Magnetic-Plasmonic Hybrid Nanoparticles Isolate Lysosomes from Cells
Researchers at the Japan Advanced Institute of Science and Technology have developed a method to isolate intact lysosomes from cells. The technique is rapid and produces samples of high purity. Lysosomes are the garbage-disposal organelles within a cell, and they are involved in numerous diseases, from lysosomal storage diseases to autoimmune disorders, certain cancers, and neurodegenerative diseases. However, they are difficult to study, as current techniques to isolate lysosomes from cells result in samples with poor purity and damaged or altered lysosomes. This new approach uses nanotechnology to rapidly extract a high-...
Source: Medgadget - January 13, 2022 Category: Medical Devices Authors: Conn Hastings Tags: etc. Genetics Nanomedicine Pathology Source Type: blogs
Self-Assembling Coating Protects Bacteria for Therapeutic Delivery
Scientists are beginning to appreciate the importance of the gut microbiome in health and disease, and administering microbes that can enhance our health or prevent disease is the next logical step. However, bacteria are delicate and require protection. Researchers at MIT have now engineered a method to coat bacteria so that they are protected from oxygen and other stressors during processing and delivery to the gut. This self-assembling protective coating may pave the way for more bacterial therapies.
The gut microbiome is increasingly recognized as important in a variety of diseases, and scientists are just beginning ...
Source: Medgadget - December 16, 2021 Category: Medical Devices Authors: Conn Hastings Tags: GI Materials Medicine Source Type: blogs
How Much Will Biden ’s Infrastructure Plan Eventually Cost? History Suggests Some Worrisome Answers
David BoazHere at Cato we ’ve written many times about the record of big infrastructure projects and “megaprojects”:Cost overruns are rampant.“Here is a rule of thumb to remember when you hear about a proposed government project: If a politician says that it will cost $1, it will end up costing $2 or more. ”“Contractors were essentially rewarded for delays and overruns with added cash and guaranteed profits. ”“The ongoing saga of California ’s high‐speed bullet train may end up being as classic a story of Democratic politicians ’ hubris as the Solyndra debacle.”“Linda Bilmes...
Source: Cato-at-liberty - November 30, 2021 Category: American Health Authors: David Boaz Source Type: blogs
988: A New Lifeline for Mental Health Emergencies
By BEN WHEATLEY
Miles Hall, a 23-year-old Black man experiencing a psychotic episode, was shot and killed by police after 911 received calls of a disturbance in his Walnut Creek, California neighborhood. His mother Taun Hall had taken steps to warn the local police that her son had been diagnosed with schizoaffective disorder and that he might be prone to mental health crises. She believed she had done enough to ensure that, in the event of a crisis, her son would be treated with care. But when the crisis came, authorities viewed Miles’ behavior through the lens of public safety, not through the lens of mental health,...
Source: The Health Care Blog - November 22, 2021 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Politics CAHOOTS California California Department of Health Services Mental Health Miles Hall Miles Hall Foundation Source Type: blogs
Fish-Shaped Microrobots to Deliver Chemotherapy to Tumors
Researchers from the University of Science and Technology of China, working with outside collaborators, have developed shape-shifting microrobots that are designed to be guided to a target area in the body using magnets, and then release a drug cargo in response to the local environment. The application that the researchers have pursued involves guiding the microrobots to a solid tumor using magnets outside the body, and then the tumor’s naturally acidic microenvironment stimulates a shape change, resulting in the local release of a chemotherapy drug.
Researchers are devising a variety of cunning ways to de...
Source: Medgadget - November 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology Radiology Source Type: blogs
Sunday Sermonette: Military Technology
Ch. 17 is one of the best-known Bible stories, but I must say it is usually interpreted rather oddly. The Deuteronomic history is mostly about war, to the point of being very tiresome. You will notice that battles are fought hand-to-hand, with swords and spears. The spears are not thrown, but thrusted. The bow and arrow seems not to have come to Canaan. However, there is a single mention of slings as weapons of war in Judges 20, when the Benjamites are about to get massacred by the rest of the Israelites:15 And the children of Benjamin were numbered at that time out of the cities twenty and six thousand men that...
Source: Stayin' Alive - October 31, 2021 Category: American Health Source Type: blogs
Iron Oxide Nanoparticles Suppress Oral Biofilms
This study involved volunteers who wore a denture-like device that contained real tooth enamel. The volunteers regularly applied sugar solution to the denture, mimicking the sugary snacks many of us like to consume. They didn’t brush the dentures, but applied the nanoparticle/hydrogen peroxide combination twice a day. The treatment reduced the biofilm formation caused by bacteria such as S. mutans, without adversely affecting other microbial populations in the mouth or causing adverse effects.
“We found that this approach is both precise and effective,” said Hyun Koo, a researcher involved in the study, in a UPenn...
Source: Medgadget - October 26, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Dentistry Materials Medicine Nanomedicine indianauniversity upenn Source Type: blogs
Fight Aging! Newsletter, October 25th 2021
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx.
A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports
https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/
Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medic...
Source: Fight Aging! - October 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
It ’s Elementary: Celebrating National Chemistry Week
Happy National Chemistry Week! In honor of this celebration, we’re showcasing posts that focus on elements crucial for human health and scientific exploration. NIGMS-supported scientists are studying how each of these elements (and many others) can impact human health. Check out the list below to learn more, and let us know what your favorite element is in the comments section!
Credit: Adapted from Compound Interest. CC BY-NC-ND 4.0.
Helium: An Abundant History and a Shortage Threatening Scientific Tools
Scientists first discovered helium burning on the surface of the sun. Today, liquid helium plays an essential r...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 20, 2021 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Source Type: blogs
Is Iron Metabolism an Understudied Aspect of Aging?
Many of the interventions demonstrated to produce interesting effects on the pace or state of aging are challenging to learn from. This is the case because these interventions change so much of the operation of metabolism as to make it hard to pick apart what is most relevant to the progression of aging versus what is a side-effect. Calorie restriction is the canonical example - it alters the entire laundry list of cellular processes thought relevant to aging, and a good many others besides. Similar issues arise when looking at heterochronic parabiosis, as linking the circulatory systems of a young animal and an old animal...
Source: Fight Aging! - October 18, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
poem
CurrencyConsider a world where love is a currency. A means of exchange, to be traded for items or experiences of equivalent value. Or you could simply invest it in arcane financial instruments that earn interest and become a source of passive income. Ten percent growth year after year without holding a door, remembering a date, tending to anyone ill. Without doing anything at all. A perpetually appreciating asset. Plenty of people just hoard it. Store it behind iron clad vaults of impenetrability. Save it up for down turns, for hard times. These are the people who never had much of...
Source: Buckeye Surgeon - September 23, 2021 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Wednesday Bible Study: Lost in translation
I have warned you that some weirdness goes down in 1 Samuel. Exactly how weird Chapter 6 is depends on whether you ' re reading the King James or the New International Version and kindred later translations. The Philistines realize that holding on to the Ark is probably not a good idea so they ask their priests how to appease Yahweh. In the KJV they propose sending the Ark back accompanied by 5 golden mice and 5 golden hemorrhoids. In the NIV it ' s 5 golden rats and 5 golden tumors. The tumors seem strange enough but it ' s hard to imagine what a golden hemorrhoid would look like. (I suspect the Hebrew word encompasses bo...
Source: Stayin' Alive - September 22, 2021 Category: American Health Source Type: blogs
Fight Aging! Newsletter, September 20th 2021
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
NANOG Expression versus Cellular Senescence
https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living a...
Source: Fight Aging! - September 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Antioxidants to Prevent LDL Oxidation Act to Restore Macrophage Function and Reverse Atherosclerosis in Mice
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
Link: https://doi.org/10.1161/JAHA.120.017524 (Source: Fight Aging!)
Source: Fight Aging! - September 16, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
4 Reasons to Support Sustainability
When President Biden entered office, he enhanced the national sustainability standards. As we develop an eco-friendly infrastructure, we adopt new technologies and systems that reduce greenhouse gas emissions. Society may accept the alterations without understanding the expansive benefits.
By exploring sustainability’s advantages, individuals are more likely to support the transition away from fossil fuels. Utilizing electric appliances, adopting an eco-friendly diet, eliminating fast fashion purchases and more can shrink one’s carbon footprint while enhancing savings. Over time, sustainable commercial and individua...
Source: PickTheBrain | Motivation and Self Improvement - September 2, 2021 Category: Consumer Health News Authors: Kara Reynolds Tags: featured money and finance self-improvement success sustainability the environment Source Type: blogs
