Doxycycline as a Potential MMP-1 Inhibitor for the Treatment of Spondylitis Tuberculosis: A Study in Rabbit Model
CONCLUSION: Our study demonstrated the potential of doxycycline as an adjunctive treatment in spondylitis TB. However, limitations remain regarding the differences in the pathogenesis and virulence of Mycobacterium tuberculosis between rabbit and human systems, sample size, and the dose-dependent effect of doxycycline. Further studies are needed to address these issues.PMID:36743515 | PMC:PMC9897918 | DOI:10.1155/2023/7421325 (Source: Biomed Res)
Source: Biomed Res - February 6, 2023 Category: Research Authors: Otman Siregar Aznan Lelo Ahmad Jabir Rahyussalim Syafruddin Ilyas None Benny Tri Kurniawati Yohanes Augustinus None Hendra Tommy Mandagi Muhammad Luqman Labib Zufar Irfan Fathurrahman Source Type: research
Doxycycline as a Potential MMP-1 Inhibitor for the Treatment of Spondylitis Tuberculosis: A Study in Rabbit Model
CONCLUSION: Our study demonstrated the potential of doxycycline as an adjunctive treatment in spondylitis TB. However, limitations remain regarding the differences in the pathogenesis and virulence of Mycobacterium tuberculosis between rabbit and human systems, sample size, and the dose-dependent effect of doxycycline. Further studies are needed to address these issues.PMID:36743515 | PMC:PMC9897918 | DOI:10.1155/2023/7421325 (Source: Biomed Res)
Source: Biomed Res - February 6, 2023 Category: Research Authors: Otman Siregar Aznan Lelo Ahmad Jabir Rahyussalim Syafruddin Ilyas None Benny Tri Kurniawati Yohanes Augustinus None Hendra Tommy Mandagi Muhammad Luqman Labib Zufar Irfan Fathurrahman Source Type: research
Doxycycline as a Potential MMP-1 Inhibitor for the Treatment of Spondylitis Tuberculosis: A Study in Rabbit Model
CONCLUSION: Our study demonstrated the potential of doxycycline as an adjunctive treatment in spondylitis TB. However, limitations remain regarding the differences in the pathogenesis and virulence of Mycobacterium tuberculosis between rabbit and human systems, sample size, and the dose-dependent effect of doxycycline. Further studies are needed to address these issues.PMID:36743515 | PMC:PMC9897918 | DOI:10.1155/2023/7421325 (Source: Cell Research)
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Otman Siregar Aznan Lelo Ahmad Jabir Rahyussalim Syafruddin Ilyas None Benny Tri Kurniawati Yohanes Augustinus None Hendra Tommy Mandagi Muhammad Luqman Labib Zufar Irfan Fathurrahman Source Type: research
Hendra Virus
Hendra virus (HeV) emerged as a zoonotic pathogen in the 1990s, causing low morbidity but high mortality in humans and horses. Pteropid bats are the natural reservoir of HeV and other important zoonotic viruses such as Nipah and Ebola viruses. Equivac HeV, manufactured by Zoetis (Parkville, Victoria, Australia), is the only commercially available vaccine for horses. There is no commercial vaccine for humans. The epidemiology, clinical features, pathology, diagnosis, management, and prevention of HeV will be reviewed. (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - February 1, 2023 Category: Veterinary Research Authors: Xueli Wang, Jessica C. Wise, Allison J. Stewart Source Type: research
Transmission routes of neuropathogenic pathogens-Possible mechanisms of neuroinvasion
Nervenarzt. 2023 Jan 23. doi: 10.1007/s00115-022-01428-6. Online ahead of print.ABSTRACTDespite natural protective barriers, many human pathogens can penetrate the nervous system. The pathogens have developed sophisticated mechanisms to overturn the privileged immune status of the nervous system. The central nervous system (CNS) has natural barriers and immunological protective mechanisms, such as the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB), that prevent the invasion of pathogens. Bacteria enter the CNS, for example, through transcellular penetration, paracellular entry or via infected l...
Source: Der Nervenarzt - January 23, 2023 Category: Neurology Authors: Eva Maria Craemer Source Type: research
Why do bat viruses keep infecting people?
Nature, Published online: 16 November 2022; doi:10.1038/d41586-022-03682-9Landmark study reveals ‘spillover’ mechanism for the rare but deadly Hendra virus. (Source: Nature AOP)
Source: Nature AOP - November 16, 2022 Category: Research Authors: Smriti Mallapaty Source Type: research
Sensors, Vol. 22, Pages 8707: Optical Beam Steerable Visible Light Communication (VLC) System Supporting Multiple Users Using RGB and Orthogonal Frequency Division Multiplexed (OFDM) Non-Orthogonal Multiple Access (NOMA)
-Hung Yeh
In order to achieve high-capacity visible light communication (VLC), five dimensions in physics, including frequency, time, quadrature modulation, space, and polarization can be utilized. Orthogonality should be maintained in order to reduce the crosstalk among different dimensions. In this work, we illustrate a high-capacity 21.01 Gbit/s optical beam steerable VLC system with vibration mitigation based on orthogonal frequency division multiplexed (OFDM) non-orthogonal multiple access (NOMA) signals using red, green, and blue (RGB) laser-diodes (LDs). The OFDM-NOMA can increase the spectral efficiency of VLC ...
Source: Sensors - November 11, 2022 Category: Biotechnology Authors: Wahyu Hendra Gunawan Chi-Wai Chow Yang Liu Yun-Han Chang Chien-Hung Yeh Tags: Article Source Type: research
Structural Modeling of Adaptive Immune Responses to Infection
We present a method for high-throughput structural modeling of antibodies or TCRs using Repertoire Builder and its extensions. AbAdapt is an extension of Repertoire Builder for antibody-antigen docking from antibody and antigen sequences. ImmuneScape is a corresponding extension for TCR-pMHC 3D modeling. Together, these pipelines can help researchers to understand immune responses to infection from a structural point of view.PMID:36346598 | DOI:10.1007/978-1-0716-2609-2_15 (Source: Mol Biol Cell)
Source: Mol Biol Cell - November 8, 2022 Category: Molecular Biology Authors: Tina Lusiany Zichang Xu Dianita S Saputri Hendra S Ismanto Sedat Aybars Nazlica Daron M Standley Source Type: research
Knowledge and Attitudes of Indonesian General Practitioners Towards the Isoniazid Preventive Therapy Program in Indonesia
CONCLUSIONS: In general, GPs in Indonesia had favorable attitudes toward IPT. However, their knowledge of IPT was limited. GPs are an essential element of the IPT program in the country, and therefore, adequate information dissemination to improve their understanding is critical for the long-term viability and quality of the IPT program in Indonesia.PMID:36229905 | PMC:PMC9561141 | DOI:10.3961/jpmph.22.248 (Source: Journal of Preventive Medicine and Public Health)
Source: Journal of Preventive Medicine and Public Health - October 14, 2022 Category: International Medicine & Public Health Authors: Wira Winardi Widhy Yudistira Nalapraya Sarifuddin Sarifuddin Samsul Anwar Amanda Yufika Adityo Wibowo Iziddin Fadhil Hendra Wahyuni Ms Yunita Arliny Dewi Behtri Yanifitri Teuku Zulfikar Harapan Harapan Source Type: research
