The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
Acta Medica (Hradec Kralove). 2021;64(1):1-7. doi: 10.14712/18059694.2021.1.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoho...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Veronika Zub áňová Zuzana Červinková Otto Ku čera Vladim ír Palička Source Type: research

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study
Acta Medica (Hradec Kralove). 2021;64(1):8-14. doi: 10.14712/18059694.2021.2.ABSTRACTINTRODUCTION: Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in preterm neonates to prevent stress ulcers. The impact of the H2-blockers on the development of the necrotizing enterocolitis (NEC) in preterm infants is still controversial, particularly in the developing world.MATERIALS AND METHODS: One hundred twenty-two preterm infants were enrolled in the study. The multi...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Zlatan Zvizdic Emir Milisic Asmir Jonuzi Sabina Terzic Denisa Zvizdic Semir Vranic Source Type: research

Urban or Rural GP? In the Czech Republic It Is not just Distances That Matter
This article proposes a combined mixed methods approach to categorising GP practices. It looks not only at location but also at differences in the nature of the work that rural GPs perform. A data analysis was conducted of the largest health insurance company in the Czech Republic (5.9 million patients, 60% of the population, 100% coverage within the Czech Republic). We performed two data analyses, one for 2014-2015 and one for 2016, and divided GP practices into urban, intermediate, and rural groups (taking into account the OECD methodology). We compared groups in terms of the total annual cost in CZK per adult registered...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jan B ělobrádek Lud ěk Šídlo Kate řina Javorská David Halata Source Type: research

Diagnostic Value of Narrow Band Imaging in Visualization of Pathological Lesions in Larynx and Hypopharynx
Acta Medica (Hradec Kralove). 2021;64(1):22-28. doi: 10.14712/18059694.2021.4.ABSTRACTINTRODUCTION: Narrow Band Imaging (NBI) is an endoscopic optical imaging enhancement technology that improves the contrast of mucosal surface texture and enhances visualization of mucosal and submucosal vasculature. Due to its properties, it can visualize suspected malignant or precancerous lesions earlier than conventional white light endoscopy. The aim of this study was to analyze the benefit of NBI in visualization of precancerous and malignant lesions in preoperative and intraoperative diagnostics and correlation with histopathologic ...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jana Šatanková Lucia Stan íková Anna Švejdová Michal Černý Jan Laco Viktor Chrobok Source Type: research

Endoscopic Third Ventriculostomy for Obstructive Hydrocephalus and Ventriculocystostomy for Intraventricular Arachnoid Cysts
Acta Medica (Hradec Kralove). 2021;64(1):29-35. doi: 10.14712/18059694.2021.5.ABSTRACTOBJECTIVE: To evaluate and discuss the outcomes of a combination of ventriculocystostomy (VC) and endoscopic third ventriculostomy (ETV) for obstructive hydrocephalus (HCP) due to ventricular/cisternal arachnoid cysts, and only ETV for obstructive HCP due to different etiologies.METHODS: We retrospectively reviewed all 40 symptomatic patients (aged 4 months - 61 years) of obstructive HCP treated by ETV or VC+ETV during October 2014 - April 2019. VC+ETV was performed in 7 patients with intraventricular/cisternal arachnoid cyst and obstruct...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Bekir Akgun Sait Ozturk Omer Batu Hergunsel Fatih Serhat Erol Fatih Demir Source Type: research

A Case Series of Malignant Otitis Externa Mimicking Malignancy
Acta Medica (Hradec Kralove). 2021;64(1):36-41. doi: 10.14712/18059694.2021.6.ABSTRACTMalignant otitis externa is an inflammation of the external auditory canal with preceding osteomyelitis of the temporal bone and the adjacent structures that could be potentially lethal. Malignant otitis externa may present with cranial nerve involvements and massive spread of disease mimicking nasopharyngeal carcinoma or any other malignancies on imaging. Two elderly patients who presented with severe otalgia and significant facial nerve palsy and lower cranial nerve palsies showing extensive spread of disease are reported in this case s...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Vengathajalam Selvamalar Nik Adilah Nik Othman Mohd Khairi Daud Source Type: research

Ovotesticular Disorder of Sexual Development and Non-Palpable Testis
Acta Medica (Hradec Kralove). 2021;64(1):42-45. doi: 10.14712/18059694.2021.7.ABSTRACTDisorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual's genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. The external genital was matured as male and, in the left half of the scrotum, there was a testicle of...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Radek Štichhauer Anton ín Šafus David Neumann Ivo Nov ák Vladana Skutilov á Jan Laco Source Type: research

Rare Complication of Necrotizing Pancreatitis: Extension of Retroperitoneal Abscess into Femoral Region
Acta Medica (Hradec Kralove). 2021;64(1):46-49. doi: 10.14712/18059694.2021.8.ABSTRACTDistant abscesses are uncommon during the episode of acute pancreatitis (AP). However, these are possible sequalae of necrotizing pancreatitis and should be treated appropriately to prevent serious septic complications. We demonstrate a case of a 56-year-old male patient who presented with severe necrotizing pancreatitis and distant retroperitoneal abscess that reached femoral region and was detected on diagnostic imaging scans. Combination of surgical and supportive therapy was employed, and the patient recovered well with no permanent c...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Maja Karin Ante Bogut Ivan Romic Hrvoje Silovski Josip Figl Danijel Pravdic Mile Volaric Emil Babic Branko Bakula Renata Romic Source Type: research

Hirata's Disease: Rare Cause of Hypoglycaemia in Caucasian Male
We present the first case documented in the Czech Republic.PMID:33855960 | DOI:10.14712/18059694.2021.9 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Kate řina Žibřidová Barbora Havl ínová Eli ška Svobodová Pavel Žák Jan Čáp Filip Gabalec Source Type: research

Peritoneal Pseudocyst Causing Acute Abdomen as a Complication of Cronh's Disease
We present the case of a 30-year old male with known CD who presented with an acute abdomen because of a PP. PPs are developed as a complication caused in patients, suffering from mainly thee conditions. Firstly, PPs appear in patients with continuous ambulatory peritoneal dialysis (CAPD), they are also developed in patients with peritoneal trauma and finally in CD patients. Our case belongs to these three reported cases in our literature review, since it refers to a CD patient that developed PPs. He underwent emergency laparotomy and excision of the cyst, with good postoperative results. A literature review of 22 publicat...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Christos Damaskos Nikolaos Garmpis Anna Garmpi Aliki Liakea Dimitrios Mantas Source Type: research

Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature
In this study, the case of XGP developing in HSK in a young female patient was presented due to its rare incidence and the previously reported cases were reviewed, as well. The patient, who has end-stage renal disease and was under treatment, admitted to the clinic for preemptive kidney transplantation. Bilateral open en bloc nephrectomy was performed before the kidney transplantation. The histopathological examination of the specimen was reported as XGP. Eight months later, living-donor organ transplantation was performed to the patient with the kidney obtained from her father. XGP can present as a complication of HSK. Mo...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jamal Musayev Rashad Sholan Adalat Hasanov Rizvan Rustamov Source Type: research

Α Case of Severe Thyroid Eye Disease Treated with Tocilizumab
Acta Medica (Hradec Kralove). 2021;64(1):64-69. doi: 10.14712/18059694.2021.12.ABSTRACTThis is a case report describing a patient with severe thyroid eye disease complicated with dysthyroid optic neuropathy that was unresponsive to intravenous steroids and orbital radiotherapy but responded well to intravenous tocilizumab.PMID:33855963 | DOI:10.14712/18059694.2021.12 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Aysel Mehmet Eirini Kanella Panagiotopoulou Aristeidis Konstantinidis Charalampos Papagoras Panagiotis Skendros Doukas Dardabounis Athanasia Maria Mikropoulou Georgios Labiris Source Type: research

The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
Acta Medica (Hradec Kralove). 2021;64(1):1-7. doi: 10.14712/18059694.2021.1.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoho...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Veronika Zub áňová Zuzana Červinková Otto Ku čera Vladim ír Palička Source Type: research

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study
Acta Medica (Hradec Kralove). 2021;64(1):8-14. doi: 10.14712/18059694.2021.2.ABSTRACTINTRODUCTION: Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in preterm neonates to prevent stress ulcers. The impact of the H2-blockers on the development of the necrotizing enterocolitis (NEC) in preterm infants is still controversial, particularly in the developing world.MATERIALS AND METHODS: One hundred twenty-two preterm infants were enrolled in the study. The multi...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Zlatan Zvizdic Emir Milisic Asmir Jonuzi Sabina Terzic Denisa Zvizdic Semir Vranic Source Type: research

Urban or Rural GP? In the Czech Republic It Is not just Distances That Matter
This article proposes a combined mixed methods approach to categorising GP practices. It looks not only at location but also at differences in the nature of the work that rural GPs perform. A data analysis was conducted of the largest health insurance company in the Czech Republic (5.9 million patients, 60% of the population, 100% coverage within the Czech Republic). We performed two data analyses, one for 2014-2015 and one for 2016, and divided GP practices into urban, intermediate, and rural groups (taking into account the OECD methodology). We compared groups in terms of the total annual cost in CZK per adult registered...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jan B ělobrádek Lud ěk Šídlo Kate řina Javorská David Halata Source Type: research

Diagnostic Value of Narrow Band Imaging in Visualization of Pathological Lesions in Larynx and Hypopharynx
Acta Medica (Hradec Kralove). 2021;64(1):22-28. doi: 10.14712/18059694.2021.4.ABSTRACTINTRODUCTION: Narrow Band Imaging (NBI) is an endoscopic optical imaging enhancement technology that improves the contrast of mucosal surface texture and enhances visualization of mucosal and submucosal vasculature. Due to its properties, it can visualize suspected malignant or precancerous lesions earlier than conventional white light endoscopy. The aim of this study was to analyze the benefit of NBI in visualization of precancerous and malignant lesions in preoperative and intraoperative diagnostics and correlation with histopathologic ...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jana Šatanková Lucia Stan íková Anna Švejdová Michal Černý Jan Laco Viktor Chrobok Source Type: research

Endoscopic Third Ventriculostomy for Obstructive Hydrocephalus and Ventriculocystostomy for Intraventricular Arachnoid Cysts
Acta Medica (Hradec Kralove). 2021;64(1):29-35. doi: 10.14712/18059694.2021.5.ABSTRACTOBJECTIVE: To evaluate and discuss the outcomes of a combination of ventriculocystostomy (VC) and endoscopic third ventriculostomy (ETV) for obstructive hydrocephalus (HCP) due to ventricular/cisternal arachnoid cysts, and only ETV for obstructive HCP due to different etiologies.METHODS: We retrospectively reviewed all 40 symptomatic patients (aged 4 months - 61 years) of obstructive HCP treated by ETV or VC+ETV during October 2014 - April 2019. VC+ETV was performed in 7 patients with intraventricular/cisternal arachnoid cyst and obstruct...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Bekir Akgun Sait Ozturk Omer Batu Hergunsel Fatih Serhat Erol Fatih Demir Source Type: research

A Case Series of Malignant Otitis Externa Mimicking Malignancy
Acta Medica (Hradec Kralove). 2021;64(1):36-41. doi: 10.14712/18059694.2021.6.ABSTRACTMalignant otitis externa is an inflammation of the external auditory canal with preceding osteomyelitis of the temporal bone and the adjacent structures that could be potentially lethal. Malignant otitis externa may present with cranial nerve involvements and massive spread of disease mimicking nasopharyngeal carcinoma or any other malignancies on imaging. Two elderly patients who presented with severe otalgia and significant facial nerve palsy and lower cranial nerve palsies showing extensive spread of disease are reported in this case s...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Vengathajalam Selvamalar Nik Adilah Nik Othman Mohd Khairi Daud Source Type: research

Ovotesticular Disorder of Sexual Development and Non-Palpable Testis
Acta Medica (Hradec Kralove). 2021;64(1):42-45. doi: 10.14712/18059694.2021.7.ABSTRACTDisorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual's genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. The external genital was matured as male and, in the left half of the scrotum, there was a testicle of...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Radek Štichhauer Anton ín Šafus David Neumann Ivo Nov ák Vladana Skutilov á Jan Laco Source Type: research

Rare Complication of Necrotizing Pancreatitis: Extension of Retroperitoneal Abscess into Femoral Region
Acta Medica (Hradec Kralove). 2021;64(1):46-49. doi: 10.14712/18059694.2021.8.ABSTRACTDistant abscesses are uncommon during the episode of acute pancreatitis (AP). However, these are possible sequalae of necrotizing pancreatitis and should be treated appropriately to prevent serious septic complications. We demonstrate a case of a 56-year-old male patient who presented with severe necrotizing pancreatitis and distant retroperitoneal abscess that reached femoral region and was detected on diagnostic imaging scans. Combination of surgical and supportive therapy was employed, and the patient recovered well with no permanent c...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Maja Karin Ante Bogut Ivan Romic Hrvoje Silovski Josip Figl Danijel Pravdic Mile Volaric Emil Babic Branko Bakula Renata Romic Source Type: research

Hirata's Disease: Rare Cause of Hypoglycaemia in Caucasian Male
We present the first case documented in the Czech Republic.PMID:33855960 | DOI:10.14712/18059694.2021.9 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Kate řina Žibřidová Barbora Havl ínová Eli ška Svobodová Pavel Žák Jan Čáp Filip Gabalec Source Type: research

Peritoneal Pseudocyst Causing Acute Abdomen as a Complication of Cronh's Disease
We present the case of a 30-year old male with known CD who presented with an acute abdomen because of a PP. PPs are developed as a complication caused in patients, suffering from mainly thee conditions. Firstly, PPs appear in patients with continuous ambulatory peritoneal dialysis (CAPD), they are also developed in patients with peritoneal trauma and finally in CD patients. Our case belongs to these three reported cases in our literature review, since it refers to a CD patient that developed PPs. He underwent emergency laparotomy and excision of the cyst, with good postoperative results. A literature review of 22 publicat...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Christos Damaskos Nikolaos Garmpis Anna Garmpi Aliki Liakea Dimitrios Mantas Source Type: research

Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature
In this study, the case of XGP developing in HSK in a young female patient was presented due to its rare incidence and the previously reported cases were reviewed, as well. The patient, who has end-stage renal disease and was under treatment, admitted to the clinic for preemptive kidney transplantation. Bilateral open en bloc nephrectomy was performed before the kidney transplantation. The histopathological examination of the specimen was reported as XGP. Eight months later, living-donor organ transplantation was performed to the patient with the kidney obtained from her father. XGP can present as a complication of HSK. Mo...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jamal Musayev Rashad Sholan Adalat Hasanov Rizvan Rustamov Source Type: research

Α Case of Severe Thyroid Eye Disease Treated with Tocilizumab
Acta Medica (Hradec Kralove). 2021;64(1):64-69. doi: 10.14712/18059694.2021.12.ABSTRACTThis is a case report describing a patient with severe thyroid eye disease complicated with dysthyroid optic neuropathy that was unresponsive to intravenous steroids and orbital radiotherapy but responded well to intravenous tocilizumab.PMID:33855963 | DOI:10.14712/18059694.2021.12 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Aysel Mehmet Eirini Kanella Panagiotopoulou Aristeidis Konstantinidis Charalampos Papagoras Panagiotis Skendros Doukas Dardabounis Athanasia Maria Mikropoulou Georgios Labiris Source Type: research

The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
Acta Medica (Hradec Kralove). 2021;64(1):1-7. doi: 10.14712/18059694.2021.1.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoho...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Veronika Zub áňová Zuzana Červinková Otto Ku čera Vladim ír Palička Source Type: research

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study
Acta Medica (Hradec Kralove). 2021;64(1):8-14. doi: 10.14712/18059694.2021.2.ABSTRACTINTRODUCTION: Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in preterm neonates to prevent stress ulcers. The impact of the H2-blockers on the development of the necrotizing enterocolitis (NEC) in preterm infants is still controversial, particularly in the developing world.MATERIALS AND METHODS: One hundred twenty-two preterm infants were enrolled in the study. The multi...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Zlatan Zvizdic Emir Milisic Asmir Jonuzi Sabina Terzic Denisa Zvizdic Semir Vranic Source Type: research

Urban or Rural GP? In the Czech Republic It Is not just Distances That Matter
This article proposes a combined mixed methods approach to categorising GP practices. It looks not only at location but also at differences in the nature of the work that rural GPs perform. A data analysis was conducted of the largest health insurance company in the Czech Republic (5.9 million patients, 60% of the population, 100% coverage within the Czech Republic). We performed two data analyses, one for 2014-2015 and one for 2016, and divided GP practices into urban, intermediate, and rural groups (taking into account the OECD methodology). We compared groups in terms of the total annual cost in CZK per adult registered...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jan B ělobrádek Lud ěk Šídlo Kate řina Javorská David Halata Source Type: research

Diagnostic Value of Narrow Band Imaging in Visualization of Pathological Lesions in Larynx and Hypopharynx
Acta Medica (Hradec Kralove). 2021;64(1):22-28. doi: 10.14712/18059694.2021.4.ABSTRACTINTRODUCTION: Narrow Band Imaging (NBI) is an endoscopic optical imaging enhancement technology that improves the contrast of mucosal surface texture and enhances visualization of mucosal and submucosal vasculature. Due to its properties, it can visualize suspected malignant or precancerous lesions earlier than conventional white light endoscopy. The aim of this study was to analyze the benefit of NBI in visualization of precancerous and malignant lesions in preoperative and intraoperative diagnostics and correlation with histopathologic ...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jana Šatanková Lucia Stan íková Anna Švejdová Michal Černý Jan Laco Viktor Chrobok Source Type: research

Endoscopic Third Ventriculostomy for Obstructive Hydrocephalus and Ventriculocystostomy for Intraventricular Arachnoid Cysts
Acta Medica (Hradec Kralove). 2021;64(1):29-35. doi: 10.14712/18059694.2021.5.ABSTRACTOBJECTIVE: To evaluate and discuss the outcomes of a combination of ventriculocystostomy (VC) and endoscopic third ventriculostomy (ETV) for obstructive hydrocephalus (HCP) due to ventricular/cisternal arachnoid cysts, and only ETV for obstructive HCP due to different etiologies.METHODS: We retrospectively reviewed all 40 symptomatic patients (aged 4 months - 61 years) of obstructive HCP treated by ETV or VC+ETV during October 2014 - April 2019. VC+ETV was performed in 7 patients with intraventricular/cisternal arachnoid cyst and obstruct...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Bekir Akgun Sait Ozturk Omer Batu Hergunsel Fatih Serhat Erol Fatih Demir Source Type: research

A Case Series of Malignant Otitis Externa Mimicking Malignancy
Acta Medica (Hradec Kralove). 2021;64(1):36-41. doi: 10.14712/18059694.2021.6.ABSTRACTMalignant otitis externa is an inflammation of the external auditory canal with preceding osteomyelitis of the temporal bone and the adjacent structures that could be potentially lethal. Malignant otitis externa may present with cranial nerve involvements and massive spread of disease mimicking nasopharyngeal carcinoma or any other malignancies on imaging. Two elderly patients who presented with severe otalgia and significant facial nerve palsy and lower cranial nerve palsies showing extensive spread of disease are reported in this case s...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Vengathajalam Selvamalar Nik Adilah Nik Othman Mohd Khairi Daud Source Type: research

Ovotesticular Disorder of Sexual Development and Non-Palpable Testis
Acta Medica (Hradec Kralove). 2021;64(1):42-45. doi: 10.14712/18059694.2021.7.ABSTRACTDisorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual's genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. The external genital was matured as male and, in the left half of the scrotum, there was a testicle of...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Radek Štichhauer Anton ín Šafus David Neumann Ivo Nov ák Vladana Skutilov á Jan Laco Source Type: research

Rare Complication of Necrotizing Pancreatitis: Extension of Retroperitoneal Abscess into Femoral Region
Acta Medica (Hradec Kralove). 2021;64(1):46-49. doi: 10.14712/18059694.2021.8.ABSTRACTDistant abscesses are uncommon during the episode of acute pancreatitis (AP). However, these are possible sequalae of necrotizing pancreatitis and should be treated appropriately to prevent serious septic complications. We demonstrate a case of a 56-year-old male patient who presented with severe necrotizing pancreatitis and distant retroperitoneal abscess that reached femoral region and was detected on diagnostic imaging scans. Combination of surgical and supportive therapy was employed, and the patient recovered well with no permanent c...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Maja Karin Ante Bogut Ivan Romic Hrvoje Silovski Josip Figl Danijel Pravdic Mile Volaric Emil Babic Branko Bakula Renata Romic Source Type: research

Hirata's Disease: Rare Cause of Hypoglycaemia in Caucasian Male
We present the first case documented in the Czech Republic.PMID:33855960 | DOI:10.14712/18059694.2021.9 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Kate řina Žibřidová Barbora Havl ínová Eli ška Svobodová Pavel Žák Jan Čáp Filip Gabalec Source Type: research

Peritoneal Pseudocyst Causing Acute Abdomen as a Complication of Cronh's Disease
We present the case of a 30-year old male with known CD who presented with an acute abdomen because of a PP. PPs are developed as a complication caused in patients, suffering from mainly thee conditions. Firstly, PPs appear in patients with continuous ambulatory peritoneal dialysis (CAPD), they are also developed in patients with peritoneal trauma and finally in CD patients. Our case belongs to these three reported cases in our literature review, since it refers to a CD patient that developed PPs. He underwent emergency laparotomy and excision of the cyst, with good postoperative results. A literature review of 22 publicat...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Christos Damaskos Nikolaos Garmpis Anna Garmpi Aliki Liakea Dimitrios Mantas Source Type: research

Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature
In this study, the case of XGP developing in HSK in a young female patient was presented due to its rare incidence and the previously reported cases were reviewed, as well. The patient, who has end-stage renal disease and was under treatment, admitted to the clinic for preemptive kidney transplantation. Bilateral open en bloc nephrectomy was performed before the kidney transplantation. The histopathological examination of the specimen was reported as XGP. Eight months later, living-donor organ transplantation was performed to the patient with the kidney obtained from her father. XGP can present as a complication of HSK. Mo...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jamal Musayev Rashad Sholan Adalat Hasanov Rizvan Rustamov Source Type: research

Α Case of Severe Thyroid Eye Disease Treated with Tocilizumab
Acta Medica (Hradec Kralove). 2021;64(1):64-69. doi: 10.14712/18059694.2021.12.ABSTRACTThis is a case report describing a patient with severe thyroid eye disease complicated with dysthyroid optic neuropathy that was unresponsive to intravenous steroids and orbital radiotherapy but responded well to intravenous tocilizumab.PMID:33855963 | DOI:10.14712/18059694.2021.12 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Aysel Mehmet Eirini Kanella Panagiotopoulou Aristeidis Konstantinidis Charalampos Papagoras Panagiotis Skendros Doukas Dardabounis Athanasia Maria Mikropoulou Georgios Labiris Source Type: research

The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
Acta Medica (Hradec Kralove). 2021;64(1):1-7. doi: 10.14712/18059694.2021.1.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoho...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Veronika Zub áňová Zuzana Červinková Otto Ku čera Vladim ír Palička Source Type: research

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study
Acta Medica (Hradec Kralove). 2021;64(1):8-14. doi: 10.14712/18059694.2021.2.ABSTRACTINTRODUCTION: Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in preterm neonates to prevent stress ulcers. The impact of the H2-blockers on the development of the necrotizing enterocolitis (NEC) in preterm infants is still controversial, particularly in the developing world.MATERIALS AND METHODS: One hundred twenty-two preterm infants were enrolled in the study. The multi...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Zlatan Zvizdic Emir Milisic Asmir Jonuzi Sabina Terzic Denisa Zvizdic Semir Vranic Source Type: research

Urban or Rural GP? In the Czech Republic It Is not just Distances That Matter
This article proposes a combined mixed methods approach to categorising GP practices. It looks not only at location but also at differences in the nature of the work that rural GPs perform. A data analysis was conducted of the largest health insurance company in the Czech Republic (5.9 million patients, 60% of the population, 100% coverage within the Czech Republic). We performed two data analyses, one for 2014-2015 and one for 2016, and divided GP practices into urban, intermediate, and rural groups (taking into account the OECD methodology). We compared groups in terms of the total annual cost in CZK per adult registered...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jan B ělobrádek Lud ěk Šídlo Kate řina Javorská David Halata Source Type: research

Diagnostic Value of Narrow Band Imaging in Visualization of Pathological Lesions in Larynx and Hypopharynx
Acta Medica (Hradec Kralove). 2021;64(1):22-28. doi: 10.14712/18059694.2021.4.ABSTRACTINTRODUCTION: Narrow Band Imaging (NBI) is an endoscopic optical imaging enhancement technology that improves the contrast of mucosal surface texture and enhances visualization of mucosal and submucosal vasculature. Due to its properties, it can visualize suspected malignant or precancerous lesions earlier than conventional white light endoscopy. The aim of this study was to analyze the benefit of NBI in visualization of precancerous and malignant lesions in preoperative and intraoperative diagnostics and correlation with histopathologic ...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jana Šatanková Lucia Stan íková Anna Švejdová Michal Černý Jan Laco Viktor Chrobok Source Type: research

Endoscopic Third Ventriculostomy for Obstructive Hydrocephalus and Ventriculocystostomy for Intraventricular Arachnoid Cysts
Acta Medica (Hradec Kralove). 2021;64(1):29-35. doi: 10.14712/18059694.2021.5.ABSTRACTOBJECTIVE: To evaluate and discuss the outcomes of a combination of ventriculocystostomy (VC) and endoscopic third ventriculostomy (ETV) for obstructive hydrocephalus (HCP) due to ventricular/cisternal arachnoid cysts, and only ETV for obstructive HCP due to different etiologies.METHODS: We retrospectively reviewed all 40 symptomatic patients (aged 4 months - 61 years) of obstructive HCP treated by ETV or VC+ETV during October 2014 - April 2019. VC+ETV was performed in 7 patients with intraventricular/cisternal arachnoid cyst and obstruct...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Bekir Akgun Sait Ozturk Omer Batu Hergunsel Fatih Serhat Erol Fatih Demir Source Type: research

A Case Series of Malignant Otitis Externa Mimicking Malignancy
Acta Medica (Hradec Kralove). 2021;64(1):36-41. doi: 10.14712/18059694.2021.6.ABSTRACTMalignant otitis externa is an inflammation of the external auditory canal with preceding osteomyelitis of the temporal bone and the adjacent structures that could be potentially lethal. Malignant otitis externa may present with cranial nerve involvements and massive spread of disease mimicking nasopharyngeal carcinoma or any other malignancies on imaging. Two elderly patients who presented with severe otalgia and significant facial nerve palsy and lower cranial nerve palsies showing extensive spread of disease are reported in this case s...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Vengathajalam Selvamalar Nik Adilah Nik Othman Mohd Khairi Daud Source Type: research

Ovotesticular Disorder of Sexual Development and Non-Palpable Testis
Acta Medica (Hradec Kralove). 2021;64(1):42-45. doi: 10.14712/18059694.2021.7.ABSTRACTDisorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual's genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. The external genital was matured as male and, in the left half of the scrotum, there was a testicle of...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Radek Štichhauer Anton ín Šafus David Neumann Ivo Nov ák Vladana Skutilov á Jan Laco Source Type: research

Rare Complication of Necrotizing Pancreatitis: Extension of Retroperitoneal Abscess into Femoral Region
Acta Medica (Hradec Kralove). 2021;64(1):46-49. doi: 10.14712/18059694.2021.8.ABSTRACTDistant abscesses are uncommon during the episode of acute pancreatitis (AP). However, these are possible sequalae of necrotizing pancreatitis and should be treated appropriately to prevent serious septic complications. We demonstrate a case of a 56-year-old male patient who presented with severe necrotizing pancreatitis and distant retroperitoneal abscess that reached femoral region and was detected on diagnostic imaging scans. Combination of surgical and supportive therapy was employed, and the patient recovered well with no permanent c...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Maja Karin Ante Bogut Ivan Romic Hrvoje Silovski Josip Figl Danijel Pravdic Mile Volaric Emil Babic Branko Bakula Renata Romic Source Type: research

Hirata's Disease: Rare Cause of Hypoglycaemia in Caucasian Male
We present the first case documented in the Czech Republic.PMID:33855960 | DOI:10.14712/18059694.2021.9 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Kate řina Žibřidová Barbora Havl ínová Eli ška Svobodová Pavel Žák Jan Čáp Filip Gabalec Source Type: research

Peritoneal Pseudocyst Causing Acute Abdomen as a Complication of Cronh's Disease
We present the case of a 30-year old male with known CD who presented with an acute abdomen because of a PP. PPs are developed as a complication caused in patients, suffering from mainly thee conditions. Firstly, PPs appear in patients with continuous ambulatory peritoneal dialysis (CAPD), they are also developed in patients with peritoneal trauma and finally in CD patients. Our case belongs to these three reported cases in our literature review, since it refers to a CD patient that developed PPs. He underwent emergency laparotomy and excision of the cyst, with good postoperative results. A literature review of 22 publicat...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Christos Damaskos Nikolaos Garmpis Anna Garmpi Aliki Liakea Dimitrios Mantas Source Type: research

Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature
In this study, the case of XGP developing in HSK in a young female patient was presented due to its rare incidence and the previously reported cases were reviewed, as well. The patient, who has end-stage renal disease and was under treatment, admitted to the clinic for preemptive kidney transplantation. Bilateral open en bloc nephrectomy was performed before the kidney transplantation. The histopathological examination of the specimen was reported as XGP. Eight months later, living-donor organ transplantation was performed to the patient with the kidney obtained from her father. XGP can present as a complication of HSK. Mo...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Jamal Musayev Rashad Sholan Adalat Hasanov Rizvan Rustamov Source Type: research

Α Case of Severe Thyroid Eye Disease Treated with Tocilizumab
Acta Medica (Hradec Kralove). 2021;64(1):64-69. doi: 10.14712/18059694.2021.12.ABSTRACTThis is a case report describing a patient with severe thyroid eye disease complicated with dysthyroid optic neuropathy that was unresponsive to intravenous steroids and orbital radiotherapy but responded well to intravenous tocilizumab.PMID:33855963 | DOI:10.14712/18059694.2021.12 (Source: Acta Medica: Hradec Kralove)
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Aysel Mehmet Eirini Kanella Panagiotopoulou Aristeidis Konstantinidis Charalampos Papagoras Panagiotis Skendros Doukas Dardabounis Athanasia Maria Mikropoulou Georgios Labiris Source Type: research

The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
Acta Medica (Hradec Kralove). 2021;64(1):1-7. doi: 10.14712/18059694.2021.1.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoho...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Veronika Zub áňová Zuzana Červinková Otto Ku čera Vladim ír Palička Source Type: research

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study
Acta Medica (Hradec Kralove). 2021;64(1):8-14. doi: 10.14712/18059694.2021.2.ABSTRACTINTRODUCTION: Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in preterm neonates to prevent stress ulcers. The impact of the H2-blockers on the development of the necrotizing enterocolitis (NEC) in preterm infants is still controversial, particularly in the developing world.MATERIALS AND METHODS: One hundred twenty-two preterm infants were enrolled in the study. The multi...
Source: Acta Medica: Hradec Kralove - April 15, 2021 Category: General Medicine Authors: Zlatan Zvizdic Emir Milisic Asmir Jonuzi Sabina Terzic Denisa Zvizdic Semir Vranic Source Type: research