Safety of Surfactant Excipients in Oral Drug Formulations
Adv Drug Deliv Rev. 2023 Sep 20:115086. doi: 10.1016/j.addr.2023.115086. Online ahead of print.ABSTRACTSurfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the interaction of surfactant-type excipients present in oral pharmaceutical dosage forms with the intestinal epithelium of the gastrointestinal (GI) tract. Many surfactants permitted for human consumption in oral products reduce intestinal epithelia...
Source: Advanced Drug Delivery Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sam Maher Caroline Geoghegan David J Brayden Source Type: research
Safety of Surfactant Excipients in Oral Drug Formulations
Adv Drug Deliv Rev. 2023 Sep 20:115086. doi: 10.1016/j.addr.2023.115086. Online ahead of print.ABSTRACTSurfactants are a diverse group of compounds that share the capacity to adsorb at the boundary between distinct phases of matter. They are used as pharmaceutical excipients, food additives, emulsifiers in cosmetics, and as household/industrial detergents. This review outlines the interaction of surfactant-type excipients present in oral pharmaceutical dosage forms with the intestinal epithelium of the gastrointestinal (GI) tract. Many surfactants permitted for human consumption in oral products reduce intestinal epithelia...
Source: Advanced Drug Delivery Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sam Maher Caroline Geoghegan David J Brayden Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 9;201:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it ...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Functional regeneration at the blood-biomaterial interface
Adv Drug Deliv Rev. 2023 Sep 8:115085. doi: 10.1016/j.addr.2023.115085. Online ahead of print.ABSTRACTThe use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brin...
Source: Advanced Drug Delivery Reviews - September 10, 2023 Category: Drugs & Pharmacology Authors: Dina M Ibrahim Aleksandra Fomina Carlijn V C Bouten Anthal I P M Smits Source Type: research
Up-to-date molecular medicine strategies for management of ocular surface neovascularization
Adv Drug Deliv Rev. 2023 Sep 7:115084. doi: 10.1016/j.addr.2023.115084. Online ahead of print.ABSTRACTOcular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct light path to the retina, and hence is a major cause of vision loss. Various factors such as infection, irritation, trauma, dry eye, and ocular surface surgery trigger neovascularization via angiogenesis and lymphangiogenesis dependent on VEGF-related and alternative mechanisms. Recent advances in antiangiogenic drugs, nanotechnology, gene therapy, surgery equipment and techniques, animal models, and...
Source: Advanced Drug Delivery Reviews - September 9, 2023 Category: Drugs & Pharmacology Authors: Yunlong Yang Junmu Zhong Dongmei Cui Lasse D Jensen Source Type: research
Up-to-date molecular medicine strategies for management of ocular surface neovascularization
Adv Drug Deliv Rev. 2023 Sep 7:115084. doi: 10.1016/j.addr.2023.115084. Online ahead of print.ABSTRACTOcular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct light path to the retina, and hence is a major cause of vision loss. Various factors such as infection, irritation, trauma, dry eye, and ocular surface surgery trigger neovascularization via angiogenesis and lymphangiogenesis dependent on VEGF-related and alternative mechanisms. Recent advances in antiangiogenic drugs, nanotechnology, gene therapy, surgery equipment and techniques, animal models, and...
Source: Advanced Drug Delivery Reviews - September 9, 2023 Category: Drugs & Pharmacology Authors: Yunlong Yang Junmu Zhong Dongmei Cui Lasse D Jensen Source Type: research
Microneedles for advanced ocular drug delivery
Adv Drug Deliv Rev. 2023 Sep 5:115082. doi: 10.1016/j.addr.2023.115082. Online ahead of print.ABSTRACTIn the field of ocular drug delivery, topical delivery remains the most common treatment option for managing anterior segment diseases, whileintraocular injectionsare the current gold standard treatment option for treating posterior segment diseases. Nonetheless, topical eye drops are associated with low bioavailability (<5%), and theintravitreal administration procedure is highly invasive, yielding poor patient acceptability. In both cases, frequent administration is currently required. As a result, there is a clear un...
Source: Advanced Drug Delivery Reviews - September 7, 2023 Category: Drugs & Pharmacology Authors: Katie Glover Deepakkumar Mishra Shilpkala Gade Lalitkumar K None Vora Yu Wu Alejandro J Paredes Ryan F Donnelly Thakur Raghu Raj Singh Source Type: research
