Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design
Adv Drug Deliv Rev. 2024 Apr 1:115301. doi: 10.1016/j.addr.2024.115301. Online ahead of print.ABSTRACTSubcutaneous (SC) injections can be associated with local pain and discomfort that is subjective and may affect treatment adherence and overall patient experience. With innovations increasingly focused on finding ways to deliver higher doses and volumes (≥2 mL), there is a need to better understand the multiple intertwined factors that influence pain upon SC injection. As a priority for the SC Drug Development & Delivery Consortium, this manuscript provides a comprehensive review of known attributes from published li...
Source: Advanced Drug Delivery Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: Neil Mathias Sylvain Huille Marie Picci Robert P Mahoney Ronald J Pettis Brian Case Bernhard Helk David Kang Ronak Shah Junchi Ma Deep Bhattacharya Yogita Krishnamachari Dany Doucet Nathalie Maksimovikj Sahab Babaee Patrick Garidel Reza Esfandiary Rajesh Source Type: research
Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design
Adv Drug Deliv Rev. 2024 Apr 1:115301. doi: 10.1016/j.addr.2024.115301. Online ahead of print.ABSTRACTSubcutaneous (SC) injections can be associated with local pain and discomfort that is subjective and may affect treatment adherence and overall patient experience. With innovations increasingly focused on finding ways to deliver higher doses and volumes (≥2 mL), there is a need to better understand the multiple intertwined factors that influence pain upon SC injection. As a priority for the SC Drug Development & Delivery Consortium, this manuscript provides a comprehensive review of known attributes from published li...
Source: Advanced Drug Delivery Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: Neil Mathias Sylvain Huille Marie Picci Robert P Mahoney Ronald J Pettis Brian Case Bernhard Helk David Kang Ronak Shah Junchi Ma Deep Bhattacharya Yogita Krishnamachari Dany Doucet Nathalie Maksimovikj Sahab Babaee Patrick Garidel Reza Esfandiary Rajesh Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26;208:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an ...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers
Adv Drug Deliv Rev. 2024 Mar 26:115300. doi: 10.1016/j.addr.2024.115300. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient's quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an atte...
Source: Advanced Drug Delivery Reviews - March 28, 2024 Category: Drugs & Pharmacology Authors: Fabiola A Chapa-Villarreal Madeleine Stephens Rachel Pavlicin Micaela Beussman Nicholas A Peppas Source Type: research
Challenges and progress related to gene editing in rare skin diseases
Adv Drug Deliv Rev. 2024 Mar 23:115294. doi: 10.1016/j.addr.2024.115294. Online ahead of print.ABSTRACTGenodermatoses represent a large group of inherited skin disorders encompassing clinically-heterogeneous conditions that manifest in the skin and other organs. Depending on disease variant, associated clinical manifestations and secondary complications can severely impact patients' quality of life and currently available treatments are transient and not curative. Multiple emerging approaches using CRISPR-based technologies offer promising prospects for therapy. Here, we explore current advances and challenges related to g...
Source: Advanced Drug Delivery Reviews - March 25, 2024 Category: Drugs & Pharmacology Authors: Josefina Pi ñón-Hofbauer Christina Guttmann-Gruber Verena Wally Anshu Sharma Iris K Gratz Ulrich Koller Source Type: research
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research
Adv Drug Deliv Rev. 2024 Mar 23;208:115295. doi: 10.1016/j.addr.2024.115295. Online ahead of print.ABSTRACTMelanoma, the deadliest form of skin cancer, poses a significant clinical challenge for the development of effective treatments. Conventional in vivo animal studies have shown limited translational relevance to humans, raising strength to pre-clinical models for melanoma research. This review provides an in-depth analysis of alternative pre-clinical models including in vitro and ex vivo platforms such as reconstructed skin, spheroids, organoids, organotypic models, skin-on-a-chip, and bioprinting. Through a comprehens...
Source: Advanced Drug Delivery Reviews - March 25, 2024 Category: Drugs & Pharmacology Authors: Juliana Viegas Bruno Sarmento Source Type: research
Challenges and progress related to gene editing in rare skin diseases
Adv Drug Deliv Rev. 2024 Mar 23:115294. doi: 10.1016/j.addr.2024.115294. Online ahead of print.ABSTRACTGenodermatoses represent a large group of inherited skin disorders encompassing clinically-heterogeneous conditions that manifest in the skin and other organs. Depending on disease variant, associated clinical manifestations and secondary complications can severely impact patients' quality of life and currently available treatments are transient and not curative. Multiple emerging approaches using CRISPR-based technologies offer promising prospects for therapy. Here, we explore current advances and challenges related to g...
Source: Advanced Drug Delivery Reviews - March 25, 2024 Category: Drugs & Pharmacology Authors: Josefina Pi ñón-Hofbauer Christina Guttmann-Gruber Verena Wally Anshu Sharma Iris K Gratz Ulrich Koller Source Type: research
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research
Adv Drug Deliv Rev. 2024 Mar 23:115295. doi: 10.1016/j.addr.2024.115295. Online ahead of print.ABSTRACTMelanoma, the deadliest form of skin cancer, poses a significant clinical challenge for the development of effective treatments. Conventional in vivo animal studies have shown limited translational relevance to humans, raising strength to pre-clinical models for melanoma research. This review provides an in-depth analysis of alternative pre-clinical models including in vitro and ex vivo platforms such as reconstructed skin, spheroids, organoids, organotypic models, skin-on-a-chip, and bioprinting. Through a comprehensive ...
Source: Advanced Drug Delivery Reviews - March 25, 2024 Category: Drugs & Pharmacology Authors: Juliana Viegas Bruno Sarmento Source Type: research
Challenges and progress related to gene editing in rare skin diseases
Adv Drug Deliv Rev. 2024 Mar 23:115294. doi: 10.1016/j.addr.2024.115294. Online ahead of print.ABSTRACTGenodermatoses represent a large group of inherited skin disorders encompassing clinically-heterogeneous conditions that manifest in the skin and other organs. Depending on disease variant, associated clinical manifestations and secondary complications can severely impact patients' quality of life and currently available treatments are transient and not curative. Multiple emerging approaches using CRISPR-based technologies offer promising prospects for therapy. Here, we explore current advances and challenges related to g...
Source: Advanced Drug Delivery Reviews - March 25, 2024 Category: Drugs & Pharmacology Authors: Josefina Pi ñón-Hofbauer Christina Guttmann-Gruber Verena Wally Anshu Sharma Iris K Gratz Ulrich Koller Source Type: research
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research
Adv Drug Deliv Rev. 2024 Mar 23:115295. doi: 10.1016/j.addr.2024.115295. Online ahead of print.ABSTRACTMelanoma, the deadliest form of skin cancer, poses a significant clinical challenge for the development of effective treatments. Conventional in vivo animal studies have shown limited translational relevance to humans, raising strength to pre-clinical models for melanoma research. This review provides an in-depth analysis of alternative pre-clinical models including in vitro and ex vivo platforms such as reconstructed skin, spheroids, organoids, organotypic models, skin-on-a-chip, and bioprinting. Through a comprehensive ...
Source: Advanced Drug Delivery Reviews - March 25, 2024 Category: Drugs & Pharmacology Authors: Juliana Viegas Bruno Sarmento Source Type: research
Clinical perspective on topical vaccination strategies
Adv Drug Deliv Rev. 2024 Mar 22:115292. doi: 10.1016/j.addr.2024.115292. Online ahead of print.ABSTRACTVaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined herein as the introduction of a vaccine to any of the three layers of the human skin, has attracted interest in recent years as an alternative vaccination approach to the conventi...
Source: Advanced Drug Delivery Reviews - March 24, 2024 Category: Drugs & Pharmacology Authors: Petya Popova Sunny P Chen Suiyang Liao Manish Sadarangani Anna K Blakney Source Type: research
Clinical perspective on topical vaccination strategies
Adv Drug Deliv Rev. 2024 Mar 22:115292. doi: 10.1016/j.addr.2024.115292. Online ahead of print.ABSTRACTVaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined herein as the introduction of a vaccine to any of the three layers of the human skin, has attracted interest in recent years as an alternative vaccination approach to the conventi...
Source: Advanced Drug Delivery Reviews - March 24, 2024 Category: Drugs & Pharmacology Authors: Petya Popova Sunny P Chen Suiyang Liao Manish Sadarangani Anna K Blakney Source Type: research
