Recurrent Aphthous Stomatitis in Children: A Practical Guideline for Paediatric Practitioners.
Authors: Koberová R, Merglová V, Radochová V Abstract Recurrent aphthous stomatitis (RAS) is the most common chronic oral mucosal lesion affecting up to 25% of the population. The diagnosis is based on well-defined clinical characteristics, but the precise aetiology and pathogenesis remain unclear. The treatment of RAS should be based on the identification and control of possible predisposing factors. A wide range of topical medicaments is available as antiseptics, anti-inflammatory drugs and corticosteroids. The systemic treatment is indicated in patients with continuous and aggressive manifes...
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Corneal Graft Success Rates in HSV Keratitis: A Systematic Review.
In conclusion, in terms of postoperative VA, both PK and DALK demonstrate comparable efficacy. However, DALK, which is applied in less severe HSK cases, is associated with fewer complications and better graft survival rates. High dosages of ACV, topical steroids and antibiotics contribute significantly to improved postoperative outcomes. PMID: 33355075 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Development of Pharyngocutaneous Fistula after Total Laryngectomy: The Predictive Value of C-reactive Protein/Albumin Ratio.
CONCLUSIONS: CAR, performed in the early postoperative period, may be a new and useful marker for predicting PCF after total laryngectomy. PMID: 33355076 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Sensitization to Molecular Components in 104 Atopic Dermatitis Patients in Relation to Subgroups of Patients Suffering from Bronchial Asthma and Allergic Rhinitis.
CONCLUSIONS: We have confirmed the significant differences in the sensitization to molecular components in patients suffering from severe form of AD, and in subgroups of patients suffering from AB and AR. These molecular components may play the important role in the consecutive development of different allergy pathologies called atopic march. PMID: 33355077 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study.
Authors: Balík M, Košina J, Hušek P, Broďák M, Čečka F Abstract BACKGROUND: The prophylactic administration of tranexamic acid has been shown to be appropriate for procedures with a high risk of perioperative bleeding in cardiac surgery and orthopaedics. In urology the ambiguous results have been reported. Our goal was to evaluate the effect of tranexamic acid administration in robotic-assisted radical prostatectomy (RARP). A pilot, prospective, double-blind, randomized study was conducted to evaluate this effect. METHODS: The study included 100 patients who received RARP in the p...
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection.
Authors: Razavizadeh M, Arj A, Madani M, Gilassi H Abstract BACKGROUND: The aim of this study was comparison the effectiveness of sequential and standard quadruple therapy on eradication of H. pylori infection. METHODS: This clinical trial study was conducted on 160 patients with dyspepsia or gastroduodenal ulcer. Patients were randomly divided into two groups. Group A (standard regimen) received omeprazole, amoxicillin, clarithromycin and bismuth subcitrate for 2 weeks. Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days. After the en...
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Evaluation of Midpalatal Suture Ossification Using Cone-Beam Computed Tomography: A Digital Radiographic Study.
CONCLUSION: The results of the present study showed a wide variation in the initiation time and the degree of ossification and morphology of the midpalatal suture in different age groups. Although there was an increase in the closure of the suture with aging, age is not a reliable criterion for determining the open or closed nature of the suture. This finding is important in providing an idea as to how diverse is the ossification of maxillary sutures. PMID: 33355080 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Massive Traumatic Subcutaneous Emphysema.
Authors: Fernandes D, Pereira S, Guedes C, Silva D Abstract 74 year-old-man, former smoker, with chronic obstructive pulmonary disease GOLD grade 4, group D, with emphysema component, treated in a pulmonary rehabilitation program, on oxygen therapy and nocturnal bi-level positive airway pressure (BiPAP) ventilation. During the night he had a traumatic rib fracture (5-11th right ribs) but still he used BiPAP ventilation during the sleep. In the morning after he presented with a diffuse and massive emphysema in the face, thorax and abdominal regions. On physical examination, the patient presented with massive swellin...
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Atypical Presentation of Pseudoxanthoma Elasticum in Two Siblings from North India.
Authors: Misra S, Saran RK Abstract Pseudoxanthoma elasticum (PXE) is a rare hereditary disorder occurring due to metabolic defect in the liver and manifesting predominantly in the skin, eyes and arteries. It shows characteristic yellowish papules on the skin around the nape of neck along with looseness of skin over flexural surfaces. PXE shows marked phenotypic heterogeneity. Complications related to arterial wall and retinal Bruchs' membrane calcification occur later in life; early diagnosis therefore helps keep patient on follow up for development of the same. In Indian patients, classic skin changes may be miss...
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

The Biometeorology of COVID-19: A Novel Therapeutic Strategy?
Authors: Cantone E, Gamerra M PMID: 33355083 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - December 30, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Oral Manifestations of Nutritional Deficiencies: Single Centre Analysis.
CONCLUSION: The most commonly observed deficiency in dental practice over the course of 11 years was an iron deficiency in the female population. Age, diet and reported co-morbidities did not show statistically significant predictable value in recognizing these deficiencies. PMID: 33002395 [PubMed - as supplied by publisher] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Association of XPC Polymorphisms with Cutaneous Malignant Melanoma Risk: Evidence from a Meta-Analysis.
CONCLUSIONS: This meta-analysis result suggested that XPC Lys939Gln and Ala499Val polymorphisms were significantly associated with risk of CMM. PMID: 33002396 [PubMed - as supplied by publisher] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Uroflowmetry in Non-Monosymptomatic Nocturnal Enuresis in Children of Coastal Region of Croatia.
Authors: Prgomet S, Saraga M, Benzon S, Turudić D, Ledina D, Milošević D Abstract PURPOSE: The aim of the study was to describe clinical characteristics and bladder assessment in children with Non-Monosymptomatic Nocturnal Enuresis (NMNE) in coastal region of Croatia. MATERIALS AND METHODS: Records on 85 patients with NMNE were retrospectively reviewed. Bladder assessments were performed in all children. In this research we: (i) compare clinical characteristics and features of bladder assessment: uroflowmetry, post void residuals (PVR) and bladder wall thickness between boys and girls with NMNE and we ...
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria.
CONCLUSIONS: A remarkable inter-ethnic differences in autosomal recessive CYP2C8*2 allele was observed. By implication, there is a gradual incursion of genetic drift for poor CQ and AQ-Artemisinin metabolizers among the inhabitants. PMID: 33002398 [PubMed - as supplied by publisher] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Acute Compartment Syndrome.
Authors: Cepková J, Ungermann L, Ehler E Abstract Acute compartment syndrome occurs most frequently in connection with injuries, terminal or chemical damage of tissues, ischemia, the activity of toxins or in patients with tissue ischemia or muscle necrosis. Clinical findings have found pronounced pain, followed by paresthesias, pallor, and paresis. Decreased pulsation of arteries has also been a frequent finding. In severe forms decompressive fasciotomy has been indicated within the first 12-24 hours after diagnosis. In the following paper, the authors present the case report of a 68-year woman who swallowed...
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Iron Deficiency as Cause of Dysphagia and Burning Mouth (Plummer-Vinson or Kelly-Patterson Syndrome): a Case Report.
Authors: Radochová V, Slezák R, Radocha J Abstract The clinical presentation of iron deficiency can be very heterogeneous, including various oral and other mucosal problems. Here, in this case, we report the patient with burning mouth and dysphagia symptoms where iron deficiency was found to be the underlying cause after several months of investigations. This clinical syndrome is called Plummer-Vinson syndrome. It is sporadic with an incidence less than 0.1% of patients suffering from iron deficiency anemia. PMID: 33002400 [PubMed - as supplied by publisher] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Anomalous Course of Accessory Splenic Arteries in Gastrosplenic Ligament: Case Report and Clinico-Embryological Basis.
We report the case of accessory splenic arteries in an approximately 50-year-old male cadaver encountered during routine educational dissection. One of them arising from left gastroepiploic artery supplies the spleen in addition to splenic artery. Another variant vessel bifurcated to enter greater omentum and anterior pole of spleen, as discrete branches. The anatomical vascular variation, if recognized during the imaging work-ups for elective surgical procedures could avoid potential iatrogenic blood loss. PMID: 33002401 [PubMed - as supplied by publisher] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Symptomatic Hypokalemia in a 19-Year-Old Student.
Authors: Pereira S, Salgueiro A, Rosa P, Peixoto C, Ferreira M, Silva D Abstract Primary hyperaldosteronism (PA) is the most common cause of secondary arterial hypertension and is frequently undiagnosed. It affects all ages but is more frequent between 20 and 60 years old. The clinical presentation is variable, and the diagnosis is based on screening and, in equivocal cases, confirmatory tests. A 19-year-old student presented with complaints of extreme fatigue, arterial hypertension, hypokalemia and metabolic alkalosis, raising a high index of suspicion for PA. Screening tests were performed and its expressiveness ...
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Metachronous Isolated Contralateral Lung Metastasis from Pulmonary Adenosquamous Carcinoma with EGFR Mutation.
We present a case of metachronous isolated contralateral lung metastasis from pulmonary adenosquamous carcinoma with EGFR mutation. A 75-yearold woman presented with left lung nodule on a routine follow-up chest radiograph. She had had surgery for pulmonary adenocarcinoma with EGFR Ex21 L858R mutation 6 years ago. She underwent surgical resection, and histologic findings revealed adenosquamous carcinoma with the same EGFR mutation. Re-assessment of the resected specimen of the primary tumor resected 6 years ago revealed the morphologically similarity to the left lung tumor. Based on morphological and genetic identity, fina...
Source: Acta Medica: Hradec Kralove - October 2, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Hydrocele in Pediatric Population.
Authors: Patoulias I, Koutsogiannis E, Panopoulos I, Michou P, Feidantsis T, Patoulias D Abstract Hydrocele is a collection of fluid within the tunica vaginalis. Based upon the etiology and the pathophysiology, it is divided into, the primary and secondary. The primary hydrocele includes the neonatal or the congenital, the communicating and the non-communicating or the closed or the adult type. The secondary hydrocele can develop in the substrate of a pre-existing disease. After systematic and thorough systematic and thorough research of the relevant literature, we aim at describing all the aspects of this entity, ...
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Robotic Management of Fibroids: Discussion of Use, Criteria and Advantages.
Discussion of Use, Criteria and Advantages. Acta Medica (Hradec Kralove). 2020;63(2):63-66 Authors: Gkegkes ID, Iatrakis G, Iavazzo PE, Bakalianou K, Iavazzo C Abstract Fibroids are the most common benign tumors affecting fertility and quality of life. Different methods either definitive or fertility sparing are used for their management by using open, laparoscopic and robotic techniques. This is a narrative review presenting the role and the advantages of robotic surgery in fibroids (myomectomies or hysterectomies). Such a management is effective, safe and feasible in hands of well-trained teams even ...
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Perception of Undergraduate Students at the Faculty of Medicine in Hradec Kr álové Regarding Their Endodontic Education and Suggested Improvements.
CONCLUSIONS: The overall perception of the students was that their endodontic education was sufficient and largely conformed to the guidelines. Insufficient exposure to endodontic practice on patients was identified as a deficiency. There were no significant differences in perceptions between the two study groups. PMID: 32771071 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Fluoroscopic Epidural Steroid Injection: Pain Relief in Discogenic Sciatica Versus Lumbar Spinal Stenosis. A Study on Middle Eastern Patients.
CONCLUSION: ESI are more effective in patients with Sci than in single level LSS. In multiple level LSS, results are disappointing. PMID: 32771072 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Duodenal Pressure Necrosis in a Child Caused by a Migrated Percutaneous Endoscopic Gastrostomy.
Authors: Melek J, Štanclová M, Štichhauer R, Rozsíval P, Kopřiva J, Dědková J, Terifajova E, Šedivá E, Dědek P, Skálová S, Bureš J Abstract A two-year-old girl with two weeks of abdominal pain, vomiting, and food refusal, ten months after percutaneous endoscopic gastrostomy insertion because of inadequate peroral intake, was admitted to a tertiary centre hospital. On admission, the extracorporeal part of the gastrostomy was much shortened. X-ray examination revealed migration of the end of the gastrostomy tube with a left-shifted course of the...
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Candida Skull Base Osteomyelitis: a Case Report and Literature Review.
Authors: Krishnamoorthy M, Othman NAN, Hassan NEB, Hitam SB Abstract Skull base osteomyelitis (SBO) also commonly known as malignant otitis externa was first described by Meltzer and Kelemen in 1959. Prior to the advent of the antibiotic era, this disease carried a poor prognosis with significant morbidity. It often proved fatal with mortality rates as high as 50%. Commonly seen in the immunocompromised patients, diabetes mellitus is an important associated comorbidity in the pathophysiologic development of this disease. Treatment is instituted by medical therapy with surgery having a limited role. Surgical interve...
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Pierre Robin Sequence: Diagnostic Difficulties Faced while Differentiating Isolated and Syndromic Forms.
We describe two cases of PRS of Indian ethnicity and describe some of the difficulties that we faced while distinguishing isolated PRS from syndromic PRS. Both cases had a similar clinical presentation. However, one of the cases had a positive family history of congenital deafness and cleft palate, whereas the other case had apparent upper limb anomalies. These facts heightened the suspicion of an associated syndrome. However, based on the available facts and after thorough investigations, a tentative diagnosis of isolated PRS was made for both the patients. Both the cases were managed conservatively and were advised a lon...
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration.
Authors: Polamaung W, Kongkit J, Yimnoi P, Boonchaya-Anant P, Snabboon T Abstract Thyrotoxic hypokalemic periodic paralysis (THPP) is a disease characterized by recurrent episodes of muscle weakness due to intracellular potassium shifting in the presence of high levels of thyroid hormone. It occurs more commonly amongst young Asian men with underlying Graves' disease. Attacks are commonly precipitated by ingestion of carbohydrate-rich meals or alcohols, stress or strenuous exercise. Herein, we describe an adult Thai man suffering from a hypokalemic periodic paralysis attack after receiving a dexamethasone injection...
Source: Acta Medica: Hradec Kralove - August 13, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Melanoma Incidence in Czech Republic, the Relation between Histology, Body Site of Melanoma, and Duration of Lesions.
CONCLUSION: No change in the occurrence of melanoma and in age of melanoma during this period was found. The difference between men and women was not confirmed in histology, but the difference between men and women was confirmed in the body site of lesion and in the length of duration of lesion. No relation between the length of duration of lesions from which melanoma had originated and its histology was confirmed. The relation was confirmed between histology and body site of melanoma. The relation between the body site and the length of duration of previous lesions was confirmed also. The increasing occurrence of melanoma...
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Epidemiology of Melanoma in the Czech Republic in East Bohemia in the Period 2002-2017 and the Effect of the Annual Sunshine Exposure.
CONCLUSION: Our study confirmed that the number of patients with lentigo maligna and melanoma in situ had increased in East Bohemia region in the period of 2002-2017. The number of melanomas of nodular and superficial type does not increase. The total number of melanomas in this period does not increase either. No difference of the age of patients with melanoma nodulare, superficiale, lentigo maligna and melanoma in situ was confirmed. We confirmed no relation of the annual numbers of hours of sunshine to the number of melanoma and to the body site of melanoma. PMID: 32422111 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Experimental Evaluation of the Impact of Gadolinium Orthovanadate GdVO4:Eu3+ Nanoparticles on the Carrageenan-Induced Intestinal Inflammation.
CONCLUSION: No adverse effects were observed in rats orally exposed to VNPs at a dose of 20 μg/kg during two weeks. Using the experimental model of carrageenan-induced enteritis, it was demonstrated that VNPs at the dose used in our study did not affect the course of intestinal inflammation. PMID: 32422112 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Comparison of Subthreshold 532 nm Diode Micropulse Laser with Conventional Laser Photocoagulation in the Treatment of Non-Centre Involved Clinically Significant Diabetic Macular Edema.
Authors: Bougatsou P, Panagiotopoulou EK, Gkika M, Dardabounis D, Konstantinidis A, Sideroudi H, Perente I, Labiris G Abstract BACKGROUND: The aim of the study was to investigate the effect of the 532 nm (green) diode subthreshold micropulse laser (SML) in the treatment of non-centre involved clinically significant macular edema (CSME) in comparison to the conventional laser photocoagulation (CLP). METHODS: A total of 60 eyes of patients diagnosed with non-centre involved CSME were randomly divided into two groups. SML photocoagulation was performed in the first group (G1), while CLP in the second one (G2). Cen...
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Association of PAI-1 rs1799889 Polymorphism with Susceptibility to Ischemic Stroke: a Huge Meta-Analysis based on 44 Studies.
CONCLUSIONS: This meta-analysis result suggested that PAI-1 rs1799889 polymorphism was associated with an increased risk of ischemic stroke, especially in Asian and Mixed populations. PMID: 32422114 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Interdisciplinary Management of Visceral Artery Aneurysms and Visceral Artery Pseudoaneurysms.
Conclusions. The choice of the method of treating visceral artery aneurysms and visceral artery pseudoaneurysms depends on the location, size, anatomic features of the visceral arteries and the clinical course of the disease. Both endovascular and surgical treatment demonstrate good postoperative outcomes. Visceral ischemia is one of the most serious complications in the postoperative period, which can complicate both the diagnosis and the choice of treatment tactics. PMID: 32422115 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

An Alternative Treatment for Vaginal Cuff Wart: a Case Report.
We present the case of a 54 years old postmenopausal patient with a history of vaginal cuff wart and HPV persistence that we managed in our clinic for 6 months with a mix of curcumin, aloe vera, amla and other natural ingredients. As the patient was found to be intolerant to imiquimod (one of the most common conservative methods of treatment) we attempted the use of curcumin, which was applied to the area of the wart three times per week for 6 months. Both clinical and colposcopical improvement was noted in regular clinic visits with regression of the lesion. The outcome of this case encourages our view that curcumin shoul...
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Penile Degloving and Dorsal Dartos Flap Rotation Surgery in the Management of Severe Isolated Penile Torsion in a 6-Year-Old Boy.
Authors: Zvizdic Z, Milisic E, Vranic S Abstract Penile torsion is a rare congenital anomaly that is usually characterized by a counterclockwise rotation of the penile shaft or glans. Although several surgical techniques for its correction have been proposed, the consensus of choosing the most efficient technique remains controversial. Herein, we report our operational approach that successfully corrected a severe (>90 degrees) isolated penile torsion in the form of penile degloving and dorsal dartos flap rotation surgery. PMID: 32422117 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Pancreatic Adenocarcinoma: Epidemiology, Role of EUS in Diagnosis, Role of ERCP, Endoscopic Palliation.
Authors: Zar S, Kohoutová D, Bureš J Abstract Pancreatic cancer is the seventh leading cause of cancer deaths worldwide and is associated with a poor survival rate. The vast majority of pancreatic cancers are inoperable at the time of diagnosis. In the absence of metastatic disease, operability depends on the extent of local disease; in particular, the presence or absence of vascular and lymph node involvement. Adequate staging is vital in deciding an appropriate treatment plan. Cross sectional imaging including CT, MRI and PET-CT are commonly used for staging. However, EUS is a useful adjunct for acc...
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Association of IL-6 -174 G > C Polymorphism with Susceptibility to Colorectal Cancer and Gastric Cancer: a Systematic Review and Meta-Analysis.
CONCLUSION: The meta-analysis suggests that IL-6 -174G>C polymorphism was not significantly associated with the increased risk of CRC and GC in overall population. However, the results showed that IL-6 -174G>C polymorphism may be associated with risk of GC in Asians. Further studies including a larger sample size will be necessary to clarify these results. PMID: 32036845 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Robotic Management of Endometriosis: Discussion of Use, Criteria and Advantages: a Review of the Literature.
Discussion of Use, Criteria and Advantages: a Review of the Literature. Acta Medica (Hradec Kralove). 2019;62(4):147-149 Authors: Gkegkes ID, Iavazzo C, Iatrakis G, Iavazzo PE, Pechlivani F, Antoniou E, Bakalianou K Abstract Endometriosis is a very common benign condition affecting fertility and quality of life. Different methods, either definitive or fertility sparing are used for its management by using open, laparoscopic, and robotic techniques. This is a literature review presenting the role and the advantages of robotic surgery in endometriosis. Such a management is effective, safe, and feasible i...
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Genotype C/C 13910 of the Lactase Gene as a Risk Factor for the Formation of Insulin-Resistant Obesity in Children.
CONCLUSION: The presence of the C/C 13910 genotype of the lactase gene is the main factor formation of insulin resistance in children's obesity. What is known? The genotype C/C 13910 of the lactase gene as a risk factor for the chronic inflammatory process in the body. What is New? Genotype C/C 13910 of the lactase gene as a risk factor for insulin-resistant obesity in children. PMID: 32036847 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Primary Hyperparathyroidism Manifesting with Severe Hypercalcemia in a Nonagenarian Man: Pitfall of Common Imaging Techniques, Localization by 18F-Choline Positron Emission Tomography/Computed Tomography and Successful Management with Calcimimetics.
Authors: Foppiani L, Bottoni G, Piccardo A Abstract A nonagenarian hypertensive man with chronic kidney disease (CKD) was admitted to the emergency department for gastrointestinal symptoms and worsening symptoms of depression. Severe hypercalcemia (15.3 mg/dL) was found and he was hospitalized. Fluids, loop diuretics and glucocorticoids were administered intravenously, which partially reduced calcium levels over a few days and improved his clinical condition. PTH levels proved increased (306 pg/mL) and 25-OHD levels were reduced; primary hyperparathyroidism (PHPT) was diagnosed. Neck ultrasonography (USG) did not s...
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Mucopolysaccharidosis Type I in Children, a Forgotten Diagnosis Responsible for Undiagnosed Musculoskeletal Complaints: Report of Two Cases.
In this study we described two MPS patients with musculoskeletal complaints who were not diagnosed for a period of time. Although musculoskeletal manifestation are common in a variety of clinical conditions, their presence at low ages or co-occurrence of other manifestations (such as cardiac, respiratory, neurologic, etc.) in multiple systems should prompt evaluation of patients for MPS and other metabolic disorders. The rheumatologists' awareness on MPS should be promoted to achieve timely diagnosis and subsequent early treatment. PMID: 32036849 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Drug-induced Hemolysis in G6PD Deficiency: an Unusual Presentation of a Common Clinical Condition.
Authors: Padakanti A, Shenoy A, Kamath A, Chakrapani M Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency can present a diagnostic dilemma owing to the varying degrees of disease severity and the wide range of precipitating factors. Here, we report a case of a 56-year-old man who presented with signs and symptoms of heart failure and, during the course of treatment, developed intravascular hemolysis. On investigation, he was found to be G6PD deficient. Following discontinuation of the fixed-dose combination of isosorbide dinitrate and hydralazine, the clinical condition of the patient improved, and there ...
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Ultrashort ssDNA in Retinoblastoma Patients Blood Plasma Detected by a Novel High Resolution HPLC Technique: a Preliminary Report.
Authors: Ermakov KV, Bukhvostov AA, Vedenkin AS, Stovbun SV, Dvornikov AS, Kuznetsov DA Abstract A significant population of ultrashort (50-150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL-1), but not in plasma of healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve this task, a novel molecular size exclusion - anion exchange analytical technique was developed. Its applicability to diagnostics and oncogenesis research is quizzed here. PMID: 32036851 [PubMed - in process...
Source: Acta Medica: Hradec Kralove - February 11, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Foreign Bodies in the Abdominal Area: Review of the Literature.
Authors: Nastoulis E, Karakasi MV, Alexandri M, Thomaidis V, Fiska A, Pavlidis P Abstract The aim of this paper is to update and summarize the relevant literature on the anatomical localization, incidence, and diagnostic and therapeutic approaches to abdominal foreign bodies. A comprehensive review was carried out on recorded cases related to the presence of foreign bodies in the abdominal area throughout the literature. Moreover, the phenomenon was discussed in relation to different patient categories associated with childhood, mental or neurological illness, incarceration, and drug trafficking as well as sexual a...
Source: Acta Medica: Hradec Kralove - November 1, 2019 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Rhinogenic Orbital Inflammation - What Has Changed over the Past 50 Years?
Authors: Chrobok V, Pellant A, Mandysová P, Mejzlík J, Dědková J, Čelakovský P Abstract INTRODUCTION: The purpose of the study was to compare the incidence, diagnostics, and treatment of rhinogenic inflammatory complications over the past 50 years. MATERIAL AND METHODS: Retrospective study of 292 patients of ENT department, University hospital: Group A treated from 1966 to 1995, Group B treated from 1996 to 2015. RESULTS: Preseptal inflammation was the most common type (73% vs. 74%), followed by subperiosteal abscess (21% vs. 20%). Surgery was indicated in 35% vs. 37% of the pa...
Source: Acta Medica: Hradec Kralove - November 1, 2019 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Monocyte to Lymphocyte Ratio, Neutrophil to Lymphocyte Ratio, and Red Cell Distribution Width are the Associates with Gouty Arthritis.
In this study, we aimed to investigate whether they could be a predictive marker to the gout attack. MATERIAL AND METHODS: A hundred and ten gout patients (male/female, 86/24) and 90 (male/female, 64/26) age-, gender-, and body mass index-matched volunteer controls were included in the study. Blood samples were obtained in the intercritical and attack period of the patients. Hemogram, serum uric acid (SUA), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) values were studied. RESULTS: In the attack period NLR (p
Source: Acta Medica: Hradec Kralove - November 1, 2019 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Validation of the Slovakian version of Boston Carpal Tunnel Syndrome Questionnaire (BCTSQ).
Authors: Ulbrichtová R, Jakušová V, Švihrová V, Dvorštiaková B, Hudečková H Abstract INTRODUCTION: The most common occupational disease is carpal tunnel syndrome. The aim of this study was to translate and validate the Slovakian version of BCTSQ. METHODS: The original questionnaire was translated into the Slovakian language by two expert translators. Cronbach's alpha coefficient was used to analyze the internal consistency of the questionnaire. Construction validity was evaluated by using Pearson's correlation coefficient and Spearman's rank correlation. ...
Source: Acta Medica: Hradec Kralove - November 1, 2019 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Effect of Non-Surgical Periodontal Therapy on the Serum Sialic Acid Levels in Diabetic Patients with Periodontitis.
Authors: Suresh R, Jayachandran P, Fenol A, Biswas R, Krishnan S, Kumar KA, Divakar DD, Vellappally S Abstract Sialic acid (SA), a family of acetylated derivatives of neuraminic acid, an acute phase reactant by itself. It usually occurs as a terminal component at the non-reducing end of carbohydrate chains of glycoproteins and glycolipids. SA participates in multiple physiological functions, such as cell-to-cell interactions, cell migration and proliferation. Diabetes mellitus (DM) is a chronic metabolic disorder characterized by rise in blood glucose level. Periodontitis is a chronic inflammatory disease of the pe...
Source: Acta Medica: Hradec Kralove - November 1, 2019 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Fusiform Cervical Mass in a 6-Year Old Boy; Do not Forget the Thymic Cyst.
Authors: Patoulias I, Mitroudi M, Rafailidis V, Feidantsis T, Theocharides C, Kampouridou P, Patoulias D Abstract Cervical thymic cyst is a rare clinical entity, with approximately one hundred cases reported in the literature so far. The purpose of this case report is to highlight some certain features, along with an extensive research of the relevant literature. A 6-year-old boy was admitted to the Otorhinolaryngology Department due to the presence of a left-sided, painless, latero-cervical swelling, first observed by his parents 2 weeks ago. Physical examination revealed a painless, well-delineated mass, with no ...
Source: Acta Medica: Hradec Kralove - November 1, 2019 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Myelin Oligodendrocyte Glycoprotein Antibody Associated Transverse Myelitis.
Authors: Chroustová I, Mareš M, Ungermann L, Ehler E Abstract Antibodies against myelin oligodendrocyte glycoprotein cause inflammatory lesions of central myelin - in optic nerves, of the brainstem, and spinal cord. There are characteristic changes of CNS white matter, protein-cytological association in cerebrospinal fluid, MOG IgG antibodies, a very important differential diagnosis and a relatively mild course. PMID: 31663506 [PubMed - in process] (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - November 1, 2019 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research