Huntington ’s disease and a patient’s perspective on genetic testing [PODCAST]
“When I was diagnosed as gene-positive for HD, just over ten years ago, there wasn ’t anything promising on the horizon in terms of a cure. It has only been since new clinical trials were announced in the past few years that I have allowed myself to feel a tiny bit of hope, that maybe thereRead more …Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 10, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Neurology Source Type: blogs
Fight Aging! Newsletter, March 22nd 2021
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal.
Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - March 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Prevalence of Cellular Senescence May Explain the Inverse Correlation Between Cancer and Neurodegeneration
One of the more curious aspects of aging is that risk of Alzheimer's disease and risk of cancer is inversely correlated. Why is this the case? Researchers here suggest that cellular senescence may be an important component of this relationship. If cells in a given individual are more than averagely prone to becoming senescent in response to stress and damage, then this may lower the risk of cancer, as precancerous cells will be blocked from replication and removed by the immune system more efficiently. On the other hand, increased cellular senescence in the aging brain will more rapidly drive chronic inflammation and neuro...
Source: Fight Aging! - March 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 15th 2021
In conclusion, PLG attenuates high calcium/phosphate-induced vascular calcification by upregulating P53/PTEN signaling in VSMCs.
Tsimane and Moseten Hunter-Gatherers Exhibit Minimal Levels of Atrial Fibrillation
https://www.fightaging.org/archives/2021/03/tsimane-and-moseten-hunter-gatherers-exhibit-minimal-levels-of-atrial-fibrillation/
Epidemiological data for the Tsimane and Moseten populations in Bolivia shows that they suffer very little cardiovascular disease in later life, despite a presumably greater lifetime burden of infectious disease (and consequent inflammation) than is the case for people ...
Source: Fight Aging! - March 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Popular Science View of Mitochondrial Uncoupling
Mitochondrial uncoupling diverts the output of the electron transport chain into heat rather than the production of ATP. Induction of higher than usual levels of uncoupling is a calorie restriction mimetic strategy: it produces some of the same gains in health and longevity as the practice of calorie restriction, with some overlap in the processes affected and metabolic changes produced. Historically, the only available pharmacological approach to increased uncoupling, 2,4-dinitrophenol (DNP), has been regarded, correctly, as dangerous. Take a little too much and you will die, because your mitochondria generate enough heat...
Source: Fight Aging! - March 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 1st 2021
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSCs). We report increased frequencies of HSC, hematopoetic progenitor cells (HPC), and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSCs further exhibited a delay in initiating division ex vivo though without changes in their division kinetics. The activity of the small RhoGTPase Cdc42 was elevated in aged human hematopoietic cells and we identified a positive correlation between Cdc42 activity and the frequency of HSCs upon aging.
The frequency of human HSCs polar fo...
Source: Fight Aging! - January 31, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aging is Contagious within the Body
In the midst of a discussion regarding the limitations of life span studies, in that the use of death as an endpoint fails to capture all of the variances in health due to aging, the authors of this paper offer up the thought that aging is contagious within the body. Declines in one cell spread to another, directly or indirectly. Consider that the secretions of senescent cells can make nearby cells senescent. Declines in one tissue can spread to another, directly or indirectly. Consider that the progressive failure of kidney function produces cardiovascular and cognitive dysfunction as a result, because the vascular system...
Source: Fight Aging! - January 25, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Implicating Striosomes in Age-Related Changes in Decision Making
The brain is very complex, and so the ways in which comparatively simple mechanisms of aging lead to alterations in cognitive function are also very complex. The research here picks up the trail of cause and effect relating to changes in approach-avoidance conflict, a part of decision making, a fair way down the line from first causes, as is the case for much of the work taking place on the aging of the brain. It is nonetheless always interesting to see specific age-related changes in complex traits connected to specific cells and their activity, even when the further connections to underlying mechanisms of aging remain ob...
Source: Fight Aging! - November 4, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of th...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Loss of Sense of Smell as an Early Biomarker for Brain Aging
Alzheimer's disease begins in the olfactory bulb, with evidence suggesting that this is related to failing drainage of cerebrospinal fluid from that part of the brain. It has been noted that a faltering of the sense of smell takes place with aging. This may be a useful way to assess the overall state of the brain on the path towards neurodegenerative conditions, but, considered as a whole, comparatively little work has taken place on this aspect of sensory decline with age.
Olfaction, from an evolutionary aspect, is the oldest of our senses. Across different species, it modulates the interactions between an organi...
Source: Fight Aging! - October 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Your Smartphone As The Swiss Knife Of Digital Health
7:39 a.m. That’s the time that your smartphone’s sonar deems as optimal for you to wake up today. With its gentle vibration from your bedside table, you pick it up to turn off the smart alarm. As you do so, your phone asks for your permission to use the built-in sensors and camera to run your routine morning scan. It analyzes your voice; evaluates your stress level based on a facial scan; checks your vital signs; and notifies you to take a picture of that mole on your forearm in order to detect any anomalies.
Thereafter, it outputs a comprehensible report with recommendations which you can send over to your ph...
Source: The Medical Futurist - June 16, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence E-Patients Health Sensors & Trackers Telemedicine & Smartphones stress health trackers Huntington's Alzheimer's disease covid19 camera apple health google fit WHO hemoglobin SpO2 Samsung oximetry F Source Type: blogs
A medical librarian at the theatre: Jane Eyre
As part of our lockdown routine we are enjoying theNational Theatre Live on YouTube. Each week there is a recording of a National Theatre production. This week it was Treasure Island, and last week Jane Eyre. Mr Rochester is about to marry Jane Eyre, when it is made known that he is already married and Mrs Rochester is the mysterious unseen character who lives in the attic and who might be responsible for various strange goings on in the house.So why is she hidden away? What has happened to her? Is she ill?As one does as a medical librarian, I looked in PubMed and found a paper publis...
Source: Browsing - April 18, 2020 Category: Databases & Libraries Tags: Huntingdon disease medicine in fiction Source Type: blogs
A health librarian at the theatre: Jane Eyre
As part of our lockdown routine we are enjoying theNational Theatre Live on YouTube. Each week there is a recording of a National Theatre production. This week it was Treasure Island, and last week Jane Eyre. Mr Rochester is about to marry Jane Eyre, when it is made known that he is already married and Mrs Rochester is the mysterious unseen character who lives in the attic and who might be responsible for various strange goings on in the house.So why is she hidden away? What has happened to her? Is she ill?As one does as a medical librarian, I looked in PubMed and found a paper publis...
Source: Browsing - April 18, 2020 Category: Databases & Libraries Tags: Huntington disease medicine in fiction Source Type: blogs
Jane Eyre
As part of our lockdown routine we are enjoying theNational Theatre Live on YouTube. Each week there is a recording of a National Theatre production. This week it was Treasure Island, and last week Jane Eyre. Mr Rochester is about to marry Jane Eyre, when it is made known that he is already married and Mrs Rochester is the mysterious unseen character who lives in the attic and who might be responsible for various strange goings on in the house.So why is she hidden away? What has happened to her? Is she ill?As one does as a medical librarian, I looked in PubMed and found a paper publis...
Source: Browsing - April 18, 2020 Category: Databases & Libraries Tags: Huntingdon disease medicine in fiction Source Type: blogs
