Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Adv Drug Deliv Rev. 2024 Apr 8:115304. doi: 10.1016/j.addr.2024.115304. Online ahead of print.ABSTRACTThe lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role in in...
Source: Advanced Drug Delivery Reviews - April 10, 2024 Category: Drugs & Pharmacology Authors: Yisi Tang Bao Liu Yuting Zhang Yuling Liu Yongzhuo Huang Wufa Fan Source Type: research
Delivery technologies for therapeutic targeting of fibronectin fibrosis in autoimmunity and applications
Adv Drug Deliv Rev. 2024 Apr 6:115303. doi: 10.1016/j.addr.2024.115303. Online ahead of print.ABSTRACTFibronectin (FN) is a critical component of extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with cells, growth factors, ECM components, and associated signaling pathways, thus influencing the progress of diseases such...
Source: Advanced Drug Delivery Reviews - April 8, 2024 Category: Drugs & Pharmacology Authors: Jacob D Bonadio Ghazal Bashiri Patrick Halligan Michael Kegel Fatima Ahmed Karin Wang Source Type: research
Delivery technologies for therapeutic targeting of fibronectin fibrosis in autoimmunity and applications
Adv Drug Deliv Rev. 2024 Apr 6:115303. doi: 10.1016/j.addr.2024.115303. Online ahead of print.ABSTRACTFibronectin (FN) is a critical component of extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with cells, growth factors, ECM components, and associated signaling pathways, thus influencing the progress of diseases such...
Source: Advanced Drug Delivery Reviews - April 8, 2024 Category: Drugs & Pharmacology Authors: Jacob D Bonadio Ghazal Bashiri Patrick Halligan Michael Kegel Fatima Ahmed Karin Wang Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 3;208:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticulo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 3;208:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticulo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 2:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticuloendo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 2:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticuloendo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design
Adv Drug Deliv Rev. 2024 Apr 1:115301. doi: 10.1016/j.addr.2024.115301. Online ahead of print.ABSTRACTSubcutaneous (SC) injections can be associated with local pain and discomfort that is subjective and may affect treatment adherence and overall patient experience. With innovations increasingly focused on finding ways to deliver higher doses and volumes (≥2 mL), there is a need to better understand the multiple intertwined factors that influence pain upon SC injection. As a priority for the SC Drug Development & Delivery Consortium, this manuscript provides a comprehensive review of known attributes from published li...
Source: Advanced Drug Delivery Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: Neil Mathias Sylvain Huille Marie Picci Robert P Mahoney Ronald J Pettis Brian Case Bernhard Helk David Kang Ronak Shah Junchi Ma Deep Bhattacharya Yogita Krishnamachari Dany Doucet Nathalie Maksimovikj Sahab Babaee Patrick Garidel Reza Esfandiary Rajesh Source Type: research
Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design
Adv Drug Deliv Rev. 2024 Apr 1:115301. doi: 10.1016/j.addr.2024.115301. Online ahead of print.ABSTRACTSubcutaneous (SC) injections can be associated with local pain and discomfort that is subjective and may affect treatment adherence and overall patient experience. With innovations increasingly focused on finding ways to deliver higher doses and volumes (≥2 mL), there is a need to better understand the multiple intertwined factors that influence pain upon SC injection. As a priority for the SC Drug Development & Delivery Consortium, this manuscript provides a comprehensive review of known attributes from published li...
Source: Advanced Drug Delivery Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: Neil Mathias Sylvain Huille Marie Picci Robert P Mahoney Ronald J Pettis Brian Case Bernhard Helk David Kang Ronak Shah Junchi Ma Deep Bhattacharya Yogita Krishnamachari Dany Doucet Nathalie Maksimovikj Sahab Babaee Patrick Garidel Reza Esfandiary Rajesh Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an atte...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Challenges and progress related to gene editing in rare skin diseases
Adv Drug Deliv Rev. 2024 Mar 23:115294. doi: 10.1016/j.addr.2024.115294. Online ahead of print.ABSTRACTGenodermatoses represent a large group of inherited skin disorders encompassing clinically-heterogeneous conditions that manifest in the skin and other organs. Depending on disease variant, associated clinical manifestations and secondary complications can severely impact patients' quality of life and currently available treatments are transient and not curative. Multiple emerging approaches using CRISPR-based technologies offer promising prospects for therapy. Here, we explore current advances and challenges related to g...
Source: Advanced Drug Delivery Reviews - March 25, 2024 Category: Drugs & Pharmacology Authors: Josefina Pi ñón-Hofbauer Christina Guttmann-Gruber Verena Wally Anshu Sharma Iris K Gratz Ulrich Koller Source Type: research
