Interobserver agreement among cytopathologists in false-negative cases by cytological diagnosis with EUS-FNA in solid pancreatic lesions

Background and aims:Introduction:Early detection and accurate pathological assessment are critical to improving prognosis of pancreatic cancer.EUS has been widely used in diagnosing pancreatic lesions and can obtain histological diagnosis by EUS-FNA.However,comprehensive assessment of the interobserver agreement (IOA) among cytopathologists evaluating EUS-FNA specimens is still limited.Therefore,this study evaluated IOA among cytopathologists for EUS-FNA specimens of solid pancreatic lesions especially in false-negative cases of cytological diagnosis and analysed the factors that influence cytological diagnosis of EUS-FNA,so as to improve the diagnostic efficiency of EUS-FNA. Methods:We retrieved EUS-FNA samples of pancreatic solid lesions from 2017 to 2021 and collected their clinical/cytological datas.Two cytopathologists independently reviewed these cases using a quoted,novel standardized cytology scoring tool.Ultimately,we calculated IOA among cytopathologists and performed a binary logtistic regression analysis to evaluate factors influencing the cytological diagnosis of EUS-FNA. Results:161 patients were included and sixty cases with a clinical diagnosis of pancreatic cancer but a cytological diagnosis of benign and atypical constituted the false-negative group.IOA for cytologic diagnosis of overall patients and the false-negative group were perfect/moderate agreement with Kendall ’s W value of 0.896 and 0.462 respectively.The number of diagnostic cells in the scori...
Source: Acta Cytologica - Category: Cytology Source Type: research