Simple Ways to Make Your Home into Your Sanctuary
Suddenly, because of the pandemic, our homes have become one-stop shops. It’s where we work, teach our kids, and attend religious services. It’s where we sleep, eat, and relax (in theory).
Besides taking walks and running urgent errands, most of us are staying in. So, it’s helpful to make our homes into a place we actually want to be.
Currently, our homes need to “replace a lot of the ‘feel-good’ emotions we had in going out,” said Victoria Vajgrt, a professional home organizer in San Francisco. For example, she said, the yoga studio helped us to relax, while romantic restaurants helped us to reconnect to our...
Source: World of Psychology - April 16, 2020 Category: Psychiatry & Psychology Authors: Margarita Tartakovsky, M.S. Tags: General Industrial and Workplace Mental Health and Wellness Motivation and Inspiration Self-Help Stress coronavirus COVID-19 work from home Source Type: blogs
Fight Aging! Newsletter, March 16th 2020
We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.
Age-Related Epigenetic Changes that Suppress Mitochondrial Function
https://www.fightaging.org/archives/2020/03/age-related-epigenetic-changes-that-suppress-mitochondrial-function/
Today's open access research reports on two specific epigenetic changes observed in old individuals that act to reduce mitochondrial function. This joins an existing list of genes for which expression changes are known to impact mitochondrial function with age. A herd of hundreds of mitochondria are found...
Source: Fight Aging! - March 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing CD38 in Neurodegeneration and Neuroinflammation
Age-related upregulation of CD38 is quite closely related to the decline of NAD+ levels in mitochondria. That in turn causes some fraction of the age-related loss of mitochondrial quality control and mitochondrial function. As mitochondria are the power plants of the cell, providing chemical energy store molecules (adenosine triphosphate, ATP) to power cellular operations, this causes a broad range of issues in tissues throughout the body. Mitochondrial decline is particularly influential in the aging of the brain, given the high energy demands of that organ.
Due to the lack of effective treatment to at least slow...
Source: Fight Aging! - March 12, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Taiwan Election: Dealing with Disinformation while Protecting Speech
ConclusionThis development is testimony to a simple though important fact: cultures are not stable, unchanging entities, and no nation, be the US, China or Taiwan is by nature endowed with a genetic disposition toward dictatorship or democracy. Culture is something people acquire, not something they are born with. Both in Taiwan and in Chin a more than 90 percent of the population are ethnic Han Chinese, but the countries have developed very different political cultures, and the difference seems to be growing. (Source: Cato-at-liberty)
Source: Cato-at-liberty - February 7, 2020 Category: American Health Authors: Flemming Rose Source Type: blogs
Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Decline of Mitophagy in Age-Related Neurodegenerative Conditions
Mitochondria are the power plants of the cell. A herd of these bacteria-like organelles in every cell manufacture the chemical energy store molecules that are used to power cellular processes. Mitochondrial function declines with age throughout the body. Evidence suggests that this is due to changes in mitochondrial dynamics that inhibit the quality control mechanisms of mitophagy that are responsible for recycling worn and damaged mitochondria. This loss of miochondrial function is well known to contribute to the progression of neurodegenerative conditions, as the brain is an energy-hungry organ, making this an important ...
Source: Fight Aging! - January 24, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
PAR1 Inhibition Activates Remyelination
Myelin is the sheathing of nerves, essential to their function. Excessive loss produces disabling and ultimately fatal conditions such as multiple sclerosis, but we all lose myelin integrity to some degree as a consequence of the damage and dysfunction of degenerative aging. This most likely contributes to cognitive decline and other age-related issues. A number of different approaches have been identified to boost the operation of the normal maintainance processes that remyelinate nerves, such as FGF21 upregulation, or increasing the size of remyelinating cell populations. Here, researchers discover another possible trigg...
Source: Fight Aging! - January 20, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 18th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Selectively Removing Mutant Proteins by Binding them to Autophagy Components
Researchers here demonstrate a proof of principle for an interesting approach to tackling the aggregation of damaged, altered, or misfolded proteins that is a feature of most neurodegenerative conditions. They target the mutant huntingtin protein, which is probably an easier task than targeting, say, a misfolded protein with a normal sequence. The basic idea is to deploy a linking molecule that binds to the problem protein with high specificity, and also binds to an essential component of autophagy - in this case LC3B, involved in the generation of autophagosomes responsible for carrying materials to lysosomes. This ensure...
Source: Fight Aging! - November 12, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Echoes of Patient Safety Events: Errors in Third Year
Conclusion/Takeaways
These stories are constantly shaping us; when we notice, think, and share them, how can it not be for the better? None of these stories has an end, because we remember them; they echo. There is multifaceted value in their retelling and reworking, clinically and personally. The curriculum provides students with a platform (the structured assignment), mentorship (the physician reader), and dialogue within a community of peers (the class debrief). It provides faculty with new eyes: the emotion and introspection that can blur with long practice. Together the pieces of the curriculum remind us how much st...
Source: Academic Medicine Blog - October 8, 2019 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective medical errors medical students patient safety Source Type: blogs
Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD.
Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Yes, Sam Huntington Has Insights to Guide U.S. Competition with China
Many U.S. observers believe that the United States is declining relative to China. The United States ' long-term competitiveness will be served neither by assuming that China is fated to collapse on account of its internal contradictions nor by presuming that it is destined to preside over a world order with Chinese characteristics. Sustainable strategy requires a measured disposition. (Source: The RAND Blog)
Source: The RAND Blog - July 24, 2019 Category: Health Management Authors: Ali Wyne Source Type: blogs
Hippocampal Neurogenesis in Aging
In at least some portions of the brain, new neurons are created throughout life in a process called neurogenesis. This is vital to memory and learning, but declines with age. Faltering neurogenesis is arguably implicated in the development of some neurodegenerative conditions. As most of the evidence for neurogenesis in adult individuals has been established in mice, and in recent years there has been some debate over whether or not these same processes do in fact operate in humans. So far, the most recent evidence leans towards supporting the existence of human adult neurogenesis. Given this, the research community remain...
Source: Fight Aging! - July 23, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Causes of Schizophrenia: It ’ s Probably Not Genetics
For more than a century, researchers have had a deeply-held belief that schizophrenia is one form of mental illness that has its basis in genetics. In the intervening years, hundreds of millions of person-hours and billions of dollars have been funneled pursuing the genetic theory of schizophrenia.
Despite all of this enormous effort, researchers are starting to understand that perhaps the genetic component of schizophrenia has been overemphasized. And, in fact, the heritability estimates are not the 80-85 percent that some researchers claimed, but instead are far less.
A new review article published in Psychiatry Researc...
Source: World of Psychology - July 10, 2019 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: General Research Schizophrenia Causes Of Schizophrenia Schizophrenia Causes Source Type: blogs
Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age.
Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - June 23, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
