Injectable Systems for Long-lasting Insulin Therapy
Adv Drug Deliv Rev. 2023 Oct 26:115121. doi: 10.1016/j.addr.2023.115121. Online ahead of print.ABSTRACTInsulin therapy is the mainstay to treat diabetes charactered by hyperglycemia. However, its short half-life of only 4-6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue products that have up to 42 h of glycemic control. However, these insulin analogues still require once- or twice-daily injections for optimal glycemic control and have poor patient compliance and adherence issues. To achieve insulin release for mo...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kumar Kulldeep Niloy Tao L Lowe Source Type: research
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease
Adv Drug Deliv Rev. 2023 Oct 26:115117. doi: 10.1016/j.addr.2023.115117. Online ahead of print.ABSTRACTOral administration is the preferred route of administration based on the convenience for and compliance of the patient. Oral nanomedicines have been developed to overcome the limitations of free drugs and overcome gastrointestinal (GI) barriers, which are heterogeneous across healthy and diseased populations. This review aims to provide a comprehensive overview and comparison of the oral nanomedicine biointeractions in the gastrointestinal tract (GIT) in health and disease (GI and extra-GI diseases) and highlight emergin...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Cheng Chen Ana Beloqui Yining Xu Source Type: research
Emerging drug delivery systems with traditional routes - A roadmap to chronic inflammatory diseases
Adv Drug Deliv Rev. 2023 Oct 28;203:115119. doi: 10.1016/j.addr.2023.115119. Online ahead of print.ABSTRACTInflammation is prevalent and inevitable in daily life but can generally be accommodated by the immune systems. However, incapable self-healing and persistent inflammation can progress to chronic inflammation, leading to prevalent or fatal chronic diseases. This review comprehensively covers the topic of emerging drug delivery systems (DDSs) for the treatment of chronic inflammatory diseases (CIDs). First, we introduce the basic biology of the chronic inflammatory process and provide an overview of the main CIDs of th...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kiyoon Min Abhishek Sahu Sae Hyun Jeon Giyoong Tae Source Type: research
Injectable Systems for Long-lasting Insulin Therapy
Adv Drug Deliv Rev. 2023 Oct 26:115121. doi: 10.1016/j.addr.2023.115121. Online ahead of print.ABSTRACTInsulin therapy is the mainstay to treat diabetes charactered by hyperglycemia. However, its short half-life of only 4-6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue products that have up to 42 h of glycemic control. However, these insulin analogues still require once- or twice-daily injections for optimal glycemic control and have poor patient compliance and adherence issues. To achieve insulin release for mo...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kumar Kulldeep Niloy Tao L Lowe Source Type: research
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease
Adv Drug Deliv Rev. 2023 Oct 26:115117. doi: 10.1016/j.addr.2023.115117. Online ahead of print.ABSTRACTOral administration is the preferred route of administration based on the convenience for and compliance of the patient. Oral nanomedicines have been developed to overcome the limitations of free drugs and overcome gastrointestinal (GI) barriers, which are heterogeneous across healthy and diseased populations. This review aims to provide a comprehensive overview and comparison of the oral nanomedicine biointeractions in the gastrointestinal tract (GIT) in health and disease (GI and extra-GI diseases) and highlight emergin...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Cheng Chen Ana Beloqui Yining Xu Source Type: research
Emerging drug delivery systems with traditional routes - A roadmap to chronic inflammatory diseases
Adv Drug Deliv Rev. 2023 Oct 26:115119. doi: 10.1016/j.addr.2023.115119. Online ahead of print.ABSTRACTInflammation is prevalent and inevitable in daily life but can generally be accommodated by the immune systems. However, incapable self-healing and persistent inflammation can progress to chronic inflammation, leading to prevalent or fatal chronic diseases. This review comprehensively covers the topic of emerging drug delivery systems (DDSs) for the treatment of chronic inflammatory diseases (CIDs). First, we introduce the basic biology of the chronic inflammatory process and provide an overview of the main CIDs of the ma...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kiyoon Min Abhishek Sahu Sae Hyun Jeon Giyoong Tae Source Type: research
Injectable Systems for Long-lasting Insulin Therapy
Adv Drug Deliv Rev. 2023 Oct 26:115121. doi: 10.1016/j.addr.2023.115121. Online ahead of print.ABSTRACTInsulin therapy is the mainstay to treat diabetes charactered by hyperglycemia. However, its short half-life of only 4-6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue products that have up to 42 h of glycemic control. However, these insulin analogues still require once- or twice-daily injections for optimal glycemic control and have poor patient compliance and adherence issues. To achieve insulin release for mo...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kumar Kulldeep Niloy Tao L Lowe Source Type: research
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease
Adv Drug Deliv Rev. 2023 Oct 26:115117. doi: 10.1016/j.addr.2023.115117. Online ahead of print.ABSTRACTOral administration is the preferred route of administration based on the convenience for and compliance of the patient. Oral nanomedicines have been developed to overcome the limitations of free drugs and overcome gastrointestinal (GI) barriers, which are heterogeneous across healthy and diseased populations. This review aims to provide a comprehensive overview and comparison of the oral nanomedicine biointeractions in the gastrointestinal tract (GIT) in health and disease (GI and extra-GI diseases) and highlight emergin...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Cheng Chen Ana Beloqui Yining Xu Source Type: research
Emerging drug delivery systems with traditional routes - A roadmap to chronic inflammatory diseases
Adv Drug Deliv Rev. 2023 Oct 26:115119. doi: 10.1016/j.addr.2023.115119. Online ahead of print.ABSTRACTInflammation is prevalent and inevitable in daily life but can generally be accommodated by the immune systems. However, incapable self-healing and persistent inflammation can progress to chronic inflammation, leading to prevalent or fatal chronic diseases. This review comprehensively covers the topic of emerging drug delivery systems (DDSs) for the treatment of chronic inflammatory diseases (CIDs). First, we introduce the basic biology of the chronic inflammatory process and provide an overview of the main CIDs of the ma...
Source: Advanced Drug Delivery Reviews - October 28, 2023 Category: Drugs & Pharmacology Authors: Kiyoon Min Abhishek Sahu Sae Hyun Jeon Giyoong Tae Source Type: research
Transflammation in tissue regeneration and response to injury: How cell-autonomous inflammatory signaling mediates cell plasticity
Adv Drug Deliv Rev. 2023 Oct 25;203:115118. doi: 10.1016/j.addr.2023.115118. Online ahead of print.ABSTRACTInflammation is a first responder against injury and infection and is also critical for the regeneration and repair of tissue after injury. The role of professional immune cells in tissue healing is well characterized. Professional immune cells respond to pathogens with humoral and cytotoxic responses; remove cellular debris through efferocytosis; secrete angiogenic cytokines and growth factors to repair the microvasculature and parenchyma. However, non-immune cells are also capable of responding to damage or pathogen...
Source: Advanced Drug Delivery Reviews - October 26, 2023 Category: Drugs & Pharmacology Authors: John P Cooke Li Lai Source Type: research
Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
Adv Drug Deliv Rev. 2023 Oct 24:115120. doi: 10.1016/j.addr.2023.115120. Online ahead of print.ABSTRACTDiabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading to tissue regeneration and restoration of the barrier function of the skin. In contrast, in diabetic patients dysregulation of these phases leads to chronic, non-healing wounds. In particular, unresolved inflammation in the DFU microenvironment has been identified as a key facet of chronic wounds in hypergly...
Source: Advanced Drug Delivery Reviews - October 26, 2023 Category: Drugs & Pharmacology Authors: Michael G Monaghan Rajiv Borah Charlotte Thomsen Shane Browne Source Type: research
Transflammation in Tissue Regeneration and Response to Injury How cell-autonomous inflammatory signaling mediates cell plasticity
Adv Drug Deliv Rev. 2023 Oct 24:115118. doi: 10.1016/j.addr.2023.115118. Online ahead of print.ABSTRACTInflammation is a first responder against injury and infection and is also critical for the regeneration and repair of tissue after injury. The role of professional immune cells in tissue healing is well characterized. Professional immune cells respond to pathogens with humoral and cytotoxic responses; remove cellular debris through efferocytosis; secrete angiogenic cytokines and growth factors to repair the microvasculature and parenchyma. However, non-immune cells are also capable of responding to damage or pathogens. N...
Source: Advanced Drug Delivery Reviews - October 26, 2023 Category: Drugs & Pharmacology Authors: John P Cooke Li Lai Source Type: research
Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
Adv Drug Deliv Rev. 2023 Oct 24:115120. doi: 10.1016/j.addr.2023.115120. Online ahead of print.ABSTRACTDiabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading to tissue regeneration and restoration of the barrier function of the skin. In contrast, in diabetic patients dysregulation of these phases leads to chronic, non-healing wounds. In particular, unresolved inflammation in the DFU microenvironment has been identified as a key facet of chronic wounds in hypergly...
Source: Advanced Drug Delivery Reviews - October 26, 2023 Category: Drugs & Pharmacology Authors: Michael G Monaghan Rajiv Borah Charlotte Thomsen Shane Browne Source Type: research
Transflammation in Tissue Regeneration and Response to Injury How cell-autonomous inflammatory signaling mediates cell plasticity
Adv Drug Deliv Rev. 2023 Oct 24:115118. doi: 10.1016/j.addr.2023.115118. Online ahead of print.ABSTRACTInflammation is a first responder against injury and infection and is also critical for the regeneration and repair of tissue after injury. The role of professional immune cells in tissue healing is well characterized. Professional immune cells respond to pathogens with humoral and cytotoxic responses; remove cellular debris through efferocytosis; secrete angiogenic cytokines and growth factors to repair the microvasculature and parenchyma. However, non-immune cells are also capable of responding to damage or pathogens. N...
Source: Advanced Drug Delivery Reviews - October 26, 2023 Category: Drugs & Pharmacology Authors: John P Cooke Li Lai Source Type: research
Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
Adv Drug Deliv Rev. 2023 Oct 24:115120. doi: 10.1016/j.addr.2023.115120. Online ahead of print.ABSTRACTDiabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading to tissue regeneration and restoration of the barrier function of the skin. In contrast, in diabetic patients dysregulation of these phases leads to chronic, non-healing wounds. In particular, unresolved inflammation in the DFU microenvironment has been identified as a key facet of chronic wounds in hypergly...
Source: Advanced Drug Delivery Reviews - October 26, 2023 Category: Drugs & Pharmacology Authors: Michael G Monaghan Rajiv Borah Charlotte Thomsen Shane Browne Source Type: research
