Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Enabling Microglia to Better Clear Amyloid by Interfering in the LILRB4-APOE Interaction
Researchers here describe a mechanism that reduces the ability of microglia to ingest and clear misfolded amyloid-β, the protein aggregates associated with Alzheimer's disease. Interestingly, this involves APOE, and thus might be affected by the different APOE variants connected to Alzheimer's disease risk. The researchers demonstrate that interfering in the interaction between APOE and the LILRB4 receptor present on microglia can restore microglia-mediated clearance of amyloid-β.
Toxic clumps of brain proteins are features of many neurodegenerative conditions, including Alzheimer's disease (AD), Parkinson's dis...
Source: Fight Aging! - April 11, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Putting West Virginia Students on the Path to Scientific Careers
Credit: NIGMS.
Two NIGMS-funded programs are teaming up to shape the future of science and technology in West Virginia (WV). One engages high school students in science, technology, engineering, math, and medicine (STEM+M); introduces them to research; and provides direct access to college through tuition waivers. In the other program, undergraduate students are paired with a researcher at their institution for a paid internship—an important step toward a career in science.
The Health Sciences & Technology Academy
“We liken our students to rosebuds. As they grow, you see them blossom into self-confident lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 31, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education SEPA Training Source Type: blogs
Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sirtuin 2 Overexpression Fails to Extend Life in Mice
One long-lasting result of the hype engineered over sirtuin 1 overexpression as a possible avenue to modestly slow aging is a continued focus on other sirtuins in the context of aging. Sirtuin 1 overexpression turned out to be entirely unimpressive, a dead end. Sirtuin 6, however, is more interesting, and overexpression in mice does modestly extend life span, possibly by improving DNA repair efficiency. It may also be the case that sirtuin 3 overexpression can improve mitochondrial function to a great enough degree to also be interesting.
On the whole, however, this sort of approach to manipulating metabolism has y...
Source: Fight Aging! - January 4, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Failing Mitochondrial Quality Control in Aging and Neurodegeneration
Every one of our cells contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now fully integrated into our biochemistry. Mitochondria contain their own small remnant genome, the mitochondrial DNA, replicate like bacteria, and toil to produce adenosine triphosphate (ATP), a chemical energy store molecule used to power cell processes. Mitochondrial function declines with age, unfortunately, and our cells suffer for it. This contributes meaningfully to many age-related conditions. This decline appears to result in large part from changes in gene expression that impair the various quality control pro...
Source: Fight Aging! - January 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Embracing the Huntington ’ s disease community
I had chosen a seat towards the back of the conference room because I noticed the legendary Jimmy Pollard sitting there. I didn’t want to miss the chance to sit next to this Huntington’s disease (HD) advocate and all-around amazing person. I was at the Help4HD conference in Detroit, Michigan. It was my first time
Read more…
Embracing the Huntington’s disease community originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 30, 2023 Category: General Medicine Authors: Erin Paterson Tags: Conditions Neurology Source Type: blogs
Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
...
Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Glial Cell Mitochondrial Stress Can Indirectly Signal to the Whole Organism
Glia of various sorts are supporting cells in the brain, assisting the function of neurons. Dysfunction and stress in glial cells is nonetheless important. A growing body of evidence suggests that cellular senescence in astrocytes and microglia contribute to age-related neurodegenerative conditions, for example. Further, stress of various forms in these cells may be provoking both inflammation and altered signaling throughout the brain and body. Overly active, pro-inflammatory astrocytes and microglia are implicated in neurodegeneration, even when these cells are not senescent. It isn't clear as to how much of this is a re...
Source: Fight Aging! - October 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Bonus Features – September 17, 2023 – 20% of healthcare marketers worried about job security amid AI adoption, 53% of executives using AI to address drug diversion “ very confident ” in their efforts, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
Comments rolled in on the proposed Calendar Year 2024 Physician Fee Schedule. The EHR Association called for greater flexibility in the data completeness threshold and additional criteria to enhance patient matching accura...
Source: EMR and HIPAA - September 17, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT 4medica Accelecom Adventist Health Simi Valley athenahealth AvaSure Belong.life Brightside Health Brigitte Nettesheim Cerner eClinicalWorks eCW Edifecs EHR Association Epic GoodRx Healow Healthcare IT Today Source Type: blogs
Can You Take Creatine If You Have High Blood Pressure?
Conclusion
We’ve journeyed through the multifaceted world of creatine, from its role in boosting athletic performance to its potential therapeutic uses. We’ve also delved into the crucial relationship between creatine and high blood pressure, highlighting the need for caution.
The key takeaway? If you have high blood pressure, consult a healthcare provider before taking creatine. It’s not just a supplement; it’s a substance that interacts with various bodily functions and can have significant implications for your health.
So, before you consider adding creatine to your routine, make t...
Source: The EMT Spot - August 29, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Young Glial Progenitor Cells Outcompete Diseased Glial Cells in the Brain
Researchers here report on a demonstration of glial cell competition in the brain, conducted in mice but using human cells. The humanized mice started out with diseased glial cells possessing the mutation characteristic of Huntington's disease. Young human glial progenitor cells without the mutation were transplanted, and subsequently outcompeted the mutated cells, replacing them in the brain. This suggests that a similar strategy could work for a range of neurodegenerative conditions, one treatment to gradually replace problematic supporting cells in the brain. The regenerative medicine community is still struggling to ac...
Source: Fight Aging! - July 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Inhibition of Glycolysis as a Treatment for Neurodegeneration
Researchers here discuss a program of drug discovery that led to inhibitors of glycolysis as a potential approach to treatment for neurodegenerative conditions. The researchers note that elevated glycolysis is a characteristic of Alzheimer's disease, for example. There are always many, many mechanisms and altered aspects of cell metabolism one can investigate in aging and age-related disease. The question to ask when looking at any one specific mechanism in isolation is how much of the pathology of the condition lies downstream of this mechanism. It is all to easy to find oneself targeting a side-effect, or a minor mechani...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
