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Fertile offspring from sterile sex chromosome trisomic mice
Having the correct number of chromosomes is vital for normal development and health. Sex chromosome trisomy affects 0.1% of the human population and is associated with infertility. We show that during reprogramming to induced pluripotent stem cells (iPSCs), fibroblasts from sterile trisomic XXY and XYY mice lose the extra sex chromosome through a phenomenon we term trisomy-biased chromosome loss (TCL). Resulting euploid XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be used in intracytoplasmic sperm injection to produce chromosomally normal, fertile offspring. Sex chromosome lo...
Source: ScienceNOW - August 31, 2017 Category: Science Authors: Hirota, T., Ohta, H., Powell, B. E., Mahadevaiah, S. K., Ojarikre, O. A., Saitou, M., Turner, J. M. A. Tags: Genetics reports Source Type: news

Spain now sets the pace of assisted reproduction in Europe with more than 100,000 treatments a year
(European Society of Human Reproduction and Embryology) Spain is Europe's most active country in assisted reproduction. ESHRE has collected the national registry data of ART cycles performed in Europe since 1997 and for its latest report (for 2014) found that a record 109,275 treatment cycles were performed in Spain, which now sets the pace of European ART ahead of Russia (94.985 cycles) and former front runner France (90,434). The cycles monitored by ESHRE include treatments with IVF, ICSI, egg donation and intrauterine insemination (IUI). (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 4, 2017 Category: International Medicine & Public Health Source Type: news

The ABCs Of Fertility Treatments That You Need To Know
For BRIDES, by Kelsey Butler. Infertility: It’s a topic that is definitely difficult to talk about, but extremely important to discuss as you think about planning for a family. In fact, with about one in eight couples having trouble getting or staying pregnant, it’s likely that you or someone you know is going through this tough battle. To make it even harder, there is an overwhelming amount of information out there (what the heck do some of these acronyms even stand for?). We’re breaking down some important guidelines on when it’s time to head to the doctor and the key fertility treatment terms yo...
Source: Healthy Living - The Huffington Post - June 9, 2017 Category: Consumer Health News Source Type: news

What a pain! – Lisa ’ s story
The post What a pain! – Lisa’s story appeared first on Hysterectomy Association. I knew I had endometriosis as it had a laparoscopy that identified this in my mid thirties as part of infertility investigations. I tried ICSI once after that and paid privately but we were unsuccessful in having a baby. We carried on ‘leaving it up to nature’ for many years after that but nothing happened. At the age of forty three we decided that we wouldn’t actively pursue my getting pregnant any more and put the idea to bed – my husband has a 17 yr old daughter from a previous marriage and she lives...
Source: The Hysterectomy Association - February 25, 2017 Category: OBGYN Authors: Linda Tags: Your Stories endometriosis Source Type: news

Expensive IVF add-ons 'not evidence based'
Conclusion  The researchers rightly say "people seeking fertility treatment need good-quality evidence to make informed choices". As the system currently stands, people seek treatment from a variety of private UK fertility clinics. In their desire for a baby, many couples are in a vulnerable situation and rely heavily on the guidance of health professionals. But clinics may offer treatments that aren't sufficiently backed by the evidence. The researchers highlight several problems. The standard first-step recommendation is for people to ask their GP for advice. But GPs are unlikely to have the specialis...
Source: NHS News Feed - November 28, 2016 Category: Consumer Health News Tags: Pregnancy/child QA articles Source Type: news

Online calculator that tries to predict IVF success released
Conclusion This study aimed to develop a model that could predict the chances of a live birth over multiple cycles of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). The model used a large quantity of data taken from reliable UK medical records belonging to couples who had previously undergone IVF or ICSI. The model also benefits from being able to account for a large number of personal and treatment characteristics. The researchers developed two models for couples in both the pre-treatment and post-treatment phase of treatment cycles. They hope this online tool will serve as an aid for couples ...
Source: NHS News Feed - November 18, 2016 Category: Consumer Health News Tags: Pregnancy/child Source Type: news

Medical News Today: Men conceived through IVF may inherit father's fertility problems
The first ever analysis of men conceived though intracytoplasmic sperm injection reveals the procedure may be linked to poorer sperm count and quality. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 6, 2016 Category: Consumer Health News Tags: Fertility Source Type: news

Men conceived by IVF 'may inherit sperm problems'
Conclusion This small cross-sectional study aimed to assess the semen quality of young men who were conceived by ICSI. The study found that when compared with men conceived naturally, men conceived by ICSI had a lower average sperm concentration, total sperm count, and total motile sperm count. This effect remained after the team adjusted for potential confounders. This finding supports concerns that the infertility of a father could be passed on to male offspring, but does not prove it. The study does not rule in or out the possibility of the difference being a result of the ICSI procedure itself or an u...
Source: NHS News Feed - October 6, 2016 Category: Consumer Health News Tags: Pregnancy/child Medical practice Source Type: news

Tests on men born using IVF find they also suffer from low sperm counts  
Tests on the first group of men to have been born using the ICSI technique have now shown that they too suffer from low sperm counts and poor-moving sperm. (Source: the Mail online | Health)
Source: the Mail online | Health - October 6, 2016 Category: Consumer Health News Source Type: news

Boys conceived through IVF technique have lower than average fertility
Tests on young men conceived via intra-cytoplasmic sperm injection show that they have lower sperm quantity and quality that those conceived naturallyBoys conceived using an assisted reproductive technique in which sperm is injected directly into the egg have lower fertility than average, scientists have found.The results come from the first generation of boys conceived using a technique called intra-cytoplasmic sperm injection (ICSI), who are just reaching adulthood, and show that the young men have lower sperm quantity and quality than those conceived spontaneously.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - October 5, 2016 Category: Science Authors: Hannah Devlin Science correspondent Tags: Reproduction IVF Science Biology Fertility problems Health Source Type: news

Cochrane Priority Reviews List: September 2016 Update
Cochrane-wide prioritization remains an important project and has been included in theStrategy to 2020 Targets for 2016. Almost 120 priority reviews or updates have been published since the project began.The September 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Acute Respiratory Infections, Airways, Injuries, Gynaecology and Fertility, Hepato-Biliary, Oral Health, Skin, Tobacco Addiction, and Vascular Groups.The following titles on the list are open to new authors:Drugs for preventing postoperative nausea and vomitingEffectiveness and safety of skin testing before providing pen...
Source: Cochrane News and Events - September 8, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news

How Does Thyroid Autoimmunity Affect IVF Outcomes? How Does Thyroid Autoimmunity Affect IVF Outcomes?
Dr Peter Kovacs reviews a meta-analysis that evaluated the impact of isolated thyroid autoimmunity on IVF/ICSI outcome.Medscape Ob/Gyn (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 31, 2016 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Viewpoint Source Type: news

Rocky Mountain Fertility Center Joins US Fertility Network, Now...
Top Denver fertility clinic, Rocky Mountain Fertility Center, has joined the US Fertility Network and is offering 15% off treatment. Treatment is offered by an Award Winning, Board Certified Colorado...(PRWeb July 20, 2016)Read the full story at http://www.prweb.com/releases/coloradofertilitydoctor/ivf-icsi/prweb13564885.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - July 20, 2016 Category: Pharmaceuticals Source Type: news

Couples charged £1,000 extra for ICSI treatment that CUTS their chance of baby
Doctors are increasingly pushing a lab technique called ICSI, where a single sperm is injected directly into the egg. Critics say the scientific method should be a 'last resort'. (Source: the Mail online | Health)
Source: the Mail online | Health - July 10, 2016 Category: Consumer Health News Source Type: news

Most popular form of IVF given to thousands of couples is 'ineffective'
Professor Hans Evers, of Maastrich University, said intracytoplasmic sperm injection (ICSI) is expensive and is being inappropriately given to couples who won't benefit from it. (Source: the Mail online | Health)
Source: the Mail online | Health - May 23, 2016 Category: Consumer Health News Source Type: news

World report on fertility treatments reveals high use of intracytoplasmic sperm injection
Experts have attacked the rising use of intracytoplasmic sperm injection (ICSI) for the treatment of infertility, following publication of the latest world report on assisted reproductive technologies. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 21, 2016 Category: Science Source Type: news

World report on fertility treatments reveals high use of intracytoplasmic sperm injection
(European Society of Human Reproduction and Embryology) The editor-in-chief of one of the world's leading reproductive medicine journals, Human Reproduction, has attacked the rising use of intracytoplasmic sperm injection (ICSI) for the treatment of infertility, following publication of the latest world report on assisted reproductive technologies; he brands it as 'ineffective and costly care.' (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 20, 2016 Category: Global & Universal Source Type: news

Trouble Having a Baby? It Might Be Male Infertility
Infertility is often viewed as a woman's problem but when a couple has trouble conceiving, there's a good chance it's related to male factors -- in fact, that's the case 40-50 percent of the time. That's why the male partner should be part of any couple's fertility assessment. Not only is male infertility more common than most people realize, male factors are the sole reason for a couple's inability to have a baby 15 percent to 25 percent of the time. While some reasons for male infertility are well understood, at least 50 percent of problems are due to unknown factors. Male infertility can occur when men have a less t...
Source: Healthy Living - The Huffington Post - May 17, 2016 Category: Consumer Health News Source Type: news

Infertility treatments 'not linked' to developmental delays
ConclusionThis prospective cohort study aimed to assess whether use of and type of infertility treatment was associated with a child's development up to the age of 36 months. The study found no convincing evidence that infertility treatment had any impact on a child's development, which will come as a relief to parents who have undertaken treatment. However, while this type of observational study is good for looking at links between an exposure and an outcome over a period of time, it is not able to prove direct cause and effect and say for certain whether there is any link between two factors. For example, various socioec...
Source: NHS News Feed - January 5, 2016 Category: Consumer Health News Tags: Medical practice Pregnancy/child Source Type: news

Does red meat affect male fertility?
ConclusionThis study of a cohort of men attending a fertility clinic for help to conceive found fertilisation rates in the laboratory during IVF were less successful if men reported a diet high in processed meat, and more successful if they ate more chicken. Importantly, the effect of overall meat intake was not related to fertility success, which is the chance of becoming pregnant after the treatment cycles, or having a live birth. It was also not clear whether the variation in fertility rate influenced how many cycles of IVF were needed, or how long the couple needed medical assistance, before they became pregnant or had...
Source: NHS News Feed - August 11, 2015 Category: Consumer Health News Tags: Food/diet Pregnancy/child Source Type: news

Rate of ectopic pregnancy following IVF has almost halved in past 12 years
The risk of ectopic pregnancy following fertility treatment with assisted reproduction (ART) is small but significantly higher than found in natural conceptions. Now, a nationwide population-based analysis of all ART pregnancies achieved in the UK between 2000 and 2012 has found that the rate of ectopic pregnancy following IVF and ICSI progressively decreased throughout these 12 years, almost halving from an overall rate of 20 to 12 cases per thousand. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 16, 2015 Category: Science Source Type: news

Rate of ectopic pregnancy following IVF has almost halved in past 12 years
(European Society of Human Reproduction and Embryology) The risk of ectopic pregnancy following fertility treatment with assisted reproduction (ART) is small but significantly higher than found in natural conceptions. Now, a nationwide population-based analysis of all ART pregnancies achieved in the UK between 2000 and 2012 has found that the rate of ectopic pregnancy following IVF and ICSI progressively decreased throughout these 12 years, almost halving from an overall rate of 20 to 12 cases per thousand. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 16, 2015 Category: Global & Universal Source Type: news

Why are so many British women travelling abroad for fertility treatment?
With claims of better success rates, pioneering treatments and cheaper IVF, foreign clinics are cleaning up. So are 'fertility tourists' getting a better deal? (Source: Telegraph Health)
Source: Telegraph Health - March 28, 2015 Category: Consumer Health News Tags: egg freezing embryoscope stella icsi fertility tourism advances in ivf spanish fertility clinic era uk ivf success rates stella magazine eshre Source Type: news

PodMed: A Medical News Roundup From Johns Hopkins (with audio)
(MedPage Today) -- This week's topics include chlorhexidine baths in the ICU, dangers of too much sitting, intracytoplasmic sperm injection, and stem-cell therapy for MS. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - January 25, 2015 Category: Endocrinology Source Type: news

Injecting Sperm More Popular but Does Not Improve OutcomesInjecting Sperm More Popular but Does Not Improve Outcomes
Intracytoplasmic sperm injection, a relatively new technique that by 2012 had soared to represent 76.2% of fresh in vitro fertilization cycles, was not associated with improved reproductive outcomes. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)
Source: Medscape ObGyn and Womens Health Headlines - January 21, 2015 Category: OBGYN Tags: Ob/Gyn & Women ' s Health News Source Type: news

Nordic IVF outcomes improving - is the same true for the UK?
Conclusion This study found an improvement in health outcomes around the time of birth for babies conceived using artificial reproductive technology (IVF, ICSI and frozen embryo transfer) over the last 20 years in four Nordic countries (Norway, Sweden, Denmark and Finland).  The study sample was large and the methods robust. This means we can be relatively confident these results paint an accurate picture of what is going on in these countries. But two questions remain: are similar results found in the UK, and what is behind the improvement? On the first question, it is difficult to say without ha...
Source: NHS News Feed - January 21, 2015 Category: Consumer Health News Tags: Medical practice Pregnancy/child Source Type: news

Could 'DNA editing' lead to designer babies?
Conclusion This laboratory research using sperm and egg cells from mice demonstrates the use of a system to produce targeted alterations in the DNA – a process the media like to call “genetic editing”. The editing happened just before the genetic material of the egg and sperm cell fuse together. The system makes use of an enzyme (Cas9) capable of cutting bonds within DNA, and a “guide” molecule targeting it to the correct genetic location. So far, the techniques have only been tested in animals, and for “editing out” a small number of genes. However, though this is very earl...
Source: NHS News Feed - January 19, 2015 Category: Consumer Health News Tags: Genetics/stem cells Medical practice Source Type: news

Freeze-Drying of Mammalian Sperm
Long-term preservation of mammalian sperm at suprazero temperatures is desired to save storage and space costs as well as to facilitate transport of preserved samples. This can be accomplished by the freeze-drying of sperm samples. Although freeze-drying results in immotile and membrane-compromised sperm, intracytoplasmic sperm injection (ICSI) can be used to introduce such an immotile sperm into an oocyte and thus start the fertilization process. So far, it has been shown that improved freeze-drying protocols preserve chromosomal integrity and oocyte-activating factor(s) at 4 °C for several years and at ambient temper...
Source: Springer protocols feed by Biotechnology - December 2, 2014 Category: Biotechnology Source Type: news

Sperm analysis parameters as an indication for ICSI instead of IVF: Benefit still unclear
(Institute for Quality and Efficiency in Health Care) The currently available studies allow no conclusions about the type of sperm characteristics in which assisted reproduction using ICSI can be superior to IVF. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 7, 2014 Category: Global & Universal Source Type: news

Assisted Reproductive Techniques
Assisted reproductive technologies (ART) encompass fertility treatments, which involve manipulations of both oocyte and sperm in vitro. This chapter provides a brief overview of ART, including indications for treatment, ovarian reserve testing, selection of controlled ovarian hyperstimulation (COH) protocols, laboratory techniques of ART including in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI), embryo transfer techniques, and luteal phase support. This chapter also discusses potential complications of ART, namely ovarian hyperstimulation syndrome (OHSS) and multiple gestations, and the perinatal ...
Source: Springer protocols feed by Cell Biology - May 1, 2014 Category: Cytology Source Type: news

Genetics of Male Fertility
Early in embryogenesis, cells that are destined to become germ cells take on a different destiny from other cells in the embryo. The germ cells are not programmed to perform “vital” functions but to perpetuate the species through the transfer of genetic materials to the next generation. To fulfill their destiny, male germ cells undergo meiosis and extensive morphogenesis that transforms the round-shaped cells into freely motile sperm propelled by a beating flagellum to seek out their missing half. Apparently, extra genes and additional regulatory mechanisms are required to achieve all these unique features, and...
Source: Springer protocols feed by Cell Biology - May 1, 2014 Category: Cytology Source Type: news

Jo donated eggs for IVF then needed help herself to become a mother
Jo Stretton gave away her eggs aged 30 to have 'a part of me out there', but five years later discovered she couldn't conceive. She used ICSI, similar to IVF, to have Finlay, two, and Sullivan, four months (both pictured). (Source: the Mail online | Health)
Source: the Mail online | Health - March 5, 2014 Category: Consumer Health News Source Type: news

Risks of infertility treatments 'overhyped'
Conclusion The study raises concerns about the link between different types of fertility treatment and poorer outcomes at birth. However, it is uncertain whether the higher risk is down to infertility treatment, underlying health problems associated with infertility, or a combination of both. As the authors point out, the study did not control for the underlying cause of fertility problems. Although the risks appear higher, the overall risk of these problems is still low. And although the study excluded multiple births, it had no information on whether the single babies born after fertility treatment were the result of mul...
Source: NHS News Feed - January 9, 2014 Category: Consumer Health News Tags: Medical practice Pregnancy/child Source Type: news

Study 'casts doubt' on the need for a Y chromosome
Conclusion This is interesting research furthering our understanding of reproductive biology. It demonstrates that even with complete lack of the Y chromosome the addition of two genes, Sry and Eif2s3y, enabled the mice to develop testes and then to produce sperm – albeit in low numbers and with structural abnormalities. It is very unlikely that these mice would have been able to father any offspring if allowed to mate naturally. However, IVF techniques demonstrated that the sperm cells they produced were able to fertilise an egg, and apparently go on to produce live and healthy, fertile offspring. However, mice ar...
Source: NHS News Feed - November 22, 2013 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news

The amazing story of IVF: 35 years and five million babies later
The birth of Louise Brown in 1978 was the start of a revolution in fertility treatment – and there's more to comeThere's an old bell jar that sits on top of a cupboard at a Cambridgeshire fertility clinic where history was made; it was in a dish inside this jar that the world's first IVF baby spent the hours after her conception. With the success of in vitro fertilisation (IVF), scientist Robert Edwards and his gynaecologist colleague Patrick Steptoe had changed the future for infertile couples around the world.Louise Brown, that first IVF baby, is 35 this month and what was then a revolutionary scientific advance ha...
Source: Guardian Unlimited Science - July 12, 2013 Category: Science Authors: Kate Brian Tags: The Guardian Children Fertility problems Medical research Society Features Science Source Type: news

Test tube children develop mentally normal (EurekAlert, 10 July 2013)
A study published in the British Medical Journal (BMJ) compares the mental health of all children born in Denmark from 1 January 1995 to 31 December 2003 in three groups according to how they were conceived: naturally; with medical assistance via hormone treatments for induced ovulation or intrauterine insemination; via IVF/ICSI. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - July 11, 2013 Category: Endocrinology Source Type: news

Low IQ and autism risk from fertility treatment for men with poor sperm
A Swedish study found the extra risk in babies born after ICSI treatment, where a sperm is injected into the egg to compensate for low sperm count or poor quality sperm. (Source: the Mail online | Health)
Source: the Mail online | Health - July 3, 2013 Category: Consumer Health News Source Type: news

IVF poses minimal risk of autism and low IQ
Conclusion This large cohort study showed that compared with spontaneous conception, IVF treatment (all techniques combined) was not associated with autistic disorder but was associated with a small, borderline significant increase in the risk of mental retardation. For specific IVF procedures, IVF with ICSI was associated with a small increase in the risk of ASD and mental retardation compared with IVF that did not involve ICSI. This study benefits from a large sample size and robust data collection methods, and did well to address an issue few other studies have looked at. But it's worth noting that there may be other u...
Source: NHS News Feed - July 3, 2013 Category: Consumer Health News Tags: Medical practice Neurology Mental health Pregnancy/child Source Type: news

CSI Has Benefits in Unexplained Infertility: Meta-AnalysisCSI Has Benefits in Unexplained Infertility: Meta-Analysis
For couples with well-defined unexplained infertility, the routine use of intracytoplasmic sperm injection (ICSI) for some or all oocytes offers several benefits, a meta-analysis indicates. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 28, 2013 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

Picking the Best Sperm With ICSIPicking the Best Sperm With ICSI
Hyaluronan binding is a tool used in intracytoplasmic sperm injection to help select better sperm and reduce pregnancy loss. Medscape Ob/Gyn (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 10, 2013 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Viewpoint Source Type: news

New NICE guidelines for NHS fertility treatment
New standards set out for treating fertility problems dominate the health news. The coverage is based on updated infertility guidance from the National Institute for Health and Clinical Excellence (NICE). While these guidelines are wide-ranging, the media’s coverage focuses largely on recommendations that: NHS-funded IVF should now be offered up to the age of 42 (in certain circumstances) – the current IVF age limit is 39 couples having difficulty conceiving should be offered treatment after two years of regular unprotected intercourse, instead of the current three same sex co...
Source: NHS News Feed - February 20, 2013 Category: Consumer Health News Tags: QA articles Pregnancy/child Medical practice Source Type: news

NICE updates clinical guideline on fertility (CG156)
Source: NICE Area: Evidence> Guidelines NICE has updated its 2004 clinical guideline on fertility (CG 156) which offers evidence-based advice on the care and treatment of people with fertility problems.   Under the updated recommendations, NICE says that under certain criteria, women aged between 40 and 42 years should be offered one full cycle of IVF with or without intracytoplasmic sperm, if they have not conceived after two years of regular unprotected intercourse, or 12 cycles of artificial insemination where six or more are by intrauterine insemination. A full cycle is now defined as including one episode...
Source: NeLM - Guidelines - February 20, 2013 Category: UK Health Source Type: news

Azoospermic Infertility and Intracytoplasmic Sperm InjectionAzoospermic Infertility and Intracytoplasmic Sperm Injection
How can we avoid unnecessary assisted reproductive technology for male infertility? Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 8, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news