Clinical significance of < em > CDT1 < /em > mRNA expression in chronic hepatitis C or liver cirrhosis
We examined the association between the CDT1 mRNA expression and clinical conditions and long-term outcome. We then examined the association between serum cytokine/chemokine levels and CDT1 mRNA expression in 58 cases. The cumulative incidence rates of HCC development in cases with CDT1 mRNA in the low expression group showed significantly lower than those in the high expression group (p = 0.0391). A significant correlation was found between CDT1 mRNA expression and the extent of proliferation of atypical hepatocytes in hematoxylin and eosin-stained sections (p<0.0001). CDT1 mRNA expression has been associated with cyto...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Masahiro Ogawa Mitsuhiko Moriyama Hitomi Nakamura Toshikatu Shibata Kazumichi Kuroda Masahiko Sugitani Source Type: research
Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval
CONCLUSION: The study demonstrates that a combination therapy of 3 antiviral drugs does not significantly prolong the QTc interval and does not cause severe pathological changes on the ECG. Patients undergoing this treatment are not at risk of developing heart disease as an undesirable side effect.PMID:38511419 | DOI:10.14712/18059694.2024.1 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - March 21, 2024 Category: General Medicine Authors: Jakub Šimka Radek Pudil Monika Fialov á Filip Varhan ík Stanislav Pl íšek Petr Pa řízek Source Type: research
Breastfeeding Initiation in People With Hepatitis C Virus Infection in the United States
CONCLUSION: Despite leading health organizations' support for people living with HCV infection to breastfeed, our study demonstrates low breastfeeding initiation rates in this population. Our findings highlight the need for tailored breastfeeding support for people with HCV infection and for understanding the additional effects of human immunodeficiency virus (HIV) co-infection, HCV treatment, and concurrent substance use disorders on breastfeeding initiation.PMID:38513240 | DOI:10.1097/AOG.0000000000005555 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: Christine A Blauvelt Stephanie Turcios Timothy Wen John Boscardin Dominika Seidman Source Type: research
Clinical significance of < em > CDT1 < /em > mRNA expression in chronic hepatitis C or liver cirrhosis
We examined the association between the CDT1 mRNA expression and clinical conditions and long-term outcome. We then examined the association between serum cytokine/chemokine levels and CDT1 mRNA expression in 58 cases. The cumulative incidence rates of HCC development in cases with CDT1 mRNA in the low expression group showed significantly lower than those in the high expression group (p = 0.0391). A significant correlation was found between CDT1 mRNA expression and the extent of proliferation of atypical hepatocytes in hematoxylin and eosin-stained sections (p<0.0001). CDT1 mRNA expression has been associated with cyto...
Source: Clinical Biochemistry - March 21, 2024 Category: Biochemistry Authors: Masahiro Ogawa Mitsuhiko Moriyama Hitomi Nakamura Toshikatu Shibata Kazumichi Kuroda Masahiko Sugitani Source Type: research
A Rare Autopsy Case of Aggressive Combined Hepatocellular-Cholangiocarcinoma in 59-Year-Old Female
Ann Clin Lab Sci. 2024 Jan;54(1):106-111.ABSTRACTCombined hepatocellular-cholangiocarcinoma (cHCC-CC) is a liver tumor with features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). It consists of intermingled malignant biliary and hepatic tissue and thus a distinct entity, rather than two separate coexisting malignancies. A 59-year-old female with a history of hepatitis C and cirrhosis presented with abdominal pain and altered mental status. She developed hematemesis, and despite extensive interventions, she expired one day after her initial presentation. At autopsy, the liver was diffusel...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ahmed A Ahmed Brandon Gehris Michelle McDonald Suhair Al Salihi L Maximilian Buja Source Type: research
Clinical significance of < em > CDT1 < /em > mRNA expression in chronic hepatitis C or liver cirrhosis
We examined the association between the CDT1 mRNA expression and clinical conditions and long-term outcome. We then examined the association between serum cytokine/chemokine levels and CDT1 mRNA expression in 58 cases. The cumulative incidence rates of HCC development in cases with CDT1 mRNA in the low expression group showed significantly lower than those in the high expression group (p = 0.0391). A significant correlation was found between CDT1 mRNA expression and the extent of proliferation of atypical hepatocytes in hematoxylin and eosin-stained sections (p<0.0001). CDT1 mRNA expression has been associated with cyto...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Masahiro Ogawa Mitsuhiko Moriyama Hitomi Nakamura Toshikatu Shibata Kazumichi Kuroda Masahiko Sugitani Source Type: research
Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval
CONCLUSION: The study demonstrates that a combination therapy of 3 antiviral drugs does not significantly prolong the QTc interval and does not cause severe pathological changes on the ECG. Patients undergoing this treatment are not at risk of developing heart disease as an undesirable side effect.PMID:38511419 | DOI:10.14712/18059694.2024.1 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - March 21, 2024 Category: General Medicine Authors: Jakub Šimka Radek Pudil Monika Fialov á Filip Varhan ík Stanislav Pl íšek Petr Pa řízek Source Type: research
Breastfeeding Initiation in People With Hepatitis C Virus Infection in the United States
CONCLUSION: Despite leading health organizations' support for people living with HCV infection to breastfeed, our study demonstrates low breastfeeding initiation rates in this population. Our findings highlight the need for tailored breastfeeding support for people with HCV infection and for understanding the additional effects of human immunodeficiency virus (HIV) co-infection, HCV treatment, and concurrent substance use disorders on breastfeeding initiation.PMID:38513240 | DOI:10.1097/AOG.0000000000005555 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: Christine A Blauvelt Stephanie Turcios Timothy Wen John Boscardin Dominika Seidman Source Type: research
Clinical significance of < em > CDT1 < /em > mRNA expression in chronic hepatitis C or liver cirrhosis
We examined the association between the CDT1 mRNA expression and clinical conditions and long-term outcome. We then examined the association between serum cytokine/chemokine levels and CDT1 mRNA expression in 58 cases. The cumulative incidence rates of HCC development in cases with CDT1 mRNA in the low expression group showed significantly lower than those in the high expression group (p = 0.0391). A significant correlation was found between CDT1 mRNA expression and the extent of proliferation of atypical hepatocytes in hematoxylin and eosin-stained sections (p<0.0001). CDT1 mRNA expression has been associated with cyto...
Source: Clinical Biochemistry - March 21, 2024 Category: Biochemistry Authors: Masahiro Ogawa Mitsuhiko Moriyama Hitomi Nakamura Toshikatu Shibata Kazumichi Kuroda Masahiko Sugitani Source Type: research
A Rare Autopsy Case of Aggressive Combined Hepatocellular-Cholangiocarcinoma in 59-Year-Old Female
Ann Clin Lab Sci. 2024 Jan;54(1):106-111.ABSTRACTCombined hepatocellular-cholangiocarcinoma (cHCC-CC) is a liver tumor with features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). It consists of intermingled malignant biliary and hepatic tissue and thus a distinct entity, rather than two separate coexisting malignancies. A 59-year-old female with a history of hepatitis C and cirrhosis presented with abdominal pain and altered mental status. She developed hematemesis, and despite extensive interventions, she expired one day after her initial presentation. At autopsy, the liver was diffusel...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ahmed A Ahmed Brandon Gehris Michelle McDonald Suhair Al Salihi L Maximilian Buja Source Type: research
Clinical significance of < em > CDT1 < /em > mRNA expression in chronic hepatitis C or liver cirrhosis
We examined the association between the CDT1 mRNA expression and clinical conditions and long-term outcome. We then examined the association between serum cytokine/chemokine levels and CDT1 mRNA expression in 58 cases. The cumulative incidence rates of HCC development in cases with CDT1 mRNA in the low expression group showed significantly lower than those in the high expression group (p = 0.0391). A significant correlation was found between CDT1 mRNA expression and the extent of proliferation of atypical hepatocytes in hematoxylin and eosin-stained sections (p<0.0001). CDT1 mRNA expression has been associated with cyto...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Masahiro Ogawa Mitsuhiko Moriyama Hitomi Nakamura Toshikatu Shibata Kazumichi Kuroda Masahiko Sugitani Source Type: research
Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval
CONCLUSION: The study demonstrates that a combination therapy of 3 antiviral drugs does not significantly prolong the QTc interval and does not cause severe pathological changes on the ECG. Patients undergoing this treatment are not at risk of developing heart disease as an undesirable side effect.PMID:38511419 | DOI:10.14712/18059694.2024.1 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - March 21, 2024 Category: General Medicine Authors: Jakub Šimka Radek Pudil Monika Fialov á Filip Varhan ík Stanislav Pl íšek Petr Pa řízek Source Type: research
Breastfeeding Initiation in People With Hepatitis C Virus Infection in the United States
CONCLUSION: Despite leading health organizations' support for people living with HCV infection to breastfeed, our study demonstrates low breastfeeding initiation rates in this population. Our findings highlight the need for tailored breastfeeding support for people with HCV infection and for understanding the additional effects of human immunodeficiency virus (HIV) co-infection, HCV treatment, and concurrent substance use disorders on breastfeeding initiation.PMID:38513240 | DOI:10.1097/AOG.0000000000005555 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: Christine A Blauvelt Stephanie Turcios Timothy Wen John Boscardin Dominika Seidman Source Type: research
A Rare Autopsy Case of Aggressive Combined Hepatocellular-Cholangiocarcinoma in 59-Year-Old Female
Ann Clin Lab Sci. 2024 Jan;54(1):106-111.ABSTRACTCombined hepatocellular-cholangiocarcinoma (cHCC-CC) is a liver tumor with features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). It consists of intermingled malignant biliary and hepatic tissue and thus a distinct entity, rather than two separate coexisting malignancies. A 59-year-old female with a history of hepatitis C and cirrhosis presented with abdominal pain and altered mental status. She developed hematemesis, and despite extensive interventions, she expired one day after her initial presentation. At autopsy, the liver was diffusel...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ahmed A Ahmed Brandon Gehris Michelle McDonald Suhair Al Salihi L Maximilian Buja Source Type: research
Clinical significance of < em > CDT1 < /em > mRNA expression in chronic hepatitis C or liver cirrhosis
We examined the association between the CDT1 mRNA expression and clinical conditions and long-term outcome. We then examined the association between serum cytokine/chemokine levels and CDT1 mRNA expression in 58 cases. The cumulative incidence rates of HCC development in cases with CDT1 mRNA in the low expression group showed significantly lower than those in the high expression group (p = 0.0391). A significant correlation was found between CDT1 mRNA expression and the extent of proliferation of atypical hepatocytes in hematoxylin and eosin-stained sections (p<0.0001). CDT1 mRNA expression has been associated with cyto...
Source: Journal of Clinical Biochemistry and Nutrition - March 21, 2024 Category: Nutrition Authors: Masahiro Ogawa Mitsuhiko Moriyama Hitomi Nakamura Toshikatu Shibata Kazumichi Kuroda Masahiko Sugitani Source Type: research
