Aerobic exercise attenuates autophagy-lysosomal flux deficits by ADRB2/ β2-adrenergic receptor-mediated V-ATPase assembly factor VMA21 signaling in APP-PSEN1/PS1 mice
Autophagy. 2023 Nov 15:1-17. doi: 10.1080/15548627.2023.2281134. Online ahead of print.ABSTRACTGrowing evidence suggests that macroautophagy/autophagy-lysosomal pathway deficits contribute to the accumulation of amyloid-β (Aβ) in Alzheimer disease (AD). Aerobic exercise (AE) has long been investigated as an approach to delay and treat AD, although the exact role and mechanism are not well known. Here, we revealed that AE could reverse autophagy-lysosomal deficits via activation of ADRB2/β2-adrenergic receptor, leading to significant attenuation of amyloid-β pathology in APP-PSEN1/PS1 mice. Molecular mechanism research ...
Source: Autophagy - November 15, 2023 Category: Cytology Authors: Jia-Jun Wu Haitao Yu Shu-Guang Bi Zhong-Xuan Wang Juan Gong Yu-Ming Mao Fang-Zhou Wang Yu-Qi Zhang Yun-Juan Nie Gao-Shang Chai Source Type: research
Aerobic exercise attenuates autophagy-lysosomal flux deficits by ADRB2/ β2-adrenergic receptor-mediated V-ATPase assembly factor VMA21 signaling in APP-PSEN1/PS1 mice
Autophagy. 2023 Nov 15:1-17. doi: 10.1080/15548627.2023.2281134. Online ahead of print.ABSTRACTGrowing evidence suggests that macroautophagy/autophagy-lysosomal pathway deficits contribute to the accumulation of amyloid-β (Aβ) in Alzheimer disease (AD). Aerobic exercise (AE) has long been investigated as an approach to delay and treat AD, although the exact role and mechanism are not well known. Here, we revealed that AE could reverse autophagy-lysosomal deficits via activation of ADRB2/β2-adrenergic receptor, leading to significant attenuation of amyloid-β pathology in APP-PSEN1/PS1 mice. Molecular mechanism research ...
Source: Autophagy - November 15, 2023 Category: Cytology Authors: Jia-Jun Wu Haitao Yu Shu-Guang Bi Zhong-Xuan Wang Juan Gong Yu-Ming Mao Fang-Zhou Wang Yu-Qi Zhang Yun-Juan Nie Gao-Shang Chai Source Type: research
Numbers needed to treat or harm and likelihood of being helped versus harmed for fremanezumab in patients who had prior inadequate response to two to four classes of migraine preventive medications: A post hoc analysis
CONCLUSIONS: The NNT, NNH, and LHH for quarterly and monthly fremanezumab compare favorably with those for traditional oral preventive medications, including topiramate, valproate, and propranolol.PMID:37955395 | DOI:10.1111/head.14651 (Source: Headache)
Source: Headache - November 13, 2023 Category: Neurology Authors: Messoud Ashina Dimos D Mitsikostas Verena Ramirez Campos Steve Barash Xiaoping Ning Hans-Christoph Diener Source Type: research
Efficacy of timolol in the treatment of facial hemangioma and its effect on the proliferation and apoptosis of hemangioma stem cells
In conclusion, Timolol can effectively treat facial hemangioma in children, inhibit the proliferation of hemangioma stem cells and promote their apoptosis, with good curative effect, short treatment time and no obvious adverse reactions and it is economical and easy to accept.PMID:37953576 | DOI:10.14715/cmb/2023.69.10.16 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Hongjian Zhu Hua Luo Wenjuan Lai Source Type: research
Efficacy of timolol in the treatment of facial hemangioma and its effect on the proliferation and apoptosis of hemangioma stem cells
In conclusion, Timolol can effectively treat facial hemangioma in children, inhibit the proliferation of hemangioma stem cells and promote their apoptosis, with good curative effect, short treatment time and no obvious adverse reactions and it is economical and easy to accept.PMID:37953576 | DOI:10.14715/cmb/2023.69.10.16 (Source: Mol Biol Cell)
Source: Mol Biol Cell - November 13, 2023 Category: Molecular Biology Authors: Hongjian Zhu Hua Luo Wenjuan Lai Source Type: research
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells
In conclusion, propranolol inhibited glucose metabolism in HemECs by suppressing glucose metabolic pathways, particularly glycolysis.PMID:37956892 | DOI:10.1016/j.bcp.2023.115922 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - November 13, 2023 Category: Drugs & Pharmacology Authors: Kaiying Yang Xin Li Tong Qiu Jiangyuan Zhou Xue Gong Yuru Lan Yi Ji Source Type: research
Numbers needed to treat or harm and likelihood of being helped versus harmed for fremanezumab in patients who had prior inadequate response to two to four classes of migraine preventive medications: A post hoc analysis
CONCLUSIONS: The NNT, NNH, and LHH for quarterly and monthly fremanezumab compare favorably with those for traditional oral preventive medications, including topiramate, valproate, and propranolol.PMID:37955395 | DOI:10.1111/head.14651 (Source: Headache)
Source: Headache - November 13, 2023 Category: Neurology Authors: Messoud Ashina Dimos D Mitsikostas Verena Ramirez Campos Steve Barash Xiaoping Ning Hans-Christoph Diener Source Type: research
Efficacy of timolol in the treatment of facial hemangioma and its effect on the proliferation and apoptosis of hemangioma stem cells
In conclusion, Timolol can effectively treat facial hemangioma in children, inhibit the proliferation of hemangioma stem cells and promote their apoptosis, with good curative effect, short treatment time and no obvious adverse reactions and it is economical and easy to accept.PMID:37953576 | DOI:10.14715/cmb/2023.69.10.16 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Hongjian Zhu Hua Luo Wenjuan Lai Source Type: research
Efficacy of timolol in the treatment of facial hemangioma and its effect on the proliferation and apoptosis of hemangioma stem cells
In conclusion, Timolol can effectively treat facial hemangioma in children, inhibit the proliferation of hemangioma stem cells and promote their apoptosis, with good curative effect, short treatment time and no obvious adverse reactions and it is economical and easy to accept.PMID:37953576 | DOI:10.14715/cmb/2023.69.10.16 (Source: Mol Biol Cell)
Source: Mol Biol Cell - November 13, 2023 Category: Molecular Biology Authors: Hongjian Zhu Hua Luo Wenjuan Lai Source Type: research
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells
In conclusion, propranolol inhibited glucose metabolism in HemECs by suppressing glucose metabolic pathways, particularly glycolysis.PMID:37956892 | DOI:10.1016/j.bcp.2023.115922 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - November 13, 2023 Category: Drugs & Pharmacology Authors: Kaiying Yang Xin Li Tong Qiu Jiangyuan Zhou Xue Gong Yuru Lan Yi Ji Source Type: research
Numbers needed to treat or harm and likelihood of being helped versus harmed for fremanezumab in patients who had prior inadequate response to two to four classes of migraine preventive medications: A post hoc analysis
CONCLUSIONS: The NNT, NNH, and LHH for quarterly and monthly fremanezumab compare favorably with those for traditional oral preventive medications, including topiramate, valproate, and propranolol.PMID:37955395 | DOI:10.1111/head.14651 (Source: Headache)
Source: Headache - November 13, 2023 Category: Neurology Authors: Messoud Ashina Dimos D Mitsikostas Verena Ramirez Campos Steve Barash Xiaoping Ning Hans-Christoph Diener Source Type: research
Efficacy of timolol in the treatment of facial hemangioma and its effect on the proliferation and apoptosis of hemangioma stem cells
In conclusion, Timolol can effectively treat facial hemangioma in children, inhibit the proliferation of hemangioma stem cells and promote their apoptosis, with good curative effect, short treatment time and no obvious adverse reactions and it is economical and easy to accept.PMID:37953576 | DOI:10.14715/cmb/2023.69.10.16 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Hongjian Zhu Hua Luo Wenjuan Lai Source Type: research
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells
In conclusion, propranolol inhibited glucose metabolism in HemECs by suppressing glucose metabolic pathways, particularly glycolysis.PMID:37956892 | DOI:10.1016/j.bcp.2023.115922 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - November 13, 2023 Category: Drugs & Pharmacology Authors: Kaiying Yang Xin Li Tong Qiu Jiangyuan Zhou Xue Gong Yuru Lan Yi Ji Source Type: research
Efficacy of timolol in the treatment of facial hemangioma and its effect on the proliferation and apoptosis of hemangioma stem cells
In conclusion, Timolol can effectively treat facial hemangioma in children, inhibit the proliferation of hemangioma stem cells and promote their apoptosis, with good curative effect, short treatment time and no obvious adverse reactions and it is economical and easy to accept.PMID:37953576 | DOI:10.14715/cmb/2023.69.10.16 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Hongjian Zhu Hua Luo Wenjuan Lai Source Type: research
