Recent updates in laryngeal hemangioma management: a scoping review
ConclusionLaryngeal hemangioma management requires personalized approaches informed by diverse therapies, clinical expertise, and collaboration. The review introduces an algorithm spanning observation to advanced interventions, adapting to each case ’s complexity. Ongoing research promises innovative treatments. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 23, 2024 Category: ENT & OMF Source Type: research
Polymeric Propranolol Nanoparticles for Intraocular Delivery: Formulation, Characterization, and Vitreous Pharmacokinetics
CONCLUSION: PLGA NPs can prolong the existence of propranolol in both vitreous and posterior ocular tissues, and thus, may provide an effective approach in treatment of posterior segment neovascularization.PMID:38638633 | PMC:PMC11022021 | DOI:10.18502/jovr.v19i1.15436 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Farkhondeh Chaharband Reyhaneh Varshochian Rassoul Dinarvand Hamideh Sabbaghi Mozhgan Rezaei Kanavi Narsis Daftarian Ramin Nourinia Source Type: research
Polymeric Propranolol Nanoparticles for Intraocular Delivery: Formulation, Characterization, and Vitreous Pharmacokinetics
CONCLUSION: PLGA NPs can prolong the existence of propranolol in both vitreous and posterior ocular tissues, and thus, may provide an effective approach in treatment of posterior segment neovascularization.PMID:38638633 | PMC:PMC11022021 | DOI:10.18502/jovr.v19i1.15436 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - April 19, 2024 Category: Opthalmology Authors: Farkhondeh Chaharband Reyhaneh Varshochian Rassoul Dinarvand Hamideh Sabbaghi Mozhgan Rezaei Kanavi Narsis Daftarian Ramin Nourinia Source Type: research
Effect of propranolol on pharmacokinetics of clozapine in schizophrenic patients: a meta-analysis
ConclusionThe combination with propranolol could significantly increase systemic exposure and extendedT1/2 of clozapine, and thus need to be considered in prescribing decisions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Source Type: research
N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system
ConclusionThis study pointed a new compound with antidepressant-like effect, and it could be considered for the development of new antidepressants. (Source: Psychopharmacology)
Source: Psychopharmacology - April 18, 2024 Category: Psychiatry Source Type: research
Calcitonin Gene-Related Peptide Inhibitors for Treatment of Rosacea
While many treatments are available for papules and pustules of rosacea, few are available for erythema and flushing. The 2019 Global Rosacea Consensus Panel recommends general skincare, β-blockers (eg, propranolol and carvedilol), and α-adrenergic agents (eg, brimonidine and oxymetazoline) for flushing and vascular lasers for persistent erythema. Because these treatments may not always be effective or tolerated, there remains an unmet need for additional options that can address symptoms of flushing and erythema in rosacea. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 17, 2024 Category: Dermatology Source Type: research
Infantile hemangioma: the common and enigmatic vascular tumor
Infantile hemangioma (IH) is a benign vascular tumor that occurs in 5% of newborns. The tumor follows a life cycle of rapid proliferation in infancy, followed by slow involution in childhood. This unique life cycle has attracted the interest of basic and clinical scientists alike as a paradigm for vasculogenesis, angiogenesis, and vascular regression. Unanswered questions persist about the genetic and molecular drivers of the proliferating and involuting phases. The beta blocker propranolol usually accelerates regression of problematic IHs, yet its mechanism of action on vascular proliferation and differentiation is unclea...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Annegret Holm, John B. Mulliken, Joyce Bischoff Source Type: research
Elucidating the enhanced role of carbonate radical in propranolol degradation by UV/peroxymonosulfate system
Chemosphere. 2024 Apr 11:141985. doi: 10.1016/j.chemosphere.2024.141985. Online ahead of print.ABSTRACTCarbonate radical (CO3•-) has been proved to be an important secondary radical in advanced oxidation processes due to various radical reactions involved HCO3-/CO32-. However, the roles and contributions of CO3•- in organic micropollutant degradation have not been explored systematically. Here, we quantified the impact of CO3•- on the degradation kinetics of propranolol, a representative pollutant in the UV/peroxymonosulfate (PMS) system, by constructing a steady-state radical model. Substantially, the measured value...
Source: Chemosphere - April 13, 2024 Category: Chemistry Authors: Die Zhou Huaying Liu Jin Wang Yingjie Li Nian Wang Wenjie Li Source Type: research
Elucidating the enhanced role of carbonate radical in propranolol degradation by UV/peroxymonosulfate system
Chemosphere. 2024 Apr 11:141985. doi: 10.1016/j.chemosphere.2024.141985. Online ahead of print.ABSTRACTCarbonate radical (CO3•-) has been proved to be an important secondary radical in advanced oxidation processes due to various radical reactions involved HCO3-/CO32-. However, the roles and contributions of CO3•- in organic micropollutant degradation have not been explored systematically. Here, we quantified the impact of CO3•- on the degradation kinetics of propranolol, a representative pollutant in the UV/peroxymonosulfate (PMS) system, by constructing a steady-state radical model. Substantially, the measured value...
Source: Chemosphere - April 13, 2024 Category: Chemistry Authors: Die Zhou Huaying Liu Jin Wang Yingjie Li Nian Wang Wenjie Li Source Type: research
Elucidating the enhanced role of carbonate radical in propranolol degradation by UV/peroxymonosulfate system
Chemosphere. 2024 Apr 11:141985. doi: 10.1016/j.chemosphere.2024.141985. Online ahead of print.ABSTRACTCarbonate radical (CO3•-) has been proved to be an important secondary radical in advanced oxidation processes due to various radical reactions involved HCO3-/CO32-. However, the roles and contributions of CO3•- in organic micropollutant degradation have not been explored systematically. Here, we quantified the impact of CO3•- on the degradation kinetics of propranolol, a representative pollutant in the UV/peroxymonosulfate (PMS) system, by constructing a steady-state radical model. Substantially, the measured value...
Source: Chemosphere - April 13, 2024 Category: Chemistry Authors: Die Zhou Huaying Liu Jin Wang Yingjie Li Nian Wang Wenjie Li Source Type: research
Comparison of the efficacy of propranolol versus amitriptyline as monotherapy for prophylaxis of migraine
CONCLUSION: The average number of migraine attacks reduced in the amitriptyline and propranolol groups as the treatment duration increased. Amitriptyline is a popular medication with established effectiveness and manageable levels of negative side effects. It is the tricyclic antidepressant that is most frequently used to prevent headaches. When administered for migraine prevention, it generates a quick response within 3 months. Propranolol is less effective than amitriptyline at reducing the frequency, length, and severity of episodes.PMID:38605779 | PMC:PMC11006045 | DOI:10.4103/jfmpc.jfmpc_927_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Krinaben M Patel Kachhadia M Popatbhai Roshni Xavier Mohammed A S Aramin Khalid J F Faris Mohammed A Mateen Priyadarshi Prajwal Mohammed D M Marsool Hafsa Sheikh Esra H A G Mohamed Source Type: research
Comparison of the efficacy of propranolol versus amitriptyline as monotherapy for prophylaxis of migraine
CONCLUSION: The average number of migraine attacks reduced in the amitriptyline and propranolol groups as the treatment duration increased. Amitriptyline is a popular medication with established effectiveness and manageable levels of negative side effects. It is the tricyclic antidepressant that is most frequently used to prevent headaches. When administered for migraine prevention, it generates a quick response within 3 months. Propranolol is less effective than amitriptyline at reducing the frequency, length, and severity of episodes.PMID:38605779 | PMC:PMC11006045 | DOI:10.4103/jfmpc.jfmpc_927_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Krinaben M Patel Kachhadia M Popatbhai Roshni Xavier Mohammed A S Aramin Khalid J F Faris Mohammed A Mateen Priyadarshi Prajwal Mohammed D M Marsool Hafsa Sheikh Esra H A G Mohamed Source Type: research
Comparison of the efficacy of propranolol versus amitriptyline as monotherapy for prophylaxis of migraine
CONCLUSION: The average number of migraine attacks reduced in the amitriptyline and propranolol groups as the treatment duration increased. Amitriptyline is a popular medication with established effectiveness and manageable levels of negative side effects. It is the tricyclic antidepressant that is most frequently used to prevent headaches. When administered for migraine prevention, it generates a quick response within 3 months. Propranolol is less effective than amitriptyline at reducing the frequency, length, and severity of episodes.PMID:38605779 | PMC:PMC11006045 | DOI:10.4103/jfmpc.jfmpc_927_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Krinaben M Patel Kachhadia M Popatbhai Roshni Xavier Mohammed A S Aramin Khalid J F Faris Mohammed A Mateen Priyadarshi Prajwal Mohammed D M Marsool Hafsa Sheikh Esra H A G Mohamed Source Type: research
