Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition. « Back to Top Reviewing the Development of Senotherapeutics to Treat Aging https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/ Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An Update on Kimer Med, Improving on the DRACO Antiviral Technology and Moving Towards the Clinic
The state of anti-viral therapies isn't that great, all things considered. Technology has not yet advanced to the point at which a viral infection can be simply shut down, as is the case for near all bacterial infections. The present anti-viral drugs are either vaccines (useful!) or merely shift the odds somewhat by interfering in some part of the viral life cycle, but nowhere near as effectively as desired. Many persistent viral infections are thought to contribute meaningfully to forms of age-related dysfunction, and there is too little that can be done about that at the present time. This landscape is one of the ...
Source: Fight Aging! - February 23, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs

Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men. « Back to Top Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/ Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

More Evidence for Vaccination to Reduce Alzheimer's Disease Risk
There is good evidence for the various forms of later life vaccination, such as for herpes zoster or influenza, to reduce the risk of later suffering Alzheimer's disease. One possibility is that people who take the time to obtain a vaccine tend to take better care of their health across the board. Another possibility is that vaccination produces a trained immunity effect that dampens age-related inflammation for a sustained period of time. It may also be the case that suffering from influenza, pneumonia, or similar infectious diseases causes sufficient additional inflammation to move the odds on suffering later neurodegene...
Source: Fight Aging! - August 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Better Health Care Tests, Faster
This article looks at some specific problems and solutions. Speeding up Test Development We’ve seen with COVID-19 how quickly a virus can evolve and how hard it is to design both tests and vaccinations that accommodate different variants. Virax Biolabs uses data from the World Health Organization and others to develop tests quickly. For instance, new viral variants tend to spread in the southern hemisphere before hitting the northern hemisphere in our Winter, so Virax can check existing data to prepare better tests for the North. The company is developing a T-cell diagnostics and profiling platform called Virax Immu...
Source: EMR and HIPAA - June 13, 2023 Category: Information Technology Authors: Andy Oram Tags: Health IT Company Healthcare IT Hospital - Health System Interoperability CLIA COVID-19 Hydreight Immunexpress ixlayer Laboratories Labs Rolland Carlson Sepsis Sepsis Lab Tests Septicyte Shane Madden testing Tomasz George Source Type: blogs

Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing the Complexity of Immunosenescence
The immune system becomes more inflammatory and less competent with advancing age, undergoing sweeping changes in immune cell characteristics and relative population sizes. The cells, structures, and processes that produce immune cells similarly undergo significant changes. Taken together, this is called immunosenescence, though many researchers choose to break out the inflammatory component of dysfunction into its own category, calling it inflammaging. One of the most important goals for the research community is to find ways to improve immune function in older people. Evidently, the decline of the immune system is...
Source: Fight Aging! - May 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

H5N1 – It ’ s All About the Transmission
by Gertrud U. Rey Recent news headlines have been highlighting the global spread of H5N1, the strain of influenza virus that is typically associated with “bird flu.” This outbreak is the largest in recorded history, involving at least 50 million dead birds and countless non-human mammals, including sea lions, otters, mink, foxes, cats, dogs, and […] (Source: virology blog)
Source: virology blog - March 2, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey avian influenza H5N1 bird flu human-to-human transmission lower respiratory tract pandemic sialic acid upper respiratory tract vaccine Source Type: blogs

Myocarditis update from Sweden
BY ANISH KOKA The COVID19/vaccine myocarditis debate continues in large part because our public health institutions are grossly mischaracterizing the risks and benefits of vaccines to young people. A snapshot of what the establishment says as it relates to the particular area of concern: college vaccine mandates: Dr. Arthur Reingold, an epidemiology professor at UC-Berkeley, notes that UC also requires immunizations for measles and chickenpox, and people still are dying from COVID at rates that exceed those for influenza. As of Feb. 1, there were more than 400 COVID deaths a day across the U.S. “The arg...
Source: The Health Care Blog - February 27, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Anish Koka covid19 myocarditis Sweden Source Type: blogs

Avian influenza, bird flu, H5N1
A bird flu pandemic has killed thousands of wild birds over the last couple of years. Scientists have now seen infection in mammals, and very recently a person died from avian influenza and several close contacts show signs of  infection. The concern is that we might be headed for another H5N1 pandemic. Previous strains of H5N1 that infected people had a mortality rate of 60 percent. Avian influenza, bird flu, H5N1 There are fifteen known variants of avian influenza. The most virulent, and usually fatal in birds, are the H5 and H7 strains. There are then nine variants of the H5 strain and the type of most concern because ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 27, 2023 Category: Science Authors: David Bradley Tags: Bird Flu Health and Medicine Vaccines Source Type: blogs

TWiV 984: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during […] (Source: virology blog)
Source: virology blog - February 18, 2023 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation influenza Long Covid monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs

TWiV 984: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during … TWiV 984: Clinical update with Dr. Daniel Griffin Read More » (Source: virology blog)
Source: virology blog - February 18, 2023 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation influenza Long Covid monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Viral Infection in Middle Age Correlates with Later Dementia Risk
A range of evidence suggests that persistent viral infection contributes to the risk of suffering neurodegenerative conditions such as Alzheimer's disease. This may be due to mechanisms relating to amyloid-β accumulation, in its role as an anti-microbial peptide, a part of the innate immune system. It may have more to do with lasting chronic inflammation subsequent to infection. Researchers here note another addition to the epidemiological data on this topic, in this case linking severe infections requiring hospitalization with later dementia risk. The effect sizes here are large and last for a long time following infecti...
Source: Fight Aging! - February 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs