Influenza Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

High-Dose Recombinant Influenza Vaccine: NNT = 3,000 to Prevent One More Infection, No Impact on Hospitalization
Am Fam Physician. 2024 Apr;109(4):372.NO ABSTRACTPMID:38648840 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Mark H Ebell Source Type: research

A live attenuated influenza B virus vaccine expressing RBD elicits protective immunity against SARS-CoV-2 in mice
In this study, we constructed an IBV-based vector vaccine by inserting a receptor-binding domain (RBD) into a non-structural protein 1 (NS1)-truncated gene (rIBV-NS110-RBD). Subsequently, we assessed its safety, immunogenicity, and protective efficacy against SARS-CoV-2 in mice, and observed that it was safe in a mouse model. Intranasal administration of a recombinant rIBV-NS110-RBD vaccine induced high levels of SARS-CoV-2-specific IgA and IgG antibodies and T cell-mediated immunity in mice. Administering two doses of the intranasal rIBV-NS110-RBD vaccine significantly reduced the viral load and lung damage in mice. This ...
Source: Virus Research - April 21, 2024 Category: Virology Authors: Zhenfei Wang Weiyang Sun Dongxu Li Yue Sun Menghan Zhu Wenqi Wang Yiming Zhang Entao Li Feihu Yan Tiecheng Wang Na Feng Songtao Yang Xianzhu Xia Yuwei Gao Source Type: research

Safety of concomitant administration of 23-valent polysaccharide pneumococcal vaccine and influenza vaccine among the elderly
CONCLUSIONS: Concomitant administration of PPSV-23 and influenza vaccine in the elderly was not associated with a higher risk of most prespecified adverse events (AEs) compared to sequential vaccination. This study supports the safety of concomitant administration of PPSV-23 and influenza vaccine.PMID:38641496 | DOI:10.1016/j.vaccine.2024.03.078 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Heehyun Won Jeong Ah Kim Na-Young Jeong Nam-Kyong Choi Source Type: research

Immunogenicity and protective efficacy of a multivalent herpesvirus vectored vaccine against H9N2 low pathogenic avian influenza in chicken
This study investigated H9- and ND-specific humoral and mucosal responses, H9-specific cell-mediated immunity, and protection conferred by the rHVT-H9-F vaccine in specific pathogen-free (SPF) chickens. Vaccination elicited systemic NDV F- and AIV H9-specific antibody response but also local antibodies in eye wash fluid and oropharyngeal swabs. The ex vivo H9-specific stimulation of splenic and pulmonary T cells in the vaccinated group demonstrated the ability of vaccination to induce systemic and local cellular responses. The clinical protection against a challenge using a LPAIV H9N2 strain of the G1 lineage isolated in M...
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Fiona Ingrao Eva Ngabirano Fabienne Rauw Gwena ëlle Dauphin B énédicte Lambrecht Source Type: research

Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China
Emerg Infect Dis. 2024 Apr 19;30(6). doi: 10.3201/eid3006.230530. Online ahead of print.ABSTRACTWe characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease prevention and control.PMID:38640498 | DOI:10.3201/eid3006.230530 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 19, 2024 Category: Infectious Diseases Authors: Yang Liu Yuhua Chen Zhiyi Yang Yaozhong Lin Siyuan Fu Junhong Chen Lingyu Xu Tengfei Liu Beibei Niu Qiuhong Huang Haixia Liu Chaofeng Zheng Ming Liao Weixin Jia Source Type: research

Viruses, Vol. 16, Pages 626: Detection and Characterization of Influenza A Virus Endemic Circulation in Suckling and Nursery Pigs Originating from Vaccinated Farms in the Same Production System
The objective of this study was to evaluate the detection of IAV in suckling and nursery piglets from IAV-vaccinated sows from farms with endemic IAV infections. Eight nasal swab collections were obtained from 135 two-week-old suckling piglets from four farms every other week from March to September 2013. Oral fluid samples were collected from the same group of nursery piglets. IAV RNA was detected in 1.64% and 31.01% of individual nasal swabs and oral fluids, respectively. H1N2 was detected most often, with sporadic detection of H1N1 and H3N2. Whole-genome sequences of IAV isolated from suckling piglets revealed an H1 hem...
Source: Viruses - April 18, 2024 Category: Virology Authors: Alessandra Silva Dias Amy L. Vincent Baker Rodney B. Baker Jianqiang Zhang Michael A. Zeller Pravina Kitikoon Phillip C. Gauger Tags: Article Source Type: research

Comparing PCSK9 Monoclonal Antibody Treatment Strategies Following Myocardial Infarction Using Negative Control Outcomes: A Target Trial Emulation Study
CONCLUSION: A comparative effectiveness study of these treatments using the current approach would likely bias results due to the low number of PCSK9 mAb initiators.PMID:38629975 | DOI:10.1097/EDE.0000000000001730 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Rosa Sloot Alexander Breskin Lisandro D Colantonio Andrew G Allmon Ying Yu Swati Sakhuja Ligong Chen Paul Muntner M Alan Brookhart Nafeesa Dhalwani Source Type: research

Cost-effectiveness of high-dose influenza vaccination in the Netherlands: Incorporating the impact on both respiratory and cardiovascular hospitalizations
CONCLUSIONS: Implementing HD-QIV for adults aged 60 and over within the existing influenza vaccination campaign is highly cost effective. HD-QIV may support alleviating potential capacity issues in Dutch hospitals in the winter respiratory season.PMID:38631948 | DOI:10.1016/j.vaccine.2024.04.040 (Source: Vaccine)
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Simon van der Pol Florian Zeevat Maarten J Postma Cornelis Boersma Source Type: research

Influenza vaccination coverage and determinants of vaccination in peripheral arterial disease patients
Conclusions: This study highlights the low adherence to influenza vaccination in the PAD population of 2 university hospital centers. Vaccination is often related to age, and there is a need for adapted information regarding influenza consequences on cardiovascular disease overall, particularly on PAD. Addressing common information and advice about vaccination will be a challenge.PMID:38629325 | DOI:10.1024/0301-1526/a001120 (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - April 17, 2024 Category: Surgery Authors: Lucie Chastaingt Marie Laure Toba Carine Boulon Loubna Dari Joel Constans Hela Daoud Romain Chauvet Caroline Adou Julien Magne Philippe Lacroix Source Type: research