Wednesday Bible Study: Rehashing
Psalm 105 is a lengthy song of praise that recounts God ' s faithfulness to the Israelites, mostly reciting purported events in Exodus. The introduction is adapted -- largely copied actually -- from 1 Chronicles 16, in which David sets up the Ark and commissions a song of praise by Asaph. Note verse 35 -- there are no caterpillars in the canonical version of Exodus. The caterpillars have come up before, which presumably means that they were working from an alternative version of the story. I don ' t need to harp on the moral depravity of the story -- the 7 year famine God causes, the murder of Egyptian children, the g...
Source: Stayin' Alive - April 24, 2024 Category: American Health Source Type: blogs
Martin Burke: Replacing Lost Proteins to Treat Disease
As a medical student, Martin Burke, M.D., Ph.D., helped care for a young college student with cystic fibrosis (CF), an inherited disease that affects the body’s ability to make sweat and mucus. Dr. Burke had just studied CF in class, so he relayed what he had learned to her. He had a lot of information to give—doctors and researchers know the exact amino acid changes in an ion channel protein called cystic fibrosis transmembrane conductance regulator (CFTR) that cause CF.
Credit: UIUC News Bureau, Fred Zwicky.
“At one point in the conversation, she stopped me and said, ‘It sounds like you know exactly what’s...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 10, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Medicines Profiles Source Type: blogs
Important Complications of Eisenmenger Syndrome
Transcript of the video: Eisenmenger syndrome is an important complication of large left to right shunts which develop later due to development of pulmonary vascular obstructive disease and severe pulmonary hypertension. The first report of Eisenmenger was by Victor Eisenmenger in 1897 and that was in a thirty year old person who later succumbed to massive hemoptysis. This highlights one of the most important complications of Eisenmenger syndrome, that is airway hemorrhage. Airway hemorrhage can occur in those who ascend to high altitude and during air travel. But it commonly occurs at low level itself. It is one of the mo...
Source: Cardiophile MD - March 26, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Ret-He: Reticulocyte hemoglobin equivalent – Marker for iron deficiency in ADHF
It is well known that iron deficiency is associated with poor outcome in acute decompensated heart failure. Different criteria like serum ferritin less than 100 ng/mL or 100-299 ng/mL with transferrin saturation less than 20% have been used to define iron deficiency. Inflammation which is common in heart failure may hinder serum ferritin values [1]. Another marker which has been proposed is reticulocyte hemoglobin equivalent (Ret-He) which is thought to reflect the iron content in reticulocytes.
In a study of 225 patients with ADHF from Japan, median left ventricular ejection fraction was 37%. Median hemoglobin level was ...
Source: Cardiophile MD - March 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Lowered Iron Levels in Hematopoietic Stem Cells Reverse Some Age-Related Dysfunction
Researchers here report on a way to reverse some of the age-related dysfunction observed in the hematopoietic stem cell population resident in bone marrow. These cells are responsible for generating red blood cells and immune cells. Some fraction of the age-related decline in immune function derives from issues in the hematopoietic cell populations originating with hematopoietic stem cells. It seems that hematopoietic stem cells have a distinct iron metabolism, and iron accumulation produces dysregulation in these cells. Reducing the presence of iron in hematopoietic stem cells reverses some of these changes. In the bigger...
Source: Fight Aging! - March 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
poem
Poetry Is Making A ComebackAll the things we decided not to talk about Now get written aboutIn the only wayThat can ' t be said.It ’s progressBut it can ’t lastSome asshole will ruin itPretty soon our lives will be meteredAnd broken into stanzas.Schools will arise to tell usWhy certain poems are goodAnd all these others are bad. Schisms inevitably ensueBetween rival schools Over the true definition of a sonnet.There will be a heraldryOf pompous inanityA cacophony of competing reveillesPlatoons of Shakespeare cosplayersWielding iron quills.A king declares : poem, poem, not a poem, poem, not a poemAt...
Source: Buckeye Surgeon - February 7, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CISD2 Upregulation Reduces the Senescence-Associated Secretory Phenotype in Aged Skin
CISD2 expression declines with age, while upregulation of CISD2 expression has been shown in mice to improve liver function and extend life span. This strategy is expected to have broad effects on function in many tissues beyond the liver. At least some of those benefits result from an increase in the efficiency of the complex cell maintenance processes of autophagy, recycling damaged and unwanted proteins and cell structures. As is the case for other approaches to slowing aging that function via autophagy, CISD2 upregulation has the effect of reducing senescent cell burden and suppressing the harmful senescence-associated...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Case of the Week 737
This week ' s case was generously donated by Dr. Richard Bradbury. The is a permanent mounted stool sample from a Gambian child with watery diarrhea. It is stained with iron haematoxylin; objects of interest are approximately 10-15 micrometers long. Check out the video for a 3D view and classic motility pattern! (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - February 1, 2024 Category: Parasitology Source Type: blogs
A talk with Andy Bell on thriving with diabetes
Andy Bell:Experiencing diabetes beyond just numbers
I recently had the privilege of catching up with Andy Bell. A good friend and part of the diabetes community, Andy shared his story, which is packed with perseverance and resilience.Andy was diagnosed with type 1 diabetes in 1994 at the age of 14. His experience, like that of many others living with diabetes, has been a rollercoaster ride. During our conversation, Andy touched on his diagnosis story, how living with diabetes has impacted his life, his unique career path, and how he manages now that heâ€...
Source: Scott's Diabetes Blog - January 26, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
The superhero spectrum in health care
Strategic thinking: The Doctor Strange of health care. Health care professionals, much like Doctor Strange, often engage in complex decision-making, foreseeing multiple outcomes to choose the best path for patient care. Your ability to strategize and anticipate is crucial in saving lives and ensuring quality care. Innovation: Channeling Iron Man. Innovation is key in health care. Just
Read more…
The superhero spectrum in health care originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 26, 2024 Category: General Medicine Authors: Harvey Castro, MD, MBA Tags: Physician Primary Care Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Flavonoid 4,4 ′-dimethoxychalcone is Senolytic
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
poem
Small and InsecureI am small and insecureYet assert a certain feigned Savoir faire of the martyrDown to the last arrowIn his quiver Some of it is made of plasticJust touch me untilYou find the places I can ’t feel Some of it is made of wood.As I get closer to the endI ’ll use it for kindling.Some is iron But in all the wrong placesJust makes me feel heavyI sink, but faster As for more precious metals I like to think I gave it all awayBut no, it ’s still stashed thereIn the locked room where I never go The rest is fleshThe rest is bone1/16/24 (Source: Buckeye Surgeon)
Source: Buckeye Surgeon - January 16, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Science Snippet: Zooming In on Nanoparticles
Nanoparticles come in many different shapes and configurations. Credit: Adapted from Stevens, et. al., under Creative Commons License 4.0.
Nanoparticles may sound like gadgets from a science fiction movie, but they exist in real life. They’re particles of any material that are less than 100 nanometers (one-billionth of a meter) in all dimensions. Nanoparticles appear in nature, and humans have, mostly unknowingly, used them since ancient times. For example, hair dyeing in ancient Egypt involved lead sulfite nanoparticles, and artisans in the Middle Ages added gold and silver nanoparticles to stained-glass windows. Over...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 13, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Cool Videos Medicines Science Snippet Source Type: blogs
