Molecular characterization of the nonstructural 5A (NS5A) region of hepatitis C virus in Thai blood donors
In conclusion, NS5A RASs at amino acid positions 30, 62, 54, 58, and 98 are present within HCV genotypes 3a and 1. While keeping in mind that additional information was not available on the anonymous blood donors tested in this study, these findings can contribute to understand the NS5A mutation. Further study with known patients under drug treatment is recommended.PMID:38619622 | DOI:10.1007/s00203-024-03950-4 (Source: Archives of Microbiology)
Source: Archives of Microbiology - April 15, 2024 Category: Microbiology Authors: Anchalee Sistayanarain Duangkamol Kunthalert Source Type: research
Cancers, Vol. 16, Pages 1505: The Role of Hepatitis Viruses as Drivers of Hepatocancerogenesis
a Morisco
Recently, metabolic associated steatotic liver disease (MASLD) became the leading cause of chronic liver disease worldwide and one of the most frequent causes of hepatocellular carcinoma (HCC). Nonetheless, in this epidemiological trend, viral hepatitis remains the major driver in hepatic carcinogenesis. Globally, hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma, with an overall attributable risk of approximately 40%, followed by hepatitis C virus (HCV), which accounts for 28–30% of cases, with significant geographic variations between the Eastern and Western world. Consi...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Mario Capasso Valentina Cossiga Maria Guarino Luisa Ranieri Filomena Morisco Tags: Review Source Type: research
Hepatitis C virus core antigen: A diagnostic and treatment monitoring marker of hepatitis C virus in Indian population
ConclusionsHCV core Ag assay is a cost-effective, practically feasible substitute of HCV RTPCR viral load assay for diagnosis as well as long duration treatment monitoring of hepatitis C infection in resource-limited settings.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Source Type: research
Elevation of S2-bound α1-acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma
J Viral Hepat. 2024 Apr 12. doi: 10.1111/jvh.13943. Online ahead of print.ABSTRACTThere is an urgent need for new high-quality markers for the early detection of hepatocellular carcinoma (HCC). Åström et al. suggested that S2-bound α1-acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2-bound AGP in the early detection of HCC. In a retrospective case-control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct-acting antiviral agents (n = 93), we measured S2-bound AGP using the HepaCheC® ELISA kit (Glycobond AB, Linköping,...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Carlos Oltmanns Birgit Bremer Laura Kusche Per St ål Robin Zenlander Jan Tauwaldt Ingvar Ryd én Peter P åhlsson Markus Cornberg Heiner Wedemeyer Source Type: research
Real-world performance of the NeuMoDx ™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA
J Virol Methods. 2024 Apr 11:114937. doi: 10.1016/j.jviromet.2024.114937. Online ahead of print.ABSTRACTQuantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800 system (Roche). HCV-RNA from 131 plasma/serum samples from chronically infected patients was determined in parallel on the NeuMoDx and c6800 systems. Linearity was analysed using the four most common HCV genotypes (1-4) in our cohort. The coefficient of variation (CV) within (intra-a...
Source: Journal of Virological Methods - April 13, 2024 Category: Virology Authors: Nadine L übke Andreas Walker Martin Obermeier Jennifer Camdereli Martha Paluschinski Lara Walotka Anna-Kathrin Schupp Inga Tometten Sandra Hauka Eva Heger J örg Timm Source Type: research
Real-world performance of the NeuMoDx ™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA
J Virol Methods. 2024 Apr 11:114937. doi: 10.1016/j.jviromet.2024.114937. Online ahead of print.ABSTRACTQuantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800 system (Roche). HCV-RNA from 131 plasma/serum samples from chronically infected patients was determined in parallel on the NeuMoDx and c6800 systems. Linearity was analysed using the four most common HCV genotypes (1-4) in our cohort. The coefficient of variation (CV) within (intra-a...
Source: Journal of Virological Methods - April 13, 2024 Category: Virology Authors: Nadine L übke Andreas Walker Martin Obermeier Jennifer Camdereli Martha Paluschinski Lara Walotka Anna-Kathrin Schupp Inga Tometten Sandra Hauka Eva Heger J örg Timm Source Type: research
Real-world performance of the NeuMoDx ™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA
J Virol Methods. 2024 Apr 11:114937. doi: 10.1016/j.jviromet.2024.114937. Online ahead of print.ABSTRACTQuantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800 system (Roche). HCV-RNA from 131 plasma/serum samples from chronically infected patients was determined in parallel on the NeuMoDx and c6800 systems. Linearity was analysed using the four most common HCV genotypes (1-4) in our cohort. The coefficient of variation (CV) within (intra-a...
Source: Journal of Virological Methods - April 13, 2024 Category: Virology Authors: Nadine L übke Andreas Walker Martin Obermeier Jennifer Camdereli Martha Paluschinski Lara Walotka Anna-Kathrin Schupp Inga Tometten Sandra Hauka Eva Heger J örg Timm Source Type: research
Real-world performance of the NeuMoDx ™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA
J Virol Methods. 2024 Apr 11:114937. doi: 10.1016/j.jviromet.2024.114937. Online ahead of print.ABSTRACTQuantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800 system (Roche). HCV-RNA from 131 plasma/serum samples from chronically infected patients was determined in parallel on the NeuMoDx and c6800 systems. Linearity was analysed using the four most common HCV genotypes (1-4) in our cohort. The coefficient of variation (CV) within (intra-a...
Source: Journal of Virological Methods - April 13, 2024 Category: Virology Authors: Nadine L übke Andreas Walker Martin Obermeier Jennifer Camdereli Martha Paluschinski Lara Walotka Anna-Kathrin Schupp Inga Tometten Sandra Hauka Eva Heger J örg Timm Source Type: research
Real-world performance of the NeuMoDx ™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA
J Virol Methods. 2024 Apr 11;327:114937. doi: 10.1016/j.jviromet.2024.114937. Online ahead of print.ABSTRACTQuantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800 system (Roche). HCV-RNA from 131 plasma/serum samples from chronically infected patients was determined in parallel on the NeuMoDx and c6800 systems. Linearity was analysed using the four most common HCV genotypes (1-4) in our cohort. The coefficient of variation (CV) within (int...
Source: Journal of Virological Methods - April 13, 2024 Category: Virology Authors: Nadine L übke Andreas Walker Martin Obermeier Jennifer Camdereli Martha Paluschinski Lara Walotka Anna-Kathrin Schupp Inga Tometten Sandra Hauka Eva Heger J örg Timm Source Type: research
Dynamic change of metabolic dysfunction-associated steatotic liver disease in patients with hepatitis C virus infection after achieving sustained virologic response with direct-acting antivirals
ConclusionsThe prevalence of MASLD decreased after achieving SVR12 with DAAs. Patients with pre-existing T2D showed a diminished probability of MASLD regression and a heightened risk of MASLD emergence post-SVR12. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 13, 2024 Category: Gastroenterology Source Type: research
STAT activation in regulatory CD4+ T cells of patients with primary sclerosing cholangitis
ConclusionsIn PSC, we observed enhanced STAT3 responsiveness of CD4+ Tregs together with reduced CD39 expression probably reflecting inflammatory activity of the disease. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 12, 2024 Category: Allergy & Immunology Authors: Leona Dold,
Sandra Kalthoff,
Leonie Frank,
Taotao Zhou,
Pia Esser,
Philipp Lutz,
Christian P. Strassburg,
Ulrich Spengler,
Bettina Langhans Tags: ORIGINAL ARTICLE Source Type: research
Transfusion-transmitted infections
Blood Res. 2024 Apr 12;59(1):14. doi: 10.1007/s44313-024-00014-w.ABSTRACTThe risk of transfusion-transmitted infection (TTI) has always existed because transfused blood products are biological materials derived from humans. To prevent TTIs, screening strategies have been developed for various infectious diseases, such as hepatitis B virus, hepatitis C virus, and human immunodeficiency virus, contributing significantly to reducing TTI globally. Nevertheless, septic transfusion reactions (STRs) due to bacterial contamination remain an unresolved issue. Various infectious diseases can be transmitted through blood products, an...
Source: Blood Research - April 12, 2024 Category: Hematology Authors: Han Joo Kim Dae-Hyun Ko Source Type: research
Exploring kidney dialysis costs in the United States: a scoping review
CONCLUSIONS: These findings indicate that prevention of or delay in progression to ESRD could have considerable cost savings for Medicare and private payers, particularly in patients with high-risk conditions such as type 2 diabetes. More efficient use of resources is needed, including low-cost medication, to improve clinical outcomes and lower overall costs, especially in high-risk groups. Widening access to PD where it is safe and appropriate may help to reduce dialysis costs.PMID:38605648 | DOI:10.1080/13696998.2024.2342210 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 12, 2024 Category: Health Management Authors: Fiona Stewart Kristin Kistler Yuxian Du Rakesh R Singh Bonnie B Dean Sheldon X Kong Source Type: research
