Preparation and characterization of curdlan-chitosan conjugate nanoparticles as mucosal adjuvants for intranasal influenza H1N1 subunit vaccine
In this study, stable nanoparticles formed by curdlan-O-HTCC conjugate (CO NP) were prepared and characterized. Furthermore, the efficacy of CO NP was evaluated as a mucosal adjuvant in an intranasal influenza H1N1 subunit vaccine. The results revealed that CO NP exhibits uniform and spherical morphology, with a size of 190.53 ± 4.22 nm, and notably, it remains stable in PBS at 4 °C for up to 6 weeks. Biological evaluation demonstrated that CO NP stimulates the activation of antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), both in vitro and in vivo. Furthermore, intranasal administration ...
Source: International Journal of Biological Macromolecules - April 3, 2024 Category: Biochemistry Authors: Honglei Jiang Shu Zhang Yipan Chen Fengshan Wang Wenjie Jiang Source Type: research
High-Dose Quadrivalent Influenza Vaccine for Prevention of Cardiovascular and Respiratory Hospitalizations in Older Adults
CONCLUSIONS: Despite insufficient statistical power due to the impact of COVID-19, rVE point estimates demonstrated a trend toward a benefit of QIV-HD over QIV-SD. QIV-HD was associated with lower respiratory or cardiovascular hospitalization rates than QIV-SD, with a comparable safety profile. Adequately powered studies conducted over multiple influenza seasons are needed to determine statistical significance of QIV-HD compared with QIV-SD against preventing respiratory and cardiovascular hospitalizations.TRIAL REGISTRATION: ClinicalTrials.gov number: NCT04137887.PMID:38569647 | PMC:PMC10990679 | DOI:10.1111/irv.13270 (So...
Source: Respiratory Care - April 3, 2024 Category: Respiratory Medicine Authors: Arto A Palmu Stephanie Pepin Ritva K Syrj änen Karine Mari Tamala Mallett Moore Jukka Jokinen Heta Nieminen Terhi Kilpi Sandrine I Samson Iris De Bruijn Source Type: research
Swine influenza A virus: challenges and novel vaccine strategies
Swine Influenza A Virus (IAV-S) imposes a significant impact on the pork industry and has been deemed a significant threat to global public health due to its zoonotic potential. The most effective method of preventing IAV-S is vaccination. While there are tremendous efforts to control and prevent IAV-S in vulnerable swine populations, there are considerable challenges in developing a broadly protective vaccine against IAV-S. These challenges include the consistent diversification of IAV-S, increasing the strength and breadth of adaptive immune responses elicited by vaccination, interfering maternal antibody responses, and ...
Source: Frontiers in cellular and infection microbiology - April 3, 2024 Category: Microbiology Source Type: research
Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus
In this study, we selected the putative recombinant viruses and performed genomic characterization of these viruses. Some putative recombinant viruses displayed plaque morphology distinct of that of the parental viruses. Our analysis demonstrated that they had mosaic genomes of different lengths. The recombinant viruses, with a genome more similar to MVA-HANP (>50%), rescued deleted and/or fragmented genes in MVA and gained new host ranges genes. Our analysis also revealed that some MVA-HANP contained a partially deleted transgene expression cassette and one recombinant virus contained part of the transgene expression c...
Source: Frontiers in Immunology - April 3, 2024 Category: Allergy & Immunology Source Type: research
Attitudes, motivators, and barriers toward influenza vaccination for children: a study from a conflict-ridden country
Despite the increased recommendations for influenza vaccination, particularly among high-risk groups such as young children, Yemen lacks an influenza vaccination program, and the influenza vaccine is not inclu... (Source: Conflict and Health)
Source: Conflict and Health - April 3, 2024 Category: International Medicine & Public Health Authors: Wesam S. Ahmed, Abdulsalam M. Halboup, Arwa Alshargabi, Ahmed Al-mohamadi, Yousf K. Al-Ashbat and Sayida Al-Jamei Tags: Research Source Type: research
Global vaccine coverage and childhood survival estimates: 1990-2019
CONCLUSION: Vaccines continue to reduce childhood mortality significantly, especially in Gavi-supported countries, emphasizing the need for increased investment in routine immunization programmes.PMID:38562199 | PMC:PMC10976869 | DOI:10.2471/BLT.23.290129 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - April 2, 2024 Category: International Medicine & Public Health Authors: Haijun Zhang Bryan Patenaude Haonan Zhang Mark Jit Hai Fang Source Type: research
Consensus Guidelines for Influenza Vaccination in Patients with Diabetes
Acta Med Indones. 2024 Jan;56(1):126-133.ABSTRACTInfluenza is a prevalent health issue encountered in daily practice. Patients with diabetes mellitus face a higher risk of infections, including influenza, owing to the compromised immune system associated with diabetes. This susceptibility arises from the potential of diabetes mellitus to weaken the immune system. Moreover, elevated blood glucose levels can create a conducive environment for the growth of bacteria and viruses. This consensus is formulated by a multidisciplinary team to serve as practical guidance for the administration of influenza vaccinations to patients ...
Source: Acta medica Indonesiana - April 2, 2024 Category: Internal Medicine Authors: Sukamto Koesnoe Anshari Saifuddin Hasibuan Ketut Suastika Cissy Kartasasmita Andi Makbul Aman Ida Ayu Kshanti Wismandari Wisnu Samsuridjal Djauzi Iris Rengganis Alvina Widhani Suzy Maria Erwanto Budi Winulyo Hindra Irawan Heri Nugroho Nanny Soetedjo Sobag Source Type: research
Global vaccine coverage and childhood survival estimates: 1990-2019
CONCLUSION: Vaccines continue to reduce childhood mortality significantly, especially in Gavi-supported countries, emphasizing the need for increased investment in routine immunization programmes.PMID:38562199 | PMC:PMC10976869 | DOI:10.2471/BLT.23.290129 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - April 2, 2024 Category: International Medicine & Public Health Authors: Haijun Zhang Bryan Patenaude Haonan Zhang Mark Jit Hai Fang Source Type: research
Consensus Guidelines for Influenza Vaccination in Patients with Diabetes
Acta Med Indones. 2024 Jan;56(1):126-133.ABSTRACTInfluenza is a prevalent health issue encountered in daily practice. Patients with diabetes mellitus face a higher risk of infections, including influenza, owing to the compromised immune system associated with diabetes. This susceptibility arises from the potential of diabetes mellitus to weaken the immune system. Moreover, elevated blood glucose levels can create a conducive environment for the growth of bacteria and viruses. This consensus is formulated by a multidisciplinary team to serve as practical guidance for the administration of influenza vaccinations to patients ...
Source: Acta medica Indonesiana - April 2, 2024 Category: Internal Medicine Authors: Sukamto Koesnoe Anshari Saifuddin Hasibuan Ketut Suastika Cissy Kartasasmita Andi Makbul Aman Ida Ayu Kshanti Wismandari Wisnu Samsuridjal Djauzi Iris Rengganis Alvina Widhani Suzy Maria Erwanto Budi Winulyo Hindra Irawan Heri Nugroho Nanny Soetedjo Sobag Source Type: research
Global vaccine coverage and childhood survival estimates: 1990-2019
CONCLUSION: Vaccines continue to reduce childhood mortality significantly, especially in Gavi-supported countries, emphasizing the need for increased investment in routine immunization programmes.PMID:38562199 | PMC:PMC10976869 | DOI:10.2471/BLT.23.290129 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - April 2, 2024 Category: International Medicine & Public Health Authors: Haijun Zhang Bryan Patenaude Haonan Zhang Mark Jit Hai Fang Source Type: research
Consensus Guidelines for Influenza Vaccination in Patients with Diabetes
Acta Med Indones. 2024 Jan;56(1):126-133.ABSTRACTInfluenza is a prevalent health issue encountered in daily practice. Patients with diabetes mellitus face a higher risk of infections, including influenza, owing to the compromised immune system associated with diabetes. This susceptibility arises from the potential of diabetes mellitus to weaken the immune system. Moreover, elevated blood glucose levels can create a conducive environment for the growth of bacteria and viruses. This consensus is formulated by a multidisciplinary team to serve as practical guidance for the administration of influenza vaccinations to patients ...
Source: Acta medica Indonesiana - April 2, 2024 Category: Internal Medicine Authors: Sukamto Koesnoe Anshari Saifuddin Hasibuan Ketut Suastika Cissy Kartasasmita Andi Makbul Aman Ida Ayu Kshanti Wismandari Wisnu Samsuridjal Djauzi Iris Rengganis Alvina Widhani Suzy Maria Erwanto Budi Winulyo Hindra Irawan Heri Nugroho Nanny Soetedjo Sobag Source Type: research
Global vaccine coverage and childhood survival estimates: 1990-2019
CONCLUSION: Vaccines continue to reduce childhood mortality significantly, especially in Gavi-supported countries, emphasizing the need for increased investment in routine immunization programmes.PMID:38562199 | PMC:PMC10976869 | DOI:10.2471/BLT.23.290129 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - April 2, 2024 Category: International Medicine & Public Health Authors: Haijun Zhang Bryan Patenaude Haonan Zhang Mark Jit Hai Fang Source Type: research
Consensus Guidelines for Influenza Vaccination in Patients with Diabetes
Acta Med Indones. 2024 Jan;56(1):126-133.ABSTRACTInfluenza is a prevalent health issue encountered in daily practice. Patients with diabetes mellitus face a higher risk of infections, including influenza, owing to the compromised immune system associated with diabetes. This susceptibility arises from the potential of diabetes mellitus to weaken the immune system. Moreover, elevated blood glucose levels can create a conducive environment for the growth of bacteria and viruses. This consensus is formulated by a multidisciplinary team to serve as practical guidance for the administration of influenza vaccinations to patients ...
Source: Acta medica Indonesiana - April 2, 2024 Category: Internal Medicine Authors: Sukamto Koesnoe Anshari Saifuddin Hasibuan Ketut Suastika Cissy Kartasasmita Andi Makbul Aman Ida Ayu Kshanti Wismandari Wisnu Samsuridjal Djauzi Iris Rengganis Alvina Widhani Suzy Maria Erwanto Budi Winulyo Hindra Irawan Heri Nugroho Nanny Soetedjo Sobag Source Type: research
Global vaccine coverage and childhood survival estimates: 1990-2019
CONCLUSION: Vaccines continue to reduce childhood mortality significantly, especially in Gavi-supported countries, emphasizing the need for increased investment in routine immunization programmes.PMID:38562199 | PMC:PMC10976869 | DOI:10.2471/BLT.23.290129 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - April 2, 2024 Category: International Medicine & Public Health Authors: Haijun Zhang Bryan Patenaude Haonan Zhang Mark Jit Hai Fang Source Type: research
