Science Snippet: Zooming In on Nanoparticles
Nanoparticles come in many different shapes and configurations. Credit: Adapted from Stevens, et. al., under Creative Commons License 4.0.
Nanoparticles may sound like gadgets from a science fiction movie, but they exist in real life. They’re particles of any material that are less than 100 nanometers (one-billionth of a meter) in all dimensions. Nanoparticles appear in nature, and humans have, mostly unknowingly, used them since ancient times. For example, hair dyeing in ancient Egypt involved lead sulfite nanoparticles, and artisans in the Middle Ages added gold and silver nanoparticles to stained-glass windows. Over...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 13, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Cool Videos Medicines Science Snippet Source Type: blogs
Wednesday Bible Study: Sing that Thing!
The Book of Psalms is a hymnal, consisting of song lyrics believed to be associated with worship at the Temple. The psalms are thought to have been composed from the 9th through 5th Centuries BCE, but they were compiled in the 5th Century, i.e. the Second Temple period. The canonical version in the protestant Old Testament largely corresponds to the Masoretic text. There are some small differences in numbering and content with the Septuagint, but I won ' t waste your time with that. We don ' t know much of anything about the music. There was instrumental accompaniment, at least to many of them, as it is occasionally r...
Source: Stayin' Alive - November 8, 2023 Category: American Health Source Type: blogs
Sunday Sermonette: Let's get it over with
I ' m going to post the last three chapters of Job today because we really need to move on. In chapters 40 and 41, God rants about creatures called respectively behemoth and leviathan. No-one is sure what these are supposed to be. The NIV footnote actually suggests that behemoth is a hippopotamus, and the footnote to chapter 41 suggests that leviathan is a crocodile. Neither of these solutions would seem to justify the vast powers God attributes to these creatures, but anyway, theirs existence is supposed to demonstrate the greatness of God. So Job says " Okay, I ' m just shit, " which is the answer God wants to hear, wher...
Source: Stayin' Alive - November 5, 2023 Category: American Health Source Type: blogs
Aspects of Iron Metabolism Correlate with Epigenetic Age Acceleration
In conclusion, the results of the present investigation unveiled the causality of iron overload on acceleration of epigenetic clocks. Researches are warranted to illuminate the underlying mechanisms and formulate strategies for potential interventions.
Link: https://doi.org/10.1186/s13148-023-01575-w (Source: Fight Aging!)
Source: Fight Aging! - October 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Sunday Sermonette: Desperate to get this over with
neJob now goes on a three chapter rant saying the same shit over and over again that he already said nineteen times. I ' m really sorry about this, I ' m as anxious to come to the end of it as you are. So I ' m going to post three chapters today, they ' re all Job yammering on so why not? It ' s just more of God and His creation are beyond understanding; and I ' m righteous, I don ' t deserve this, but nevertheless I ' m not going to say anything bad about God. I ' ll just make a couple of notes.First, all of the stuff Job says we can ' t possibly understand -- notably in Chapter 28 -- we do understand, at least a lo...
Source: Stayin' Alive - October 15, 2023 Category: American Health Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Delivering Senolytic Nanoparticles to Atherosclerotic Plaques in Mice
Cells become senescent in response to stress and damage, and there is a great deal of stress and damage taking place in the toxic environment of an atherosclerotic plaque. These fatty plaques develop with age in blood vessel walls throughout the body. Many contributing factors determine the age of onset and pace of progression of atherosclerosis, but at the center of it all, atherosclerotic plaques form and grow because macrophage cells of the innate immune system fail to keep up with clearance of excess cholesterol delivered from the bloodstream into blood vessel walls. After a plaque becomes established, it contains toxi...
Source: Fight Aging! - October 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Novel Approach to Exploiting the Peculiar Biochemistry of Senescent Cells to Produce a Highly Targeted Senolytic
Senolytic drugs selectively destroy senescent cells. First generation senolytic drugs generally target apoptosis-resistance mechanisms and have off-target effects, though these appear quite acceptable in the case of dasatinib and quercetin, given the potential benefits. Nonetheless, researchers are expending a great deal of effort to search for ways to produce far more selective targeting of senescent cells. One example is the category of prodrugs that are only transformed into their cytotoxic form via the activity of β-galactosidase, upregulated in senescent cells. Another type of prodrug employs iron metabolism peculiar...
Source: Fight Aging! - October 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Wednesday Bible Study: Going around in circles
The ridiculous repetition continues, and I ' m not sure what to do about it. This is incredibly boring. They just keep saying the same thing, over and over, at absurd length. I pledged we ' d read the whole damn thing however so in order to keep my word, we just need to plow ahead. Unfortunately, I must warn you, it goes on for quite a while longer in the same circles. This does give us a few popular cliches, e.g. nothing but skin and bones, the skin of my teeth. Whether that makes the whole thing worthwhile I can ' t say. Anyway I ' ll give you two chapters to try to get this over with as soon as possible.19 Then Job...
Source: Stayin' Alive - October 4, 2023 Category: American Health Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Search of Immune System Differences in Long-Lived Mammals
What are the mechanisms that allow long-lived mammals to be long-lived? It remains to be seen as to whether it will be cost-effective and of sizable benefit to isolate specific genetic differences that can be used as a basis for therapies in humans, but it isn't a terrible idea to conduct the search. Clearly cancer suppression is an interesting topic, and one it might well be possible to build novel therapies based on the study of whales and elephants. Another good place to start is the operation of the immune system. The age-related decline of immune function is clearly important to the onset and progression of age-relate...
Source: Fight Aging! - September 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How Cold Weather Affects Blood Pressure? New Study Reveals Surprising Facts
Conclusion
In the vast tapestry of medical research, the recent study on seasonal trends in high blood pressure is a particularly illuminating thread. It’s shown us that something as seemingly benign as the changing of the seasons can impact a major health metric – our blood pressure.
This isn’t just about statistics and numbers. It’s about lives. Recognizing and anticipating these patterns means healthcare providers can be better equipped to offer timely, effective care. And for those living with high blood pressure? It offers a roadmap. A guide to navigate the challenges of each season, with...
Source: The EMT Spot - September 8, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Bonus Features – August 27, 2023 – Trilliant Health Opens its National Provider Directory for the First Time Ever, 60% of Patients Trust Independent Practices over Corporate Healthcare, and More
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
Levita received FDA clearance for its new product, the MARS™ platform. MARS expands on the Levita Magnetic Surgical System, to create a first-of-its-kind minimally invasive surgical platform aimed at the abdominal surger...
Source: EMR and HIPAA - August 27, 2023 Category: Information Technology Authors: Grayson Miller Tags: Healthcare IT AstraZeneca Carefeed Carium Cerner Community Health Network Danyele Homer Dignity Health Global Education DUOS eClinicalWorks Eliciting Insights Entira Family Clinics Fast Company Filecoin Health-Alert (Canada) Source Type: blogs
Vertical Integration Doesn ’t Work in Healthcare: Time to Move On
Conclusion
Healthcare providers of all stripes must leave the industrial world behind. The value chains in health services are not physical, but rather comprised of human relationships, sustained by trust. Virtual care, the advent of AI in healthcare and consumer demand will require a flexible, 24/7 and care anywhere business model. Those who build the best modern clinical mousetrap will end up with a committed clinical staff and loyal patients. Healthcare isn’t about the building, or the brand, or scale. Surviving and thriving in the future will require engaged clinicians who foster trust on the part o...
Source: The Health Care Blog - August 14, 2023 Category: Consumer Health News Authors: matthew holt Tags: The Business of Health Care Hospitals Jeff Goldsmith Physicians Vertical integration Source Type: blogs
Copper Keeps Us Going
Copper pipes, copper wires, copper…food? Copper is not only a useful metal for conducting electricity, but it’s also an essential element we need in our bodies for a variety of important activities—from metabolizing iron to pigmenting skin. (Source: Biomedical Beat Blog - National Institute of General Medical Sciences)
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 9, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Element Proteins Source Type: blogs
