A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma
In conclusion, this study highlights a novel co-targeting strategy using miR-105-5p mimics, MALAT-1, CCAT-1 and H19 siRNAs to efficiently hampers the immune checkpoints; PD-L1/PD-1 and CD155/TIGIT immune evasion properties in HCC.PMID:38631259 | DOI:10.1016/j.tranon.2024.101961 (Source: Translational Oncology)
Source: Translational Oncology - April 17, 2024 Category: Cancer & Oncology Authors: Reem A Assal Noha M Elemam Radwa Y Mekky Abdelrahman A Attia Aya Hesham Soliman Asmaa Ibrahim Gomaa Eleni K Efthimiadou Maria Braoudaki Sherif Ashraf Fahmy Rana A Youness Source Type: research
Genes, Vol. 15, Pages 503: Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus
night
Post-transplant diabetes mellitus (PTDM) is a common complication of solid organ transplantation. PTDM prevalence varies due to different diabetes definitions. Consensus guidelines for the diagnosis of PTDM have been published based on random blood glucose levels, glycated hemoglobin (HbA1c), and oral glucose tolerance test (OGTT). The task of diagnosing PTDM continues to pose challenges, given the potential for diabetes to manifest at different time points after transplantation, thus demanding constant clinical vigilance and repeated testing. Interpreting HbA1c levels can be challenging after renal transplantati...
Source: Genes - April 17, 2024 Category: Genetics & Stem Cells Authors: Zeinab Abdelrahman Alexander Peter Maxwell Amy Jayne McKnight Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1513: Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Manasi Das Deepak Kumar Consuelo Sauceda Alexis Oberg Lesley G. Ellies Liping Zeng Lily J. Jih Isabel G. Newton Nicholas J. G. Webster Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1521: Hepatitis-C-Related Hepatocellular Carcinoma, Still a Relevant Etiology beyond a Hepatitis C Infection Cure
Conclusions: Whereas accessibility to antiviral therapy is granted, HCV infection remains as one of the main HCC etiologies. MASLD-related HCC, although growing globally, is not as relevant in our area. Strong public policies need to be implemented to prevent alcohol consumption, the main etiology of liver disease and liver cancer. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Elena Vargas-Accarino M ónica Higuera Mar ía Buti Beatriz M ínguez Tags: Article Source Type: research
Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation
ConclusionsThe quantitative measurement system for M2BPGi depends on liver fibrosis and inflammation, regardless of etiology. Liver inflammation complicates the interpretation of M2BPGi-Qt results when assessing the fibrosis stage. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 16, 2024 Category: Gastroenterology Source Type: research
Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells
High expression of phosphatidylinositol 4-kinase III alpha (PI4KIII α) correlates with poor survival rates in patients with hepatocellular carcinoma (HCC). In addition, Hepatitis C virus (HCV) infections activate PI4KIIIα and contribute to HCC progression. We aimed at mechanistically understanding the impact of PI4KIIIα on the progression of liver cancer and the potential contribution of HCV in this process. (Source: Gastroenterology)
Source: Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Cong Si Tran, Julia Kersten, Jingyi Yan, Marco Breinig, Thorben Huth, Tanja Poth, Ombretta Colasanti, Tobias Riedl, Suzanne Faure-Dupuy, Stefan Diehl, Lieven Verhoye, Teng-Feng Li, Marit Lingemann, Philipp Schult, Gustaf Ahl én, Lars Frelin, Florian Küh Tags: Basic and Translational - Liver Source Type: research
How robust are estimates of key parameters in standard viral dynamic models?
by Carolin Zitzmann, Ruian Ke, Ruy M. Ribeiro, Alan S. Perelson
Mathematical models of viral infection have been developed, fitted to data, and provide insight into disease pathogenesis for multiple agents that cause chronic infection, including HIV, hepatitis C, and B virus. However, for agents that cause acute infections or during the acute stage of agents that cause chronic infections, viral load data are often collected after symptoms develop, usually around or after the peak viral load. Consequently, we frequently lack data in the initial phase of viral growth, i.e., when pre-symptomatic transmission events occur. Mi...
Source: PLoS Computational Biology - April 16, 2024 Category: Biology Authors: Carolin Zitzmann Source Type: research
In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches
This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research
Molecular characterization of the nonstructural 5A (NS5A) region of hepatitis C virus in Thai blood donors
In conclusion, NS5A RASs at amino acid positions 30, 62, 54, 58, and 98 are present within HCV genotypes 3a and 1. While keeping in mind that additional information was not available on the anonymous blood donors tested in this study, these findings can contribute to understand the NS5A mutation. Further study with known patients under drug treatment is recommended.PMID:38619622 | DOI:10.1007/s00203-024-03950-4 (Source: Archives of Microbiology)
Source: Archives of Microbiology - April 15, 2024 Category: Microbiology Authors: Anchalee Sistayanarain Duangkamol Kunthalert Source Type: research
In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches
This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research
In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches
This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research
Molecular characterization of the nonstructural 5A (NS5A) region of hepatitis C virus in Thai blood donors
In conclusion, NS5A RASs at amino acid positions 30, 62, 54, 58, and 98 are present within HCV genotypes 3a and 1. While keeping in mind that additional information was not available on the anonymous blood donors tested in this study, these findings can contribute to understand the NS5A mutation. Further study with known patients under drug treatment is recommended.PMID:38619622 | DOI:10.1007/s00203-024-03950-4 (Source: Archives of Microbiology)
Source: Archives of Microbiology - April 15, 2024 Category: Microbiology Authors: Anchalee Sistayanarain Duangkamol Kunthalert Source Type: research
Cancers, Vol. 16, Pages 1505: The Role of Hepatitis Viruses as Drivers of Hepatocancerogenesis
a Morisco
Recently, metabolic associated steatotic liver disease (MASLD) became the leading cause of chronic liver disease worldwide and one of the most frequent causes of hepatocellular carcinoma (HCC). Nonetheless, in this epidemiological trend, viral hepatitis remains the major driver in hepatic carcinogenesis. Globally, hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma, with an overall attributable risk of approximately 40%, followed by hepatitis C virus (HCV), which accounts for 28–30% of cases, with significant geographic variations between the Eastern and Western world. Consi...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Mario Capasso Valentina Cossiga Maria Guarino Luisa Ranieri Filomena Morisco Tags: Review Source Type: research
Hepatitis C virus core antigen: A diagnostic and treatment monitoring marker of hepatitis C virus in Indian population
ConclusionsHCV core Ag assay is a cost-effective, practically feasible substitute of HCV RTPCR viral load assay for diagnosis as well as long duration treatment monitoring of hepatitis C infection in resource-limited settings.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Source Type: research
Elevation of S2-bound α1-acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma
J Viral Hepat. 2024 Apr 12. doi: 10.1111/jvh.13943. Online ahead of print.ABSTRACTThere is an urgent need for new high-quality markers for the early detection of hepatocellular carcinoma (HCC). Åström et al. suggested that S2-bound α1-acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2-bound AGP in the early detection of HCC. In a retrospective case-control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct-acting antiviral agents (n = 93), we measured S2-bound AGP using the HepaCheC® ELISA kit (Glycobond AB, Linköping,...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Carlos Oltmanns Birgit Bremer Laura Kusche Per St ål Robin Zenlander Jan Tauwaldt Ingvar Ryd én Peter P åhlsson Markus Cornberg Heiner Wedemeyer Source Type: research
