Molecules, Vol. 29, Pages 1945: Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation
This study investigated the H9N2 AIV antiviral properties of Oxymatrine (OMT), a compound derived from traditional Chinese medicine, particularly focusing on its interaction with pulmonary microvascular endothelial cells (PMVECs). Employing an array of in vitro assays, including 50% tissue culture infectious dose, Cell Counting Kit-8, reverse transcription-quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and Western blot, we systematically elucidated the multifaceted effects of OMT. OMT dose-dependently inhibited critical antiviral proteins (PKR and Mx1) and modulated the expression of type I inte...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Yan Zhi Xinping Zhao Zhenyi Liu Guoyu Shen Taiming Zhang Tao Zhang Ge Hu Tags: Article Source Type: research
Pharmacy-Based Influenza Vaccination: A Study of Patient Acceptance in Romania
(Source: Risk Management and Healthcare Policy)
Source: Risk Management and Healthcare Policy - April 23, 2024 Category: Health Management Tags: Risk Management and Healthcare Policy Source Type: research
Interim Estimates of 2023-2024 Seasonal Influenza Vaccine Effectiveness Among Adults in Korea
In this study, we aimed to estimate the interim vaccine effectiveness (VE) of the influenza vaccination to prevent influenza during the early season. From November 1, 2023, to December 31, 2023, we enrolled 2,632 subjects with influenza-like illness from eight hospitals participating in hospital-based influenza morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted to estimate the VE. The results showed an adjusted VE of 22.5% (95% confidence interval [CI], 6.6 to 35.8) for the total population. The adjusted VE was 22.3% (95% CI, 6.1 to 35.7) for influenza A and 9.4% (95% CI, -...
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Yu Jung Choi Jang Wook Sohn Won Suk Choi Seong-Heon Wie Jacob Lee Jin-Soo Lee Hye Won Jeong Joong Sik Eom Eliel Nham Hye Seong Jin Gu Yoon Ji Yun Noh Joon Young Song Hee Jin Cheong Woo Joo Kim Source Type: research
The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel
Expert Rev Respir Med. 2024 Apr 23. doi: 10.1080/17476348.2024.2340470. Online ahead of print.ABSTRACTINTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel.AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza ...
Source: Expert Review of Respiratory Medicine - April 23, 2024 Category: Respiratory Medicine Authors: George Kassianos Jean-Marie Cohen Rok Civljak Nadav Davidovitch Oana Falup Pecurariu Filipe Froes Andrei Galev Inga Ivaskeviciene Kadri K õivumägi Zuzana Kristufkova Ernest Kuchar Jan Kyncl Helena C Maltezou Milo š Marković Aneta Nitsch-Osuch Raul Ort Source Type: research
Interim Estimates of 2023-2024 Seasonal Influenza Vaccine Effectiveness Among Adults in Korea
In this study, we aimed to estimate the interim vaccine effectiveness (VE) of the influenza vaccination to prevent influenza during the early season. From November 1, 2023, to December 31, 2023, we enrolled 2,632 subjects with influenza-like illness from eight hospitals participating in hospital-based influenza morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted to estimate the VE. The results showed an adjusted VE of 22.5% (95% confidence interval [CI], 6.6 to 35.8) for the total population. The adjusted VE was 22.3% (95% CI, 6.1 to 35.7) for influenza A and 9.4% (95% CI, -...
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Yu Jung Choi Jang Wook Sohn Won Suk Choi Seong-Heon Wie Jacob Lee Jin-Soo Lee Hye Won Jeong Joong Sik Eom Eliel Nham Hye Seong Jin Gu Yoon Ji Yun Noh Joon Young Song Hee Jin Cheong Woo Joo Kim Source Type: research
The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel
Expert Rev Respir Med. 2024 Apr 23. doi: 10.1080/17476348.2024.2340470. Online ahead of print.ABSTRACTINTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel.AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza ...
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: George Kassianos Jean-Marie Cohen Rok Civljak Nadav Davidovitch Oana Falup Pecurariu Filipe Froes Andrei Galev Inga Ivaskeviciene Kadri K õivumägi Zuzana Kristufkova Ernest Kuchar Jan Kyncl Helena C Maltezou Milo š Marković Aneta Nitsch-Osuch Raul Ort Source Type: research
Safety of concomitant administration of 23-valent polysaccharide pneumococcal vaccine and influenza vaccine among the elderly
CONCLUSIONS: Concomitant administration of PPSV-23 and influenza vaccine in the elderly was not associated with a higher risk of most prespecified adverse events (AEs) compared to sequential vaccination. This study supports the safety of concomitant administration of PPSV-23 and influenza vaccine.PMID:38641496 | DOI:10.1016/j.vaccine.2024.03.078 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Heehyun Won Jeong Ah Kim Na-Young Jeong Nam-Kyong Choi Source Type: research
Immunogenicity and protective efficacy of a multivalent herpesvirus vectored vaccine against H9N2 low pathogenic avian influenza in chicken
This study investigated H9- and ND-specific humoral and mucosal responses, H9-specific cell-mediated immunity, and protection conferred by the rHVT-H9-F vaccine in specific pathogen-free (SPF) chickens. Vaccination elicited systemic NDV F- and AIV H9-specific antibody response but also local antibodies in eye wash fluid and oropharyngeal swabs. The ex vivo H9-specific stimulation of splenic and pulmonary T cells in the vaccinated group demonstrated the ability of vaccination to induce systemic and local cellular responses. The clinical protection against a challenge using a LPAIV H9N2 strain of the G1 lineage isolated in M...
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Fiona Ingrao Eva Ngabirano Fabienne Rauw Gwena ëlle Dauphin B énédicte Lambrecht Source Type: research
Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China
Emerg Infect Dis. 2024 Apr 19;30(6). doi: 10.3201/eid3006.230530. Online ahead of print.ABSTRACTWe characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease prevention and control.PMID:38640498 | DOI:10.3201/eid3006.230530 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 19, 2024 Category: Infectious Diseases Authors: Yang Liu Yuhua Chen Zhiyi Yang Yaozhong Lin Siyuan Fu Junhong Chen Lingyu Xu Tengfei Liu Beibei Niu Qiuhong Huang Haixia Liu Chaofeng Zheng Ming Liao Weixin Jia Source Type: research
Viruses, Vol. 16, Pages 626: Detection and Characterization of Influenza A Virus Endemic Circulation in Suckling and Nursery Pigs Originating from Vaccinated Farms in the Same Production System
The objective of this study was to evaluate the detection of IAV in suckling and nursery piglets from IAV-vaccinated sows from farms with endemic IAV infections. Eight nasal swab collections were obtained from 135 two-week-old suckling piglets from four farms every other week from March to September 2013. Oral fluid samples were collected from the same group of nursery piglets. IAV RNA was detected in 1.64% and 31.01% of individual nasal swabs and oral fluids, respectively. H1N2 was detected most often, with sporadic detection of H1N1 and H3N2. Whole-genome sequences of IAV isolated from suckling piglets revealed an H1 hem...
Source: Viruses - April 18, 2024 Category: Virology Authors: Alessandra Silva Dias Amy L. Vincent Baker Rodney B. Baker Jianqiang Zhang Michael A. Zeller Pravina Kitikoon Phillip C. Gauger Tags: Article Source Type: research
Comparing PCSK9 Monoclonal Antibody Treatment Strategies Following Myocardial Infarction Using Negative Control Outcomes: A Target Trial Emulation Study
CONCLUSION: A comparative effectiveness study of these treatments using the current approach would likely bias results due to the low number of PCSK9 mAb initiators.PMID:38629975 | DOI:10.1097/EDE.0000000000001730 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Rosa Sloot Alexander Breskin Lisandro D Colantonio Andrew G Allmon Ying Yu Swati Sakhuja Ligong Chen Paul Muntner M Alan Brookhart Nafeesa Dhalwani Source Type: research
Cost-effectiveness of high-dose influenza vaccination in the Netherlands: Incorporating the impact on both respiratory and cardiovascular hospitalizations
CONCLUSIONS: Implementing HD-QIV for adults aged 60 and over within the existing influenza vaccination campaign is highly cost effective. HD-QIV may support alleviating potential capacity issues in Dutch hospitals in the winter respiratory season.PMID:38631948 | DOI:10.1016/j.vaccine.2024.04.040 (Source: Vaccine)
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Simon van der Pol Florian Zeevat Maarten J Postma Cornelis Boersma Source Type: research
Influenza vaccination coverage and determinants of vaccination in peripheral arterial disease patients
Conclusions: This study highlights the low adherence to influenza vaccination in the PAD population of 2 university hospital centers. Vaccination is often related to age, and there is a need for adapted information regarding influenza consequences on cardiovascular disease overall, particularly on PAD. Addressing common information and advice about vaccination will be a challenge.PMID:38629325 | DOI:10.1024/0301-1526/a001120 (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - April 17, 2024 Category: Surgery Authors: Lucie Chastaingt Marie Laure Toba Carine Boulon Loubna Dari Joel Constans Hela Daoud Romain Chauvet Caroline Adou Julien Magne Philippe Lacroix Source Type: research
Cost-effectiveness of high-dose influenza vaccination in the Netherlands: Incorporating the impact on both respiratory and cardiovascular hospitalizations
CONCLUSIONS: Implementing HD-QIV for adults aged 60 and over within the existing influenza vaccination campaign is highly cost effective. HD-QIV may support alleviating potential capacity issues in Dutch hospitals in the winter respiratory season.PMID:38631948 | DOI:10.1016/j.vaccine.2024.04.040 (Source: Vaccine)
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Simon van der Pol Florian Zeevat Maarten J Postma Cornelis Boersma Source Type: research
Influenza vaccination coverage and determinants of vaccination in peripheral arterial disease patients
Conclusions: This study highlights the low adherence to influenza vaccination in the PAD population of 2 university hospital centers. Vaccination is often related to age, and there is a need for adapted information regarding influenza consequences on cardiovascular disease overall, particularly on PAD. Addressing common information and advice about vaccination will be a challenge.PMID:38629325 | DOI:10.1024/0301-1526/a001120 (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - April 17, 2024 Category: Surgery Authors: Lucie Chastaingt Marie Laure Toba Carine Boulon Loubna Dari Joel Constans Hela Daoud Romain Chauvet Caroline Adou Julien Magne Philippe Lacroix Source Type: research
