Efficacy of immune checkpoint inhibitors differs in various status of carcinoma: a study based on 29 cohorts with 3255 participants
ConclusionsThis study indicated that the presence of viral infection was evidently associated with improved outcomes in cancer patients undergoing ICIs, particularly in cases of HBV/HCV and HPV infections. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - March 30, 2024 Category: Cancer & Oncology Source Type: research
The Integrated Prediction of Clinical and Pathological Factors on the Prognosis of Intrahepatic Cholangiocarcinoma
CONCLUSION: We successfully developed and validated a prognostic nomogram for iCCA, demonstrating its excellent accuracy in predicting patient outcomes and providing clinicians with a potential prognostic tool.PMID:38549438 | DOI:10.1177/00031348241241730 (Source: The American Surgeon)
Source: The American Surgeon - March 29, 2024 Category: Surgery Authors: Guoliang Chen Song Li Adong Xia Yuelong Xing Wenbo Liang Source Type: research
The Integrated Prediction of Clinical and Pathological Factors on the Prognosis of Intrahepatic Cholangiocarcinoma
CONCLUSION: We successfully developed and validated a prognostic nomogram for iCCA, demonstrating its excellent accuracy in predicting patient outcomes and providing clinicians with a potential prognostic tool.PMID:38549438 | DOI:10.1177/00031348241241730 (Source: The American Surgeon)
Source: The American Surgeon - March 29, 2024 Category: Surgery Authors: Guoliang Chen Song Li Adong Xia Yuelong Xing Wenbo Liang Source Type: research
Evaluating hepatitis C cascade of care surveillance system in Tuscany, Italy, through a population retrospective data-linkage study, 2015 –2021
This comprehensive retrospective data-linkage study aimed at evaluating the impact of Direct-Acting Antivirals (DAAs) on Hepatitis C Virus (HCV) testing, treatment trends, and access to care in Tuscany over si... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 29, 2024 Category: Infectious Diseases Authors: Luca Ceccarelli, Giaele Moretti, Sara Mazzilli, Davide Petri, Ilaria Corazza, Caterina Rizzo, Ersilia Lucenteforte, Milena Vainieri, Chiara Seghieri and Lara Tavoschi Tags: Research Source Type: research
Cardiac allograft vasculopathy in heart transplant recipients from hepatitis C viremic donors
CONCLUSION: Our data show that NAT+ donors conferred no increased risk for early CAV or subclinical IVUS disease following transplantation in a cohort of heart transplant patients who were treated for HCV, suggesting the short-term safety of this strategy to maximize the pool of available donor hearts.PMID:38545881 | DOI:10.1111/ctr.15294 (Source: Atherosclerosis)
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Bernard S Kadosh Antoinette S Birs Erin Flattery Maxine Stachel Kimberly N Hong Yuhe Xia Claudia Gidea Saima Aslam Louai Razzouk Tajinderpal Saraon Randal Goldberg Shaline Rao Victor Pretorius Nader Moazami Deane E Smith Eric D Adler Alex Reyentovich Source Type: research
Impact of direct-acting antiviral on subclinical atherosclerosis in chronic hepatitis C infected patients
CONCLUSIONS: SVR, in CHC patients treated with DAA, was associated with worsening of carotid atherosclerotic lesions.PMID:38545713 | DOI:10.62438/tunismed.v102i3.4601 (Source: Atherosclerosis)
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Sarra Laabidi Mouna Medhioub Amal Khsiba Asma Bach Ali Asma Ben Mohamed Lamine Hamzaoui Source Type: research
Cardiac allograft vasculopathy in heart transplant recipients from hepatitis C viremic donors
CONCLUSION: Our data show that NAT+ donors conferred no increased risk for early CAV or subclinical IVUS disease following transplantation in a cohort of heart transplant patients who were treated for HCV, suggesting the short-term safety of this strategy to maximize the pool of available donor hearts.PMID:38545881 | DOI:10.1111/ctr.15294 (Source: Atherosclerosis)
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Bernard S Kadosh Antoinette S Birs Erin Flattery Maxine Stachel Kimberly N Hong Yuhe Xia Claudia Gidea Saima Aslam Louai Razzouk Tajinderpal Saraon Randal Goldberg Shaline Rao Victor Pretorius Nader Moazami Deane E Smith Eric D Adler Alex Reyentovich Source Type: research
Impact of direct-acting antiviral on subclinical atherosclerosis in chronic hepatitis C infected patients
CONCLUSIONS: SVR, in CHC patients treated with DAA, was associated with worsening of carotid atherosclerotic lesions.PMID:38545713 | DOI:10.62438/tunismed.v102i3.4601 (Source: Atherosclerosis)
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Sarra Laabidi Mouna Medhioub Amal Khsiba Asma Bach Ali Asma Ben Mohamed Lamine Hamzaoui Source Type: research
Viruses, Vol. 16, Pages 522: Peripheral Neuropathy in Patients with Hepatitis C Infection & mdash;Reversibility after HCV Eradication: A Single Center Study
Viruses, Vol. 16, Pages 522: Peripheral Neuropathy in Patients with Hepatitis C Infection—Reversibility after HCV Eradication: A Single Center Study
Viruses doi: 10.3390/v16040522
Authors:
Androutsakos
Tsantzali
Karagiannakis
Flevari
Iakovou
Pouliakis
Kykalos
Doris
Xyla
Chronic hepatitis C virus (HCV) infection is characterized by a variety of extra-hepatic manifestations; peripheral neuropathy (PN) is one of the most common, especially when mixed cryoglobulinemia (MCG) is present. The prevalence and risk factors of HCV-related PN in the absence of MCG are largely unknown. We cond...
Source: Viruses - March 28, 2024 Category: Virology Authors: Androutsakos Tsantzali Karagiannakis Flevari Iakovou Pouliakis Kykalos Doris Xyla Tags: Article Source Type: research
Investigating the correlation between prominent viruses and hematological malignancies: a literature review
AbstractExtensive research has been conducted on the correlation between viral infections and hematological cancers ever since the identification of the Rous Sarcoma Virus as a cancer-causing agent. Numerous viruses, such as the Epstein-Barr virus, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, human T-lymphotropic virus 1, and severe acute respiratory syndrome-related coronavirus 2, have been identified as potential contributors to the development and progression of cancer by disrupting normal cellular processes. Different viruses are associated with distinct forms of blood cancers, each exhibiting un...
Source: Medical Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Pro: Normothermic Regional Perfusion Should Be Utilized In Orthotopic Heart Transplantation.
The prevalence of heart failure has increased in the last few decades with an estimate of over 8 million American to have heart failure by 2030.1 At the same time, the number of Donation after Brain Death (DBD) heart donors has remained overall unchanged for over a decade.2 This imbalance led to a surge in the demand for heart transplants. This rising need has propelled the transplant communities to explore new avenues to expand the donor pool like the inclusion of public health services high-risk donors, such as hepatitis C or COVID positive donors, xenografts, and more recently, Donation after Circulatory Death (DCD). (S...
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 27, 2024 Category: Anesthesiology Authors: Mohammad Alarfaj, Zubair Shah Tags: Pro and Con Source Type: research
Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection
Microb Cell Fact. 2024 Mar 25;23(1):90. doi: 10.1186/s12934-024-02355-8.ABSTRACTCellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend significantly on lipid rafts for infection at virtually every stage of their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) ...
Source: Atherosclerosis - March 26, 2024 Category: Cardiology Authors: Khursheed Muzammil Mohammad Hosseini Hooshiar Shirin Varmazyar Thabit Moath Omar Manal Morad Karim Sadeq Aadi Shaylan Kalavi Saman Yasamineh Source Type: research
Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection
Microb Cell Fact. 2024 Mar 25;23(1):90. doi: 10.1186/s12934-024-02355-8.ABSTRACTCellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend significantly on lipid rafts for infection at virtually every stage of their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) ...
Source: Atherosclerosis - March 26, 2024 Category: Cardiology Authors: Khursheed Muzammil Mohammad Hosseini Hooshiar Shirin Varmazyar Thabit Moath Omar Manal Morad Karim Sadeq Aadi Shaylan Kalavi Saman Yasamineh Source Type: research
Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.
ConclusionsBTR varies by sex and age even among healthy adults, and decreasing process and timing of BTR during disease progression is different among CLD etiologies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Source Type: research
