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Validation of Distinct Bladder Pain Phenotypes Utilizing the MAPP Research Network Cohort
ConclusionsThe reproducible identification of IC/BPS phenotypes, distinguishing bladder-specific pain from myofascial and genital pain, using independent ML analysis of a multicenter database suggests these phenotypes reflect true pathophysiologic differences in IC/BPS patients. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - February 1, 2024 Category: OBGYN Source Type: research

Validation of Distinct Bladder Pain Phenotypes Utilizing the MAPP Research Network Cohort
ConclusionsThe reproducible identification of IC/BPS phenotypes, distinguishing bladder-specific pain from myofascial and genital pain, using independent ML analysis of a multicenter database suggests these phenotypes reflect true pathophysiologic differences in IC/BPS patients. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - February 1, 2024 Category: OBGYN Source Type: research

Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles
ConclusionsEuploidy rates and pregnancy outcomes were comparable among patients of different racial backgrounds who underwent a SEET. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 31, 2024 Category: Reproduction Medicine Source Type: research

Comprehensive analysis of ovarian granulosa cell proteomics and phosphoproteomics in PCOS patients without insulin resistance
In this study, we describe the qu antitative protein expression profiles and phosphorylation-modified protein expression profiles of ovarian granulosa cells from patients with PCOS-NIR, providing a new research perspective for these patients. Further studies are required to elucidate the role of protein phosphorylation in PCOS. (Source: Molecular Human Reproduction)
Source: Molecular Human Reproduction - January 30, 2024 Category: Molecular Biology Source Type: research

Impact of COVID-19 convalescence on pregnancy outcomes in patients undergoing IVF/ICSI during fresh ART cycles: a retrospective cohort study
ConclusionsOur findings present no substantial evidence of adverse effects on clinical pregnancy outcomes in fresh ART cycles in patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) during the period of convalescence from COVID-19. However, age emerges as a significant factor influencing these outcomes. Notably, for women above 38 years of age, the likelihood of clinical pregnancy in patients with a prior COVID-19 infection decreased by 53% with each additional year. This highlights the importance of considering maternal age, especially in the context of COVID-19, when evaluating the ...
Source: Frontiers in Endocrinology - January 29, 2024 Category: Endocrinology Source Type: research

Potential Costs and Benefits of Incorporating PGT-A Across Age Groups: A Canadian Clinic Perspective
CONCLUSION: Based on our cost analysis, it may be advantageous to incorporate PGT-A when maternal age is ≥38, given the lower financial costs associated with each cycle and the low likelihood of transferring a euploid embryo on the first attempt for this age group. Nevertheless, we acknowledge that PGT-A remains a complex decision influenced by a multitude of factors.PMID:38272217 | DOI:10.1016/j.jogc.2024.102361 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - January 25, 2024 Category: OBGYN Authors: Ola S Davis Laura A Favetta Stacy Deniz Mehrnoosh Faghih Shilpa Amin Megan Karnis Michael S Neal Source Type: research

Comparison of embryo quality and pregnancy outcomes for patients with low ovarian reserve in natural cycles and mildly stimulated cycles: a cohort study
CONCLUSION: Natural cycles with appropriately timed oocyte retrieval may present a valuable option for patients with low ovarian reserve.PMID:38263614 | DOI:10.1080/01443615.2024.2303693 (Source: Journal of Obstetrics and Gynaecology)
Source: Journal of Obstetrics and Gynaecology - January 24, 2024 Category: OBGYN Authors: Rui-Ying Yuan Sen Li Xie Feng Xiao-Long Li Xiao-Ting Lin Fu-Min Gao Hai-Jing Zhu Yong-Shi Li Yan-Chu Li Xiang-Hong Ou Source Type: research

Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment
ConclusionOur findings suggest that the use of PCPs in women of reproductive age have a potential adverse impact on IVF/ICSI outcomes, particularly skin care and cosmetic products. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 24, 2024 Category: Endocrinology Source Type: research

Improved fertilization, degeneration and embryo quality rates with PIEZO-ICSI compared with conventional ICSI – A sibling oocyte split multi-center trial.
To investigate whether PIEZO-ICSI increases the fertilization rate, decreases the degeneration rate, and increases utilization rate per oocyte injected compared with conventional ICSI. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 23, 2024 Category: Reproduction Medicine Authors: Deirdre Zander-Fox, Mark Green, Kate Watson, Ross Turner, Hassan W. Bakos, Jinny Foo, Leanne Pacella-Ince, Melissa Caddy, Nicole O. McPherson, Luk Rombauts Tags: Assisted reproduction Source Type: research

Microdissection Testicular Sperm Extraction
Semin Reprod Med DOI: 10.1055/s-0043-1777833Nonobstructive azoospermia (NOA) is among the most common causes of male infertility. For men with NOA seeking fertility treatment, microdissection testicular sperm extraction (microTESE) is the best option for retrieving sperm, which can be used with in vitro fertilization–intracytoplasmic sperm injection to achieve pregnancy in their partner. With the aid of the operating microscope, microTESE allows for thorough evaluation of the testis tissue and selection of seminiferous tubules that appear most capable of sperm production. Rates of success with microTESE vary depending on...
Source: Seminars in Reproductive Medicine - January 23, 2024 Category: Reproduction Medicine Authors: Brant, Aaron Schlegel, Peter N. Tags: Review Article Source Type: research

Improved fertilization, degeneration, and embryo quality rates with PIEZO –intracytoplasmic sperm injection compared with conventional intracytoplasmic sperm injection: a sibling oocyte split multicenter trial
To investigate whether PIEZO –intracytoplasmic sperm injection (PIEZO-ICSI) increases the fertilization rate, decreases the degeneration rate, and increases the utilization rate per oocyte injected compared with conventional intracytoplasmic sperm injection (ICSI). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 23, 2024 Category: Reproduction Medicine Authors: Deirdre Zander-Fox, Mark Green, Kate Watson, Ross Turner, Hassan W. Bakos, Jinny Foo, Leanne Pacella-Ince, Melissa Caddy, Nicole O. McPherson, Luk Rombauts Tags: Assisted reproduction Source Type: research

Sensors, Vol. 24, Pages 711: Intuitive Cell Manipulation Microscope System with Haptic Device for Intracytoplasmic Sperm Injection Simplification
asegawa In recent years, the demand for effective intracytoplasmic sperm injection (ICSI) for the treatment of male infertility has increased. The ICSI operation is complicated as it involves delicate organs and requires a high level of skill. Several cell manipulation systems that do not require such skills have been proposed; notably, several automated methods are available for cell rotation. However, these methods are unfeasible for the delicate ICSI medical procedure because of safety issues. Thus, this study proposes a microscopic system that enables intuitive micropipette manipulation using a haptic device that s...
Source: Sensors - January 22, 2024 Category: Biotechnology Authors: Kazuya Sakamoto Tadayoshi Aoyama Masaru Takeuchi Yasuhisa Hasegawa Tags: Article Source Type: research

A comparison of pregnancy outcomes and congenital malformations in offspring between patients undergoing intracytoplasmic sperm injection and conventional in vitro fertilization: A retrospective cohort study
To explore whether ICSI would increase the malformation risk in fetuses and live births compared with conventional in vitro fertilization (IVF) (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2024 Category: Reproduction Medicine Authors: Nan Zhang, Tian Tian, Jia Li, Xiaxuan Zhu, Dina Jiesisibieke, Shilin Fang, Ping Liu, Rong Li, Jie Qiao, Rui Yang Tags: Assisted reproduction Source Type: research

Compound heterozygous mutations in CFTR causing congenital bilateral absence of the vas deferens in a Chinese pedigree
ConclusionOur study revealed that compound heterozygous mutations ofCFTR are involved in CBAVD, expanding the knownCFTR gene mutation spectrum of CBAVD patients and providing more evidence that compound heterozygous mutations can cause familial CBAVD. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - January 18, 2024 Category: Genetics & Stem Cells Authors: Lingyi Li, Xiaowei Qu, Chenchen Cui, Ke Feng, Yanqing Xia, Feng Wan, Hengtao Ge, Yinghong Fang, Cuilian Zhang, Haibin Guo Tags: ORIGINAL ARTICLE Source Type: research