A brief treatment for veterans with PTSD: an open-label case-series study
ConclusionTo summarize, there are grounds for optimism regarding this brief treatment of combat-related PTSD. It appears that the potential for positive outcomes is far greater than commonly believed, as demonstrated by the encouraging results of this pilot study. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - October 19, 2023 Category: Psychiatry Source Type: research
Propranolol or Beta-Blockers for Cerebral Cavernous Malformation: a Systematic Review and Meta-analysis of Literature in Both Preclinical and Clinical Studies
AbstractCerebral cavernous malformation (CCM), either sporadic or familial, is a devastating vascular malformation affecting the central nervous system that can present with intracerebral hemorrhage, seizure, and new focal neurologic deficits resulting in substantial morbidity and mortality. To date, there is no effective evidence-based preventive regimen. There have been several preclinical and clinical studies investigating the potential mechanisms and benefits of beta-blockers, especially on propranolol. We aimed to conduct a systematic review on the published literature investigating the use of beta-blockers in the tre...
Source: Translational Stroke Research - October 19, 2023 Category: Neurology Source Type: research
Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and In Silioc investigations
This study aimed to investigate the effect of aqueous ethanol extract of Cuminum cyminum (AEECC) on oxidative stress, inflammation and overactivity of the urinary bladder induced by cyclophosphamide (CYP). The enhanced nociception behavior, bladder weight, vascular permeability, edema, hemorrhage, nitric oxide, IL-6 and TNF-α levels by CYP administration were significantly reduced by AEECC (250 and 500 mg/kg). A significant increase in serum antioxidant systems such as CAT and GPx was also observed in AEECC-treated rats. The AEECC (3 mg/ml) significantly reduced urinary bladder tone in the strips pre-contracted with carba...
Source: Chemistry and Biodiversity - October 16, 2023 Category: Biochemistry Authors: Mohammed Bourhia Irfan Anjum Daanyaal Ali Mueen Ahmad Chaudhry Farhan Siddique Mehvish Bibi Abdel-Rhman Z Gaafar Touriya Zair Farid Khallouki Source Type: research
Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and In Silioc investigations
This study aimed to investigate the effect of aqueous ethanol extract of Cuminum cyminum (AEECC) on oxidative stress, inflammation and overactivity of the urinary bladder induced by cyclophosphamide (CYP). The enhanced nociception behavior, bladder weight, vascular permeability, edema, hemorrhage, nitric oxide, IL-6 and TNF-α levels by CYP administration were significantly reduced by AEECC (250 and 500 mg/kg). A significant increase in serum antioxidant systems such as CAT and GPx was also observed in AEECC-treated rats. The AEECC (3 mg/ml) significantly reduced urinary bladder tone in the strips pre-contracted with carba...
Source: Chemistry and Biodiversity - October 16, 2023 Category: Biochemistry Authors: Mohammed Bourhia Irfan Anjum Daanyaal Ali Mueen Ahmad Chaudhry Farhan Siddique Mehvish Bibi Abdel-Rhman Z Gaafar Touriya Zair Farid Khallouki Source Type: research
Immunomodulatory chitosan nanoparticles for Toxoplasma gondii infection: Novel application of chitosan in complex propranolol-hydrochloride as an adjuvant in vaccine delivery
Int J Biol Macromol. 2023 Oct 13:127228. doi: 10.1016/j.ijbiomac.2023.127228. Online ahead of print.ABSTRACTThe study aimed to investigate the immunomodulatory effects of propranolol hydrochloride (PRO) in combination with chitosan nanoparticles (CS NPs) as an adjuvant to develop an effective vaccine against T. gondii. A total of 105 BALB/c mice were randomly divided into seven equal groups including PBS alone, CS NPs, SAG1 (Surface antigen 1), CS-SAG1 NPs, CS-PRO NPs, SAG1-PRO, and CS-SAG1-PRO NPs. The immunostimulatory effect of each adjuvant used for vaccine delivery was evaluated in a mice immunization model. The resul...
Source: International Journal of Biological Macromolecules - October 15, 2023 Category: Biochemistry Authors: Zohreh Khorshidvand Sadegh Shirian Hanieh Amiri Alireza Zamani Amir Hossein Maghsood Source Type: research
Immunomodulatory chitosan nanoparticles for Toxoplasma gondii infection: Novel application of chitosan in complex propranolol-hydrochloride as an adjuvant in vaccine delivery
Int J Biol Macromol. 2023 Oct 13:127228. doi: 10.1016/j.ijbiomac.2023.127228. Online ahead of print.ABSTRACTThe study aimed to investigate the immunomodulatory effects of propranolol hydrochloride (PRO) in combination with chitosan nanoparticles (CS NPs) as an adjuvant to develop an effective vaccine against T. gondii. A total of 105 BALB/c mice were randomly divided into seven equal groups including PBS alone, CS NPs, SAG1 (Surface antigen 1), CS-SAG1 NPs, CS-PRO NPs, SAG1-PRO, and CS-SAG1-PRO NPs. The immunostimulatory effect of each adjuvant used for vaccine delivery was evaluated in a mice immunization model. The resul...
Source: International Journal of Biological Macromolecules - October 15, 2023 Category: Biochemistry Authors: Zohreh Khorshidvand Sadegh Shirian Hanieh Amiri Alireza Zamani Amir Hossein Maghsood Source Type: research
Cost analysis and utilization of antihypertensive drug therapy in Saudi Arabia
ConclusionOur study suggested that the prescription pattern of drugs used for the treatment of hypertension adhered with the JNC 8 guidelines. Monotherapy was reliably more recommended in the initial stages of hypertension. Higher percentage of patients (78.32%) was found to be on monotherapy. The Saudi Food and Drug Authority (SFDA) has overwhelmed for fixation of prices of drugs. (Source: Journal of Pharmaceutical Health Services Research)
Source: Journal of Pharmaceutical Health Services Research - October 2, 2023 Category: Drugs & Pharmacology Authors: Mohammad Daud Ali Tags: Research Paper Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study
CONCLUSIONS: This study supports previous findings that the CCM volume is the only factor influencing the bleeding risk. Antithrombotic agents and propranolol seem to have a protective role against the bleeding events. A high HAS-BLED score was not associated with an increased bleeding risk. Further studies are needed to confirm these results.PMID:37778034 | DOI:10.3171/2023.7.FOCUS23355 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2023 Category: Neurosurgery Authors: Alba Scerrati Giorgio Mantovani Francesco Travaglini Leonardo Bradaschia Pasquale De Bonis Marco Farneti Michele Alessandro Cavallo Flavia Dones Maria Elena Flacco Anna Maria Auricchio Alberto Benato Alessio Albanese Carmelo Lucio Sturiale Source Type: research
