Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Copy Number in Immune Cells Strongly Correlates with 15-Year Mortality
We examined a random population sample in 2003/2005 (n = 9,360, age 45-69, the HAPIEE project) and followed up for 15 years. Using a nested case-control design, we selected non-external deaths among those free from baseline cardiovascular diseases (CVD) and cancer (n = 371), and a sex- and age-stratified control (n = 785). The odds ratios (ORs) of death were 1.06 per one-decile decrease in mtDNA-CN independent of age, sex, metabolic factors, smoking, alcohol intake, and education.
The age-sex-adjusted ORs of death in the second and first tertiles of mtDNA-CN vs. the top tertile were 2.35 and 1.59; an increased risk ...
Source: Fight Aging! - July 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
SENS Research Foundation 2023 Annual Report
The SENS Research Foundation has released its 2023 annual report. This is one of the few non-profit organizations focused on advancing the state of research and development of rejuvenation therapies. It exists in the same family tree as the Methuselah Foundation and LEV Foundation, and all three now have somewhat different areas of focus within the same broad outline. In comparison to the SENS Research Foundation, the Methuselah Foundation gives more attention to tissue engineering, while LEV Foundation is presently investigating combinations of potential rejuvenation therapies in animal models, a sorely neglected area of ...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rat Kidneys Vitrified, Warmed with Magnetic Nanoparticles, then Transplanted Successfully
Another step forward for the magnetic nanoparticle approach to thawing vitrified tissues was recently reported. Vitrification for low-temperature storage is a fairly well established technique, at least for organs. The challenge lies in thawing vitrified organ tissue without causing so much damage that it becomes non-viable for transplantation. Researchers have now managed to make this work for rat kidneys, albeit just barely. The kidneys were damaged, and it remains the case that scaling up to human organs will have its challenges. A greater volume of tissue makes cryopreservation and later thawing much harder, but succes...
Source: Fight Aging! - June 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
8 Risk Factors Of Low Blood Pressure
Conclusion
In a nutshell, understanding the risk factors associated with low blood pressure is essential for maintaining good health.
Individuals with certain risk factors, such as age, medication usage, underlying medical conditions, dehydration, prolonged bed rest, nutritional deficiencies, pregnancy, and inherited factors, should be particularly aware of the potential for low blood pressure.
Regular monitoring of blood pressure, communication with healthcare providers, and appropriate management strategies are important for individuals with these risk factors to ensure their well-being.
Furthermore, diet pla...
Source: The EMT Spot - June 23, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Can You Follow A Vegan Diet With Hypertension?
Conclusion
Returning to our original question—can you follow a vegan diet with hypertension?—current research suggests a tentative ‘yes.’
With thoughtful planning and balanced nutrition, the potential benefits can outweigh the challenges.
However, it’s vital to remember that managing hypertension is a multifaceted undertaking, and dietary changes should be just one part of a comprehensive lifestyle and medical management plan.
Read also: Can You Consume High-Sodium Foods With Hypertension?
Reference
Vegetarian Diets and Blood Pressure Among White Subjects: Results from the Adventist H...
Source: The EMT Spot - June 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Nanorobots Release Reactive Oxygen Species to Kill Fungal Biofilms
Researchers at the University of Pennsylvania have developed nanorobots that can travel to the site of a fungal infection under the influence of an external magnetic field, bind to the fungal cells, and then release reactive oxygen species to completely destroy the fungus. The tiny particles are an example of catalytic nanoparticles, which the researchers have dubbed ‘nanozymes’. Made using iron oxide, they are maneuverable under the influence of magnet fields, allowing the researchers to localize them in a specific part of the body. In tests so far, the nanorobots have been shown to destroy fungal biofilms, which are ...
Source: Medgadget - June 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine nanozymes upenn Source Type: blogs
5 Low Blood Pressure Treatment Methods: From Lifestyle Changes To Medication
Conclusion
Treating low blood pressure is essential for maintaining overall health and well-being. While low blood pressure is often considered a healthy sign of a well-functioning heart, it can cause troublesome symptoms and potentially lead to complications.
Medications, such as Fludrocortisone, Midodrine, and Alpha-1 agonists, are commonly prescribed to stabilize blood pressure and address the underlying causes.
Lifestyle changes, such as augmenting salt consumption, maintaining adequate hydration, and utilizing compression stockings, can also positively impact the management of low blood pressure.
Additiona...
Source: The EMT Spot - June 12, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Chronic Inflammation in Age-Related Anemia
In this study, low Hb concentration was observed to be associated with subclinical, chronic inflammation, exhibited by high levels of IL-1β and TNFα. In the large InCHIANTI study, the unexplained anemia cohort (36% of all the anemic population) was found to have higher levels of pro-inflammatory markers and higher resistance of bone marrow erythroid progenitors to erythropoietin compared to non-anemic controls. The mechanisms underlying low Hb levels in older adults are multifactorial and complex. Our study suggested that the underlying mechanisms involve subclinical chronic low-grade inflammation, bone marrow resistance...
Source: Fight Aging! - June 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
In an Ideal World, How Much Would We Spend on Health Care? – Part 1
BY BEN WHEATLEY
We have heard it said before, and it is no longer shocking to say, that in 2021 the United States spent $4.3 trillion on health care. To put this gaudy number in some perspective, we measure it as a share of our economy and report that health care comprised 18.3% of our gross domestic product. CMS projects that health care will approach 20% of GDP in coming years—one-fifth of everything we buy and sell in this country.
In a recent report, the Health Affairs Council on Health Care Spending and Value said that “it is unclear what percentage of GDP would represent the ideal level to devote to healt...
Source: The Health Care Blog - May 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health care spending medical debt Patent Source Type: blogs
In an Ideal World, How Much Would We Spend on Health Care?
BY BEN WHEATLEY
We have heard it said before, and it is no longer shocking to say, that in 2021 the United States spent $4.3 trillion on health care. To put this gaudy number in some perspective, we measure it as a share of our economy and report that health care comprised 18.3% of our gross domestic product. CMS projects that health care will approach 20% of GDP in coming years—one-fifth of everything we buy and sell in this country.
In a recent report, the Health Affairs Council on Health Care Spending and Value said that “it is unclear what percentage of GDP would represent the ideal level to devote to h...
Source: The Health Care Blog - May 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health care spending medical debt Patent Source Type: blogs
Arizona Governor Hobbs Makes the Right Call by Vetoing Fentanyl Mandatory Minimums Bill
Jeffrey A. SingerToday Arizona Governor Katie Hobbs vetoedSB 1027, which would have placed a mandatory minimum of 10 years in prison on the first offense, and 15 years on the second offense, for anyone convicted of possessing, distributing, transferring, selling, or manufacturing heroin, fentanyl, or fentanyl analogs. In 2006 Arizona voters passedProposition 301, imposing mandatory minimum prison sentences for possessing, transferring, selling, distributing, or manufacturing methamphetamine. This did nothing to decrease meth ‐related deaths.Meth ‐related drug deaths per 100,000 increased nationally...
Source: Cato-at-liberty - April 11, 2023 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
