Propranolol monotherapy in angiosarcoma - A window-of-opportunity study (PropAngio)
Angiosarcoma is a rare and aggressive cancer of the endothelial cells. Propranolol, a non-selective β-blocker, was able to initiate apoptosis in angiosarcoma cell lines and its anti-tumor activity has been described in several case reports. The aim of this trial was to prospectively evaluate the anti-tumor activity of propranolol monotherapy in patients with angiosarcoma before proceeding to stan dard of care treatment. (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Alaa Embaby, Kimberley M. Heinhuis, Nikki S. IJzerman, Anne Miek Koenen, Stephanie van der Kleij, Ingrid Hofland, Hester van Boven, Joyce Sanders, Winette T.A. van der Graaf, Rick L. Haas, Alwin D.R. Huitema, Winan J. van Houdt, Neeltje Steeghs Tags: Original Research Source Type: research

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status
In conclusion, glipizide has shown promising therapeutic efficacy across a variety of disorders. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - February 26, 2024 Category: Drugs & Pharmacology Authors: Mohammad, Saad Mahmood, Tarique Shamim, Arshiya Ahsan, Farogh Shariq, Mohammad Parveen, Saba Waseem, Rufaida Singh, Aditya Tags: Review Source Type: research

Chiral separation of propranolol by electrokinetic chromatography using nanodiamonds and human serum albumin as a pseudo-stationary phase in river water
In this study, R- and S-propranolol were determined in river samples by electrokinetic chromatography (EKC) using nanodiamonds (NDs) and human serum albumin (HSA) as a pseudo-stationary phase in order to achieve enantioseparation. Previously, river samples were preconcentrated using a column filled with Amberlite® IR-120 and Dowex® 50WX8 resins. The setting up of influential factors such as temperature, voltage, pH, and HSA and NDs concentration is accurately described along this manuscript. A multivariate study and optimization was carried out to obtain the enantioseparation of propranolol (Rs = 2.91), which was reached...
Source: Chirality - February 22, 2024 Category: Molecular Biology Authors: Ver ónica M Lanaro Lorena L Sombra Jorgelina C Altamirano C ésar A Almeida Patricia W Stege Source Type: research

Chiral separation of propranolol by electrokinetic chromatography using nanodiamonds and human serum albumin as a pseudo-stationary phase in river water
In this study, R- and S-propranolol were determined in river samples by electrokinetic chromatography (EKC) using nanodiamonds (NDs) and human serum albumin (HSA) as a pseudo-stationary phase in order to achieve enantioseparation. Previously, river samples were preconcentrated using a column filled with Amberlite® IR-120 and Dowex® 50WX8 resins. The setting up of influential factors such as temperature, voltage, pH, and HSA and NDs concentration is accurately described along this manuscript. A multivariate study and optimization was carried out to obtain the enantioseparation of propranolol (Rs = 2.91), which was reached...
Source: Chirality - February 22, 2024 Category: Molecular Biology Authors: Ver ónica M Lanaro Lorena L Sombra Jorgelina C Altamirano C ésar A Almeida Patricia W Stege Source Type: research

Chiral separation of propranolol by electrokinetic chromatography using nanodiamonds and human serum albumin as a pseudo-stationary phase in river water
In this study, R- and S-propranolol were determined in river samples by electrokinetic chromatography (EKC) using nanodiamonds (NDs) and human serum albumin (HSA) as a pseudo-stationary phase in order to achieve enantioseparation. Previously, river samples were preconcentrated using a column filled with Amberlite® IR-120 and Dowex® 50WX8 resins. The setting up of influential factors such as temperature, voltage, pH, and HSA and NDs concentration is accurately described along this manuscript. A multivariate study and optimization was carried out to obtain the enantioseparation of propranolol (Rs = 2.91), which was reached...
Source: Chirality - February 22, 2024 Category: Molecular Biology Authors: Ver ónica M Lanaro Lorena L Sombra Jorgelina C Altamirano C ésar A Almeida Patricia W Stege Source Type: research

The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons
Comp Biochem Physiol A Mol Integr Physiol. 2024 Feb 17:111608. doi: 10.1016/j.cbpa.2024.111608. Online ahead of print.ABSTRACTVertebrates elevate heart rate when metabolism increases during digestion. Part of this tachycardia is due to a non-adrenergic-non-cholinergic (NANC) stimulation of the cardiac pacemaker, and it has been suggested these NANC factors are circulating hormones that are released from either gastrointestinal or endocrine glands. The NANC stimulation is particularly pronounced in species with large metabolic responses to digestion, such as reptiles. To investigate the possibility that the pancreas may rel...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - February 19, 2024 Category: Physiology Authors: Igor Noll Guagnoni Katja B Last Emil Rindom Tobias Wang Source Type: research

The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons
Comp Biochem Physiol A Mol Integr Physiol. 2024 Feb 17:111608. doi: 10.1016/j.cbpa.2024.111608. Online ahead of print.ABSTRACTVertebrates elevate heart rate when metabolism increases during digestion. Part of this tachycardia is due to a non-adrenergic-non-cholinergic (NANC) stimulation of the cardiac pacemaker, and it has been suggested these NANC factors are circulating hormones that are released from either gastrointestinal or endocrine glands. The NANC stimulation is particularly pronounced in species with large metabolic responses to digestion, such as reptiles. To investigate the possibility that the pancreas may rel...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - February 19, 2024 Category: Physiology Authors: Igor Noll Guagnoni Katja B Last Emil Rindom Tobias Wang Source Type: research

The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons
Comp Biochem Physiol A Mol Integr Physiol. 2024 Feb 18;291:111608. doi: 10.1016/j.cbpa.2024.111608. Online ahead of print.ABSTRACTVertebrates elevate heart rate when metabolism increases during digestion. Part of this tachycardia is due to a non-adrenergic-non-cholinergic (NANC) stimulation of the cardiac pacemaker, and it has been suggested these NANC factors are circulating hormones that are released from either gastrointestinal or endocrine glands. The NANC stimulation is particularly pronounced in species with large metabolic responses to digestion, such as reptiles. To investigate the possibility that the pancreas may...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - February 19, 2024 Category: Physiology Authors: Igor Noll Guagnoni Katja Bundgaard Last Emil Rindom Tobias Wang Source Type: research

The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons
Comp Biochem Physiol A Mol Integr Physiol. 2024 Feb 18;291:111608. doi: 10.1016/j.cbpa.2024.111608. Online ahead of print.ABSTRACTVertebrates elevate heart rate when metabolism increases during digestion. Part of this tachycardia is due to a non-adrenergic-non-cholinergic (NANC) stimulation of the cardiac pacemaker, and it has been suggested these NANC factors are circulating hormones that are released from either gastrointestinal or endocrine glands. The NANC stimulation is particularly pronounced in species with large metabolic responses to digestion, such as reptiles. To investigate the possibility that the pancreas may...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - February 19, 2024 Category: Physiology Authors: Igor Noll Guagnoni Katja Bundgaard Last Emil Rindom Tobias Wang Source Type: research

The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons
Comp Biochem Physiol A Mol Integr Physiol. 2024 Feb 18;291:111608. doi: 10.1016/j.cbpa.2024.111608. Online ahead of print.ABSTRACTVertebrates elevate heart rate when metabolism increases during digestion. Part of this tachycardia is due to a non-adrenergic-non-cholinergic (NANC) stimulation of the cardiac pacemaker, and it has been suggested these NANC factors are circulating hormones that are released from either gastrointestinal or endocrine glands. The NANC stimulation is particularly pronounced in species with large metabolic responses to digestion, such as reptiles. To investigate the possibility that the pancreas may...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - February 19, 2024 Category: Physiology Authors: Igor Noll Guagnoni Katja Bundgaard Last Emil Rindom Tobias Wang Source Type: research

Preparation of a bis-triazolyl bridged β-cyclodextrin stationary phase and its application for enantioseparation of chiral compounds by HPLC
Chirality. 2024 Feb;36(2):e23644. doi: 10.1002/chir.23644.ABSTRACTA novel bis-triazolyl bridged β-cyclodextrin was first synthesized by the Click reaction between azido-β-cyclodextrin and 1,6-heptadiyne. Then it was bonded onto silica gel to obtain a bis-triazolyl bridged β-cyclodextrin-based chiral stationary phase (BCDP). After structure characterization, the HPLC performance of BCDP was systematically evaluated by using different types of compounds as probes. The results showed that BCDP could well separate 18 kinds of achiral aromatic compounds (homologues, positional isomers, etc.) and 35 kinds of chiral drugs or p...
Source: Chirality - February 14, 2024 Category: Molecular Biology Authors: Qingli Zeng Zhiqin Huang Dan Li Laisheng Li Source Type: research

Circulating noradrenaline leads to release of neuropeptide Y from cardiac sympathetic nerve terminals via activation of β-adrenergic receptors
In this study, fast-scan cyclic voltammetry and capacitive immunoprobes were used to allow for real-time in vivo measurements of interstitial myocardial neurotransmitters and neuropeptides, respectively. Using an in vivo porcine model with cardiac fast-scan cyclic voltammetry and capacitive immunoprobes, it was shown that systemic NA can increase ventricular interstitial NPY levels, suggesting that NA induces NPY release from postganglionic sympathetic nerves. The release of NPY was blocked by administration of the non-selective β-blocker propranolol, suggesting that release of NPY is dependent on activation of β-adrener...
Source: The Journal of Physiology - February 14, 2024 Category: Physiology Authors: Valerie Y H van Weperen Jonathan D Hoang Neil R Jani Artin Khaky Neil Herring Corey Smith Marmar Vaseghi Source Type: research

Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial
ConclusionDepression is common among patients with FCCM. Patients randomized to propranolol had a lower proportion of participants with depression after 2 years.Clinical trial registration: https://clinicaltrials.gov/, identifier (NCT03589014). (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 14, 2024 Category: Neurology Source Type: research

β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
Conclusionsβ‑adrenergic signaling seems to affect cell viability through targeting IL-6/gp130 and SOCS‑1 signaling in MM, underscoring the importance of further studies on stress hormones and IL‑6 suppressors as potent candidates for MM therapy. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - February 9, 2024 Category: Cancer & Oncology Source Type: research

Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep
J Physiol. 2024 Feb 8. doi: 10.1113/JP285079. Online ahead of print.ABSTRACTSympathetic transduction is the study of how impulses of sympathetic nerve activity (SNA) affect end-organ function. Recently, the transduction of resting bursts of muscle SNA (MSNA) has been investigated and shown to have a role in the maintenance of blood pressure through changes in vascular tone in humans. In the present study, we investigate whether directly recorded resting cardiac SNA (CSNA) regulates heart rate (HR), coronary blood flow (CoBF), coronary vascular conductance (CVC), cardiac output (CO) and mean arterial pressure. Instrumentati...
Source: The Journal of Physiology - February 8, 2024 Category: Physiology Authors: Dilsha Gimhani Julia Shanks Mridula Pachen Joshua W-H Chang Rohit Ramchandra Source Type: research