How to Diagnose Anaplastic Large Cell Lymphoma on Cytological Samples? A Series with Emphasis on Diagnostic Clue and Pitfalls
Conclusion: The cytological diagnosis of ALCL may be challenging, and the proper management of the collected sample is mandatory. The rapid on-site evaluation and the realization of a cell block are strongly recommended. Immunocytochemistry is mandatory for the diagnosis and a large antibodies panel is needed as differential diagnosis includes many different neoplasms. FISH may be useful to evaluate ALK rearrangements. When properly managed, cytology can lead to a reliable final diagnosis of ALCL.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - January 12, 2023 Category: Cytology Source Type: research
Comprehensive Review of Anal Cytology
Background: The incidence of anal cancer has increased over at least the past decade, with estimates of a continued increase in the coming years. Women are more commonly affected than men in the general population; separate high-risk populations have also been identified. While the pathophysiology of anal cancer is thought to be similar to its cervical counterpart, well-defined and standardized screening guidelines have not been established as is seen in cervical cancer prevention. Nonetheless, multiple screening modalities have been examined and are components of proposed institutional and societal screening programs.Summ...
Source: Acta Cytologica - January 10, 2023 Category: Cytology Source Type: research
Cytology of Benign Peritoneal Fluids and Pelvic Washing Specimens: Diagnostic Cytomorphologic Features and Pitfalls
Background: Pelvic washing and peritoneal fluid cytology specimens are used to detect peritoneal spread of malignancies. In most cases, identification of malignancy in these specimens is straightforward, but benign processes may occasionally mimic neoplasia and cause diagnostic difficulty.Summary: In this article, we perform a focused review of common benign entities encountered in pelvic washing and peritoneal fluid specimens during routine practice which may cause difficulty and discuss helpful features for avoiding diagnostic pitfalls.Key Messages: Application of strict cytomorphologic criteria, along with judicious use...
Source: Acta Cytologica - January 10, 2023 Category: Cytology Source Type: research
Diagnostic Value of Epithelial Cell Adhesion Molecule Flow Cytometry for Diagnosis of Metastatic Carcinoma in Serous Effusions
Conclusion: The EpCAM flow cytometry and cytology showed comparable performance in detecting metastatic effusions. The EpCAM flow cytometry might have a diagnostic value in decreasing the false-negative rate of cytomorphology, while maintaining excellent specificity.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - January 10, 2023 Category: Cytology Source Type: research
Cytopathology in Gynecology and Gynecologic Oncology: Updates, Recent Advances, and Practical Considerations
The role of cytopathology in the diagnosis, management, and follow-up of patients with gynecologic neoplasms has expanded tremendously since the introduction of the Papanicolaou test, more than 50 years ago. Evidently, advances in HPV testing have revolutionized cervical cancer screening, which now faces new challenges in the setting of increasingly available HPV vaccines. In addition, recent changes in gynecologic tumor nomenclature and staging of gynecologic neoplasms have introduced challenges specific to cytopathology, which if not taken into consideration, might lead to incorrect diagnoses, confusion on the part of th...
Source: Acta Cytologica - January 5, 2023 Category: Cytology Source Type: research
Editorial - Cytopathology in Gynecology and Gynecologic Oncology: Updates, Recent Advances, and Practical Considerations
The role of cytopathology in the diagnosis, management, and follow-up of patients with gynecologic neoplasms has expanded tremendously since the introduction of the Papanicolaou test, more than 50 years ago. Evidently, advances in HPV testing have revolutionized cervical cancer screening, which now faces new challenges in the setting of increasingly available HPV vaccines. In addition, recent changes in gynecologic tumor nomenclature and staging of gynecologic neoplasms have introduced challenges specific to cytopathology, which if not taken into consideration, might lead to incorrect diagnoses, confusion on the part of th...
Source: Acta Cytologica - January 5, 2023 Category: Cytology Source Type: research
Overview of Ancillary Techniques in Cervical Cytology
Background: The association between high-risk serotypes of human papillomavirus (hr-HPV) and cervical cancer is well-established.
Summary: In order to improve the sensitivity of cervical cytology testing, hr-HPV testing has rapidly become part of routine cervical cancer screening, either in conjunction with cytology or as primary testing. In this review, we discuss the overall utility and strategies of hr-HPV testing, as wel l as the advantages and limitations of potential triage strategies for hr-HPV positive women, including HPV genotyping, p16/Ki-67 dual staining, and methylation assays.
Key Message: hr-HPV testing i...
Source: Acta Cytologica - January 4, 2023 Category: Cytology Source Type: research
Chondroblastoma: Cytomorphologic Analysis of Ten Cases with Review of the Literature
Conclusion: We concluded that with the appropriate clinical and radiologic setting, the diagnosis of CB can be achieved on cytology if characteristic chondroblasts are present. The presence of chondromyxoid matrix is a helpful clue but is not necessary for the diagnosis. As in surgical pathology, cytologic evaluation of bone tumors should be interpreted in conjunction with clinical and radiologic findings. (Source: Acta Cytologica)
Source: Acta Cytologica - January 4, 2023 Category: Cytology Source Type: research
Subtyping of Non-small Cell Lung Carcinoma into Adenocarcinoma and Squamous Cell Carcinoma by Cytological Structural Features
This study aimed to clarify the diagnostic structural features in cytology specimens that are useful in subtyping non-small cell lung carcinoma (NSCLC) into adenocarcinoma (ADC) and squamous cell carcinoma (SQCC).
Methods: Cytology specimens (n = 233) of NSCLCs, which included ADCs (n = 149) and SQCCs (n = 84), were analyzed. The following cytological features were evaluated: isolated cell, flat sheet, three-dimensional cluster with irregular arrangement, papillary-like structure, micropapillary-like structure, acinar-like structure, palisading pattern, protrusion of nuclei at the periphery of the cluster, honeycomb patte...
Source: Acta Cytologica - January 2, 2023 Category: Cytology Source Type: research
Thyroid fine needle aspiration, the Bethesda System and the BRAFV600E mutation in Papillary Thyroid Carcinoma. Association and prediction for biopsy.
ABSTRACT
Introduction: BRAFV600E mutations have been associated with papillary thyroid carcinoma histological types including Tall-cell and Classical, peritumoral infiltration, and nuclear signs, whereas cytological features such as plump cells and sickle nuclei have also been associated with favorable thyroid FNA results for this tumor. BRAF and RAS are considered early driver mutations that contribute to the development of BRAF-like PTCs and RAS-like PTCs. Our aim was to assess the possible association between all Bethesda System cytological features and thyroid FNAs for papillary thyroid carcinoma and their potential p...
Source: Acta Cytologica - January 2, 2023 Category: Cytology Source Type: research
Transthoracic fine needle aspiration cytology of pulmonary spindle and mesenchymal neoplasms: a pandora ’s box
Conclusion: FNA along with clot core and IHC plays a pivotal role in the subsequent pathway taken for diagnostic or therapeutic management of these patients without the need for second sampling or trucut biopsies in a low resource setting. (Source: Acta Cytologica)
Source: Acta Cytologica - December 29, 2022 Category: Cytology Source Type: research
Practical Approach to the Evaluation of Malignant Peritoneal Fluids in the Setting of Gynecologic Neoplasms
Background: Evaluation of peritoneal fluid cytology, either from ascitic fluids or as result of peritoneal washings, is a fundamental aspect in the evaluation of women presenting with clinically concerning or histologically confirmed gynecologic neoplasms.
Summary: Ascitic fluid samples are often the initial and only source of diagnostic material in women presenting with gynecologic malignancies, and important therapeutic decisions will result from the information provided in the cytology report. On the other hand, cytologic evaluation of peritoneal washing specimens obtained during surgical excision of a presumed gyneco...
Source: Acta Cytologica - December 26, 2022 Category: Cytology Source Type: research
Interobserver agreement among cytopathologists in false-negative cases by cytological diagnosis with EUS-FNA in solid pancreatic lesions
Background and aims:Introduction:Early detection and accurate pathological assessment are critical to improving prognosis of pancreatic cancer.EUS has been widely used in diagnosing pancreatic lesions and can obtain histological diagnosis by EUS-FNA.However,comprehensive assessment of the interobserver agreement (IOA) among cytopathologists evaluating EUS-FNA specimens is still limited.Therefore,this study evaluated IOA among cytopathologists for EUS-FNA specimens of solid pancreatic lesions especially in false-negative cases of cytological diagnosis and analysed the factors that influence cytological diagnosis of EUS-FNA,...
Source: Acta Cytologica - December 20, 2022 Category: Cytology Source Type: research
The Impact Factor of Baltimore: Thank You to the American Society of Cytopathology and the International Academy of Cytology
(Source: Acta Cytologica)
Source: Acta Cytologica - December 16, 2022 Category: Cytology Source Type: research
“The impact factor of Baltimore”: Thank you the American Society of cytopathology and the International Academy of Cytology
NA (Source: Acta Cytologica)
Source: Acta Cytologica - December 16, 2022 Category: Cytology Source Type: research
