Vasculature organotropism in drug delivery
This article highlights organ-specific vasculature properties, nanodelivery strategies that exploit vasculature organotropism, and overlooked challenges and opportunities in targeting and simultaneously overcoming the endothelial barrier. Impediments in the clinical translation of vasculature organotropism in drug delivery are also discussed.PMID:37591370 | DOI:10.1016/j.addr.2023.115054 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - August 17, 2023 Category: Drugs & Pharmacology Authors: A Amruta Dalila Iannotta Seth W Cheetham Twan Lammers Joy Wolfram Source Type: research
Theme Issue: In vitro mucus models
Adv Drug Deliv Rev. 2023 Aug 11:115053. doi: 10.1016/j.addr.2023.115053. Online ahead of print.NO ABSTRACTPMID:37573950 | DOI:10.1016/j.addr.2023.115053 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Jessica Kramer Katharina Ribbeck Source Type: research
Biosafety of mesoporous silica nanoparticles; towards clinical translation
Adv Drug Deliv Rev. 2023 Aug 11:115049. doi: 10.1016/j.addr.2023.115049. Online ahead of print.ABSTRACTMesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have developed numerous systems for the encapsulation of a plethora of molecules, allowing the use of mesoporous silica nanoparticles for biomedical applications. MSNs have been extensively studied for their use in nanomedicine, in applications such as drug delivery, diagnosis, and bioimaging, demonstrating significant in vivo efficacy in different preclinical models. Nevertheless, for the transition of MSNs into clinical trials, it is im...
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Araceli L érida-Viso Alejandra Estepa-Fern ández Alba Garc ía-Fernández Vicente Mart í-Centelles Ram ón Martínez-Máñez Source Type: research
Theme Issue: In vitro mucus models
Adv Drug Deliv Rev. 2023 Aug 11:115053. doi: 10.1016/j.addr.2023.115053. Online ahead of print.NO ABSTRACTPMID:37573950 | DOI:10.1016/j.addr.2023.115053 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Jessica Kramer Katharina Ribbeck Source Type: research
Biosafety of mesoporous silica nanoparticles; towards clinical translation
Adv Drug Deliv Rev. 2023 Aug 11:115049. doi: 10.1016/j.addr.2023.115049. Online ahead of print.ABSTRACTMesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have developed numerous systems for the encapsulation of a plethora of molecules, allowing the use of mesoporous silica nanoparticles for biomedical applications. MSNs have been extensively studied for their use in nanomedicine, in applications such as drug delivery, diagnosis, and bioimaging, demonstrating significant in vivo efficacy in different preclinical models. Nevertheless, for the transition of MSNs into clinical trials, it is im...
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Araceli L érida-Viso Alejandra Estepa-Fern ández Alba Garc ía-Fernández Vicente Mart í-Centelles Ram ón Martínez-Máñez Source Type: research
Theme Issue: In vitro mucus models
Adv Drug Deliv Rev. 2023 Aug 11:115053. doi: 10.1016/j.addr.2023.115053. Online ahead of print.NO ABSTRACTPMID:37573950 | DOI:10.1016/j.addr.2023.115053 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Jessica Kramer Katharina Ribbeck Source Type: research
Biosafety of mesoporous silica nanoparticles; towards clinical translation
Adv Drug Deliv Rev. 2023 Aug 11:115049. doi: 10.1016/j.addr.2023.115049. Online ahead of print.ABSTRACTMesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have developed numerous systems for the encapsulation of a plethora of molecules, allowing the use of mesoporous silica nanoparticles for biomedical applications. MSNs have been extensively studied for their use in nanomedicine, in applications such as drug delivery, diagnosis, and bioimaging, demonstrating significant in vivo efficacy in different preclinical models. Nevertheless, for the transition of MSNs into clinical trials, it is im...
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Araceli L érida-Viso Alejandra Estepa-Fern ández Alba Garc ía-Fernández Vicente Mart í-Centelles Ram ón Martínez-Máñez Source Type: research
Theme Issue: In vitro mucus models
Adv Drug Deliv Rev. 2023 Aug 11:115053. doi: 10.1016/j.addr.2023.115053. Online ahead of print.NO ABSTRACTPMID:37573950 | DOI:10.1016/j.addr.2023.115053 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Jessica Kramer Katharina Ribbeck Source Type: research
Biosafety of mesoporous silica nanoparticles; towards clinical translation
Adv Drug Deliv Rev. 2023 Aug 11:115049. doi: 10.1016/j.addr.2023.115049. Online ahead of print.ABSTRACTMesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have developed numerous systems for the encapsulation of a plethora of molecules, allowing the use of mesoporous silica nanoparticles for biomedical applications. MSNs have been extensively studied for their use in nanomedicine, in applications such as drug delivery, diagnosis, and bioimaging, demonstrating significant in vivo efficacy in different preclinical models. Nevertheless, for the transition of MSNs into clinical trials, it is im...
Source: Advanced Drug Delivery Reviews - August 13, 2023 Category: Drugs & Pharmacology Authors: Araceli L érida-Viso Alejandra Estepa-Fern ández Alba Garc ía-Fernández Vicente Mart í-Centelles Ram ón Martínez-Máñez Source Type: research
A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics
Adv Drug Deliv Rev. 2023 Aug 9:115052. doi: 10.1016/j.addr.2023.115052. Online ahead of print.ABSTRACTSmall interfering RNAs (siRNAs) are among the most promising therapeutic platforms in many life-threatening diseases. Owing to the significant advances in siRNA design, many challenges in the stability, specificity and delivery of siRNA have been addressed. However, safety concerns and dose-limiting toxicities still stand among the reasons for the failure of clinical trials of potent siRNA therapies, calling for a need of more comprehensive understanding of their potential mechanisms of toxicity. This review delves into th...
Source: Advanced Drug Delivery Reviews - August 11, 2023 Category: Drugs & Pharmacology Authors: Sheyda Ranjbar Xiao-Bo Zhong Jos é Manautou Xiuling Lu Source Type: research
A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics
Adv Drug Deliv Rev. 2023 Aug 9:115052. doi: 10.1016/j.addr.2023.115052. Online ahead of print.ABSTRACTSmall interfering RNAs (siRNAs) are among the most promising therapeutic platforms in many life-threatening diseases. Owing to the significant advances in siRNA design, many challenges in the stability, specificity and delivery of siRNA have been addressed. However, safety concerns and dose-limiting toxicities still stand among the reasons for the failure of clinical trials of potent siRNA therapies, calling for a need of more comprehensive understanding of their potential mechanisms of toxicity. This review delves into th...
Source: Advanced Drug Delivery Reviews - August 11, 2023 Category: Drugs & Pharmacology Authors: Sheyda Ranjbar Xiao-Bo Zhong Jos é Manautou Xiuling Lu Source Type: research
Emerging Strategies to Bypass Transplant Rejection via Biomaterial-Assisted Immunoengineering: Insights from Islets and Beyond
Adv Drug Deliv Rev. 2023 Aug 5:115050. doi: 10.1016/j.addr.2023.115050. Online ahead of print.ABSTRACTNovel transplantation techniques are currently under development to preserve the function of impaired tissues or organs. While current technologies can enhance the survival of recipients, they have remained elusive to date due to graft rejection by undesired in vivo immune responses despite systemic prescription of immunosuppressants. The need for life-long immunomodulation and serious adverse effects of current medicines, the development of novel biomaterial-based immunoengineering strategies has attracted much attention ...
Source: Advanced Drug Delivery Reviews - August 7, 2023 Category: Drugs & Pharmacology Authors: Samin Abbaszadeh Vahideh Nosrati-Siahmazgi Kiyan Musaie Saman Rezaei Mostafa Qahremani Bo Xiao H élder A Santos Mohammad-Ali Shahbazi Source Type: research
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine
Adv Drug Deliv Rev. 2023 Aug 5:115051. doi: 10.1016/j.addr.2023.115051. Online ahead of print.ABSTRACTImbalance in the tissue microenvironment is the main obstacle to drug delivery and distribution in the human body. Before penetrating the pathological tissue microenvironment to the target site, therapeutic agents are usually accompanied by three consumption steps: the first step is tissue physical barriers for prevention of their penetration, the second step is inactivation of them by biological molecules, and the third step is a cytoprotective mechanism for preventing them from functioning on specific subcellular organel...
Source: Advanced Drug Delivery Reviews - August 7, 2023 Category: Drugs & Pharmacology Authors: Han Han Lei Xing Bi-Te Chen Yang Liu Tian-Jiao Zhou Yi Wang Ling-Feng Zhang Ling Li Chong-Su Cho Hu-Lin Jiang Source Type: research
Emerging Strategies to Bypass Transplant Rejection via Biomaterial-Assisted Immunoengineering: Insights from Islets and Beyond
Adv Drug Deliv Rev. 2023 Aug 5:115050. doi: 10.1016/j.addr.2023.115050. Online ahead of print.ABSTRACTNovel transplantation techniques are currently under development to preserve the function of impaired tissues or organs. While current technologies can enhance the survival of recipients, they have remained elusive to date due to graft rejection by undesired in vivo immune responses despite systemic prescription of immunosuppressants. The need for life-long immunomodulation and serious adverse effects of current medicines, the development of novel biomaterial-based immunoengineering strategies has attracted much attention ...
Source: Advanced Drug Delivery Reviews - August 7, 2023 Category: Drugs & Pharmacology Authors: Samin Abbaszadeh Vahideh Nosrati-Siahmazgi Kiyan Musaie Saman Rezaei Mostafa Qahremani Bo Xiao H élder A Santos Mohammad-Ali Shahbazi Source Type: research
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine
Adv Drug Deliv Rev. 2023 Aug 5:115051. doi: 10.1016/j.addr.2023.115051. Online ahead of print.ABSTRACTImbalance in the tissue microenvironment is the main obstacle to drug delivery and distribution in the human body. Before penetrating the pathological tissue microenvironment to the target site, therapeutic agents are usually accompanied by three consumption steps: the first step is tissue physical barriers for prevention of their penetration, the second step is inactivation of them by biological molecules, and the third step is a cytoprotective mechanism for preventing them from functioning on specific subcellular organel...
Source: Advanced Drug Delivery Reviews - August 7, 2023 Category: Drugs & Pharmacology Authors: Han Han Lei Xing Bi-Te Chen Yang Liu Tian-Jiao Zhou Yi Wang Ling-Feng Zhang Ling Li Chong-Su Cho Hu-Lin Jiang Source Type: research
