The interaction between particles and vascular endothelium in blood flow
Adv Drug Deliv Rev. 2024 Feb 20:115216. doi: 10.1016/j.addr.2024.115216. Online ahead of print.ABSTRACTParticle-based drug delivery systems have shown promising application potential to treat human diseases; however, an incomplete understanding of their interactions with vascular endothelium in blood flow prevents their inclusion into mainstream clinical applications. The flow behaviors of nano/micro-sized particles in the blood are disturbed by many external/internal factors, including blood constituents, particle properties, and endothelium bioactivities, affecting the fate of particles in vivo and therapeutic effects fo...
Source: Advanced Drug Delivery Reviews - February 22, 2024 Category: Drugs & Pharmacology Authors: Xiaotong Li Jiahui Zou Zhongshan He Yanhua Sun Xiangrong Song Wei He Source Type: research
Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy
Adv Drug Deliv Rev. 2024 Feb 14:115200. doi: 10.1016/j.addr.2024.115200. Online ahead of print.ABSTRACTNanoscale contrast agents have emerged as a versatile platform in the field of biomedical research, offering great potential for ultrasound imaging and therapy. Various kinds of nanoscale contrast agents have been extensively investigated in preclinical experiments to satisfy diverse biomedical applications. This paper provides a comprehensive review of the structure and composition of various nanoscale contrast agents, as well as their preparation and functionalization, encompassing both chemosynthetic and biosynthetic s...
Source: Advanced Drug Delivery Reviews - February 16, 2024 Category: Drugs & Pharmacology Authors: Jieqiong Wang Yuanyuan Wang Lin Zhong Fei Yan Hairong Zheng Source Type: research
Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy
Adv Drug Deliv Rev. 2024 Feb 14:115200. doi: 10.1016/j.addr.2024.115200. Online ahead of print.ABSTRACTNanoscale contrast agents have emerged as a versatile platform in the field of biomedical research, offering great potential for ultrasound imaging and therapy. Various kinds of nanoscale contrast agents have been extensively investigated in preclinical experiments to satisfy diverse biomedical applications. This paper provides a comprehensive review of the structure and composition of various nanoscale contrast agents, as well as their preparation and functionalization, encompassing both chemosynthetic and biosynthetic s...
Source: Advanced Drug Delivery Reviews - February 16, 2024 Category: Drugs & Pharmacology Authors: Jieqiong Wang Yuanyuan Wang Lin Zhong Fei Yan Hairong Zheng Source Type: research
Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy
Adv Drug Deliv Rev. 2024 Feb 14:115200. doi: 10.1016/j.addr.2024.115200. Online ahead of print.ABSTRACTNanoscale contrast agents have emerged as a versatile platform in the field of biomedical research, offering great potential for ultrasound imaging and therapy. Various kinds of nanoscale contrast agents have been extensively investigated in preclinical experiments to satisfy diverse biomedical applications. This paper provides a comprehensive review of the structure and composition of various nanoscale contrast agents, as well as their preparation and functionalization, encompassing both chemosynthetic and biosynthetic s...
Source: Advanced Drug Delivery Reviews - February 16, 2024 Category: Drugs & Pharmacology Authors: Jieqiong Wang Yuanyuan Wang Lin Zhong Fei Yan Hairong Zheng Source Type: research
Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy
Adv Drug Deliv Rev. 2024 Feb 14:115200. doi: 10.1016/j.addr.2024.115200. Online ahead of print.ABSTRACTNanoscale contrast agents have emerged as a versatile platform in the field of biomedical research, offering great potential for ultrasound imaging and therapy. Various kinds of nanoscale contrast agents have been extensively investigated in preclinical experiments to satisfy diverse biomedical applications. This paper provides a comprehensive review of the structure and composition of various nanoscale contrast agents, as well as their preparation and functionalization, encompassing both chemosynthetic and biosynthetic s...
Source: Advanced Drug Delivery Reviews - February 16, 2024 Category: Drugs & Pharmacology Authors: Jieqiong Wang Yuanyuan Wang Lin Zhong Fei Yan Hairong Zheng Source Type: research
Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy
Adv Drug Deliv Rev. 2024 Feb 14:115200. doi: 10.1016/j.addr.2024.115200. Online ahead of print.ABSTRACTNanoscale contrast agents have emerged as a versatile platform in the field of biomedical research, offering great potential for ultrasound imaging and therapy. Various kinds of nanoscale contrast agents have been extensively investigated in preclinical experiments to satisfy diverse biomedical applications. This paper provides a comprehensive review of the structure and composition of various nanoscale contrast agents, as well as their preparation and functionalization, encompassing both chemosynthetic and biosynthetic s...
Source: Advanced Drug Delivery Reviews - February 16, 2024 Category: Drugs & Pharmacology Authors: Jieqiong Wang Yuanyuan Wang Lin Zhong Fei Yan Hairong Zheng Source Type: research
Encapsulation and immune protection for type 1 diabetes cell therapy
Adv Drug Deliv Rev. 2024 Feb 13:115205. doi: 10.1016/j.addr.2024.115205. Online ahead of print.ABSTRACTType 1 Diabetes (T1D) involves the autoimmune destruction of insulin-producing β-cells in the pancreas. Exogenous insulin injections are the current therapy but are user-dependent and cannot fully recapitulate physiological insulin secretion dynamics. Since the emergence of allogeneic cell therapy for T1D, the Edmonton Protocol has been the most promising immunosuppression protocol for cadaveric islet transplantation, but the lack of donor islets, poor cell engraftment, and required chronic immunosuppression have limited...
Source: Advanced Drug Delivery Reviews - February 15, 2024 Category: Drugs & Pharmacology Authors: Sophia Kioulaphides Andr és J García Source Type: research
Encapsulation and immune protection for type 1 diabetes cell therapy
Adv Drug Deliv Rev. 2024 Feb 13:115205. doi: 10.1016/j.addr.2024.115205. Online ahead of print.ABSTRACTType 1 Diabetes (T1D) involves the autoimmune destruction of insulin-producing β-cells in the pancreas. Exogenous insulin injections are the current therapy but are user-dependent and cannot fully recapitulate physiological insulin secretion dynamics. Since the emergence of allogeneic cell therapy for T1D, the Edmonton Protocol has been the most promising immunosuppression protocol for cadaveric islet transplantation, but the lack of donor islets, poor cell engraftment, and required chronic immunosuppression have limited...
Source: Advanced Drug Delivery Reviews - February 15, 2024 Category: Drugs & Pharmacology Authors: Sophia Kioulaphides Andr és J García Source Type: research
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers
Adv Drug Deliv Rev. 2024 Feb 9;207:115197. doi: 10.1016/j.addr.2024.115197. Online ahead of print.ABSTRACTSkin cancer is a heterogeneous disease that can be divided into two main groups, melanoma and nonmelanoma skin cancers. Conventional therapies for skin cancer have numerous systemic side effects and a high recurrence rate. Topical treatment is an alternative approach, but drug permeability remains a challenge. Therefore, nanocarriers appear as important nanotechnology tools that reduces both the side effects and improves clinical outcomes. This is why they are attracting growing interest. In this review, scientific art...
Source: Advanced Drug Delivery Reviews - February 11, 2024 Category: Drugs & Pharmacology Authors: Beatriz da Silva Gomes Ana Cl áudia Paiva-Santos Francisco Veiga Filipa Mascarenhas-Melo Source Type: research
Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders
Adv Drug Deliv Rev. 2024 Feb 9:115204. doi: 10.1016/j.addr.2024.115204. Online ahead of print.ABSTRACTTargeting specific organs and cell types using nanotechnology and sophisticated delivery methods has been at the forefront of applicative biomedical sciences lately. Macrophages are an appealing target for immunomodulation by nanodelivery as they are heavily involved in various aspects of many diseases and are highly plastic in their nature. Their continuum of functional "polarization" states has been a research focus for many years yielding a profound understanding of various aspects of these cells. The ability of monocyt...
Source: Advanced Drug Delivery Reviews - February 11, 2024 Category: Drugs & Pharmacology Authors: Ahmad Zaid Amiram Ariel Source Type: research
Extracellular vesicles are key players in mesenchymal stem cells' dual potential to regenerate and modulate the immune system
Adv Drug Deliv Rev. 2024 Feb 9;207:115203. doi: 10.1016/j.addr.2024.115203. Online ahead of print.ABSTRACTMSCs are used for treatment of inflammatory conditions or for regenerative purposes. MSCs are complete cells and allogenic transplantation is in principle possible, but mostly autologous use is preferred. In recent years, it was discovered that cells secrete extracellular vesicles. These are active budded off vesicles that carry a cargo. The cargo can be miRNA, protein, lipids etc. The extracellular vesicles can be transported through the body and fuse with target cells. Thereby, they influence the phenotype and modula...
Source: Advanced Drug Delivery Reviews - February 11, 2024 Category: Drugs & Pharmacology Authors: Martijn van Griensven Elizabeth R Balmayor Source Type: research
Emerging strategies for nanomedicine in autoimmunity
Adv Drug Deliv Rev. 2024 Feb 9:115194. doi: 10.1016/j.addr.2024.115194. Online ahead of print.ABSTRACTAutoimmune disorders have risen to be among the most prevalent chronic diseases across the globe, affecting approximately 5-7% of the population. As autoimmune diseases steadily rise in prevalence, so do the number of potential therapeutic strategies to combat them. In recent years, fundamental research investigating these autoimmune pathologies has led to the emergence of several cellular targets that provide new therapeutic opportunities. However, key challenges persist in terms of accessing and specifically combating th...
Source: Advanced Drug Delivery Reviews - February 11, 2024 Category: Drugs & Pharmacology Authors: Ajay S Thatte Margaret M Billingsley Drew Weissman Jilian R Melamed Michael J Mitchell Source Type: research
Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy
Adv Drug Deliv Rev. 2024 Feb 9;207:115198. doi: 10.1016/j.addr.2024.115198. Online ahead of print.ABSTRACTGene therapy is one of the most advanced therapies in current medicine. In particular, interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in recent years as it is a highly versatile, selective and specific therapy. In dermatological conditions, topical delivery of siRNA offers numerous therapeutic advantages, mainly by inhibiting the expression of target transcripts directly in the skin. However, crossing the stratum corneum and overcoming intracellular barriers is an inherent challeng...
Source: Advanced Drug Delivery Reviews - February 10, 2024 Category: Drugs & Pharmacology Authors: Ana Vitoria Pupo Silvestrini Milena Finazzi Morais Bryan Wender Debiasi Fab íola Garcia Praça Maria Vit ória Lopes Badra Bentley Source Type: research
Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway
Adv Drug Deliv Rev. 2024 Feb 7:115196. doi: 10.1016/j.addr.2024.115196. Online ahead of print.ABSTRACTWe overviewed the anatomy and physiology of the nose-to-brain pathway, along with the mechanisms involved. We then summarized the interaction process between nanoparticles and this pathway as well as the potential strategies inspired from natural nano-sized substances. This review may help inspire the potential of intranasal drug delivery in the application to treat various brain diseases. Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a cruci...
Source: Advanced Drug Delivery Reviews - February 9, 2024 Category: Drugs & Pharmacology Authors: Yaoxing Chen Chenyun Zhang Yukun Huang Yuxiao Ma Qingxiang Song Hongzhuan Chen Gan Jiang Xiaoling Gao Source Type: research
Revealing the clinical potential of high-resolution organoids
Adv Drug Deliv Rev. 2024 Feb 8;207:115202. doi: 10.1016/j.addr.2024.115202. Online ahead of print.ABSTRACTThe symbiotic interplay of organoid technology and advanced imaging strategies yields innovative breakthroughs in research and clinical applications. Organoids, intricate three-dimensional cell cultures derived from pluripotent or adult stem/progenitor cells, have emerged as potent tools for in vitro modeling, reflecting in vivo organs and advancing our grasp of tissue physiology and disease. Concurrently, advanced imaging technologies such as confocal, light-sheet, and two-photon microscopy ignite fresh explorations, ...
Source: Advanced Drug Delivery Reviews - February 9, 2024 Category: Drugs & Pharmacology Authors: Jihoon Ko Sujin Hyung Sunghun Cheong Yoojin Chung Noo Li Jeon Source Type: research
