation Development: The Increasing Impact of Machine Learning
Adv Drug Deliv Rev. 2023 Sep 27:115108. doi: 10.1016/j.addr.2023.115108. Online ahead of print.ABSTRACTOver the past few years, the adoption of machine learning (ML) techniques has rapidly expanded across many fields of research including formulation science. At the same time, the use of lipid nanoparticles to enable the successful delivery of mRNA vaccines in the recent COVID-19 pandemic demonstrated the impact of formulation science. Yet, the design of advanced pharmaceutical formulations is non-trivial and primarily relies on costly and time-consuming wet-lab experimentation. In 2021, our group published a review articl...
Source: Advanced Drug Delivery Reviews - September 29, 2023 Category: Drugs & Pharmacology Authors: Zeqing Bao Jack Bufton Riley J Hickman Al án Aspuru-Guzik Pauric Bannigan Christine Allen Source Type: research
Revolutionizing Drug Formulation Development: The Increasing Impact of Machine Learning
Adv Drug Deliv Rev. 2023 Sep 27:115108. doi: 10.1016/j.addr.2023.115108. Online ahead of print.ABSTRACTOver the past few years, the adoption of machine learning (ML) techniques has rapidly expanded across many fields of research including formulation science. At the same time, the use of lipid nanoparticles to enable the successful delivery of mRNA vaccines in the recent COVID-19 pandemic demonstrated the impact of formulation science. Yet, the design of advanced pharmaceutical formulations is non-trivial and primarily relies on costly and time-consuming wet-lab experimentation. In 2021, our group published a review articl...
Source: Advanced Drug Delivery Reviews - September 29, 2023 Category: Drugs & Pharmacology Authors: Zeqing Bao Jack Bufton Riley J Hickman Al án Aspuru-Guzik Pauric Bannigan Christine Allen Source Type: research
Quantitative Raman Chemical Imaging of Intracellular Drug-Membrane Aggregates and Small Molecule Drug Precipitates In Cytoplasmic Organelles
Adv Drug Deliv Rev. 2023 Sep 26:115107. doi: 10.1016/j.addr.2023.115107. Online ahead of print.ABSTRACTRaman confocal microscopes have been used to visualize the distribution of small molecule drugs within different subcellular compartments. This visualization allows the discovery, characterization, and detailed analysis of the molecular transport phenomena underpinning the Volume of Distribution - a key parameter governing the systemic pharmacokinetics of small molecule drugs. In the specific case of lipophilic small molecules with large Volumes of Distribution, chemical imaging studies using Raman confocal microscopes ha...
Source: Advanced Drug Delivery Reviews - September 28, 2023 Category: Drugs & Pharmacology Authors: Vernon LaLone Doug Smith Jennifer Diaz-Espinosa Gus R Rosania Source Type: research
Quantitative Raman Chemical Imaging of Intracellular Drug-Membrane Aggregates and Small Molecule Drug Precipitates In Cytoplasmic Organelles
Adv Drug Deliv Rev. 2023 Sep 26:115107. doi: 10.1016/j.addr.2023.115107. Online ahead of print.ABSTRACTRaman confocal microscopes have been used to visualize the distribution of small molecule drugs within different subcellular compartments. This visualization allows the discovery, characterization, and detailed analysis of the molecular transport phenomena underpinning the Volume of Distribution - a key parameter governing the systemic pharmacokinetics of small molecule drugs. In the specific case of lipophilic small molecules with large Volumes of Distribution, chemical imaging studies using Raman confocal microscopes ha...
Source: Advanced Drug Delivery Reviews - September 28, 2023 Category: Drugs & Pharmacology Authors: Vernon LaLone Doug Smith Jennifer Diaz-Espinosa Gus R Rosania Source Type: research
Safety of Surfactant Excipients in Oral Drug Formulations
Adv Drug Deliv Rev. 2023 Sep 20:115086. doi: 10.1016/j.addr.2023.115086. Online ahead of print.ABSTRACTSurfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the interaction of surfactant-type excipients present in oral pharmaceutical dosage forms with the intestinal epithelium of the gastrointestinal (GI) tract. Many surfactants permitted for human consumption in oral products reduce intestinal epithelia...
Source: Advanced Drug Delivery Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sam Maher Caroline Geoghegan David J Brayden Source Type: research
Safety of Surfactant Excipients in Oral Drug Formulations
Adv Drug Deliv Rev. 2023 Sep 20:115086. doi: 10.1016/j.addr.2023.115086. Online ahead of print.ABSTRACTSurfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the interaction of surfactant-type excipients present in oral pharmaceutical dosage forms with the intestinal epithelium of the gastrointestinal (GI) tract. Many surfactants permitted for human consumption in oral products reduce intestinal epithelia...
Source: Advanced Drug Delivery Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sam Maher Caroline Geoghegan David J Brayden Source Type: research
Safety of Surfactant Excipients in Oral Drug Formulations
Adv Drug Deliv Rev. 2023 Sep 20:115086. doi: 10.1016/j.addr.2023.115086. Online ahead of print.ABSTRACTSurfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the interaction of surfactant-type excipients present in oral pharmaceutical dosage forms with the intestinal epithelium of the gastrointestinal (GI) tract. Many surfactants permitted for human consumption in oral products reduce intestinal epithelia...
Source: Advanced Drug Delivery Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sam Maher Caroline Geoghegan David J Brayden Source Type: research
Safety of Surfactant Excipients in Oral Drug Formulations
Adv Drug Deliv Rev. 2023 Sep 20:115086. doi: 10.1016/j.addr.2023.115086. Online ahead of print.ABSTRACTSurfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the interaction of surfactant-type excipients present in oral pharmaceutical dosage forms with the intestinal epithelium of the gastrointestinal (GI) tract. Many surfactants permitted for human consumption in oral products reduce intestinal epithelia...
Source: Advanced Drug Delivery Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sam Maher Caroline Geoghegan David J Brayden Source Type: research
Safety of Surfactant Excipients in Oral Drug Formulations
Adv Drug Deliv Rev. 2023 Sep 20:115086. doi: 10.1016/j.addr.2023.115086. Online ahead of print.ABSTRACTSurfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the interaction of surfactant-type excipients present in oral pharmaceutical dosage forms with the intestinal epithelium of the gastrointestinal (GI) tract. Many surfactants permitted for human consumption in oral products reduce intestinal epithelia...
Source: Advanced Drug Delivery Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sam Maher Caroline Geoghegan David J Brayden Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 9;201:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it ...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
