A Clinical Trial to Verify the Efficiency of the LC-1000 Exfoliative Cell Analyzer as a New Method of Cervical Cancer Screening
Conclusions: LC-1000 may be useful for cervical cancer screening as an index to qualitatively evaluate CIN and cancer based on the changes in characteristics of cells.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - June 19, 2019 Category: Cytology Source Type: research
HPV-ISH-Negative Invasive Cervical Squamous Cell Carcinoma: Histologic and Pap Test Results
Conclusion: A subset of patients exist in whom hrHPV is not detectable at or near the time of progression to SCC. Additional research is necessary to further describe this population and determine whether maintaining cytological screening would provide benefit.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - June 13, 2019 Category: Cytology Source Type: research
What Has Changed Since the Introduction of Human Papillomavirus Testing with the Cytology-Based Cervical Cancer Screening System in Japan A Social Experiment
Conclusion: These data suggested that the introduction of HPV testing with cytology-based cervical cancer screening as an adjunct to conventional cytology resulted in better efficiency and more accurate screening among the Japanese population.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - June 4, 2019 Category: Cytology Source Type: research
Histopathology and Cytopathology of Neuroendocrine Tumors and Carcinomas of the Breast: A Review
Neuroendocrine tumors (NET) and carcinomas (NEC) of the breast are rare diseases, but NEC has attracted attention in both cytopathology and surgical pathology because of its specific management and prognosis. Fine-needle aspiration biopsy (FNAB) cytology can make the diagnosis in many cases particularly with high-grade NEC, with definitive diagnosis based on histopathology and immunohistochemistry. This review describes the characteristics of the disease based on the WHO classification 2012 and recent literature and includes discussion related to the International Academy of Cytology Yokohama System of Reporting Breast F...
Source: Acta Cytologica - June 4, 2019 Category: Cytology Source Type: research
International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy Cytology: A Review of Predictive Values and Risks of Malignancy
Conclusions: This meta-analysis demonstrates that the diagnostic categories of the new IAC Yokohama System each carry an implied ROM, which increases from the benign to malignant categories. This study also shows the high sensitivity and specificity of FNAB for breast lesions.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - May 29, 2019 Category: Cytology Source Type: research
Ancillary Tests in Breast Cytology: A Practical Guide
Utilization of fine-needle aspiration biopsy (FNAB) cytology for the diagnosis of diseases of the breast has been met with both excitement and uncertainty during the last couple of decades. Presently, FNAB for the diagnosis of primary and metastatic breast lesions is on the rise again. This is probably due to its fast turnaround time, cost efficiency, and minimal invasiveness, characteristics of this sampling modality which are particularly crucial for patients requiring frequent repeat biopsy in the setting of metastatic lesions. In this article, we will briefly review the main modern applications of FNAB of the breast wh...
Source: Acta Cytologica - May 29, 2019 Category: Cytology Source Type: research
The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytology
Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - May 28, 2019 Category: Cytology Source Type: research
Metastatic < b > < i > SMARCB1 < /i > < /b > ( < b > < i > INI-1 < /i > < /b > )-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature
SMARCB1 (INI-1)-deficient sinonasal carcinoma is a rare entity within the subgroup of poorly differentiated sinonasal tract carcinomas. As there are only two papers describing the cytologic features of this entity, herein we describe the unique cytomorphologic features of a pulmonary metastasis of this tumor and include the differential diagnosis based on tumor location. The patient was a 53-year-old male who initially presented with sinus congestion and vision changes including left-eye proptosis and diplopia. The initial biopsy of the ethmoid-centered sinonasal mass was non-keratinizing squamous cell carcinoma based on s...
Source: Acta Cytologica - May 27, 2019 Category: Cytology Source Type: research
Touch Imprint Cytology: A Rapid and Accurate Method for Diagnosis of Oral Cancer
Conclusions: TIC is an accurate, simple, rapid, and cost-effective method that aids the diagnosis of oral squamous cell carcinoma but does not replace incisional biopsy. The cytologic examination of imprints of biopsies also helps determine the adequacy of the specimen for histologic examination.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - May 23, 2019 Category: Cytology Source Type: research
Role of Ancillary Techniques in Biliary Cytopathology Specimens
Biliary brushing cytology has become the standard of practice for the investigation of strictures of the biliary and pancreatic duct systems. The methodology however has a limitation in that it has low diagnostic sensitivity when only cytologic evaluation is used. A number of testing methodologies have been applied to brushing specimens in an attempt to improve overall sensitivity without loss of specificity. These have included DNA ploidy analysis, immunocytochemistry, individual gene mutational analysis, fluorescence in-situ hybridization (FISH), and next generation sequencing (NGS). Currently, FISH coupled with routine ...
Source: Acta Cytologica - May 23, 2019 Category: Cytology Source Type: research
Spindle Cell Lesions of the Breast on Fine-Needle Aspiration Biopsy: A Miscellany of Masses
A variety of primary breast and metastatic lesions to the breast can present with spindle cell cytomorphology. These lesions may range from benign reactive or inflammatory lesions to high-grade malignancies. Spindle cell lesions of the breast are not often seen on fine-needle aspiration biopsy (FNAB) but need to be correctly managed when they are encountered. While mesenchymal lesions of the breast have a spindle morphology, lesions derived from the epithelium and myoepithelium can be spindled as well. By assessing if the lesion comprises spindle cells only or if other components such as epithelial cells are apparent and t...
Source: Acta Cytologica - May 22, 2019 Category: Cytology Source Type: research
The International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy Cytology
The International Academy of Cytology (IAC) gathered together a group of cytopathologists expert in breast cytology who, working with clinicians expert in breast diagnostics and management, have developed the IAC Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy (FNAB) Cytology. The project was initiated with the first cytopathology group meeting in Yokohama at the 2016 International Congress of Cytology. This IAC Yokohama System defines five categories for reporting breast cytology, each with a clear descriptive term for the category, a definition, a risk of malignancy (ROM) and a suggested management alg...
Source: Acta Cytologica - May 21, 2019 Category: Cytology Source Type: research
The Diagnostic Role of Methyl Green-Pyronin Y Staining in Oral Leukoplakia and Oral Squamous Cell Carcinoma: An Exfoliative Cytology-Based Cytomorphometric Analysis
The objective of the present study was to analyze methyl green-pyronin Y (MGP)-stained oral exfoliated cells (OECs) of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) by cytomorphometry.Materials and Method: An observational study was conducted on 150 individuals equally divided into three groups: normal mucosa, OL, and OSCC. Smears were prepared from OECs and stained with MGP. Cytomorphometry was done for 100 cells per subject, and various cell and nuclear parameters were measured and calculated.Results: The Kruskal-Wallis test with post hoc correlation showed significant differences in nucleus and cell diam...
Source: Acta Cytologica - May 21, 2019 Category: Cytology Source Type: research
The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytology: A Single Institutional Retrospective Study of the Application of the System Categories and the Impact of Rapid Onsite Evaluation
Conclusion: Breast FNAB is an accurate test enabling effective diagnosis of breast lesions. ROSE improved the performance by decreasing the proportion of “insufficient” and “atypical” and increasing the “suspicious of malignancy” and “malignant” diagnoses and enabling immediate triage for further biopsy where necessary.Acta Cytologica (Source: Acta Cytologica)
Source: Acta Cytologica - May 21, 2019 Category: Cytology Source Type: research
Liquid Biopsy: General Concepts
Liquid biopsy provides the opportunity of detecting, analyzing and monitoring cancer in various body effluents such as blood or urine instead of a fragment of cancer tissue. It is composed of different biological matrices such as circulating tumor cells (CTCs), cell free nucleic acids, exosomes or tumors “educated platelets.” In addition to representing a non- or minimally invasive procedure, it should represent a better view of tumor heterogeneity and allows for real-time monitoring of cancer evolution. Recent technological and molecular advances, greatly facilitated by the use of microfluidics in many cases, have per...
Source: Acta Cytologica - May 15, 2019 Category: Cytology Source Type: research
