Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers
Adv Drug Deliv Rev. 2023 Oct 14:115115. doi: 10.1016/j.addr.2023.115115. Online ahead of print.ABSTRACTSilica nanoparticles (SNP) have gained tremendous attention in the recent decades. They have been used in many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer, anti-microbial and theranostic applications are especially prominent due to their exceptional performance to deliver many different small molecules and recently biologics (mRNA, siRNA, antigens, antibodies, proteins, and peptides) at targeted sites. The physical and chemical properties of SNP such a...
Source: Advanced Drug Delivery Reviews - October 16, 2023 Category: Drugs & Pharmacology Authors: Taskeen Iqbal Janjua Yuxue Cao Freddy Kleitz Mika Linden Chengzhong Yu Amirali Popat Source Type: research
Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers
Adv Drug Deliv Rev. 2023 Oct 14:115115. doi: 10.1016/j.addr.2023.115115. Online ahead of print.ABSTRACTSilica nanoparticles (SNP) have gained tremendous attention in the recent decades. They have been used in many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer, anti-microbial and theranostic applications are especially prominent due to their exceptional performance to deliver many different small molecules and recently biologics (mRNA, siRNA, antigens, antibodies, proteins, and peptides) at targeted sites. The physical and chemical properties of SNP such a...
Source: Advanced Drug Delivery Reviews - October 16, 2023 Category: Drugs & Pharmacology Authors: Taskeen Iqbal Janjua Yuxue Cao Freddy Kleitz Mika Linden Chengzhong Yu Amirali Popat Source Type: research
Lysosomal Therapies and Drug Delivery Strategies: An Overview
Adv Drug Deliv Rev. 2023 Oct 10:115112. doi: 10.1016/j.addr.2023.115112. Online ahead of print.NO ABSTRACTPMID:37827335 | DOI:10.1016/j.addr.2023.115112 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Silvia Muro Source Type: research
Protein corona on brain targeted nanocarriers: Challenges and prospects
Adv Drug Deliv Rev. 2023 Oct 11;202:115114. doi: 10.1016/j.addr.2023.115114. Online ahead of print.ABSTRACTSafe and efficient medical therapy for brain diseases is still an unmet clinical need due to various barriers represented by the blood-brain barrier. Well-designed brain targeted nanocarriers are potential solutions for enhanced brain drug delivery; however, the complicated in vivo process attenuates performance of nanocarriers, which severely hampers clinical translation. The formation of protein corona (PC) is inevitable for nanocarriers circulation and transport in biofluids, acting as an important factor to regula...
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Kuan Jiang Yifei Yu Wei Qiu Kaisong Tian Zhiwei Guo Jun Qian Huiping Lu Changyou Zhan Source Type: research
Editorial: Ocular Drug delivery - Challenges, Opportunities, and Developments
Adv Drug Deliv Rev. 2023 Oct 10:115113. doi: 10.1016/j.addr.2023.115113. Online ahead of print.NO ABSTRACTPMID:37827337 | DOI:10.1016/j.addr.2023.115113 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Jian Ji Yong Tao Yan Pang Source Type: research
Lysosomal Therapies and Drug Delivery Strategies: An Overview
Adv Drug Deliv Rev. 2023 Oct 10:115112. doi: 10.1016/j.addr.2023.115112. Online ahead of print.NO ABSTRACTPMID:37827335 | DOI:10.1016/j.addr.2023.115112 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Silvia Muro Source Type: research
Protein Corona on Brain Targeted Nanocarriers: Challenges and Prospects
Adv Drug Deliv Rev. 2023 Oct 10:115114. doi: 10.1016/j.addr.2023.115114. Online ahead of print.ABSTRACTSafe and efficient medical therapy for brain diseases is still an unmet clinical need due to various barriers represented by the blood-brain barrier. Well-designed brain targeted nanocarriers are potential solutions for enhanced brain drug delivery; however, the complicated in vivo process attenuates performance of nanocarriers, which severely hampers clinical translation. The formation of protein corona (PC) is inevitable for nanocarriers circulation and transport in biofluids, acting as an important factor to regulate i...
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Kuan Jiang Yifei Yu Wei Qiu Kaisong Tian Zhiwei Guo Jun Qian Huiping Lu Changyou Zhan Source Type: research
Editorial: Ocular Drug delivery - Challenges, Opportunities, and Developments
Adv Drug Deliv Rev. 2023 Oct 10:115113. doi: 10.1016/j.addr.2023.115113. Online ahead of print.NO ABSTRACTPMID:37827337 | DOI:10.1016/j.addr.2023.115113 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Jian Ji Yong Tao Yan Pang Source Type: research
Lysosomal Therapies and Drug Delivery Strategies: An Overview
Adv Drug Deliv Rev. 2023 Oct 10:115112. doi: 10.1016/j.addr.2023.115112. Online ahead of print.NO ABSTRACTPMID:37827335 | DOI:10.1016/j.addr.2023.115112 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Silvia Muro Source Type: research
Protein Corona on Brain Targeted Nanocarriers: Challenges and Prospects
Adv Drug Deliv Rev. 2023 Oct 10:115114. doi: 10.1016/j.addr.2023.115114. Online ahead of print.ABSTRACTSafe and efficient medical therapy for brain diseases is still an unmet clinical need due to various barriers represented by the blood-brain barrier. Well-designed brain targeted nanocarriers are potential solutions for enhanced brain drug delivery; however, the complicated in vivo process attenuates performance of nanocarriers, which severely hampers clinical translation. The formation of protein corona (PC) is inevitable for nanocarriers circulation and transport in biofluids, acting as an important factor to regulate i...
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Kuan Jiang Yifei Yu Wei Qiu Kaisong Tian Zhiwei Guo Jun Qian Huiping Lu Changyou Zhan Source Type: research
Editorial: Ocular Drug delivery - Challenges, Opportunities, and Developments
Adv Drug Deliv Rev. 2023 Oct 10:115113. doi: 10.1016/j.addr.2023.115113. Online ahead of print.NO ABSTRACTPMID:37827337 | DOI:10.1016/j.addr.2023.115113 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Jian Ji Yong Tao Yan Pang Source Type: research
Lysosomal Therapies and Drug Delivery Strategies: An Overview
Adv Drug Deliv Rev. 2023 Oct 10:115112. doi: 10.1016/j.addr.2023.115112. Online ahead of print.NO ABSTRACTPMID:37827335 | DOI:10.1016/j.addr.2023.115112 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Silvia Muro Source Type: research
Protein Corona on Brain Targeted Nanocarriers: Challenges and Prospects
Adv Drug Deliv Rev. 2023 Oct 10:115114. doi: 10.1016/j.addr.2023.115114. Online ahead of print.ABSTRACTSafe and efficient medical therapy for brain diseases is still an unmet clinical need due to various barriers represented by the blood-brain barrier. Well-designed brain targeted nanocarriers are potential solutions for enhanced brain drug delivery; however, the complicated in vivo process attenuates performance of nanocarriers, which severely hampers clinical translation. The formation of protein corona (PC) is inevitable for nanocarriers circulation and transport in biofluids, acting as an important factor to regulate i...
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Kuan Jiang Yifei Yu Wei Qiu Kaisong Tian Zhiwei Guo Jun Qian Huiping Lu Changyou Zhan Source Type: research
Editorial: Ocular Drug delivery - Challenges, Opportunities, and Developments
Adv Drug Deliv Rev. 2023 Oct 10:115113. doi: 10.1016/j.addr.2023.115113. Online ahead of print.NO ABSTRACTPMID:37827337 | DOI:10.1016/j.addr.2023.115113 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - October 12, 2023 Category: Drugs & Pharmacology Authors: Jian Ji Yong Tao Yan Pang Source Type: research
Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy
Adv Drug Deliv Rev. 2023 Oct 9:115110. doi: 10.1016/j.addr.2023.115110. Online ahead of print.ABSTRACTSonodynamic therapy (SDT) has been developed as a promising alternative therapeutic modality for cancer treatment, involving the synergetic application of sonosensitizers and low-intensity ultrasound. However, the antitumor efficacy of SDT is significantly limited due to the poor performance of conventional sonosensitizers in vivo and the constrained tumor microenvironment (TME). Recent breakthroughs in lipid bilayer-based nanovesicles (LBBNs), including multifunctional liposomes, exosomes, and isolated cellular membranes,...
Source: Advanced Drug Delivery Reviews - October 11, 2023 Category: Drugs & Pharmacology Authors: Songhao Li Greta S P Mok Yunlu Dai Source Type: research
