Vaccines for immune tolerance against autoimmune disease
Adv Drug Deliv Rev. 2023 Nov 17:115140. doi: 10.1016/j.addr.2023.115140. Online ahead of print.ABSTRACTThe high prevalence and rising incidence of autoimmune diseases have become a prominent public health issue. Autoimmune disorders result from the immune system erroneously attacking the body's own healthy cells and tissues, causing persistent inflammation, tissue injury, and impaired organ function. Existing treatments primarily rely on broad immunosuppression, leaving patients vulnerable to infections and necessitating lifelong treatments. To address these unmet needs, an emerging frontier of vaccine development aims to ...
Source: Advanced Drug Delivery Reviews - November 19, 2023 Category: Drugs & Pharmacology Authors: April Kim Fang Xie Omar A Abed James J Moon Source Type: research
Cell and biomaterial delivery strategies to induce immune tolerance
Adv Drug Deliv Rev. 2023 Nov 17:115141. doi: 10.1016/j.addr.2023.115141. Online ahead of print.ABSTRACTThe prevalence of immune-mediated disorders, including autoimmune conditions and allergies, is steadily increasing. However, current therapeutic approaches are often non-specific and do not address the underlying pathogenic condition, often resulting in impaired immunity and a state of generalized immunosuppression. The emergence of technologies capable of selectively inhibiting aberrant immune activation in a targeted, antigen (Ag)-specific manner by exploiting the body's intrinsic tolerance pathways, all without inducin...
Source: Advanced Drug Delivery Reviews - November 19, 2023 Category: Drugs & Pharmacology Authors: Brianna L Scotland Jacob R Shaw Shruti Dharmaraj Nicholas Caprio Andrea L Cottingham Jackline Joy Mart ín Lasola Junsik J Sung Ryan M Pearson Source Type: research
Advanced optical imaging for the rational design of nanomedicines
Adv Drug Deliv Rev. 2023 Nov 17:115138. doi: 10.1016/j.addr.2023.115138. Online ahead of print.ABSTRACTDespite the enormous potential of nanomedicines to shape the future of medicine, their clinical translation remains suboptimal. Translational challenges are present in every step of the development pipeline, from lack of understanding of patient heterogeneity to insufficient insights on nanoparticle properties and their impact on material-cell interactions. Here, we discuss how the adoption of advanced optical microscopy techniques, such as super-resolution optical microscopies, correlative techniques, and high-content mo...
Source: Advanced Drug Delivery Reviews - November 19, 2023 Category: Drugs & Pharmacology Authors: Ana Ortiz-P érez Miao Zhang Laurence W Fitzpatrick Cristina Izquierdo-Lozano Lorenzo Albertazzi Source Type: research
Vaccines for immune tolerance against autoimmune disease
Adv Drug Deliv Rev. 2023 Nov 17:115140. doi: 10.1016/j.addr.2023.115140. Online ahead of print.ABSTRACTThe high prevalence and rising incidence of autoimmune diseases have become a prominent public health issue. Autoimmune disorders result from the immune system erroneously attacking the body's own healthy cells and tissues, causing persistent inflammation, tissue injury, and impaired organ function. Existing treatments primarily rely on broad immunosuppression, leaving patients vulnerable to infections and necessitating lifelong treatments. To address these unmet needs, an emerging frontier of vaccine development aims to ...
Source: Advanced Drug Delivery Reviews - November 19, 2023 Category: Drugs & Pharmacology Authors: April Kim Fang Xie Omar A Abed James J Moon Source Type: research
Cell and biomaterial delivery strategies to induce immune tolerance
Adv Drug Deliv Rev. 2023 Nov 17:115141. doi: 10.1016/j.addr.2023.115141. Online ahead of print.ABSTRACTThe prevalence of immune-mediated disorders, including autoimmune conditions and allergies, is steadily increasing. However, current therapeutic approaches are often non-specific and do not address the underlying pathogenic condition, often resulting in impaired immunity and a state of generalized immunosuppression. The emergence of technologies capable of selectively inhibiting aberrant immune activation in a targeted, antigen (Ag)-specific manner by exploiting the body's intrinsic tolerance pathways, all without inducin...
Source: Advanced Drug Delivery Reviews - November 19, 2023 Category: Drugs & Pharmacology Authors: Brianna L Scotland Jacob R Shaw Shruti Dharmaraj Nicholas Caprio Andrea L Cottingham Jackline Joy Mart ín Lasola Junsik J Sung Ryan M Pearson Source Type: research
Advanced optical imaging for the rational design of nanomedicines
Adv Drug Deliv Rev. 2023 Nov 17:115138. doi: 10.1016/j.addr.2023.115138. Online ahead of print.ABSTRACTDespite the enormous potential of nanomedicines to shape the future of medicine, their clinical translation remains suboptimal. Translational challenges are present in every step of the development pipeline, from lack of understanding of patient heterogeneity to insufficient insights on nanoparticle properties and their impact on material-cell interactions. Here, we discuss how the adoption of advanced optical microscopy techniques, such as super-resolution optical microscopies, correlative techniques, and high-content mo...
Source: Advanced Drug Delivery Reviews - November 19, 2023 Category: Drugs & Pharmacology Authors: Ana Ortiz-P érez Miao Zhang Laurence W Fitzpatrick Cristina Izquierdo-Lozano Lorenzo Albertazzi Source Type: research
Interaction of 2D nanomaterial with cellular barrier: membrane attachment and intracellular trafficking
Adv Drug Deliv Rev. 2023 Nov 15:115131. doi: 10.1016/j.addr.2023.115131. Online ahead of print.ABSTRACTThe cell membrane serves as a barrier against the free entry of foreign substances into the cell. Limited by factors such as solubility and targeting, it is difficult for some drugs to pass through the cell membrane barrier and exert the expected therapeutic effect. Two-dimensional nanomaterial (2D NM) has the advantages of high drug loading capacity, flexible modification, and multimodal combination therapy, making them a novel drug delivery vehicle for drug membrane attachment and intracellular transport. By modulating ...
Source: Advanced Drug Delivery Reviews - November 17, 2023 Category: Drugs & Pharmacology Authors: Li Miao Yaoyao Wei Xue Lu Min Jiang Yixuan Liu Peishan Li Yuxin Ren Hua Zhang Wen Chen Bo Han Wanliang Lu Source Type: research
Interaction of 2D nanomaterial with cellular barrier: membrane attachment and intracellular trafficking
Adv Drug Deliv Rev. 2023 Nov 15:115131. doi: 10.1016/j.addr.2023.115131. Online ahead of print.ABSTRACTThe cell membrane serves as a barrier against the free entry of foreign substances into the cell. Limited by factors such as solubility and targeting, it is difficult for some drugs to pass through the cell membrane barrier and exert the expected therapeutic effect. Two-dimensional nanomaterial (2D NM) has the advantages of high drug loading capacity, flexible modification, and multimodal combination therapy, making them a novel drug delivery vehicle for drug membrane attachment and intracellular transport. By modulating ...
Source: Advanced Drug Delivery Reviews - November 17, 2023 Category: Drugs & Pharmacology Authors: Li Miao Yaoyao Wei Xue Lu Min Jiang Yixuan Liu Peishan Li Yuxin Ren Hua Zhang Wen Chen Bo Han Wanliang Lu Source Type: research
Engineered organoids for biomedical applications
Adv Drug Deliv Rev. 2023 Nov 13:115142. doi: 10.1016/j.addr.2023.115142. Online ahead of print.ABSTRACTAs miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications. With their potential for personalized therapeutic interventions and high-throughput drug screening, organoids have gained significant attention recently. In this review, we discuss the latest developments in engineering organoids and using materials engineering, biochemical modifications, and advanced manufacturing technologies to improve organoid culture and replicate vi...
Source: Advanced Drug Delivery Reviews - November 15, 2023 Category: Drugs & Pharmacology Authors: Natan Roberto de Barros Canran Wang Surjendu Maity Arne Peirsman Rohollah Nasiri Anna Herland Menekse Ermis Satoru Kawakita Bruna Gregatti Carvalho Negar Hosseinzadeh Kouchehbaghi Rondinelli Donizetti Herculano Zuzana Tirp áková Seyed Mohammad Hossein D Source Type: research
Engineered organoids for biomedical applications
Adv Drug Deliv Rev. 2023 Nov 13:115142. doi: 10.1016/j.addr.2023.115142. Online ahead of print.ABSTRACTAs miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications. With their potential for personalized therapeutic interventions and high-throughput drug screening, organoids have gained significant attention recently. In this review, we discuss the latest developments in engineering organoids and using materials engineering, biochemical modifications, and advanced manufacturing technologies to improve organoid culture and replicate vi...
Source: Advanced Drug Delivery Reviews - November 15, 2023 Category: Drugs & Pharmacology Authors: Natan Roberto de Barros Canran Wang Surjendu Maity Arne Peirsman Rohollah Nasiri Anna Herland Menekse Ermis Satoru Kawakita Bruna Gregatti Carvalho Negar Hosseinzadeh Kouchehbaghi Rondinelli Donizetti Herculano Zuzana Tirp áková Seyed Mohammad Hossein D Source Type: research
Engineered organoids for biomedical applications
Adv Drug Deliv Rev. 2023 Nov 13:115142. doi: 10.1016/j.addr.2023.115142. Online ahead of print.ABSTRACTAs miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications. With their potential for personalized therapeutic interventions and high-throughput drug screening, organoids have gained significant attention recently. In this review, we discuss the latest developments in engineering organoids and using materials engineering, biochemical modifications, and advanced manufacturing technologies to improve organoid culture and replicate vi...
Source: Advanced Drug Delivery Reviews - November 15, 2023 Category: Drugs & Pharmacology Authors: Natan Roberto de Barros Canran Wang Surjendu Maity Arne Peirsman Rohollah Nasiri Anna Herland Menekse Ermis Satoru Kawakita Bruna Gregatti Carvalho Negar Hosseinzadeh Kouchehbaghi Rondinelli Donizetti Herculano Zuzana Tirp áková Seyed Mohammad Hossein D Source Type: research
Peptide-containing nanoformulations: Skin barrier penetration and activity contribution
This article presents an overview of the current developments in peptides and nanotechnology to address this challenge. Initially, we sum up peptide-containing nanoformulations for transdermal drug delivery, examining them through the lenses of both inorganic and organic materials. Particular emphasis is placed on the diverse roles that peptides play within these nanoformulations, including conferring functionality upon nanocarriers and enhancing the biological efficacy of drugs. Subsequently, we summarize innovative strategies for enhancing skin penetration, categorizing them into passive and active approaches. Lastly, we...
Source: Advanced Drug Delivery Reviews - November 11, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhang Xuan Luo Keming Xu Wenying Zhong Source Type: research
Peptide-containing nanoformulations: Skin barrier penetration and activity contribution
This article presents an overview of the current developments in peptides and nanotechnology to address this challenge. Initially, we sum up peptide-containing nanoformulations for transdermal drug delivery, examining them through the lenses of both inorganic and organic materials. Particular emphasis is placed on the diverse roles that peptides play within these nanoformulations, including conferring functionality upon nanocarriers and enhancing the biological efficacy of drugs. Subsequently, we summarize innovative strategies for enhancing skin penetration, categorizing them into passive and active approaches. Lastly, we...
Source: Advanced Drug Delivery Reviews - November 11, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhang Xuan Luo Keming Xu Wenying Zhong Source Type: research
Peptide-containing nanoformulations: Skin barrier penetration and activity contribution
This article presents an overview of the current developments in peptides and nanotechnology to address this challenge. Initially, we sum up peptide-containing nanoformulations for transdermal drug delivery, examining them through the lenses of both inorganic and organic materials. Particular emphasis is placed on the diverse roles that peptides play within these nanoformulations, including conferring functionality upon nanocarriers and enhancing the biological efficacy of drugs. Subsequently, we summarize innovative strategies for enhancing skin penetration, categorizing them into passive and active approaches. Lastly, we...
Source: Advanced Drug Delivery Reviews - November 11, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhang Xuan Luo Keming Xu Wenying Zhong Source Type: research
The spatiotemporal journey of nanomedicines in solid tumors on their therapeutic efficacy
Adv Drug Deliv Rev. 2023 Nov 8:115137. doi: 10.1016/j.addr.2023.115137. Online ahead of print.ABSTRACTThe rapid development of nanomedicines is revolutionizing the landscape of cancer treatment, while effectively delivering them into solid tumors remains a formidable challenge. Currently, there is a huge disconnect on therapeutic response between regulatory approved nanomedicines and laboratory reported nanoparticles. The discrepancy is mainly resulted from the failure of using the classic overall pharmacokinetics behaviors of nanomedicines in tumors to predict the antitumor efficacy. Increasing evidence has revealed that ...
Source: Advanced Drug Delivery Reviews - November 10, 2023 Category: Drugs & Pharmacology Authors: Mengmeng Qin Heming Xia Wenhao Xu Binlong Chen Yiguang Wang Source Type: research
