Clinical perspective on topical vaccination strategies
Adv Drug Deliv Rev. 2024 Mar 22:115292. doi: 10.1016/j.addr.2024.115292. Online ahead of print.ABSTRACTVaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined herein as the introduction of a vaccine to any of the three layers of the human skin, has attracted interest in recent years as an alternative vaccination approach to the conventi...
Source: Advanced Drug Delivery Reviews - March 24, 2024 Category: Drugs & Pharmacology Authors: Petya Popova Sunny P Chen Suiyang Liao Manish Sadarangani Anna K Blakney Source Type: research
Emerging Voices in Drug Delivery - Harnessing and Modulating Complex Biological Systems
Adv Drug Deliv Rev. 2024 Mar 21:115293. doi: 10.1016/j.addr.2024.115293. Online ahead of print.NO ABSTRACTPMID:38521245 | DOI:10.1016/j.addr.2024.115293 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - March 23, 2024 Category: Drugs & Pharmacology Authors: Shawn Owen Juliane Nguyen Source Type: research
Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies
Adv Drug Deliv Rev. 2024 Mar 19;208:115291. doi: 10.1016/j.addr.2024.115291. Online ahead of print.ABSTRACTAmong non-viral vectors, lipid nanovectors are considered the gold standard for the delivery of RNA therapeutics. The success of lipid nanoparticles for RNA delivery, with three products approved for human use, has stimulated further investigation into RNA therapeutics for different pathologies. This requires decoding the pathological intracellular processes and tailoring the delivery system to the target tissue and cells. The complexity of the lipid nanovectors morphology originates from the assembling of the lipidic...
Source: Advanced Drug Delivery Reviews - March 21, 2024 Category: Drugs & Pharmacology Authors: Valeria Nele Virginia Campani Seyedeh Alia Moosavian Giuseppe De Rosa Source Type: research
Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies
Adv Drug Deliv Rev. 2024 Mar 19:115291. doi: 10.1016/j.addr.2024.115291. Online ahead of print.ABSTRACTAmong non-viral vectors, lipid nanovectors are considered the gold standard for the delivery of RNA therapeutics. The success of lipid nanoparticles for RNA delivery, with three products approved for human use, has stimulated further investigation into RNA therapeutics for different pathologies. This requires decoding the pathological intracellular processes and tailoring the delivery system to the target tissue and cells. The complexity of the lipid nanovectors morphology originates from the assembling of the lipidic com...
Source: Advanced Drug Delivery Reviews - March 21, 2024 Category: Drugs & Pharmacology Authors: Valeria Nele Virginia Campani Seyedeh Alia Moosavian Giuseppe De Rosa Source Type: research
Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies
Adv Drug Deliv Rev. 2024 Mar 19:115291. doi: 10.1016/j.addr.2024.115291. Online ahead of print.ABSTRACTAmong non-viral vectors, lipid nanovectors are considered the gold standard for the delivery of RNA therapeutics. The success of lipid nanoparticles for RNA delivery, with three products approved for human use, has stimulated further investigation into RNA therapeutics for different pathologies. This requires decoding the pathological intracellular processes and tailoring the delivery system to the target tissue and cells. The complexity of the lipid nanovectors morphology originates from the assembling of the lipidic com...
Source: Advanced Drug Delivery Reviews - March 21, 2024 Category: Drugs & Pharmacology Authors: Valeria Nele Virginia Campani Seyedeh Alia Moosavian Giuseppe De Rosa Source Type: research
RNA therapies for CNS diseases
Adv Drug Deliv Rev. 2024 Mar 16;208:115283. doi: 10.1016/j.addr.2024.115283. Online ahead of print.ABSTRACTNeurological disorders are a diverse group of conditions that pose an increasing health burden worldwide. There is a general lack of effective therapies due to multiple reasons, of which a key obstacle is the presence of the blood-brain barrier, which limits drug delivery to the central nervous system, and generally restricts the pool of candidate drugs to small, lipophilic molecules. However, in many cases, these are unable to target key pathways in the pathogenesis of neurological disorders. As a group, RNA therapie...
Source: Advanced Drug Delivery Reviews - March 17, 2024 Category: Drugs & Pharmacology Authors: Valentina Di Francesco Andy J Chua Di Huang Anisha D'Souza Alicia Yang Benjamin S Bleier Mansoor M Amiji Source Type: research
RNA therapies for CNS diseases
Adv Drug Deliv Rev. 2024 Mar 15:115283. doi: 10.1016/j.addr.2024.115283. Online ahead of print.ABSTRACTNeurological disorders are a diverse group of conditions that pose an increasing health burden worldwide. There is a general lack of effective therapies due to multiple reasons, of which a key obstacle is the presence of the blood-brain barrier, which limits drug delivery to the central nervous system, and generally restricts the pool of candidate drugs to small, lipophilic molecules. However, in many cases, these are unable to target key pathways in the pathogenesis of neurological disorders. As a group, RNA therapies ha...
Source: Advanced Drug Delivery Reviews - March 17, 2024 Category: Drugs & Pharmacology Authors: Valentina Di Francesco Andy J Chua Di Huang Anisha D'Souza Alicia Yang Benjamin S Bleier Mansoor M Amiji Source Type: research
RNA therapies for CNS diseases
Adv Drug Deliv Rev. 2024 Mar 15:115283. doi: 10.1016/j.addr.2024.115283. Online ahead of print.ABSTRACTNeurological disorders are a diverse group of conditions that pose an increasing health burden worldwide. There is a general lack of effective therapies due to multiple reasons, of which a key obstacle is the presence of the blood-brain barrier, which limits drug delivery to the central nervous system, and generally restricts the pool of candidate drugs to small, lipophilic molecules. However, in many cases, these are unable to target key pathways in the pathogenesis of neurological disorders. As a group, RNA therapies ha...
Source: Advanced Drug Delivery Reviews - March 17, 2024 Category: Drugs & Pharmacology Authors: Valentina Di Francesco Andy J Chua Di Huang Anisha D'Souza Alicia Yang Benjamin S Bleier Mansoor M Amiji Source Type: research
Translating ultrasound-mediated drug delivery technologies for CNS applications
Adv Drug Deliv Rev. 2024 Mar 6;208:115274. doi: 10.1016/j.addr.2024.115274. Online ahead of print.ABSTRACTUltrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood-brain barrier. Wh...
Source: Advanced Drug Delivery Reviews - March 7, 2024 Category: Drugs & Pharmacology Authors: Ederlyn Perolina Svenja Meissner Brad Raos Bruce Harland Sachin Thakur Darren Svirskis Source Type: research
Translating ultrasound-mediated drug delivery technologies for CNS applications
Adv Drug Deliv Rev. 2024 Mar 6;208:115274. doi: 10.1016/j.addr.2024.115274. Online ahead of print.ABSTRACTUltrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood-brain barrier. Wh...
Source: Advanced Drug Delivery Reviews - March 7, 2024 Category: Drugs & Pharmacology Authors: Ederlyn Perolina Svenja Meissner Brad Raos Bruce Harland Sachin Thakur Darren Svirskis Source Type: research
Translating ultrasound-mediated drug delivery technologies for CNS applications
Adv Drug Deliv Rev. 2024 Mar 6;208:115274. doi: 10.1016/j.addr.2024.115274. Online ahead of print.ABSTRACTUltrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood-brain barrier. Wh...
Source: Advanced Drug Delivery Reviews - March 7, 2024 Category: Drugs & Pharmacology Authors: Ederlyn Perolina Svenja Meissner Brad Raos Bruce Harland Sachin Thakur Darren Svirskis Source Type: research
Translating ultrasound-mediated drug delivery technologies for CNS applications
Adv Drug Deliv Rev. 2024 Mar 6;208:115274. doi: 10.1016/j.addr.2024.115274. Online ahead of print.ABSTRACTUltrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood-brain barrier. Wh...
Source: Advanced Drug Delivery Reviews - March 7, 2024 Category: Drugs & Pharmacology Authors: Ederlyn Perolina Svenja Meissner Brad Raos Bruce Harland Sachin Thakur Darren Svirskis Source Type: research
Translating ultrasound-mediated drug delivery technologies for CNS applications
Adv Drug Deliv Rev. 2024 Mar 6;208:115274. doi: 10.1016/j.addr.2024.115274. Online ahead of print.ABSTRACTUltrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood-brain barrier. Wh...
Source: Advanced Drug Delivery Reviews - March 7, 2024 Category: Drugs & Pharmacology Authors: Ederlyn Perolina Svenja Meissner Brad Raos Bruce Harland Sachin Thakur Darren Svirskis Source Type: research
Translating ultrasound-mediated drug delivery technologies for CNS applications
Adv Drug Deliv Rev. 2024 Mar 6;208:115274. doi: 10.1016/j.addr.2024.115274. Online ahead of print.ABSTRACTUltrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood-brain barrier. Wh...
Source: Advanced Drug Delivery Reviews - March 7, 2024 Category: Drugs & Pharmacology Authors: Ederlyn Perolina Svenja Meissner Brad Raos Bruce Harland Sachin Thakur Darren Svirskis Source Type: research
Translating ultrasound-mediated drug delivery technologies for CNS applications
Adv Drug Deliv Rev. 2024 Mar 5:115274. doi: 10.1016/j.addr.2024.115274. Online ahead of print.ABSTRACTUltrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood-brain barrier. While ...
Source: Advanced Drug Delivery Reviews - March 7, 2024 Category: Drugs & Pharmacology Authors: Ederlyn Perolina Svenja Meissner Brad Raos Bruce Harland Sachin Thakur Darren Svirskis Source Type: research
