Guided Needle Aspirations of Intra-Abdominal Masses: Analogy between Liquid-Based and Conventional Smear Preparation Methods
Conclusion: CS may be complimented with LBC sample collection method to enhance the sensitivity of intra-abdominal FNA.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - March 4, 2022 Category: Cytology Source Type: research
Rapid On-Site Evaluation Technical Exercise Using Digital Pathology: Peer Comparison in an External Quality Assurance Setting
Conclusions: ROSE has been adopted as a standard procedure in many laboratories worldwide. A peer comparison of participating laboratories in an EQA exercise has highlighted ROSE as susceptible to variation across standard operating procedures, the provision of diagnostic adequacy, diagnostic feedback to the attending clinician, and technical recommendation.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - March 2, 2022 Category: Cytology Source Type: research
Endocervical Cytology: Inter- and Intra-Observer Variability in Conventional Pap Smears
Conclusions: The reproducibility of preneoplasia/neoplasia diagnoses was better than that of atypia and NILM both in the inter- and intra-observer part in this study. In the smears from AIS and EAC patients, general neoplasia-associated features were more common in samples with good agreement by the four cytopathologists of the neoplastic nature and the endocervical origin of the lesion.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - February 28, 2022 Category: Cytology Source Type: research
Fine-Needle Aspiration Biopsy of Pediatric Salivary Gland Tumors: Analysis of Patient Tolerability, Sedation Requirement, and Procedural Complication
Conclusion: FNA biopsy of salivary gland tumors is safe, well tolerated by the pediatric population, and can be effectively performed in an outpatient setting without sedation in most cases. FNA biopsy is a useful tool in the preoperative management of pediatric patients with salivary gland tumors.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - February 28, 2022 Category: Cytology Source Type: research
Usefulness of Five-Parameter System Reconfirmed for Cytopathology of Oral Squamous Cell Carcinoma regardless of Differentiation Degree
This study was conducted to determine whether FPS parameters are detectable even in oral SCC/CIS specimens with apparent nuclear atypia.Summary: Oral cytology specimens were obtained together with biopsy tissue samples. They were obtained from 59 malignant (HSIL and SCC) and 29 not-definitely malignant (NILM to ASC-H) specimens diagnosed using TBS. Following re-confirmation of the original TBS categorization, the specimens were re-evaluated using FPS. One or more of the FPS parameters were noted in 69 of 70 malignant specimens examined, of which 11 had been diagnosed by TBS as not-definitely malignant. The remaining one ma...
Source: Acta Cytologica - February 11, 2022 Category: Cytology Source Type: research
Warthin-Like Mucoepidermoid Carcinoma: A Morphological Spectrum – A Report of 3 Cases with Histological and Cytological Findings and Review of the Literature
Conclusion: Cytological and histopathological features revealed a spectrum. Differentiating WT-like MECs from ordinary WTs may be challenging. On the one end of the spectrum, they may look very much like WT, and on the other end, even though usual MEC features are present, still, WT-like appearance may pose diagnostic difficulty. Showing MAML2 rearrangement in these cases is very helpful. The presence of mucinous and squamous cells in an otherwise WT-like looking tumor should be alarming for MEC, and if possible, each case should be analyzed for MAML2 rearrangement.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - February 4, 2022 Category: Cytology Source Type: research
Accuracy of Thyroid Fine-Needle Aspiration Cytology: A Cyto-Histologic Correlation Study in an Integrated Canadian Health Care Region with Centralized Pathology Service
We report higher usage of ND and AUS/FLUS categories than the literature (19% vs. #x3c;10% and 15% vs. #x3c;10%, respectively). Our surgical resection rate for malignant cytology is substantially higher than the literature (94% vs. 50%, respectively). The ROM by the TBSRTC category in our cohort was similar to the literature. The overall diagnostic accuracy of thyroid FNAC was 92%, which is similar to other studies. Inclusion of incidental PMC as histologically malignant raised the ROM in the ND, benign, and AUS/FLUS categories.Discussion: The diagnostic performance of thyroid FNAC in our study is similar to the reported l...
Source: Acta Cytologica - February 2, 2022 Category: Cytology Source Type: research
Back from the Future: Rational Accountabilities for Cytopathology in Pap Test Cervical Cancer Screening Arising from Covid19
Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - January 28, 2022 Category: Cytology Source Type: research
Small-Cell Malignancies of Thyroid: Challenge Solved?
“Small-cell malignancies of thyroid” is an unsolved dilemma. This term represents an umbrella terminology in thyroid, encompassing for a small group of tumors in which some of them are well-recognized tumors like medullary thyroid carcinoma, poorly differentiated thyroid carcinoma, and primary t hyroid lymphomas and teratoma, whereas the remaining are less known as primary neuroendocrine carcinoma of thyroid, primary extraskeletal Ewing family tumors, and adamantinoma-like Ewing sarcoma. When the issue comes to evaluate a cytological sample predominantly composed of small-cell morphology, m etastatic small-cell carcino...
Source: Acta Cytologica - January 11, 2022 Category: Cytology Source Type: research
Challenges in the Intraoperative Consultation of Low-Grade Epilepsy-Associated Neuroepithelial Tumors by Cytomorphology in Squash Preparations
Conclusion: A higher diagnostic accuracy can be obtained when squash smears are applied with frozen sections. However, it is important to integrate clinical and radiologic features of the patient as well as to know the cytopathologic features of the LEAT spectrum in the context of differential diagnosis to prevent misinterpretation in the IC.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - January 11, 2022 Category: Cytology Source Type: research
Application of the Paris Reporting System for Urine Cytology: The Three-Year Experience of a Single Tertiary Care Institute in Thailand
Conclusions: TPSRUC provides reliable results that are reproducible by different interpreters and is a helpful tool for the detection of HGUC.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - January 7, 2022 Category: Cytology Source Type: research
Comparison of Morphological Similarities and Differences between Liquid-Based Cytology and Conventional Techniques of Serous Effusion Cytology Specimens
Conclusion: Although there are advantages of liquid-based technique such as standardized fixation and cleaner background, since the cellular and background components required for morphological analysis and diagnosis are better preserved in cytospin, it is considered to be better to use liquid-based technique not alone but together with CT.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - December 30, 2021 Category: Cytology Source Type: research
Malignant Small Cell Neoplasia: Cytopathological Puzzle or an Intriguing Scientific Window?
Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - December 23, 2021 Category: Cytology Source Type: research
Primary Small Cell Malignancies of the Breast: Are They Rare Malignancies?
In contrast with the other organs such as the lung, small cell tumors have been less studied in the breast due to their relatively less frequency. Although rare, neuroendocrine neoplasms, some lymphomas, and some small cell sarcomas such as undifferentiated small round cell sarcoma and rhabdomyosarcoma can be seen in small cell morphology in the breast. Many cytological specimens such as fine-needle aspiration biopsies and touch imprint cytology are used for diagnosis and further prognostic/predictive marker determination in primary breast masses, sentinel and axillary lymph nodes, and metastatic masses. Lobular carcinoma ...
Source: Acta Cytologica - December 17, 2021 Category: Cytology Source Type: research
Clinical Usefulness of Endometrial Cytology in Determining the Therapeutic Effect of Fertility Preserving Therapy
Conclusion: The sensitivity of endometrial cytology in determining the therapeutic effect of MPA therapy is low, and we confirmed that the omission of Damp;C is unacceptable. Our findings also suggested that the addition of cytological evaluation to Damp;C during MPA therapy had a low clinical significance.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - December 15, 2021 Category: Cytology Source Type: research
