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Preclinical animal models to evaluate therapeutic antiviral antibodies
Antiviral Res. 2024 Mar 26:105843. doi: 10.1016/j.antiviral.2024.105843. Online ahead of print.ABSTRACTDespite the availability of effective preventative vaccines and potent small-molecule antiviral drugs, effective non-toxic prophylactic and therapeutic measures are still lacking for many viruses. The use of monoclonal and polyclonal antibodies in an antiviral context could fill this gap and provide effective virus-specific medical interventions. In order to develop these therapeutic antibodies, preclinical animal models are of utmost importance. Due to the variability in viral pathogenesis, immunity and overall character...
Source: Antiviral Research - March 28, 2024 Category: Virology Authors: Amse De Meyer Philip Meuleman Source Type: research

COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 BA.1/BA.2 lineages among adults and adolescents in a multicentre primary care study, Europe, December 2021 to June 2022
ConclusionPrimary series and booster VE against symptomatic infection with BA.1/BA.2 ranged from 37% to 42%, with similar waning post vaccination. Comprehensive data on previous SARS-CoV-2 infection would help disentangle vaccine- and infection-induced immunity. (Source: Eurosurveillance)
Source: Eurosurveillance - March 28, 2024 Category: Infectious Diseases Authors: Charlotte Lani èce Delaunay, Iván Martínez-Baz, Noémie Sève, Lisa Domegan, Clara Mazagatos, Silke Buda, Adam Meijer, Irina Kislaya, Catalina Pascu, AnnaSara Carnahan, Beatrix Oroszi, Maja Ilić, Marine Maurel, Aryse Melo, Virginia Sandonis Martín, C Source Type: research

Leveraging seasonal influenza health worker vaccination programmes for COVID-19 vaccine Introduction: A global qualitative analysis
CONCLUSIONS: Our findings suggest a strong justification for enhanced investment in vaccination of health workers, particularly against seasonal influenza, through country-wide programmes as a foundation for pandemic preparedness and response.PMID:38531724 | DOI:10.1016/j.vaccine.2023.12.044 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Anna-Maria Volkmann Shoshanna Goldin Britney McMurren Claire Gapare Beth Anne Pratt Laura Frost Shalini Desai Source Type: research

The early safety profile of simultaneous vaccination against influenza and Respiratory Syncytial Virus (RSV) in patients with high-risk heart failure
This study indicates the safety of simultaneous influenza and RSV vaccination in high-risk HF patients, with a low incidence of mild adverse events.PMID:38531725 | DOI:10.1016/j.vaccine.2024.03.060 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Jan Biegus Leszek Szenborn Robert Zymli ński Micha ł Zakliczyński Krzysztof Reczuch Mateusz Guzik Szymon Urban Marta Rosiek-Biegus Berenika Jankowiak Gracjan Iwanek Marat Fudim Piotr Ponikowski Source Type: research

Influenza vaccination accuracy among adults: Self-report compared with electronic health record data
CONCLUSIONS: In a multistate research network across two recent influenza seasons, there was moderate concordance between EHR-based vaccination data and self-report.PMID:38531726 | DOI:10.1016/j.vaccine.2024.03.052 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Matthew F Daley Liza M Reifler Jo Ann Shoup Jason M Glanz Bruno J Lewin Nicola P Klein Elyse O Kharbanda Huong Q McLean Simon J Hambidge Jennifer C Nelson Allison L Naleway Eric S Weintraub Michael M McNeil Hilda Razzaghi James A Singleton Source Type: research

Viruses, Vol. 16, Pages 507: Disease Burden and Inpatient Management of Children with Acute Respiratory Viral Infections during the Pre-COVID Era in Germany: A Cost-of-Illness Study
rbara A. Rath Respiratory viral infections (RVIs) are common reasons for healthcare consultations. The inpatient management of RVIs consumes significant resources. From 2009 to 2014, we assessed the costs of RVI management in 4776 hospitalized children aged 0&ndash;18 years participating in a quality improvement program, where all ILI patients underwent virologic testing at the National Reference Centre followed by detailed recording of their clinical course. The direct (medical or non-medical) and indirect costs of inpatient management outside the ICU (&lsquo;non-ICU&rsquo;) versus management r...
Source: Viruses - March 26, 2024 Category: Virology Authors: Maren Alchikh Tim O. F. Conrad Patrick E. Obermeier Xiaolin Ma Brunhilde Schweiger Onya Opota Barbara A. Rath Tags: Article Source Type: research

Viruses, Vol. 16, Pages 505: Overview of Modern Commercial Kits for Laboratory Diagnosis of African Swine Fever and Swine Influenza A Viruses
�a Montoya Rapid and early detection of infectious diseases in pigs is important, especially for the implementation of control measures in suspected cases of African swine fever (ASF), as an effective and safe vaccine is not yet available in most of the affected countries. Additionally, analysis for swine influenza is of significance due to its high morbidity rate (up to 100%) despite a lower mortality rate compared to ASF. The wide distribution of swine influenza A virus (SwIAV) across various countries, the emergence of constantly new recombinant strains, and the danger of human infection underscore the need for rapi...
Source: Viruses - March 26, 2024 Category: Virology Authors: Larysa Muzykina Luc ía Barrado-Gil Antonio Gonzalez-Bulnes Daniel Crespo-Piazuelo Jose Joaquin Cer ón Covadonga Alonso Mar ía Montoya Tags: Review Source Type: research

Evaluation of immunogenicity and protective efficacy of bacteriophage conjugated haemagglutinin based subunit vaccine against equine influenza virus in a murine model
In conclusion, the immune responses with moderate antibody titer and significantly higher cytokine responses generated by the rHA1-phage vaccine preparation without any adjuvant could be a novel vaccine candidate for quick vaccine preparation through further trials of vaccine in the natural host. (Source: Veterinary Research Communications)
Source: Veterinary Research Communications - March 26, 2024 Category: Veterinary Research Source Type: research

Maternal Vaccination in Pregnancy: An Assessment of Influenza, Pertussis, and COVID-19 Vaccination Rates in Cracow, Poland
Med Sci Monit. 2024 Mar 12;30:e943304. doi: 10.12659/MSM.943304.ABSTRACTBACKGROUND Maternal vaccination during pregnancy reduces the risk of severe course and complications from infections both for the mother and her child. As information regarding immunization status of pregnant women with recommended vaccines in Poland is scarce, this questionnaire-based study aimed to identify influenza, pertussis (whooping cough), and COVID-19 vaccination in 205 pregnant women in Cracow, Poland, between February and April 2023. Another objective was to assess whether any of the maternal factors might influence women's decision to inocu...
Source: Medical Science Monitor - March 25, 2024 Category: Research Authors: Julia Jurga Gabriela Mierzwa Justyna Agnieszka Kuciel Magdalena Ko łak Andrzej Jaworowski Hubert Huras Source Type: research

WSV2023 - The second meeting of the world society for virology: One health - One world - One virology
Discussions further explored SARS-CoV-2 RNA replicons as vaccine candidates, SARS-CoV-2 in humans and animals, and the significance of plant viruses in the 'One Health' paradigm. The presence of the presidents from three virology societies, namely the American, Indian, and Korean Societies for Virology, highlighted the event's significance. Additionally, past president of the American Society for Virology (ASV), formally declared the partnership between ASV and WSV during the conference.PMID:38527382 | DOI:10.1016/j.virol.2024.110049 (Source: Virology)
Source: Virology - March 25, 2024 Category: Virology Authors: Ahmed S Abdel-Moneim Modra Murovska Maria S öderlund-Venermo Vikram N Vakharia William C Wilson Douglas P Gladue Matthew D Moore Covadonga Alonso Sayed F Abdelwahab Marietjie Venter Yashpal S Malik Shi Zhengli Shailendra K Saxena Anupam Varma Richard J K Source Type: research

Evaluation of Strategies for Transitioning to Annual SARS-CoV-2 Vaccination Campaigns in the United States
CONCLUSION: The direct health care costs of SARS-CoV-2, particularly among adults aged 50 years or older, would be substantially reduced by administering a second dose 5 months after the initial dose.PRIMARY FUNDING SOURCE: Natural Sciences and Engineering Research Council of Canada, Notsew Orm Sands Foundation, National Institutes of Health, Centers for Disease Control and Prevention, and National Science Foundation.PMID:38527289 | DOI:10.7326/M23-2451 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 25, 2024 Category: Internal Medicine Authors: Chad R Wells Abhishek Pandey Seyed M Moghadas Meagan C Fitzpatrick Burton H Singer Alison P Galvani Source Type: research