Comparing situational influences on differential healthcare utilization trajectories in patients on home palliative care: A qualitative study
Palliat Support Care. 2024 Feb 1:1-8. doi: 10.1017/S1478951524000014. Online ahead of print.ABSTRACTOBJECTIVES: Patients with terminal cancer receiving home palliative care present differential healthcare utilization trajectories before death. It remains unclear which situational elements influence these trajectories among disparate patient groups. The aim of this study was to compare situational influences on "persistently high" and "low stable" trajectories of healthcare utilization in patients who received palliative care support at home.METHODS: Bereaved family caregivers were recruited from our prior quantitative stud...
Source: Palliative and Supportive Care - February 1, 2024 Category: Palliative Care Authors: Sungwon Yoon Hendra Goh Zhi Zheng Yeo Grace Meijuan Yang Poh Heng Chong Qingyuan Zhuang Source Type: research
Viruses, Vol. 16, Pages 195: Structural Studies of Henipavirus Glycoproteins
rya
Henipaviruses are a genus of emerging pathogens that includes the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of disease. Henipaviruses rely on two surface glycoproteins, known as the attachment and fusion proteins, to facilitate entry into host cells. As new and divergent members of the genus have been discovered and structurally characterized, key differences and similarities have been noted. This review surveys the available structural information on Henipavirus glycoproteins, complementing this with information from related biophysical and structural studies of the broader Paramyxo...
Source: Viruses - January 27, 2024 Category: Virology Authors: Aaron J. May Priyamvada Acharya Tags: Review Source Type: research
Beyond invasive biopsies: using VASARI MRI features to predict grade and molecular parameters in gliomas
Gliomas present a significant economic burden and patient management challenge. The 2021 WHO classification incorporates molecular parameters, which guide treatment decisions. However, acquiring these molecula... (Source: Cancer Imaging)
Source: Cancer Imaging - January 2, 2024 Category: Radiology Authors: Nurhuda Hendra Setyawan, Lina Choridah, Hanung Adi Nugroho, Rusdy Ghazali Malueka and Ery Kus Dwianingsih Tags: Research article Source Type: research
Viruses, Vol. 15, Pages 2421: Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies
In this study, we present refined structural models of NIEA fragment antigen-binding region (Fab)–NTD complexes, supported by molecular dynamics simulations and hydrogen–deuterium exchange mass spectrometry (HDX-MS). Furthermore, we provide direct evidence confirming the crosslinking of spike NTDs by NIEAs. Collectively, our findings advance our understanding of the molecular mechanisms underlying NIEAs and their impact on SARS-CoV-2 infection. (Source: Viruses)
Source: Viruses - December 13, 2023 Category: Virology Authors: Tina Lusiany Tohru Terada Jun-ichi Kishikawa Mika Hirose David Virya Chen Fuminori Sugihara Hendra Saputra Ismanto Floris J. van Eerden Songling Li Takayuki Kato Hisashi Arase Matsuura Yoshiharu Masato Okada Daron M. Standley Tags: Article Source Type: research
Viruses, Vol. 15, Pages 2407: Recently Emerged Novel Henipa-like Viruses: Shining a Spotlight on the Shrew
rds
Henipaviruses are zoonotic viruses, including some highly pathogenic and capable of serious disease and high fatality rates in both animals and humans. Hendra virus and Nipah virus are the most notable henipaviruses, resulting in significant outbreaks across South Asia, South-East Asia, and Australia. Pteropid fruit bats have been identified as key zoonotic reservoirs; however, the increased discovery of henipaviruses outside the geographic distribution of Pteropid fruit bats and the detection of novel henipa-like viruses in other species such as the shrew, rat, and opossum suggest that Pteropid bats are not the so...
Source: Viruses - December 11, 2023 Category: Virology Authors: Sarah Caruso Sarah J. Edwards Tags: Review Source Type: research
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how H... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 10, 2023 Category: Allergy & Immunology Authors: Kristian Barry, Christopher Harpur, Maggie Lam, Michelle D. Tate and Ashley Mansell Tags: Research Source Type: research
Viruses, Vol. 15, Pages 2048: A Survey of Henipavirus Tropism & mdash;Our Current Understanding from a Species/Organ and Cellular Level
Viruses, Vol. 15, Pages 2048: A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
Viruses doi: 10.3390/v15102048
Authors:
Sandra Diederich
Shawn Babiuk
Hani Boshra
Henipaviruses are single-stranded RNA viruses that have been shown to be virulent in several species, including humans, pigs, horses, and rodents. Isolated nearly 30 years ago, these viruses have been shown to be of particular concern to public health, as at least two members (Nipah and Hendra viruses) are highly virulent, as well as zoonotic, and are thus classified as BSL4 pathogens. Although ...
Source: Viruses - October 4, 2023 Category: Virology Authors: Sandra Diederich Shawn Babiuk Hani Boshra Tags: Review Source Type: research
Sensors, Vol. 23, Pages 8224: A Deep-Learning-Based Secure Routing Protocol to Avoid Blackhole Attacks in VANETs
eongku An
Vehicle ad hoc networks (VANETs) are a vital part of intelligent transportation systems (ITS), offering a variety of advantages from reduced traffic to increased road safety. Despite their benefits, VANETs remain vulnerable to various security threats, including severe blackhole attacks. In this paper, we propose a deep-learning-based secure routing (DLSR) protocol using a deep-learning-based clustering (DLC) protocol to establish a secure route against blackhole attacks. The main features and contributions of this paper are as follows. First, the DLSR protocol utilizes deep learning (DL) at each node to choo...
Source: Sensors - October 2, 2023 Category: Biotechnology Authors: Amalia Amalia Yushintia Pramitarini Ridho Hendra Yoga Perdana Kyusung Shim Beongku An Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1980: Animal Models for Henipavirus Research
olsey
Hendra virus (HeV) and Nipah virus (NiV) are zoonotic paramyxoviruses in the genus Henipavirus (HNV) that emerged nearly thirty years ago. Outbreaks of HeV and NiV have led to severe respiratory disease and encephalitis in humans and animals characterized by a high mortality rate. Despite the grave threat HNVs pose to public health and global biosecurity, no approved medical countermeasures for human use currently exist against HeV or NiV. To develop candidate vaccines and therapeutics and advance the field’s understanding of HNV pathogenesis, animal models of HeV and NiV have been instrumental and ...
Source: Viruses - September 22, 2023 Category: Virology Authors: Declan D. Pigeaud Thomas W. Geisbert Courtney Woolsey Tags: Review Source Type: research
Characteristics of Biofilm-Forming Ability and Antibiotic Resistance of < em > Cutibacterium acnes < /em > and < em > Staphylococcus epidermidis < /em > from Acne Vulgaris Patients
CONCLUSION: There were no significant differences in resistance against seven antibiotics between the C. acnes and S. epidermidis in BF and NBF groups. Furthermore, although statistically not significant, some resistances were observed against clindamycin, erythromycin, and azithromycin. Consequently, the use of these three antibiotics should be judiciously regulated.PMID:37719934 | PMC:PMC10503511 | DOI:10.2147/CCID.S422486 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - September 18, 2023 Category: Dermatology Authors: Kartika Ruchiatan Trustia Rizqandaru Panji Respati Satjamanggala Nisrina Tache Adi Imam Cahyadi Andri Rezano Hendra Gunawan Eva Krishna Sutedja Reiva Farah Dwiyana Risa Miliawati Nurul Hidayah Pati Aji Achdiat Endang Sutedja Oki Suwarsa Reti Hindritiani Source Type: research
Sensors, Vol. 23, Pages 7960: DLSMR: Deep Learning-Based Secure Multicast Routing Protocol against Wormhole Attack in Flying Ad Hoc Networks with Cell-Free Massive Multiple-Input Multiple-Output
ngku An
The network area is extended from ground to air. In order to efficiently manage various kinds of nodes, new network paradigms are needed such as cell-free massive multiple-input multiple-output (CF-mMIMO). Additionally, security is also considered as one of the important quality-of-services (QoS) parameters in future networks. Thus, in this paper, we propose a novel deep learning-based secure multicast routing protocol (DLSMR) in flying ad hoc networks (FANETs) with cell-free massive MIMO (CF-mMIMO). We consider the problem of wormhole attacks in the multicast routing process. To tackle this problem, we propose...
Source: Sensors - September 18, 2023 Category: Biotechnology Authors: Yushintia Pramitarini Ridho Hendra Yoga Perdana Kyusung Shim Beongku An Tags: Article Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
Sensors, Vol. 23, Pages 7653: Secrecy Performance Analysis of Cooperative Multihop Transmission for WSNs under Eavesdropping Attacks
ngku An
Multihop transmission is one of the important techniques to overcome the transmission coverage of each node in wireless sensor networks (WSNs). However, multihop transmission has a security issue due to the nature of a wireless medium. Additionally, the eavesdropper also attempts to interrupt the legitimate users&rsquo; transmission. Thus, in this paper, we study the secrecy performance of a multihop transmission under various eavesdropping attacks for WSNs. To improve the secrecy performance, we propose two node selection schemes in each cluster, namely, minimum node selection (MNS) and optimal node se...
Source: Sensors - September 4, 2023 Category: Biotechnology Authors: Yosefine Triwidyastuti Ridho Hendra Yoga Perdana Kyusung Shim Beongku An Tags: Article Source Type: research
Prognostic factors for the outcomes of COVID-19 patients infected with SARS-CoV-2 Omicron and Delta variants
The SARS-CoV-2 Omicron variant has replaced the previously dominant Delta variant because of high transmissibility. However, studies on the impact of the Omicron variant on the severity of COVID-19 are still l... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - August 29, 2023 Category: Genetics & Stem Cells Authors: Gunadi, Mohamad Saifudin Hakim, Hendra Wibawa, Khanza Adzkia Vujira, Dyah Ayu Puspitarani, Endah Supriyati, Ika Trisnawati, Kristy Iskandar, Riat El Khair, Afiahayati, Siswanto, Yunika Puspadewi, Sri Handayani Irianingsih, Dwi Aris Agung Nugrahaningsih, L Tags: Research Source Type: research
