Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
In this study, the functional interactions of human CYP2D6 with four human UGTs (UGT1A7, UGT1A8, UGT1A9, and UGT2A1) were investigated using our previously established co-expression model system in the fission yeast Schizosaccharomyces pombe. The substrate employed was propranolol because it is well metabolized by CYP2D6. Moreover, the CYP2D6 metabolite 4-hydroxypropranolol is a known substrate for the four UGTs included in this study. Co-expression of either UGT1A7, UGT1A8, or UGT1A9 was found to increase the activity of CYP2D6 by a factor of 3.3, 2.1 or 2.8, respectively, for the conversion of propranolol to 4-hydroxypro...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Fan Yang Sangeeta Shrestha Sharma Matthias Bureik Maria Kristina Parr Source Type: research
