Propranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6
ConclusionThese results suggest that propranolol may have potential as a therapeutic agent for breast cancer treatment by targeting EMT and its regulatory mechanisms. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 31, 2024 Category: Cancer & Oncology Source Type: research
Diffuse infantile hepatic hemangioma successfully treated with propranolol orally: a case report and literature review
ConclusionDIHH can induce life-threatening complications that require prompt interventions. Propranolol monotherapy can be an effective and safe first-line treatment strategy for DIHH. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 29, 2024 Category: Cancer & Oncology Source Type: research
Persulfate-enhanced degradation of propranolol over BiOCl0.5I0.5 under visible light irradiation
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3NJ05349K, PaperYuehua Deng, Jiating Luo, Hongyu Cao, Danni Chen, Yani Li, Qianqian Che, Yan He, Xiaobin Hu, Xiang Gao, Wei Zhao, Fei Wang The photodegradation of propranolol (PRO) by BiOCl0.5I0.5/persulfate under visible light was comprehensively investigated. The results demonstrated a significant increase in the removal efficiency of PRO under visible light irradiation, achieved... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - January 18, 2024 Category: Chemistry Authors: Yuehua Deng Source Type: research
Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension
CONCLUSIONS: In summary, we demonstrate pregnancy-associated differences in urinary uromodulin: creatinine ratio and uromodulin excretion rate between chronic hypertensive and normotensive pregnancies. Further research is needed to fully understand uromodulin physiology in human pregnancy and establish uromodulin's potential as a biomarker for renal adaptation and renal function in pregnancy.PMID:38236469 | DOI:10.1007/s40620-023-01830-6 (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 18, 2024 Category: Urology & Nephrology Authors: Sheon Mary Fran Conti-Ramsden Philipp Boder Humaira Parveen Dellaneira Setjiadi Jessica Fleminger Anna Brockbank Delyth Graham Kate Bramham Lucy Charlotte Chappell Christian Delles Source Type: research
Eptinezumab Demonstrated Efficacy Regardless of Prior Preventive Migraine Treatment Failure Type: Post Hoc Analyses of the DELIVER Study
ConclusionIn all subgroups, regardless of prior preventive treatment failure type, eptinezumab demonstrated greater reductions in MMDs and higher MRRs compared with placebo.Trial RegistrationClinicalTrials.gov (Identifier: NCT04418765). (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 18, 2024 Category: Neurology Source Type: research
High-throughput mass spectrometry analysis using immediate drop-on-demand technology coupled with an open port sampling interface
CONCLUSIONS: This work illustrates the development of a noncontact, automated I.DOT/OPSI-MS system with improved throughput achieved through an optimized software interface. Its achievable analysis time and precision make it a viable approach for drug discovery and in situ reaction monitoring studies.PMID:38212650 | DOI:10.1002/rcm.9687 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - January 11, 2024 Category: Chemistry Authors: Vilmos Kertesz Dana L Carper John F Cahill Source Type: research
Recent updates in laryngeal hemangioma management: a scoping review
ConclusionLaryngeal hemangioma management requires personalized approaches informed by diverse therapies, clinical expertise, and collaboration. The review introduces an algorithm spanning observation to advanced interventions, adapting to each case ’s complexity. Ongoing research promises innovative treatments. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - December 29, 2023 Category: ENT & OMF Source Type: research
Exploration of the Optimal Time to Discontinue Propranolol Treatment in Infantile Hemangiomas: A Prospective Study
Relapse of infantile hemangiomas (IHs) after withdrawal from propranolol treatment is common. Early withdrawal is believed to increase the risk of relapse. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - December 28, 2023 Category: Dermatology Authors: Luying Wang, Wenjing Wang MM, Zifu Zhou, Jing Li, Zhiyu Li, Renrong Lv, Guangqi Xu, Jianhai Bi, Ran Huo Source Type: research
Anti-inflammatory and antinociceptive effects of sitagliptin in animal models and possible mechanisms involved in the antinociceptive activity
CONCLUSIONS: : NO/cGMP/KATP, 5HT3 and D2 pathways play an important role in the antinociceptive effect of sitagliptin. Additionally significant anti-inflammatory effects observed in the carrageenan test might contribute in reduction of pain response in the second phase of the formalin test.PMID:38123184 | DOI:10.3344/kjp.23262 (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - December 20, 2023 Category: Anesthesiology Authors: Valiollah Hajhashemi Hossein Sadeghi Fatemeh Karimi Madab Source Type: research
COVISHIELD vaccine-induced thyroiditis: a case report
ConclusionThis case report adds to the growing evidence of coronavirus disease 2019 vaccine-related thyroid issues. The development of thyroiditis is rare and underreported post-coronavirus disease 2019 vaccination; hence, research to evaluate the association of coronavirus disease 2019 vaccines with thyroid dysfunction needs to be done in the future. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 15, 2023 Category: General Medicine Source Type: research
Randomized controlled trial of propranolol on social communication and anxiety in children and young adults with autism spectrum disorder
ConclusionsPropranolol did not impact social interaction measures or language, but there were indications of a beneficial effect for anxiety. This will need confirmation in a larger multicenter trial, monitoring markers or characteristics to identify those participants most likely to respond to propranolol for anxiety, and determine whether there is a subset of participants that are responsive for other previously reported outcomes. (Source: Psychopharmacology)
Source: Psychopharmacology - December 13, 2023 Category: Psychiatry Source Type: research
Reply letter to the letter to the editor entitled: “5-mthf enhances the portal pressure reduction achieved with propranolol in patients with cirrhosis: a randomized placebo-controlled trial: was an accurate statistical analysis performed?”
We thank Dr Fernandez-Garza for the interest in our work and for his comments on the statistical analysis. He underlines that our intention-to-treat analysis (ITT) did not include all planned randomized patients (30 per group) and that we do not explain why [1]. We would like to clarify this point. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 12, 2023 Category: Gastroenterology Authors: Ranka Vukotic, Roberto Di Donato, Jaime Bosch, Pietro Andreone Tags: Letter to the Editor Source Type: research
Reply to: “5-MTHF enhances the portal pressure reduction achieved with propranolol in patients with cirrhosis: A randomized placebo-controlled trial. Was an accurate statistical analysis performed?”
We thank Dr Fernandez-Garza for his interest in our work and for his comments on the statistical analysis. He underlines that our intention-to-treat analysis (ITT) did not include all planned randomized patients (30 per group) and that we do not explain why.1 We would like to clarify this point. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 12, 2023 Category: Gastroenterology Authors: Ranka Vukotic, Roberto Di Donato, Jaime Bosch, Pietro Andreone Tags: Letter to the Editor Source Type: research
