To get the most out of the least: BRAF molecular evaluation in melanoma metastases on cell suspension from fine needle aspiration cytology (FNAC) needle rinses.
Conclusion: BRAF molecular evaluation in CM metastases on cell suspension obtained from FNAC needle rinses is a time-sparing and accurate technique allowing to spare biomaterial in the clinical setting. (Source: Acta Cytologica)
Source: Acta Cytologica - February 20, 2023 Category: Cytology Source Type: research
Clinical impact of fine needle aspiration cytology on sentinel node biopsy after preoperative chemotherapy for core needle biopsy-proven metastatic lymph nodes
Conclusion: FNAC was diagnostically useful for patients with ycN0 status on US imaging. Using FNAC for LNs after NAC helped to avoid unnecessary SNB in 13% of the cases. (Source: Acta Cytologica)
Source: Acta Cytologica - February 16, 2023 Category: Cytology Source Type: research
Atypical Category of the Johns Hopkins Template Has Higher Risk of Malignancy than the Paris System but the Paris System Is More Applicable for Suspicious Category
Conclusions: Discrete negative or benign urine cytology had the same sensitivity and specificity between two systems. Although atypical category was associated with a higher ROM with the Hopkins template, the ROM for the suspicious category yielded better result with the Paris system.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - February 2, 2023 Category: Cytology Source Type: research
Atypical Category of the Johns Hopkins Template Has Higher Risk of Malignancy than the Paris System but the Paris System Is More Applicable for Suspicious Category
Conclusions: Discrete negative or benign urine cytology had the same sensitivity and specificity between two systems. Although atypical category was associated with a higher ROM with the Hopkins template, the ROM for the suspicious category yielded better result with the Paris system. (Source: Acta Cytologica)
Source: Acta Cytologica - February 2, 2023 Category: Cytology Source Type: research
Atypical category of the Johns Hopkins Template has higher ROM than the Paris System but the Paris system is more applicable for suspicious category
Introduction: To compare performance of indivisual categories between the Johns Hopkins template and the Paris system for reporting urinary cytology.
Methods: Medical records of patients with bladder biopsy and relevant cytology slides were obtained from archived material. Slides were reclassified according to Johns Hopkins Template and the Paris. Results were compared to histologic diagnoses.
Results: BD SurePath preparations from 205 cases with biopsy follow up (118 benign, 5 dysplasia, 23 low-and 59 malignant urothelial carcinoma (UC)) were reviewed. There were 2 inadequate specimens in each system. According to the J...
Source: Acta Cytologica - February 2, 2023 Category: Cytology Source Type: research
A Practical Approach to Squamous Abnormalities on Cervical Cytology: Overview of Interpretive Criteria and Guidance for Altering Thresholds in Response to Quality Assurance Findings
Background: Squamous intraepithelial lesions observed in Papanicolaou (Pap) test gynecologic cytology arise as a result of infection of the cervicovaginal tract by human papillomavirus (HPV). The viral cytopathic effect of HPV manifests as koilocytosis, also known as low-grade squamous intraepithelial lesion (LSIL) in The Bethesda System (TBS). Integration of HPV genetic material into the genome of squamous cells can, in some women, result in progressive accumulation of mutations and abnormalities of growth and maturation leading to high-grade squamous intraepithelial lesion (HSIL) and possibly invasive squamous cell carci...
Source: Acta Cytologica - January 26, 2023 Category: Cytology Source Type: research
Impact of the COVID-19 Pandemic on Cervical Cancer Screening in S ão Paulo State, Brazil
Conclusion: A reduction in testing for cervical cancer in the first year of the COVID-19 pandemic, accompanied by an elevated incidence of precancerous lesions in each of the first 2 years following its initiation, may portend a subsequent increased occurrence of cervical cancer in Brazil. (Source: Acta Cytologica)
Source: Acta Cytologica - January 20, 2023 Category: Cytology Source Type: research
Impact of the covid-19 pandemic on cervical cancer screening in s Ão
paulo state, brazil
INTRODUCTION: The early identification of precursor lesions followed by appropriate treatment prevents development of cervical cancer and its consequences OBJECTIVE: The present study evaluated the influence of the Covid-19 pandemic on cervical cancer screening by comparing the quantity of tests to detect cervical cellular changes performed in Sao Paulo state in 2019, prior to the detection of SARS-CoV-2 in Brazil, to the first (2020) and second (2021) years following its appearance. MATERIALS AND METHODS: Data from Funda ção Oncocentro de São Paulo (FOSP), the agency that analyses approximately 220,000 Pap tests annual...
Source: Acta Cytologica - January 20, 2023 Category: Cytology Source Type: research
The Future Role of Cytology in Cervical Cancer Screening in the Era of HPV Vaccination
Background: Up until recently, cervical cytology was the mainstay for cervical cancer screening. However, the established association between human papillomavirus (HPV) infection and cervical cancer has led to changes in preventive strategies with cytology being replaced by the use of high risk HPV (hrHPV) testing and primary prevention being achieved by HPV vaccination. In this context, the role of cervical cytology is shifting to secondary triage of HPV positive women. As vaccination is leading to decreased HPV infections and significant cervical abnormalities (CIN2+), data on the impact of HPV vaccination of cervical cy...
Source: Acta Cytologica - January 16, 2023 Category: Cytology Source Type: research
Utility of TRPS1 in Malignant Effusion Cytology
Conclusion: TRPS1 is a sensitive marker for mBC and can be reliably performed on cytology specimens. TRPS1 expression was also identified in a significant proportion of mMC, creating a potential diagnostic pitfall. Therefore, caution should be exercised when evaluating MEC of mBC with TRPS1. Consequently, a combination of immunoperoxidase panels should be employed in this setting.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - January 12, 2023 Category: Cytology Source Type: research
Utility of Trichorhinophalangeal Syndrome Type 1 in Malignant Effusion Cytology
Conclusion: TRPS1 is a sensitive marker for mBC and can be reliably performed on cytology specimens. TRPS1 expression was also identified in a significant proportion of mMC, creating a potential diagnostic pitfall. Therefore, caution should be exercised when evaluating MEC of mBC with TRPS1. Consequently, a combination of immunoperoxidase panels should be employed in this setting.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - January 12, 2023 Category: Cytology Source Type: research
