Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects."
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease
Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cisd2 in Aging and Exercise
This open access paper provides an overview of Cisd2, one of many genes for which upregulation extends life and improves health in mice. This is potentially mediated by its effects on the cellular maintenance processes of autophagy and on mitochondrial function. It reduces the loss of mitochondrial function that occurs in aging, perhaps through improved removal of damaged mitochondria via mitophagy, but perhaps through other mechanisms. The researchers show that Cisd2 expression is upregulated as a result of exercise, making it plausibly a part of the regulatory system by which the response to exercise can improve health a...
Source: Fight Aging! - December 18, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
It Seems The Lawyers Are As Worried As Others Concerning The Victorian Clinical Information Sharing Plans.
This appeared last week: Victorian government must ensure its proposed healthcare database has iron-clad security and privacy December 7, 2020 3.59pm AEDT Author Rick Sarre Emeritus Professor of Law and Criminal Justice, University of South Australia Last weekend, The Age reported on a Victorian government plan, quietly unveiled three months ago, that would revolutionise the collection of the private medical data of every Victorian who has ever used public hospitals or health services. Known as clinical information sharing (CIS), the plan allows the Department of Health and Human Services (DHHS) to gather and collate ...
Source: Australian Health Information Technology - December 18, 2020 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
poem
Poem #18This poem can ’t figure outWhether it's a distracted daydreamOr the proof of one who pays attentionTo all the divergence of the existent.It ’s both, one cannot doubt.How can you conjure visionsWithout the careful quiltingOf all observed quickenings?My son, my daughter,Carbon, iron, oxygen.Even the flights of imagination:Gryphon, unicorn, fire breathing dragon.There ’s nothing ever new under the sun,Just ever more interesting combinations.12/15/20 (Source: Buckeye Surgeon)
Source: Buckeye Surgeon - December 15, 2020 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Sunday Sermonette: Mo rambles on
Deuteronomy 8 doesn ' t say a whole lot that ' s new -- it ' s just more of the endless exhortation to worship YHWH and not to stray, and more recapitulation of events of Exodus and Numbers. The book generally is very turgid and this chapter is pretty much filler. There are a couple of items worth noting, however.8 “All the commandment which I command you this day you shall be careful to do, that you may live and multiply, and go in and possess the land which theLord swore to give to your fathers.2 And you shall remember all the way which theLord your God has led you these forty years in the wilderness, that he...
Source: Stayin' Alive - December 13, 2020 Category: American Health Source Type: blogs
Get Further, Faster in your Career: 4 Steps to Finding a Mentor
Behind every successful person is at least one mentor — who believed in and supported them from the very beginning.
A mentor is the cheerleader who encourages your dreams and the advisor who helps you find your way. When things aren’t going well, your mentor provides you with a safe and supportive environment. You can confide in them with your challenges and frustrations, and trust them to provide honest, supportive feedback.
Your mentor is your champion — filling three crucial roles:
Sounding board: A champion provides wisdom and adviceand challenges you in ways that refine your perspectives and ...
Source: PickTheBrain | Motivation and Self Improvement - December 9, 2020 Category: Consumer Health News Authors: Erin Falconer Tags: career featured motivation self-improvement success mentor pickthebrain Source Type: blogs
Case of the Week 617
Here is our monthly case from Idzi Potters and theInstitute of Tropical Medicine, Antwerp. The following were seen in a stool specimens in a patient with diarrhea and recent travel to sub-Saharan Africa. Unstained wet mount: Combined iron hematoxylin-Kinyoun stain:Identification? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - December 7, 2020 Category: Parasitology Source Type: blogs
Answer to Case 617
Answer toParasite Case of the Week 617:Cystoisospora(formerly Isospora)belliThe diagnostic features in this case include the size of the oocyst (~25 micrometers), oval shape, internal structure (single sporoblast in the wet prep) and acid fast positivity on the iron hematoxylin Kinyoun stain. The acid fast positivity allows us to rule-outSarcocystissp. as the oocysts of this parasite are not acid fast. Kamran and Florida Fan noted that the oocysts ofC. belliautofluoresce beautifully when examined with an excitation filter of 330 to 365 nm. As Blaine will tell us, they also exhibit a less intense fluor...
Source: Creepy Dreadful Wonderful Parasites - December 7, 2020 Category: Parasitology Source Type: blogs
Fictional patients as literature search examples
Not simulated patients used in exams, but fictional patients as literature search topics.I have used fictional patients for some years. I looked back to see if I have ever given them names, and can ' t find any evidence of that. That is good, as perhaps there is a danger the names would not be diverse. For the medical students who started in 2017, I had this:" Your patient is a five year old with head lice. Their parent asks if they should use an insecticide lotion to eradicate the lice. Will this work, and better than the alternatives? Are there any adver...
Source: Browsing - November 30, 2020 Category: Databases & Libraries Tags: literature searching Source Type: blogs
Bias: Is pain all the same?
The topic of how we define pain, and how humans respond to pain has come up for me as I mull over the IASP definition of pain. The current (new) definition is this:
An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage.
Six key notes:
Pain is always a personal experience that is influenced to varying degrees by biological, psychological, and social factors.Pain and nociception are different phenomena. Pain cannot be inferred solely from activity in sensory neurons.Through their life experiences, individuals learn the concept of pain.A...
Source: HealthSkills Weblog - November 29, 2020 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Clinical reasoning Education Education/CME Pain conditions acute pain function IASP definition maldynia metaphor pain definition persistent pain purpose Source Type: blogs
Sunday Sermonette: Sculpt not!
With Deuteronomy 4, Moses begins a long spell of hectoring. There ' s a lot of scolding in general about following the law exactly, but there ' s also a particular emphasis on not making graven images. The New International Version, which I ' ve been using, translates the word as " idols, " which would seem to imply that it ' s only bad if you ' re planning to worship the thing, but most translations just have " images, " including the Revised Standard Version I present here. This is evidently consistent with the Hebrew because over the millennia rabbinical authorities have interpreted the prohibition as restricting any fo...
Source: Stayin' Alive - November 29, 2020 Category: American Health Source Type: blogs
Wednesday Bible Study: Mister big stuff
Deuteronomy 3 retells the story of the defeat of Og told earlier in Numbers, but with more detailed and specific slaughter. Also, the obsession with giants continues, Og apparently having been the biggest of them all. I repeat myself, but I would ask you again to reflect on the concept of " Biblical morality " and what it means to be " pro-life. "3 Next we turned and went up along the road toward Bashan, and Og king of Bashan with his whole army marched out to meet us in battle at Edrei.2 TheLord said to me, “Do not be afraid of him, for I have delivered him into your hands, along with his whole army and his la...
Source: Stayin' Alive - November 25, 2020 Category: American Health Source Type: blogs
Wednesday Bible Study: Law and Order
Numbers 35 may be difficult to understand for modern people, because it ' s set in a legal regime that seems very strange to us. The Israelite culture represented here is similar to many others in that vengeance for murder is the right of the victim ' s close kin. " The avenger " mentioned here is presumably a brother or son or father who has the obligation to kill his relative ' s murderer. The law here distinguishes manslaughter from murder, but rather than tempering the right of vengeance in the case of manslaughter in a straightforward manner, it assumes that the avenger will act anyway and therefore provides for a pla...
Source: Stayin' Alive - November 11, 2020 Category: American Health Source Type: blogs
Freezing a Moment in Time: Snapshots of Cryo-EM Research
To get a look at cell components that are too small to see with a normal light microscope, scientists often use cryo-electron microscopy (cryo-EM). As the prefix cryo- means “cold” or “freezing,” cryo-EM involves rapidly freezing a cell, virus, molecular complex, or other structure to prevent water molecules from forming crystals. This preserves the sample in its natural state and keeps it still so that it can be imaged with an electron microscope, which uses beams of electrons instead of light. Some electrons are scattered by the sample, while others pass through it and through magnetic lenses to land on a detecto...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 4, 2020 Category: Research Authors: Chrissa Chverchko Tags: Molecular Structures Tools and Techniques Cellular Imaging Cellular Processes Cool Tools/Techniques Cryo-Electron Microscopy Research Roundup Source Type: blogs
Fight Aging! Newsletter, November 2nd 2020
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings.
In Vivo Reprogramming Improves Cognitive Function in Old Mice
https://www.fightaging.org/archives/2020/10/in-vivo-reprogramming-improves-cognitive-function-in-old-mi...
Source: Fight Aging! - November 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
